WO1999035169A3 - Methods and compositions for treating and diagnosing insulin related disorders - Google Patents

Methods and compositions for treating and diagnosing insulin related disorders Download PDF

Info

Publication number
WO1999035169A3
WO1999035169A3 PCT/US1999/000471 US9900471W WO9935169A3 WO 1999035169 A3 WO1999035169 A3 WO 1999035169A3 US 9900471 W US9900471 W US 9900471W WO 9935169 A3 WO9935169 A3 WO 9935169A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compositions
treating
related disorders
insulin related
Prior art date
Application number
PCT/US1999/000471
Other languages
French (fr)
Other versions
WO1999035169A9 (en
WO1999035169A2 (en
Inventor
William Clifford Duckworth
Frederick G Hamel
Original Assignee
William Clifford Duckworth
Frederick G Hamel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by William Clifford Duckworth, Frederick G Hamel filed Critical William Clifford Duckworth
Priority to CA002317674A priority Critical patent/CA2317674A1/en
Priority to AU23138/99A priority patent/AU2313899A/en
Priority to EP99903019A priority patent/EP1045860A2/en
Priority to JP2000527564A priority patent/JP2002500234A/en
Priority to BR9906833-8A priority patent/BR9906833A/en
Publication of WO1999035169A2 publication Critical patent/WO1999035169A2/en
Publication of WO1999035169A3 publication Critical patent/WO1999035169A3/en
Publication of WO1999035169A9 publication Critical patent/WO1999035169A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to methods and compositions for treating or reducing the symptoms of a disorder of absolute or relative insulin deficiency, severe insulin resistance, of lipid accumulation or excess lipid synthesis, or of protein catabolism or degradation. The invention also includes methods for detecting and for assessing treatments of such disorders.
PCT/US1999/000471 1998-01-08 1999-01-08 Methods and compositions for treating and diagnosing insulin related disorders WO1999035169A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002317674A CA2317674A1 (en) 1998-01-08 1999-01-08 Methods and compositions for treating and diagnosing insulin related disorders
AU23138/99A AU2313899A (en) 1998-01-08 1999-01-08 Methods and compositions for treating and diagnosing insulin related disorders
EP99903019A EP1045860A2 (en) 1998-01-08 1999-01-08 Methods and compositions for treating and diagnosing insulin related disorders
JP2000527564A JP2002500234A (en) 1998-01-08 1999-01-08 Methods and compositions for treating and diagnosing insulin-related diseases
BR9906833-8A BR9906833A (en) 1998-01-08 1999-01-08 Processes and compositions to treat diagnosing insulin-related disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7082198P 1998-01-08 1998-01-08
US60/070,821 1998-01-08

Publications (3)

Publication Number Publication Date
WO1999035169A2 WO1999035169A2 (en) 1999-07-15
WO1999035169A3 true WO1999035169A3 (en) 1999-10-07
WO1999035169A9 WO1999035169A9 (en) 1999-11-11

Family

ID=22097585

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/000471 WO1999035169A2 (en) 1998-01-08 1999-01-08 Methods and compositions for treating and diagnosing insulin related disorders

Country Status (7)

Country Link
EP (1) EP1045860A2 (en)
JP (1) JP2002500234A (en)
CN (1) CN1292798A (en)
AU (1) AU2313899A (en)
BR (1) BR9906833A (en)
CA (1) CA2317674A1 (en)
WO (1) WO1999035169A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465714B2 (en) * 1999-11-05 2002-10-15 Arexis Ab Congenic animal models of non-insulin dependent diabetes mellitus
WO2006132530A2 (en) * 2005-01-31 2006-12-14 Leiden University Medical Center Methods and means for use in diagnostics and treatment of diabetes
JP2012507021A (en) * 2008-10-31 2012-03-22 ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング Methods and assays for classifying foods and / or beverages and / or diets and / or nutrition plans and / or drugs for effects on the cardiovascular system
EP2391377A2 (en) * 2009-02-02 2011-12-07 Ramot at Tel-Aviv University Ltd. Peptides, pharmaceutical compositions comprising same and uses thereof
WO2012017439A2 (en) 2010-08-04 2012-02-09 Ramot At Tel-Aviv University Ltd. Methods of treating autoimmune diseases of the central nervous system (cns) and neurodegenerative diseases
CN104961706B (en) * 2015-07-06 2017-03-01 成都知普莱生物医药科技有限公司 A kind of method of insulin synthesis degraded enzyme inhibitor ML345
CN115477686B (en) * 2022-09-22 2024-01-30 北海黑珍珠海洋生物科技有限公司 Pearl shell active peptide with whitening effect and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994023737A1 (en) * 1993-04-16 1994-10-27 Research Corporation Technologies, Inc. Methods and compositions for delaying or preventing the onset of autoimmune disease
WO1995023166A1 (en) * 1994-02-25 1995-08-31 Deakin Research Limited Synthetic inverso or retro-inverso t-cell epitopes
US5594100A (en) * 1995-02-22 1997-01-14 Regents Of The University Of Colorado Epitope for prevention of type I diabetes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994023737A1 (en) * 1993-04-16 1994-10-27 Research Corporation Technologies, Inc. Methods and compositions for delaying or preventing the onset of autoimmune disease
WO1995023166A1 (en) * 1994-02-25 1995-08-31 Deakin Research Limited Synthetic inverso or retro-inverso t-cell epitopes
US5594100A (en) * 1995-02-22 1997-01-14 Regents Of The University Of Colorado Epitope for prevention of type I diabetes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
W.C. DUCKWORTH ET AL.: "A Direct Inhibitory Effect of Insulin on a Cytosolic Proteolytic Complex Containing Insulin-degrading enzyme and Multicatalytic Proteinase", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 40, 7 October 1994 (1994-10-07), BALTIMORE, MD US, pages 24575 - 24580, XP002111260, ISSN: 0006-291X *

Also Published As

Publication number Publication date
CA2317674A1 (en) 1999-07-15
WO1999035169A9 (en) 1999-11-11
JP2002500234A (en) 2002-01-08
AU2313899A (en) 1999-07-26
CN1292798A (en) 2001-04-25
EP1045860A2 (en) 2000-10-25
BR9906833A (en) 2001-11-27
WO1999035169A2 (en) 1999-07-15

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