WO1999025739A1 - Variable region fusion peptides that form effector complexes in the presence of antigen - Google Patents
Variable region fusion peptides that form effector complexes in the presence of antigen Download PDFInfo
- Publication number
- WO1999025739A1 WO1999025739A1 PCT/US1998/020017 US9820017W WO9925739A1 WO 1999025739 A1 WO1999025739 A1 WO 1999025739A1 US 9820017 W US9820017 W US 9820017W WO 9925739 A1 WO9925739 A1 WO 9925739A1
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- WIPO (PCT)
- Prior art keywords
- antigen
- effector
- fusion polypeptides
- pair
- sequences
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- 238000003118 sandwich ELISA Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 229940126586 small molecule drug Drugs 0.000 description 1
- IRHWMYKYLWNHTL-UHFFFAOYSA-M sodium 2-(N-morpholino)ethanesulfonate Chemical compound [Na+].[O-]S(=O)(=O)CCN1CCOCC1 IRHWMYKYLWNHTL-UHFFFAOYSA-M 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 210000004988 splenocyte Anatomy 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000006918 subunit interaction Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 239000005460 tetrahydrofolate Substances 0.000 description 1
- 108010050736 thermostable direct hemolysin Proteins 0.000 description 1
- 108060008226 thioredoxin Proteins 0.000 description 1
- 229940094937 thioredoxin Drugs 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000005030 transcription termination Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000007039 two-step reaction Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000521118A JP2002502585A (en) | 1997-11-14 | 1998-09-24 | Variable region fusion peptide forming effector complex in the presence of antigen |
CA002309763A CA2309763A1 (en) | 1997-11-14 | 1998-09-24 | Variable region fusion peptides that form effector complexes in the presence of antigen |
EP98948515A EP1028979A1 (en) | 1997-11-14 | 1998-09-24 | Variable region fusion peptides that form effector complexes in the presence of antigen |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6571997P | 1997-11-14 | 1997-11-14 | |
US60/065,719 | 1997-11-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999025739A1 true WO1999025739A1 (en) | 1999-05-27 |
Family
ID=22064634
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/020017 WO1999025739A1 (en) | 1997-11-14 | 1998-09-24 | Variable region fusion peptides that form effector complexes in the presence of antigen |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1028979A1 (en) |
JP (1) | JP2002502585A (en) |
CA (1) | CA2309763A1 (en) |
WO (1) | WO1999025739A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102197306A (en) * | 2008-10-24 | 2011-09-21 | 富士胶片株式会社 | Immobilization substrate and method for producing the same |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5518450B2 (en) * | 2008-12-04 | 2014-06-11 | 富士フイルム株式会社 | Fragmented antibody-immobilized carrier and method for producing the same |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995034646A1 (en) * | 1994-06-14 | 1995-12-21 | American Cyanamid Company | Novel cell systems having specific interaction of peptide binding pairs |
WO1998044350A1 (en) * | 1997-04-02 | 1998-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Detection of molecular interactions by reporter subunit complementation |
-
1998
- 1998-09-24 CA CA002309763A patent/CA2309763A1/en not_active Abandoned
- 1998-09-24 WO PCT/US1998/020017 patent/WO1999025739A1/en not_active Application Discontinuation
- 1998-09-24 EP EP98948515A patent/EP1028979A1/en not_active Withdrawn
- 1998-09-24 JP JP2000521118A patent/JP2002502585A/en not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995034646A1 (en) * | 1994-06-14 | 1995-12-21 | American Cyanamid Company | Novel cell systems having specific interaction of peptide binding pairs |
WO1998044350A1 (en) * | 1997-04-02 | 1998-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Detection of molecular interactions by reporter subunit complementation |
Non-Patent Citations (2)
Title |
---|
A. ELCOCK ET AL.: "Evidence for electrostatic channeling in a fusion protein of malate dehydrogenase and citrate synthase.", BIOCHEMISTRY, vol. 35, no. 39, 1996, Washington, DC, USA, pages 12652 - 12658, XP002100802 * |
Y. UEDA ET AL.: "Synthesis and expression of a DNA encoding the Fv domain of an anti-lysozyme monoclonal antibody, HyHEL10, in Streptomyces lividans.", GENE, vol. 129, no. 1, 15 July 1993 (1993-07-15), Amsterdam, The Netherlands, pages 129 - 134, XP002100801 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102197306A (en) * | 2008-10-24 | 2011-09-21 | 富士胶片株式会社 | Immobilization substrate and method for producing the same |
US9487592B2 (en) | 2008-10-24 | 2016-11-08 | Fujifilm Corporation | Immobilization substrate and method for producing the same |
Also Published As
Publication number | Publication date |
---|---|
CA2309763A1 (en) | 1999-05-27 |
EP1028979A1 (en) | 2000-08-23 |
JP2002502585A (en) | 2002-01-29 |
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