WO1999020096A2 - Pince a biopsie endoscopique a prelevements multiples pour echantillons multiples - Google Patents

Pince a biopsie endoscopique a prelevements multiples pour echantillons multiples Download PDF

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Publication number
WO1999020096A2
WO1999020096A2 PCT/US1998/022516 US9822516W WO9920096A2 WO 1999020096 A2 WO1999020096 A2 WO 1999020096A2 US 9822516 W US9822516 W US 9822516W WO 9920096 A2 WO9920096 A2 WO 9920096A2
Authority
WO
WIPO (PCT)
Prior art keywords
tubular member
biopsy forceps
specimen
specimens
grasper
Prior art date
Application number
PCT/US1998/022516
Other languages
English (en)
Inventor
Michael R. Treat
Original Assignee
The Trustees Of Columbia University In The City Of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Trustees Of Columbia University In The City Of New York filed Critical The Trustees Of Columbia University In The City Of New York
Priority to CA002307237A priority Critical patent/CA2307237A1/fr
Priority to AU12757/99A priority patent/AU1275799A/en
Priority to US09/530,173 priority patent/US6632182B1/en
Publication of WO1999020096A2 publication Critical patent/WO1999020096A2/fr

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • A61B10/06Biopsy forceps, e.g. with cup-shaped jaws
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • A61B2010/0225Instruments for taking cell samples or for biopsy for taking multiple samples

Definitions

  • the invention relates to the field of endoscopic biopsy devices for use in obtaining samples of tissue. More particularly, this invention relates to the field of endoscopic biopsy devices, both flexible and rigid, for use in obtaining multiple samples of tissue without the need for withdrawal and reinsertion of the device during the procedure.
  • An endoscope is a long, narrow instrument which is provided with a means of visualization of the tissue, and also with a means of obtaining tissue biopsy or other manipulations of tissue.
  • the endoscope may be flexible or rigid.
  • the means of visualization may be by fiberoptic imaging or by means of a small video chip which is mounted in the distal end of the endoscope.
  • the means of obtaining the biopsy specimen is via a long narrow channel (the "instrument channel” or “biopsy channel”) which is within the body of the endoscope. Through this instrument channel a biopsy forceps is passed, which forceps is a long and narrow instrument that can fit through the channel and which has jaws or another cutting or tearing device at its distal end.
  • This jaws device can be actuated by a lever or trigger at the proximal end (the handle) of the biopsy device .
  • the biopsy forceps itself can be rigid in the case of rigid endoscopes or flexible in the case of flexible endoscopes.
  • a typical example of a flexible endoscope would be a colonoscope for examining the colon, a gastroscope for examining the stomach and upper intestine and a bronchoscope for examining the pulmonary bronchi.
  • a typical diameter for the instrument channel of a colonoscope or gastroscope would be around 2.8 mm or slightly larger.
  • the biopsy channel would be around 2 mm in diameter. Biopsy instruments compatible with these scopes must obviously be narrow enough to comfortably fit in the channel and must also be flexible, since these are all examples of flexible endoscopes.
  • a needle is usually what is used to tease out the separate pieces from the clump. Also, this process is somewhat unesthetic and messy to perform. After the separation is done, the nurse or technician must transfer each individual bit to a separate specimen container which must be separately labelled. When one is dealing with multiple specimens, keeping all of these separate and organized and properly labelled is difficult, particularly under the time constraints of a busy endoscopy unit.
  • This invention provides a means of overcoming the problems and disadvantages of previous multiple sample biopsy devices.
  • the device of the invention one can obtain multiple biopsies with a single placement of the forceps within the instrument channel of the endoscope.
  • the specimen bits are automatically separated into individual compartments of the multi-chambered specimen storage container. These compartments may be easily labelled as to anatomic site (i.e., cecum, transverse colon, descending colon, etc.) ahead of time by stick-on labels or by use of a marking pen.
  • no one in the endoscopy unit itself has to try to handle or separate out individual tiny bits of tissue which may contain infectious human bodily fluids.
  • the endoscopic biopsy forceps of the present invention consists of a long, narrow, flexible or rigid, inner tubular member or tube to which are attached at the distal end, or molded integrally onto the distal end, serrated or cutting jaws.
  • the inner lumen of this inner tubular member is such that the bits of tissue cut by the jaws can be suctioned to the proximal end of this tube.
  • the proximal end of this tubular member is connected via an actuator such as a trumpet valve to the rotatable, revolver- type, multi-chambered specimen trap.
  • the revolver specimen trap is attached to the actuator in such a way that each one of its separate chambers can singly or individually be connected to the proximal orifice of the actuator.
  • the other end of the revolver specimen holder is connected to a suction source such as wall suction.
  • a suction source such as wall suction.
  • the jaws of the inner tubular member are actuated by pushing an outer tubing or sheath distally to close or compress the jaws together, producing the biting or cutting action.
  • Other biting or cutting arrangements may be used as well. See, for example, the grasping/biting/cutting configurations disclosed in U.S. Patents Nos. 5,601,585, 5,524,634, 5,636,639, 5,638,827, 5,645,075, 5,647,115, and 5,746,216, all of which are incorporated herein by reference.
  • the device of the present invention permits the taking of biopsies via an endoscope in such as way that:
  • the biopsies can be kept separate and quite distinct from each other. Although there is a type of biopsy forceps which can "stack" or accumulate several pieces of tissue in the jaws of the forceps, there is no way to really keep these pieces distinct and separate from each other. Obviously, if one is taking specimens from different areas (some of which are benign and some of which may be malignant) , it is highly desirable to have an unequivocal way of keeping the specimens separate. (3) The person operating the forceps does not need to actually touch or directly handle the tissue specimens obtained, as is the case presently. With current biopsy forceps, the tissue specimens must be manually extracted from the jaws using a needle or other fine pointed tool.
  • each tissue specimen must be transferred to a separate specimen container.
  • These tissue specimens are quite small (a square millimeter or so) , and manipulating them is somewhat tedious and delicate to perform. Manipulating the tissue with a needle or another pointed instrument exposes the staff to the possibility of a puncture wound.
  • FIG. 1 is a schematic representation of the distal end of the device of the invention showing a grasper/cutter;
  • FIG. 2 is a schematic representation of the proximal end of the device of the invention showing a finger grip and trumpet valve;
  • FIG. 3 is a schematic representation of a suction trap mechanism attached to the proximal end of the device of the invention.
  • device 10 comprises two concentric tubular members 12,14, wherein inner tubular member 12 has attached at its distal end 11 two springy jaws 16 with serrated teeth 18.
  • Outer tubular member 14 is slidable over inner tubular member 12. Jaws 16 are closed by pulling inner tubular member 12 into outer tubular member 14 or pushing outer tubular member 14 over jaws 16.
  • FIG. 2 the proximal end 17 of outer tubular member 14 comprises a finger grip 20.
  • finger grip 20 When finger grip 20 is moved distally by an operator, the distal end of outer tubular member 14 causes jaws 16 to close, thereby taking a biopsy sample.
  • the lumen 21 of inner tubular member 12 is in fluid communication with at least one lumen 23 of a connecting tubular member or connector 25.
  • the distal end 27 of connector 25 is sealingly attached to the proximal end 29 of inner tubular member 12.
  • An actuator 31 such as a trumpet valve, allows the operator to open a channel 33 between lumens 21 and 23, or within lumen 23, that causes a vacuum in lumen 21 due to a suction means in fluid communication with lumen 23.
  • connector 25 is connected to a multi- chambered specimen trap 36.
  • This multi-chambered trap 36 has several radially arranged specimen areas 38, which are configured like the bullet chambers of a revolver.
  • the bottom 40 of each area 38 comprises a sieve-type material.
  • the sieve bottoms 40 of the specimen areas 38 allow the suction to pull a biopsy tissue sample into specimen trap 36 through channel 33 via tubular members 12, 25, while preventing the tissue sample from getting lost in the suction.
  • the lower portion 42 of trap 36 is in fluid connection with additional tubing 44 that is in fluid communication with a suction or vacuum-inducing apparatus or fixture (not shown) .
  • Specimen trap 36 is preferably configured so that only one specimen area will be exposed at a time. Then, by rotation of multi-chambered specimen trap 36, each of the individual specimen areas 38 can be brought in-line with connector 25. In this way, biopsy specimens are kept separate from each other in the separate specimen areas 38. Preferably each specimen area 38 will have a separate number or other identifying indicia imprinted thereupon.
  • the multi-chambered trap 36 is disconnected from tubular members 25 and 44, capped and send directly to a pathology lab. The operator does not have to handle the tissue directly. If more biopsies are needed than there are chambers in a trap, then another chambered trap 36 can be attached to the end of tube 12 and used to gather additional samples.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endoscopes (AREA)

Abstract

L'invention concerne un dispositif de biopsie endoscopique flexible ou rigide, qui sert à prélever de multiples échantillons de biopsie provenant de différents sites, et à séparer et stocker ces échantillons dans un conteneur cloisonné. L'extrémité distale de ce dispositif consiste en un moyen de préhension qui peut prélever ou couper un morceau de tissu. L'extrémité proximale du tubage intérieur est connecté via l'extrémité de poignée du dispositif à un dispositif de stockage d'échantillons à chambres multiples, qui est lui-même connecté à un moyen d'aspiration. Le dispositif de stockage comporte plusieurs chambres, chacune de celles-ci pouvant être alignée sur le tubage intérieur par rotation du sommet du dispositif de stockage. Après que certains ou tous les sous-compartiments de stockage ont été remplis d'échantillons, on peut séparer le dispositif de stockage du tubage intérieur et de la poignée du dispositif, l'étiqueter et l'envoyer au laboratoire de pathologie.
PCT/US1998/022516 1997-10-23 1998-10-23 Pince a biopsie endoscopique a prelevements multiples pour echantillons multiples WO1999020096A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002307237A CA2307237A1 (fr) 1997-10-23 1998-10-23 Pince a biopsie endoscopique a prelevements multiples pour echantillons multiples
AU12757/99A AU1275799A (en) 1997-10-23 1998-10-23 Multiple bite, multiple specimen endoscopic biopsy forceps
US09/530,173 US6632182B1 (en) 1998-10-23 1998-10-23 Multiple bit, multiple specimen endoscopic biopsy forceps

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6300897P 1997-10-23 1997-10-23
US60/063,008 1997-10-23

Publications (1)

Publication Number Publication Date
WO1999020096A2 true WO1999020096A2 (fr) 1999-04-29

Family

ID=22046291

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/022516 WO1999020096A2 (fr) 1997-10-23 1998-10-23 Pince a biopsie endoscopique a prelevements multiples pour echantillons multiples

Country Status (3)

Country Link
AU (1) AU1275799A (fr)
CA (1) CA2307237A1 (fr)
WO (1) WO1999020096A2 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19905311B4 (de) * 1998-02-17 2006-11-30 Olympus Optical Co., Ltd. Medizinisches Instrument zur kombinierten Verwendung mit einem Endoskop
EP1774896A1 (fr) * 2005-10-17 2007-04-18 Olympus Medical Systems Corp. Endoscope
WO2008148903A1 (fr) * 2007-06-04 2008-12-11 Soriano Romero Francisco Santi Dispositif médical pour biopsies
US7740595B2 (en) 2002-07-26 2010-06-22 Stuart Brown Tissue and fluid sampling device
US7909850B2 (en) 1999-10-25 2011-03-22 Boston Scientific Scimed, Inc. Forceps for medical use
US7942896B2 (en) 2003-11-25 2011-05-17 Scimed Life Systems, Inc. Forceps and collection assembly and related methods of use and manufacture
US8083686B2 (en) 2003-09-10 2011-12-27 Boston Scientific Scimed, Inc. Forceps and collection assembly with accompanying mechanisms and related methods of use
CN104306049A (zh) * 2014-11-10 2015-01-28 纪勇 带负压吸引功能的手术钳
US9414814B2 (en) 2005-08-05 2016-08-16 Devicor Medical Products, Inc. Biopsy device with rotatable tissue sample holder
US9901327B2 (en) 2005-08-05 2018-02-27 Devicor Medical Products, Inc. Biopsy device with translating valve member

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19905311B4 (de) * 1998-02-17 2006-11-30 Olympus Optical Co., Ltd. Medizinisches Instrument zur kombinierten Verwendung mit einem Endoskop
US7909850B2 (en) 1999-10-25 2011-03-22 Boston Scientific Scimed, Inc. Forceps for medical use
US7740595B2 (en) 2002-07-26 2010-06-22 Stuart Brown Tissue and fluid sampling device
US8460205B2 (en) 2003-09-10 2013-06-11 Boston Scientific Scimed, Inc. Forceps and collection assembly with accompanying mechanisms and related methods of use
US8083686B2 (en) 2003-09-10 2011-12-27 Boston Scientific Scimed, Inc. Forceps and collection assembly with accompanying mechanisms and related methods of use
US7942896B2 (en) 2003-11-25 2011-05-17 Scimed Life Systems, Inc. Forceps and collection assembly and related methods of use and manufacture
US9414814B2 (en) 2005-08-05 2016-08-16 Devicor Medical Products, Inc. Biopsy device with rotatable tissue sample holder
US9901327B2 (en) 2005-08-05 2018-02-27 Devicor Medical Products, Inc. Biopsy device with translating valve member
US9907542B2 (en) 2005-08-05 2018-03-06 Devicor Medical Products, Inc. Biopsy device with translating valve member
US9968339B2 (en) 2005-08-05 2018-05-15 Devicor Medical Products, Inc. Biopsy device with rotatable tissue sample holder
US8303489B2 (en) 2005-10-17 2012-11-06 Olympus Medical Systems Corp. Endoscope with built-in filtering means
EP1774896A1 (fr) * 2005-10-17 2007-04-18 Olympus Medical Systems Corp. Endoscope
ES2310130A1 (es) * 2007-06-04 2008-12-16 Francisco Santi Soriano Romero Dispositivo medico para biopsias.
WO2008148903A1 (fr) * 2007-06-04 2008-12-11 Soriano Romero Francisco Santi Dispositif médical pour biopsies
CN104306049A (zh) * 2014-11-10 2015-01-28 纪勇 带负压吸引功能的手术钳

Also Published As

Publication number Publication date
CA2307237A1 (fr) 1999-04-29
AU1275799A (en) 1999-05-10

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