WO1999040924A3 - Treatment of neurodegeneration - Google Patents

Treatment of neurodegeneration Download PDF

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Publication number
WO1999040924A3
WO1999040924A3 PCT/IB1999/000246 IB9900246W WO9940924A3 WO 1999040924 A3 WO1999040924 A3 WO 1999040924A3 IB 9900246 W IB9900246 W IB 9900246W WO 9940924 A3 WO9940924 A3 WO 9940924A3
Authority
WO
WIPO (PCT)
Prior art keywords
neurodegeneration
treatment
aggregate
cerebrovascular disorder
neuromodulators
Prior art date
Application number
PCT/IB1999/000246
Other languages
French (fr)
Other versions
WO1999040924A2 (en
Inventor
Barneo Jose Lopez
Butron De Mugica Jose Armengol
Laseca Rafael Jesus Montoro
Espejo Emilio Fernandez
Original Assignee
Univ Seville
Barneo Jose Lopez
Butron De Mugica Jose Armengol
Laseca Rafael Jesus Montoro
Espejo Emilio Fernandez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Seville, Barneo Jose Lopez, Butron De Mugica Jose Armengol, Laseca Rafael Jesus Montoro, Espejo Emilio Fernandez filed Critical Univ Seville
Publication of WO1999040924A2 publication Critical patent/WO1999040924A2/en
Publication of WO1999040924A3 publication Critical patent/WO1999040924A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ophthalmology & Optometry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

An isolated aggregate of hypoxia sensitive cells that release one or more neurotransmitters, neuromodulators or enzymes is provided characterised in that the aggregate is dimensioned such as to be capable of surviving, preferably for 3 months or more, in a host brain suffering from neurodegeneration or cerebrovascular disorder while substantially reversing some or all of the symptoms of that neurodegeneration or cerebrovascular disorder.
PCT/IB1999/000246 1998-02-11 1999-02-11 Treatment of neurodegeneration WO1999040924A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES9800313 1998-02-11
ES009800313A ES2145694B1 (en) 1998-02-11 1998-02-11 INSULATION METHOD OF A CELLULAR ADDED AND RESULTING CELLULAR AGGREGATE.

Publications (2)

Publication Number Publication Date
WO1999040924A2 WO1999040924A2 (en) 1999-08-19
WO1999040924A3 true WO1999040924A3 (en) 1999-11-25

Family

ID=8302792

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1999/000246 WO1999040924A2 (en) 1998-02-11 1999-02-11 Treatment of neurodegeneration

Country Status (2)

Country Link
ES (1) ES2145694B1 (en)
WO (1) WO1999040924A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2578165A1 (en) * 2011-10-08 2013-04-10 Martin Ivanov Denev Method for stopping aging of the body by replacing of the old biocathode centers by young biocathode centers

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BARINAGA M.: "Unusual cells may help treat Parkinson 's disease.", SCIENCE, (27 FEB 1998) 279/5355 (1301)., XP002116912 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; MOKRY J: "Parkinson 's disease: contemporary state and perspectives.", XP002116914, retrieved from STN Database accession no. 95281952 *
ESPEJO E F ET AL: "Cellular and functional recovery of Parkinsonian rats after intrastriatal transplantation of carotid body cell aggregates.", NEURON, (1998 FEB) 20 (2) 197-206., XP002116911 *
ESPEJO E. ET AL.: "Recovery of Parkinsonian rats after intrastriatal transplantation of carotid bdy cell aggregates", EUROPEAN JOURNAL OF NEUROSCIENCE, vol. 10, no. suppl 10, April 1998 (1998-04-01), pages 13104, XP002116913 *
SBORNIK VEDECKYCH PRACI LEKARSKE FAKULTY KARLOVY UNIVERZITY V HRADCI KRALOVE, (1994) 37 (1) 5-12 *

Also Published As

Publication number Publication date
ES2145694B1 (en) 2001-02-01
ES2145694A1 (en) 2000-07-01
WO1999040924A2 (en) 1999-08-19

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