WO1999040882A3 - STEREOSELECTIVE Tc-99m LIGANDS - Google Patents

STEREOSELECTIVE Tc-99m LIGANDS Download PDF

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Publication number
WO1999040882A3
WO1999040882A3 PCT/US1999/002513 US9902513W WO9940882A3 WO 1999040882 A3 WO1999040882 A3 WO 1999040882A3 US 9902513 W US9902513 W US 9902513W WO 9940882 A3 WO9940882 A3 WO 9940882A3
Authority
WO
WIPO (PCT)
Prior art keywords
tcvo
formulae
compounds
complexes
ligands
Prior art date
Application number
PCT/US1999/002513
Other languages
French (fr)
Other versions
WO1999040882A2 (en
Inventor
Hank F Kung
Mei-Ping Kung
Zhi-Ping Zhuang
Original Assignee
Univ Pennsylvania
Hank F Kung
Kung Mei Ping
Zhuang Zhi Ping
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania, Hank F Kung, Kung Mei Ping, Zhuang Zhi Ping filed Critical Univ Pennsylvania
Priority to AU40678/99A priority Critical patent/AU4067899A/en
Publication of WO1999040882A2 publication Critical patent/WO1999040882A2/en
Publication of WO1999040882A3 publication Critical patent/WO1999040882A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3

Abstract

The present invention concerns novel ligands, represented by Formulae (I), (II), (I') and (II'), that form complexes with a radioactive metal through a chelate bond. The complexes are useful in radiodiagnostic compositions employed for imaging. In said formulae, X, R?1 and R2, R3 and R4, R5 and R6¿, m and n are defined herein. The compounds of the invention avoid the formation of diastereomers based on incorporating [TcvO]+3N2S2 as a chelating moiety since these compounds form only one isomer when complexed with [?99mTc][TcvO]+¿.
PCT/US1999/002513 1998-02-06 1999-02-05 STEREOSELECTIVE Tc-99m LIGANDS WO1999040882A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU40678/99A AU4067899A (en) 1998-02-06 1999-02-05 Stereoselective tc-99m ligands

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7395798P 1998-02-06 1998-02-06
US60/073,957 1998-02-06
US7805298P 1998-03-16 1998-03-16
US60/078,052 1998-03-16

Publications (2)

Publication Number Publication Date
WO1999040882A2 WO1999040882A2 (en) 1999-08-19
WO1999040882A3 true WO1999040882A3 (en) 1999-11-04

Family

ID=26755097

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/002513 WO1999040882A2 (en) 1998-02-06 1999-02-05 STEREOSELECTIVE Tc-99m LIGANDS

Country Status (2)

Country Link
AU (1) AU4067899A (en)
WO (1) WO1999040882A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4883862A (en) * 1988-04-13 1989-11-28 Albert Einstein College Of Medicine - Of Yeshiva University Mercaptosuccinyl glycyl-glycyl-glycine a complex thereof with Tc-99m, and methods of making the same
US5279811A (en) * 1987-02-18 1994-01-18 The Du Pont Merck Pharmaceutical Company Ester-substituted diaminedithiols and radiolabeled complexes thereof
WO1994022494A1 (en) * 1993-03-30 1994-10-13 The Du Pont Merck Pharmaceutical Company RADIOLABELED PLATELET GPIIb/IIIa RECEPTOR ANTAGONISTS AS IMAGING AGENTS FOR THE DIAGNOSIS OF THROMBOEMBOLIC DISORDERS

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5279811A (en) * 1987-02-18 1994-01-18 The Du Pont Merck Pharmaceutical Company Ester-substituted diaminedithiols and radiolabeled complexes thereof
US4883862A (en) * 1988-04-13 1989-11-28 Albert Einstein College Of Medicine - Of Yeshiva University Mercaptosuccinyl glycyl-glycyl-glycine a complex thereof with Tc-99m, and methods of making the same
WO1994022494A1 (en) * 1993-03-30 1994-10-13 The Du Pont Merck Pharmaceutical Company RADIOLABELED PLATELET GPIIb/IIIa RECEPTOR ANTAGONISTS AS IMAGING AGENTS FOR THE DIAGNOSIS OF THROMBOEMBOLIC DISORDERS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KASINA S, ET AL.: "TISSUE DISTRIBUTION PROPERTIES OF TECHNETIUM-99M-DIAMIDE-DIMERCAPTIDE COMPLEXES AND POTENTIAL USE A RENAL RADIOPHARMACEUTICALS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 29, no. 10, 1 May 1986 (1986-05-01), US, pages 1933 - 1940, XP002921580, ISSN: 0022-2623, DOI: 10.1021/jm00160a023 *

Also Published As

Publication number Publication date
AU4067899A (en) 1999-08-30
WO1999040882A2 (en) 1999-08-19

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