WO1999031274A3 - Reagents and methods useful for detecting diseases of the pancreas - Google Patents

Reagents and methods useful for detecting diseases of the pancreas Download PDF

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Publication number
WO1999031274A3
WO1999031274A3 PCT/US1998/026441 US9826441W WO9931274A3 WO 1999031274 A3 WO1999031274 A3 WO 1999031274A3 US 9826441 W US9826441 W US 9826441W WO 9931274 A3 WO9931274 A3 WO 9931274A3
Authority
WO
WIPO (PCT)
Prior art keywords
pancreas
diseases
reagents
useful
pancreatic
Prior art date
Application number
PCT/US1998/026441
Other languages
French (fr)
Other versions
WO1999031274A2 (en
Inventor
Patricia A Billing-Medel
Maurice Cohen
Tracey L Colpitts
Paula N Friedman
Julian Gordon
Edward N Granados
Steven C Hodges
Michael R Klass
Jon D Kratochvil
Lisa Roberts-Rapp
John C Russell
Stephen D Stroupe
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to EP98963112A priority Critical patent/EP1038030A2/en
Priority to CA002315263A priority patent/CA2315263A1/en
Publication of WO1999031274A2 publication Critical patent/WO1999031274A2/en
Publication of WO1999031274A3 publication Critical patent/WO1999031274A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Abstract

A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PA153 and transcribed from pancreatic tissue, are described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the pancreas, such as pancreatic cancer. Also provided are antibodies which specifically bind to PA153-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PA153 polypeptide, which molecules are useful for the therapeutic treatment of pancreatic diseases, tumors or metastases.
PCT/US1998/026441 1997-12-15 1998-12-11 Reagents and methods useful for detecting diseases of the pancreas WO1999031274A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP98963112A EP1038030A2 (en) 1997-12-15 1998-12-11 Reagents and methods useful for detecting diseases of the pancreas
CA002315263A CA2315263A1 (en) 1997-12-15 1998-12-11 Reagents and methods useful for detecting diseases of the pancreas

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99056897A 1997-12-15 1997-12-15
US08/990,568 1997-12-15

Publications (2)

Publication Number Publication Date
WO1999031274A2 WO1999031274A2 (en) 1999-06-24
WO1999031274A3 true WO1999031274A3 (en) 1999-09-02

Family

ID=25536289

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/026441 WO1999031274A2 (en) 1997-12-15 1998-12-11 Reagents and methods useful for detecting diseases of the pancreas

Country Status (3)

Country Link
EP (1) EP1038030A2 (en)
CA (1) CA2315263A1 (en)
WO (1) WO1999031274A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000040722A2 (en) * 1999-01-07 2000-07-13 Incyte Pharmaceuticals, Inc. Insulin-synthesis genes
US7034132B2 (en) 2001-06-04 2006-04-25 Anderson David W Therapeutic polypeptides, nucleic acids encoding same, and methods of use
ES2320443T3 (en) 2002-09-30 2009-05-22 Oncotherapy Science, Inc. GENES AND POLYPEPTIDES RELATED TO HUMAN PANCREATIC CANCERS.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997024437A1 (en) * 1995-12-29 1997-07-10 Incyte Pharmaceuticals, Inc. Novel polynucleotides panc1a and panc1b associated with pancreatic cancer
EP0807689A1 (en) * 1994-12-29 1997-11-19 Eiken Kagaku Kabushiki Kaisha Method of cell detection
US5817479A (en) * 1996-08-07 1998-10-06 Incyte Pharmaceuticals, Inc. Human kinase homologs

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0807689A1 (en) * 1994-12-29 1997-11-19 Eiken Kagaku Kabushiki Kaisha Method of cell detection
WO1997024437A1 (en) * 1995-12-29 1997-07-10 Incyte Pharmaceuticals, Inc. Novel polynucleotides panc1a and panc1b associated with pancreatic cancer
US5817479A (en) * 1996-08-07 1998-10-06 Incyte Pharmaceuticals, Inc. Human kinase homologs

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CALDAS C ET AL: "DETECTION OF K-RAS MUTATIONS IN THE STOOL OF PATIENTS WITH PANCREATIC ADENOCARCINOMA AND PANCREATIC DUCTAL HYPERPLASIA", CANCER RESEARCH, vol. 54, 1 July 1994 (1994-07-01), pages 3568 - 3573, XP002050203 *
DATABASE EMBL "contains Seq.ID.Nr. 8+9 (100% identity), fragnent of Seq.ID.Nr. 10 and 11 (97% identity)", XP002105777 *
DATABASE EMBL 18 April 1997 (1997-04-18), "fragment of Seq.ID.Nr. 2,10 and 11 (97% identity)", XP002105775 *
DATABASE EMBL 9 February 1996 (1996-02-09), "238 bp overlap with Seq.ID.Nr. 3, fragment of Seq.ID.Nr. 10 and 11 (97% identity)", XP002105776 *
ZHANG L E AL: "Gene expression profiles in normal and cancer cells", SCIENCE, vol. 276, 23 May 1997 (1997-05-23), pages 1268 - 1272, XP002089890 *

Also Published As

Publication number Publication date
CA2315263A1 (en) 1999-06-24
WO1999031274A2 (en) 1999-06-24
EP1038030A2 (en) 2000-09-27

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