WO1999031256A3 - Proteines cathepsine dc, adn codant pour ces proteines et utilisation de ces proteines dans l'etablissement de pronostics pour les cancers chez l'homme - Google Patents

Proteines cathepsine dc, adn codant pour ces proteines et utilisation de ces proteines dans l'etablissement de pronostics pour les cancers chez l'homme Download PDF

Info

Publication number
WO1999031256A3
WO1999031256A3 PCT/US1998/026920 US9826920W WO9931256A3 WO 1999031256 A3 WO1999031256 A3 WO 1999031256A3 US 9826920 W US9826920 W US 9826920W WO 9931256 A3 WO9931256 A3 WO 9931256A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
polypeptides
cathepsin
dna encoding
human cancer
Prior art date
Application number
PCT/US1998/026920
Other languages
English (en)
Other versions
WO1999031256A2 (fr
Inventor
Dirk Michael Anderson
Terry Y Nakagawa
Original Assignee
Immunex Corp
Dirk Michael Anderson
Terry Y Nakagawa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corp, Dirk Michael Anderson, Terry Y Nakagawa filed Critical Immunex Corp
Priority to AU19266/99A priority Critical patent/AU1926699A/en
Publication of WO1999031256A2 publication Critical patent/WO1999031256A2/fr
Publication of WO1999031256A3 publication Critical patent/WO1999031256A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne de nouveaux polypeptides cathepsine DC isolés et purifiés, les acide nucléiques codant pour ces polypeptides, les protéinases ainsi codées, des techniques permettant de produire des formes recombinantes de ces polypeptides, les anticorps produits contre ces polypeptides, des peptides fragmentés dérivés de ces polypeptides, ainsi que les utilisations de ces diverses formes.
PCT/US1998/026920 1997-12-18 1998-12-18 Proteines cathepsine dc, adn codant pour ces proteines et utilisation de ces proteines dans l'etablissement de pronostics pour les cancers chez l'homme WO1999031256A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU19266/99A AU1926699A (en) 1997-12-18 1998-12-18 Cathepsin dc proteins, dna encoding the proteins, and their use in human cancer prognosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6940997P 1997-12-18 1997-12-18
US60/069,409 1997-12-18

Publications (2)

Publication Number Publication Date
WO1999031256A2 WO1999031256A2 (fr) 1999-06-24
WO1999031256A3 true WO1999031256A3 (fr) 1999-11-04

Family

ID=22088795

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/026920 WO1999031256A2 (fr) 1997-12-18 1998-12-18 Proteines cathepsine dc, adn codant pour ces proteines et utilisation de ces proteines dans l'etablissement de pronostics pour les cancers chez l'homme

Country Status (2)

Country Link
AU (1) AU1926699A (fr)
WO (1) WO1999031256A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1336847B1 (fr) * 2002-02-14 2007-12-12 Biofrontera Pharmaceuticals AG Inhibiteurs de la Cathepsine Y pour le développement de médicaments pour le traitement de la douleur
EP1497642A2 (fr) 2002-03-19 2005-01-19 Tularik, Inc. Amplification de genes en cas de cancer
WO2004077053A1 (fr) * 2003-02-25 2004-09-10 Biofrontera Pharmaceuticals Gmbh Cathepsine y pour le traitement de la douleur
WO2005065693A2 (fr) * 2003-12-30 2005-07-21 Aventis Pharmaceuticals Inc. Utilisation d'inhibiteurs de la cathepsine z dans le traitement de la polyarthrite rhumatoide et d'autres maladies auto-immunes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039194A1 (fr) * 1995-06-06 1996-12-12 Athena Neurosciences, Inc. Nouvelle cathepsine et procedes et compositions d'inhibition de cathepsine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039194A1 (fr) * 1995-06-06 1996-12-12 Athena Neurosciences, Inc. Nouvelle cathepsine et procedes et compositions d'inhibition de cathepsine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NÄGLER D AND MÉNARD R: "Human cathepsin X: a novel cysteine protease of the papain family with a very short proregion and unique insertions", FEBS LETTERS., vol. 434, 1998, AMSTERDAM NL, pages 135 - 139, XP002101279 *
SANTAMARIA I ET AL: "Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 273, no. 27, 3 July 1998 (1998-07-03), MD US, pages 16816 - 16823, XP002101278 *

Also Published As

Publication number Publication date
AU1926699A (en) 1999-07-05
WO1999031256A2 (fr) 1999-06-24

Similar Documents

Publication Publication Date Title
IL195812A0 (en) Human tslp dna and polypeptides
IL137037A0 (en) Acpl dna and polypeptides
WO2001070775A3 (fr) Nouveaux polypeptides et acides nucleiques codant ces polypeptides
WO2003016342A3 (fr) Antigenes tumoraux pour la prevention et/ou le traitement du cancer
WO1999031256A3 (fr) Proteines cathepsine dc, adn codant pour ces proteines et utilisation de ces proteines dans l'etablissement de pronostics pour les cancers chez l'homme
WO1999041388A3 (fr) Metalloprotease-desintegrines, adn svph3-13 et svph3-17 et polypeptides
WO2000059942A3 (fr) COMPOSITIONS hOB-BP2h, LEURS TECHNIQUES ET LEURS UTILISATIONS
CY1105226T1 (el) Dna και πολυπεπτιδια il-1 εψιλον ανθρωπου
AU5163500A (en) Il-1 eta dna and polypeptides
WO2000036108A3 (fr) Polypeptides et adn de il-1 zeta, d'alleles d'epissage de il-1 zeta, et de xrec2
WO2000043525A3 (fr) Membres de la famille de la metalloproteinase-disintegrine: adn svph et polypeptides
WO2001055211A3 (fr) Polypeptides et adn fil-1 theta
WO2000008178A3 (fr) Molecules d'adn murin codant pour des polypeptides presentant des fonctions kinases
WO2000008177A3 (fr) Kinase associee a l'apoptose contenant des repetitions d'ankyrine (dakar)
WO2002072765A3 (fr) Proteines de type ras humaines isolees, molecule d'acides nucleiques codant pour ces proteines de type ras, et leurs utilisations
WO2002077190A3 (fr) Proteines isolees humaines de type ras, molecules d'acide nucleique les codant et leurs utilisations
WO2003074675A3 (fr) Proteines de type ras humaines isolees, molecules d'acide nucleique codant ces proteines de type ras humaines et leurs utilisations
WO2002079494A3 (fr) Proteines humaines isolees de type ras, molecules d'acides nucleiques codant ces dernieres et leurs utilisations
WO2002074976A3 (fr) Proteines humaines isolees du type ras, molecules d'acide nucleique codant lesdites proteines et utilisations associees
NZ505866A (en) V196 (also known as RAMP2) DNA and polypeptides
EP1690871A3 (fr) ADN de Xrec2 et polypeptides
WO2002079407A8 (fr) Proteines humaines isolees du genre ras, molecules d'acide nucleique codant pour elles et leurs utilisations
WO2002079386A3 (fr) Proteines humaines isolees du type ras, molecules d'acides nucleiques codant ces proteines humaines du type ras et utilisation de ces proteines
WO2002061088A3 (fr) Proteines de type ras isolees de l'homme, molecules d'acide nucleique codant ces proteines et utilisation de ces dernieres
WO2002062849A3 (fr) Proteines humaines isolees du type ras, molecules d'acide nucleique codant pour lesdites proteines et leurs utilisations

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase