WO1999041413A3 - Prostate cancer drug screening - Google Patents

Prostate cancer drug screening Download PDF

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Publication number
WO1999041413A3
WO1999041413A3 PCT/US1999/003117 US9903117W WO9941413A3 WO 1999041413 A3 WO1999041413 A3 WO 1999041413A3 US 9903117 W US9903117 W US 9903117W WO 9941413 A3 WO9941413 A3 WO 9941413A3
Authority
WO
WIPO (PCT)
Prior art keywords
prostate cancer
drug screening
cancer drug
compounds
cell line
Prior art date
Application number
PCT/US1999/003117
Other languages
French (fr)
Other versions
WO1999041413A2 (en
Inventor
Daniel R Henderson
Henry G Lamparski
Eric R Schuur
De Chao Yu
Original Assignee
Calydon Inc
Daniel R Henderson
Henry G Lamparski
Eric R Schuur
De Chao Yu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calydon Inc, Daniel R Henderson, Henry G Lamparski, Eric R Schuur, De Chao Yu filed Critical Calydon Inc
Priority to AU32924/99A priority Critical patent/AU3292499A/en
Publication of WO1999041413A2 publication Critical patent/WO1999041413A2/en
Publication of WO1999041413A3 publication Critical patent/WO1999041413A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Screening of compounds for activity toward inhibition of prostate cancer cell proliferation is provided. A cell line is employed which can be used in conventional equipment for determining activity of compounds, where the cell line uses a marker whose expression is responsive to therapeutically active compounds.
PCT/US1999/003117 1998-02-12 1999-02-11 Prostate cancer drug screening WO1999041413A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU32924/99A AU3292499A (en) 1998-02-12 1999-02-11 Prostate cancer drug screening

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2273298A 1998-02-12 1998-02-12
US09/022,732 1998-02-12

Publications (2)

Publication Number Publication Date
WO1999041413A2 WO1999041413A2 (en) 1999-08-19
WO1999041413A3 true WO1999041413A3 (en) 1999-11-11

Family

ID=21811137

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/003117 WO1999041413A2 (en) 1998-02-12 1999-02-11 Prostate cancer drug screening

Country Status (2)

Country Link
AU (1) AU3292499A (en)
WO (1) WO1999041413A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019434A1 (en) * 1994-01-13 1995-07-20 Calydon, Inc. Tissue-specific enhancer active in prostate
WO1998005797A1 (en) * 1996-08-06 1998-02-12 Cell Genesys, Inc. Prostate cancer drug screening
WO1999006576A1 (en) * 1997-08-04 1999-02-11 Calydon, Inc. A human glandular kallikrein enhancer, vectors comprising the enhancer and methods of use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019434A1 (en) * 1994-01-13 1995-07-20 Calydon, Inc. Tissue-specific enhancer active in prostate
WO1998005797A1 (en) * 1996-08-06 1998-02-12 Cell Genesys, Inc. Prostate cancer drug screening
WO1999006576A1 (en) * 1997-08-04 1999-02-11 Calydon, Inc. A human glandular kallikrein enhancer, vectors comprising the enhancer and methods of use thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
MURTHA P ET AL: "ANDROGEN INDUCTION OF A HUMAN PROSTATE-SPECIFIC KALLIKREIN, HKLK2: CHARACTERIZATION OF AN ANDROGEN RESPONSE ELEMENT IN THE 5' PROMOTER REGION OF THE GENE", BIOCHEMISTRY, vol. 32, no. 25, 1 January 1993 (1993-01-01), pages 6459 - 6464, XP002050777, ISSN: 0006-2960 *
PANG S ET AL.: "Prostate tissue specificity of the prostate-specific antigen promotor isolated from a patient with prostate cancer", HUMAN GENE THERAPY, vol. 6, 1995, pages 1417 - 1426, XP002115547 *
RIEGMAN P H J ET AL: "THE PROMOTER OF THE PROSTATE-SPECIFIC ANTIGEN GENE CONTAINS A FUNCTIONAL ANDROGEN RESPONSIVE ELEMENT", MOLECULAR ENDOCRINOLOGY, vol. 5, no. 12, 1 December 1991 (1991-12-01), pages 1921 - 1930, XP002039278, ISSN: 0888-8809 *
SCHUUR E R ET AL: "PROSTATE-SPECIFIC ANTIGEN EXPRESSION IS REGULATED BY AN UPSTREAM ENHANCER", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 12, 22 March 1996 (1996-03-22), pages 7043 - 7051, XP002050776, ISSN: 0021-9258 *
WEI C ET AL.: "Regulation of human prostate-specific antigen gene expression in transgenic mice: Evidence fo an enhancer between the PSA and human glandular kallikrein-1 genes", INTERNATIONAL JOURNAL OF MEDICINE, vol. 2, 1998, pages 487 - 496, XP002115548 *
WILLIAMS T M ET AL: "ADVANTAGES OF FIREFLY LUCIFERASE AS A REPORTER GENE: APPLICATION TO THE INTERLEUKIN-2 GENE PROMOTER", ANALYTICAL BIOCHEMISTRY, vol. 176, no. 1, 1 January 1989 (1989-01-01), pages 28 - 32, XP000601607, ISSN: 0003-2697 *
YU D-C ET AL.: "Identification of the transcriptional regulatory sequences of human kallikrein 2 and their use in the construction of Calydon vris 764, an attenuated replication competent adenovirus for prostate cancer therapy", CANCER RESEARCH, vol. 59, 1999, pages 1498 - 1504, XP002115549 *

Also Published As

Publication number Publication date
WO1999041413A2 (en) 1999-08-19
AU3292499A (en) 1999-08-30

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