WO1999034189A3 - Process and device to solidify and thaw a polarized gas comprising xenon - Google Patents

Process and device to solidify and thaw a polarized gas comprising xenon Download PDF

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Publication number
WO1999034189A3
WO1999034189A3 PCT/US1998/026450 US9826450W WO9934189A3 WO 1999034189 A3 WO1999034189 A3 WO 1999034189A3 US 9826450 W US9826450 W US 9826450W WO 9934189 A3 WO9934189 A3 WO 9934189A3
Authority
WO
WIPO (PCT)
Prior art keywords
polarized
thawing
thaw
xenon
solidify
Prior art date
Application number
PCT/US1998/026450
Other languages
French (fr)
Other versions
WO1999034189A8 (en
WO1999034189A2 (en
Inventor
Bastiaan Driehuys
David Zollinger
Daniel Deaton
Kenton C Hasson
Alan Langhorn
Original Assignee
Magnetic Imaging Technologies
Bastiaan Driehuys
David Zollinger
Daniel Deaton
Kenton C Hasson
Alan Langhorn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/989,604 external-priority patent/US6079213A/en
Priority to DK98967030T priority Critical patent/DK1051602T3/en
Priority to AT98967030T priority patent/ATE238540T1/en
Priority to EP98967030A priority patent/EP1051602B1/en
Priority to IL15523998A priority patent/IL155239A0/en
Priority to BR9813492-2A priority patent/BR9813492A/en
Priority to IL15524098A priority patent/IL155240A0/en
Priority to IL13649498A priority patent/IL136494A/en
Application filed by Magnetic Imaging Technologies, Bastiaan Driehuys, David Zollinger, Daniel Deaton, Kenton C Hasson, Alan Langhorn filed Critical Magnetic Imaging Technologies
Priority to DE69813904T priority patent/DE69813904T2/en
Priority to JP2000526791A priority patent/JP4558931B2/en
Priority to HU0004441A priority patent/HU222711B1/en
Priority to CA002313480A priority patent/CA2313480C/en
Priority to AU34484/99A priority patent/AU757090B2/en
Publication of WO1999034189A2 publication Critical patent/WO1999034189A2/en
Publication of WO1999034189A3 publication Critical patent/WO1999034189A3/en
Publication of WO1999034189A8 publication Critical patent/WO1999034189A8/en
Priority to NO20002930A priority patent/NO20002930L/en
Priority to AU2003203796A priority patent/AU2003203796B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/26—Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
    • F25J3/00—Processes or apparatus for separating the constituents of gaseous or liquefied gaseous mixtures involving the use of liquefaction or solidification
    • F25J3/06—Processes or apparatus for separating the constituents of gaseous or liquefied gaseous mixtures involving the use of liquefaction or solidification by partial condensation
    • F25J3/063—Processes or apparatus for separating the constituents of gaseous or liquefied gaseous mixtures involving the use of liquefaction or solidification by partial condensation characterised by the separated product stream
    • F25J3/0685—Processes or apparatus for separating the constituents of gaseous or liquefied gaseous mixtures involving the use of liquefaction or solidification by partial condensation characterised by the separated product stream separation of noble gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
    • B01J2219/00099—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor the reactor being immersed in the heat exchange medium
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
    • F25J2205/00—Processes or apparatus using other separation and/or other processing means
    • F25J2205/20—Processes or apparatus using other separation and/or other processing means using solidification of components
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
    • F25J2210/00—Processes characterised by the type or other details of the feed stream
    • F25J2210/42—Nitrogen
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
    • F25J2215/00—Processes characterised by the type or other details of the product stream
    • F25J2215/36—Xenon
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
    • F25J2270/00—Refrigeration techniques used
    • F25J2270/90—External refrigeration, e.g. conventional closed-loop mechanical refrigeration unit using Freon or NH3, unspecified external refrigeration
    • F25J2270/904—External refrigeration, e.g. conventional closed-loop mechanical refrigeration unit using Freon or NH3, unspecified external refrigeration by liquid or gaseous cryogen in an open loop

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Mechanical Engineering (AREA)
  • Thermal Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Separation By Low-Temperature Treatments (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Filling Or Discharging Of Gas Storage Vessels (AREA)

Abstract

Methods of collecting, thawing, and extending the useful polarized life of frozen polarized gases include heating a portion of the flow path and/or directly liquefying the frozen gas during thawing. A polarized noble gas product with an extended polarized life product is also included. Associated apparatus such as an accumulator and heating jacket for collecting, storing, and transporting polarized noble gases include a secondary flow channel which provides heat to a portion of the collection path during accumulation and during thawing.
PCT/US1998/026450 1997-12-12 1998-12-11 Process and device to solidify and thaw a polarized gas comprising xenon WO1999034189A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
DE69813904T DE69813904T2 (en) 1997-12-12 1998-12-11 METHOD FOR SAWING AND DEFROSTING A POLARIZED GAS CONTAINING XENON
JP2000526791A JP4558931B2 (en) 1997-12-12 1998-12-11 Freezing and thawing method of polarized noble gases
AT98967030T ATE238540T1 (en) 1997-12-12 1998-12-11 METHOD FOR SAWING AND DEFROSTING A POLARIZED GAS CONTAINING XENON
HU0004441A HU222711B1 (en) 1997-12-12 1998-12-11 Accumulator and heating jacket for collecting and thawing polarized gases and polarized gas
BR9813492-2A BR9813492A (en) 1997-12-12 1998-12-11 Processes for extending the polarization life of a polarized noble gas product, freezing and defrosting frozen polarized noble gas and performing defrost and / or conversion steps, cryogenic accumulator to collect frozen polarized noble gases, jacket heating, and 129x polarized pharmaceutical gas, 129x hyperpolarized noble gas and polarized noble gas products
IL15524098A IL155240A0 (en) 1997-12-12 1998-12-11 Polarized gas accumulators and heating jackets and associated gas collection and thaw methods and polarized gas products
IL13649498A IL136494A (en) 1997-12-12 1998-12-11 Polarized gas accumulators and heating jackets and associated gas collection and thaw methods and polarized gas products
DK98967030T DK1051602T3 (en) 1997-12-12 1998-12-11 A process by which a polarized gas comprising xenon is solidified and thawed
AU34484/99A AU757090B2 (en) 1997-12-12 1998-12-11 Polarized gas accumulators and heating jackets and associated gas collection and thaw methods and polarized gas products
EP98967030A EP1051602B1 (en) 1997-12-12 1998-12-11 Process to solidify and thaw a polarized gas comprising xenon
IL15523998A IL155239A0 (en) 1997-12-12 1998-12-11 Polarized gas accumulators and heating jackets and associated gas collection and thaw methods and polarized gas products
CA002313480A CA2313480C (en) 1997-12-12 1998-12-11 Polarized gas accumulators and heating jackets and associated gas collection and thaw methods and polarized gas products
NO20002930A NO20002930L (en) 1997-12-12 2000-06-08 Apparatus for the production of frozen noble gas
AU2003203796A AU2003203796B2 (en) 1997-12-12 2003-04-22 Polarized gas accumulators and heating jackets and associated gas collection and thaw methods and polarized gas products

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6943597P 1997-12-12 1997-12-12
US08/989,604 US6079213A (en) 1997-12-12 1997-12-12 Methods of collecting, thawing, and extending the useful life of polarized gases and associated accumulators and heating jackets
US60/069,435 1997-12-12

Publications (3)

Publication Number Publication Date
WO1999034189A2 WO1999034189A2 (en) 1999-07-08
WO1999034189A3 true WO1999034189A3 (en) 1999-09-30
WO1999034189A8 WO1999034189A8 (en) 1999-11-04

Family

ID=26750056

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/026450 WO1999034189A2 (en) 1997-12-12 1998-12-11 Process and device to solidify and thaw a polarized gas comprising xenon

Country Status (2)

Country Link
HU (1) HU222711B1 (en)
WO (1) WO1999034189A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002004709A1 (en) 2000-07-12 2002-01-17 Hersman F William Apparatus and method for polarizing polarizable nuclear species
KR101321862B1 (en) 2006-02-21 2013-10-28 밀리켈빈 테크놀로지스 엘엘씨 Hyperpolarization methods, systems and compositions
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
US7928359B2 (en) 2006-09-20 2011-04-19 University Of New Hampshire Thermal management technology for polarizing Xenon
US8405022B2 (en) 2006-09-20 2013-03-26 University Of New Hampshire Thermal management technology for polarizing xenon
CN103830929B (en) * 2014-03-17 2016-01-20 中国科学院武汉物理与数学研究所 A kind of sublimation apparatus of laser pre-polarizing solid xenon
CN118009222B (en) * 2024-04-10 2024-05-31 常州优达电子科技有限公司 SF6-N2 mixed gas filling device

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US5642625A (en) * 1996-03-29 1997-07-01 The Trustees Of Princeton University High volume hyperpolarizer for spin-polarized noble gas

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US5642625A (en) * 1996-03-29 1997-07-01 The Trustees Of Princeton University High volume hyperpolarizer for spin-polarized noble gas

Also Published As

Publication number Publication date
WO1999034189A8 (en) 1999-11-04
WO1999034189A2 (en) 1999-07-08
HUP0004441A2 (en) 2001-04-28
HU222711B1 (en) 2003-09-29
HUP0004441A3 (en) 2001-05-28

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