WO1999036560A3 - Viral vectors encoding neurofilament light proteins and their use - Google Patents

Viral vectors encoding neurofilament light proteins and their use Download PDF

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Publication number
WO1999036560A3
WO1999036560A3 PCT/CA1999/000008 CA9900008W WO9936560A3 WO 1999036560 A3 WO1999036560 A3 WO 1999036560A3 CA 9900008 W CA9900008 W CA 9900008W WO 9936560 A3 WO9936560 A3 WO 9936560A3
Authority
WO
WIPO (PCT)
Prior art keywords
neurofilament light
viral vectors
vectors encoding
light proteins
proteins
Prior art date
Application number
PCT/CA1999/000008
Other languages
French (fr)
Other versions
WO1999036560A2 (en
Inventor
Jean-Pierre Julien
Claude Gravel
Jurgen Meier
Original Assignee
Julien Jean Pierre
Claude Gravel
Jurgen Meier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Julien Jean Pierre, Claude Gravel, Jurgen Meier filed Critical Julien Jean Pierre
Priority to AU19565/99A priority Critical patent/AU1956599A/en
Publication of WO1999036560A2 publication Critical patent/WO1999036560A2/en
Publication of WO1999036560A3 publication Critical patent/WO1999036560A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Abstract

Novel viral vectors encoding neurofilament light proteins are described. The invention also provides methods of using these vectors in gene therapy to deliver neurofilament light proteins to subjects having neurodegenerative diseases, neural injuries, and neural degeneration due to aging.
PCT/CA1999/000008 1998-01-13 1999-01-13 Viral vectors encoding neurofilament light proteins and their use WO1999036560A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU19565/99A AU1956599A (en) 1998-01-13 1999-01-13 Viral vectors encoding neurofilament light proteins and their use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA2220839 1998-01-13
CA2,220,839 1998-01-13

Publications (2)

Publication Number Publication Date
WO1999036560A2 WO1999036560A2 (en) 1999-07-22
WO1999036560A3 true WO1999036560A3 (en) 1999-09-30

Family

ID=4161756

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1999/000008 WO1999036560A2 (en) 1998-01-13 1999-01-13 Viral vectors encoding neurofilament light proteins and their use

Country Status (2)

Country Link
AU (1) AU1956599A (en)
WO (1) WO1999036560A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018317807A1 (en) * 2017-08-16 2020-02-06 Roxiant ApS VTFT isoform of a BPIFB4 protein for use in neuronal diseases and injuries

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994008026A1 (en) * 1992-09-25 1994-04-14 Rhone-Poulenc Rorer S.A. Adenovirus vectors for the transfer of foreign genes into cells of the central nervous system, particularly in brain

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994008026A1 (en) * 1992-09-25 1994-04-14 Rhone-Poulenc Rorer S.A. Adenovirus vectors for the transfer of foreign genes into cells of the central nervous system, particularly in brain

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BETT ET AL: "DNA sequence of the deletion/insertion in early region 3 of Ad5 dl309", VIRUS RESEARCH, vol. 39, no. 1, 1995, pages 75 - 82, XP002106222 *
JACOBS ET AL: "Recovery of Neurofilament Expression Selectively in Regenerating Reticulospinal Neurons", JOURNAL OF NEUROSCIENCE, vol. 17, no. 13, 1 July 1997 (1997-07-01), pages 5206 - 5220, XP002106229 *
KARPATI ET AL: "The principles of gene therapy for the nervous system", TRENDS IN NEUROSCIENCE, vol. 19, 1996, pages 49 - 54, XP002106220 *
MEIER J (REPRINT) ET AL: "In vivo alleviation of neurofilament swellings by viral mediated gene transfer.", MOLECULAR BIOLOGY OF THE CELL, (DEC 1996) VOL. 7, SUPP. [S], PP. 1263-1263A, XP002106218 *
ZHU ET AL: "Delayed Maturation of Regenerating Myelinated Axons in Mice Lacking Neurofilaments", EXPERIMENTAL NEUROLOGY, vol. 148, 1997, pages 299 - 316, XP002106228 *

Also Published As

Publication number Publication date
AU1956599A (en) 1999-08-02
WO1999036560A2 (en) 1999-07-22

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