WO1999036441A3 - Haemopoietic stem cell inhibitor(s) - Google Patents

Haemopoietic stem cell inhibitor(s) Download PDF

Info

Publication number
WO1999036441A3
WO1999036441A3 PCT/EP1999/000318 EP9900318W WO9936441A3 WO 1999036441 A3 WO1999036441 A3 WO 1999036441A3 EP 9900318 W EP9900318 W EP 9900318W WO 9936441 A3 WO9936441 A3 WO 9936441A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
protein
stem cell
cell inhibitor
haemopoietic stem
Prior art date
Application number
PCT/EP1999/000318
Other languages
French (fr)
Other versions
WO1999036441A2 (en
Inventor
Eckart Wunder
Philipp Henon
Original Assignee
Telistar International
Eckart Wunder
Philipp Henon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telistar International, Eckart Wunder, Philipp Henon filed Critical Telistar International
Priority to AU30269/99A priority Critical patent/AU3026999A/en
Publication of WO1999036441A2 publication Critical patent/WO1999036441A2/en
Publication of WO1999036441A3 publication Critical patent/WO1999036441A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A protein or proteins contained in a supernatant inhibiting recruitment of haemopoietic progenitor or stem cells, preferably of the myeloid lineages, is described. Furthermore, a process for the preparation of the protein or proteins in the supernatant and the enrichment of such an acidic protein or proteins by means of affinity and ion exchange chromatography and an assay to determine the activity of such an acidic protein or such acidic proteins are disclosed.
PCT/EP1999/000318 1998-01-17 1999-01-18 Haemopoietic stem cell inhibitor(s) WO1999036441A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU30269/99A AU3026999A (en) 1998-01-17 1999-01-18 Inhibition of cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98100779.2 1998-01-17
EP98100779 1998-01-17

Publications (2)

Publication Number Publication Date
WO1999036441A2 WO1999036441A2 (en) 1999-07-22
WO1999036441A3 true WO1999036441A3 (en) 1999-10-28

Family

ID=8231275

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/000318 WO1999036441A2 (en) 1998-01-17 1999-01-18 Haemopoietic stem cell inhibitor(s)

Country Status (2)

Country Link
AU (1) AU3026999A (en)
WO (1) WO1999036441A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988005788A1 (en) * 1987-01-30 1988-08-11 Techne Corporation Tranforming growth factor-beta
WO1989010133A1 (en) * 1988-04-21 1989-11-02 Cancer Research Campaign Technology Limited Stem cell inhibitors
WO1996022693A1 (en) * 1995-01-24 1996-08-01 The Board Of Regents Of The University Of Texas System Self-renewing pluripotent hematopoietic stem cell compositions, methods of use, and culture systems therefor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988005788A1 (en) * 1987-01-30 1988-08-11 Techne Corporation Tranforming growth factor-beta
WO1989010133A1 (en) * 1988-04-21 1989-11-02 Cancer Research Campaign Technology Limited Stem cell inhibitors
WO1996022693A1 (en) * 1995-01-24 1996-08-01 The Board Of Regents Of The University Of Texas System Self-renewing pluripotent hematopoietic stem cell compositions, methods of use, and culture systems therefor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MOORE M A: "Review: Stratton Lecture 1990. Clinical implications of positive and negative hematopoietic stem cell regulators.", BLOOD, (1991 JUL 1) 78 (1) 1-19. REF: 139 JOURNAL CODE: A8G. ISSN: 0006-4971., United States, XP002104510 *
QUESADA, S. ET AL.: "FUNCTIONAL AND BIOCHEMICAL CHARACTERISTICS OF A SOLUBLE B-LYMPHOCYTE PROLIFERATION-INHIBITING ACTIVITY ....", CELLULAR IMMONOLOGY, vol. 162, no. 2, May 1995 (1995-05-01), pages 275 - 281, XP002104511 *

Also Published As

Publication number Publication date
AU3026999A (en) 1999-08-02
WO1999036441A2 (en) 1999-07-22

Similar Documents

Publication Publication Date Title
Morgan et al. Exol and Exo2 proteins stimulate calcium-dependent exocytosis in permeabilized adrenal chromaff in cells
Yin et al. Human liver alcohol dehydrogenase: purification and kinetic characterization of the. beta. 2. beta. 2,. beta. 2. beta. 1,. alpha.. beta. 2, and. beta. 2. gamma. 1" Oriental" isoenzymes
Parsons et al. p60c-src activity detected in the chromaffin granule membrane
Takazawa et al. Cloning and expression in Escherichia coli of a rat brain cDNA encoding a Ca2+/calmodulin-sensitive inositol 1, 4, 5-trisphosphate 3-kinase
WO1997036916B1 (en) dUTPASE, ITS ISOFORMS, AND DIAGNOSTIC AND OTHER USES
Takahashi et al. In vivo glycation of aldehyde reductase, a major 3-deoxyglucosone reducing enzyme: identification of glycation sites
IE852913L (en) Purifying proteins
von BAHR‐LINDSTRÖM et al. The cytoplasmic isoenzyme of horse liver aldehyde dehydrogenase: relationship to the corresponding human isoenzyme
NZ296748A (en) Peripheral nervous system specific sodium channel proteins, DNA coding therefor, compositions and methods
WO1995028487A3 (en) Recombinant pgp3, methods of preparation and use in diagnosis and therapy
Matsuoka et al. Covalent structure of bovine brain calreticulin
Strunk et al. Complement biosynthesis in vitro by rat hepatoma cell strains
Flschhr-Colbrle et al. Bovine chromaffin granules: immunological studies with antisera against neuropeptide Y,[Met] enkephalin and bombesin
WO1999025878A3 (en) Methods for modulating and identifying cellular senescence
Pilkis et al. Active site sequence of hepatic fructose-2, 6-bisphosphatase. Homology in primary structure with phosphoglycerate mutase.
Nishigaki et al. Purification of aromatic L-amino acid decarboxylase from bovine brain with a monoclonal antibody
Cook Subunit interactions in aspartate transcarbamylase
CA2306820A1 (en) Improved methods for producing factor viii proteins
HENSCHEN et al. Novel structure elucidation strategy for genetically abnormal fibrinogens with incomplete fibrinopeptide release as applied to fibrinogen Schwarzach
WO1999036441A3 (en) Haemopoietic stem cell inhibitor(s)
Tanada et al. Interaction of initiator Met-tRNAfMet (Escherichia coli) and Gly-tRNA1Gly (Staphylococcus epidermidis) with bacterial elongation factor Tu: GTP complex
ES8900018A1 (en) Rennin- and acid proteases-inhibitor peptidic amino alcohol derivatives, preparation process thereof and therapeutical application thereof.
Tojo et al. Purification of intracellular phospholipase A2 from rat spleen supernatant by reverse-phase high-performance liquid chromatography
EP0152346A3 (en) Method for purifying gamma-interferon
Kunio et al. Separation of human renin substrate from renin and a major contaminating albumin using a concanavalin A-Sepharose column

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AT AU BR CA CH CN CZ DE DK ES FI GB HU IL IS JP KR LU MX NO NZ PL PT RU SE SG US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AT AU BR CA CH CN CZ DE DK ES FI GB HU IL IS JP KR LU MX NO NZ PL PT RU SE SG US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)

Free format text: (EXCEPT EA (RU))

NENP Non-entry into the national phase

Ref country code: KR

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: CA