WO1999019711B1 - Method for producing arrays and devices relating thereto - Google Patents

Method for producing arrays and devices relating thereto

Info

Publication number
WO1999019711B1
WO1999019711B1 PCT/US1998/021860 US9821860W WO9919711B1 WO 1999019711 B1 WO1999019711 B1 WO 1999019711B1 US 9821860 W US9821860 W US 9821860W WO 9919711 B1 WO9919711 B1 WO 9919711B1
Authority
WO
WIPO (PCT)
Prior art keywords
array
members
bundle
wafer
array members
Prior art date
Application number
PCT/US1998/021860
Other languages
French (fr)
Other versions
WO1999019711A1 (en
Inventor
Larry S Millstein
Original Assignee
Larry S Millstein
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Larry S Millstein filed Critical Larry S Millstein
Priority to CA002306970A priority Critical patent/CA2306970A1/en
Priority to AU98062/98A priority patent/AU9806298A/en
Publication of WO1999019711A1 publication Critical patent/WO1999019711A1/en
Publication of WO1999019711B1 publication Critical patent/WO1999019711B1/en
Priority to CA002347125A priority patent/CA2347125A1/en
Priority to PCT/US1999/023860 priority patent/WO2000023803A1/en
Priority to AU65158/99A priority patent/AU6515899A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B01J2219/00367—Pipettes capillary
    • B01J2219/00369—Pipettes capillary in multiple or parallel arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00511—Walls of reactor vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00513—Essentially linear supports
    • B01J2219/0052—Essentially linear supports in the shape of elongated tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00664—Three-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00673—Slice arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

An invention that relates to arrays, to methods and devices for producing arrays and to methods and devices for using arrays is described. In a particular aspect the invention relates to methods in which array members are aligned in a bundle and the bundle then is sectioned across the alignment to produce replicate arrays. In a further particular aspect the invention relates to arrays of analyte binding reagents. In another particular aspect the invention relates to micro-arrays.

Claims

AMENDED CLAIMS
[received by the Internar onal Bureau on 2 April (02 04 99), original claims 1-47 amended (6 pages)]
1 A method of making arrays of a plurality of array members, comprising the steps of.
(A) providing a plurality of bundle members, each bundle member comprising at least one array member;
(B) forming the bundle members Into a bundle in which the array members are aligned;
(C) sectioning the bundle to produce wafers that comprise an array of the array members, wherein at least one array member is hom╬▒ganeous
2. A method of making arrays of a plurality of array members, comprising the steps of:
(A) providing a plurality of bundle members, each bundle member comprising at least one array member,
(B) forming the bundle members into a bundle in which the array members are aligned,
(C) sectioning the bundle to produce wafers that comprise an array of the array members, wherein at least one bundle member comprises an array member disposed within a structural member
3. A method of making arrays of a plurality of array members, comprising the steps of:
(A) providing a plurality of bundle members, each bundle member comprising at least one array member;
(B) forming the bundle members into a bundle in which the array members are aligned;
(C) sectioning the bundle to produce wafers that comprise an array of the array members, wherein at least one bundle member comprises a homogeneous array member disposed within a structural member
4. A method of making arrays of a plurality of array members, comprising the steps of;
(A) providing a plurality of bundle members, each bundle member comprising at least one array member;
(B) forming the bundle members into a bundle in which the array members are aligned;
(C) sectioning the bundle to produce wafers that comprise an array of the array members; wherein at least one array member is acellular.
5. A method according to any of claims 1-4, wherein the array members are cross- sectioned perpendicular to their alignment.
6. A method according to any of claims 1-4, wherein the array members are cross- sectioned at an angle of 10 to 80 degrees or 100 to 170 degrees to their alignment.
7. A method according to any of the foregoing claims, wherein the array members are cross-sectioned by a smooth planar cut.
8. A method according to any of claims 1-6, wherein the array members are cross- sectioned by a non-planar cut.
9. A method according to claim 8, wherein the surface area of array members exposed by cross-sectioning is increased over that provided by a smooth, planar cut.
10. A method according to any one of claims 1 -4, wherein array members are comprised of or are disposed within a plastic, a glass, a metal or a ceramic.
1 1. A method according to claim 10, wherein array members are comprised of or disposed within a glass.
12. A method according to claim 10, wherein array members are comprised of or disposed within a plastic.
13. A method according to claim 12, wherein the plastic is a polycarbonate, polyethylene, polymethylmethacrylate, polystyrene, a copolymer of polystyrene, polysulfone, polyvinylch ride, polyester, polyamide, polyacetal, polyethyleneterephthalate, polytetra- fluoroethylene or polyurethane.
14. A method according to claim 13, wherein the plastic Is a polycarbonate, polyethylene, polystyrene, a copolymer of polystyrene, polysulfone or polyvinylchbride.
15. A method according to any one of claims 1-4, wherein the array members are spaced about 1.0 to about 1 ,000 micrometers apart.
16. A method according to any one of claims 1-4, wherein the array members have a cross-sectional area of about 1.0 to about 1 ,000,000 μmΛ
17. A method according to any one of claims 1-4, wherein the density of array members in the array is about 250 to about 2,500,000 array members per square centimeter of cross sectional surface area of the array.
18. A method according to any one of claims 1 -4, wherein the density in the array is about 10 to about 100,000 array members per square centimeter of total surface area at the assay.
19. A method according to any one of claims 1 -4, wherein there are about 100 to about 2,500,000 aligned array members.
20. A method according to any one of claims 1-4, wherein there are about 100 to 2,500,000 different aligned array members.
21. A method according to any one of claims 1-4, wherein cross-sectioning produces sections about 2.5 to about 2,500 micrometers thick.
22. A method according to any one of claims 1-4, wherein at least two array members are different from one another 5 1
23. A method according to any one of claims 1-4, wherein (C) comprises repeatedly cross-sectioning a plurality of aligned array members to produce sections with at least one surface that exposes array members in the same disposition, thereby replicating the array.
24. A method according to any one of claims 1-4, wherein the array members comprise analyte binding reagents.
25. A method according to claim 24, wherein the array comprises analyte binding reagents that hybridize to DNA or RNA having specific nucleotide sequences.
26. A method according to claim 25, wherein the sequence specific binding reagents are polynucleotides, peptide-nucleic acids or polyamides.
27. A method according to claim 26, wherein the sequence specific binding reagents are oligoπudeotides.
28. A method according to claim 24, wherein the array comprises analyte binding reagents that bind specific polypeptides.
29. A method according to claim 28, wherein the polypeptide-specific binding reagents are polyclonal antibodies, monoclonal antibodies, a single chain antibody, or an antigen-binding fragment of an antibody.
30. A method according to claim 24, wherein analyte binding reagents are one or more of a nucleic acid, a polynucl╬▓otide, a DNA, an RNA, an oligonucleotide, a protein-nucleic acid, an aptamer, a ribozyme, a nucleic acid-binding polyamide, a protein, a peptide, a polypeptide, a glycoprotein, an antibody, an antibody-derived polypeptide, a receptor protein, a fusion protein, a mutein, a lipid, a polysacc aride, a lectin, a ligand, an antigen or a hapten.
31. A method according to claim 24, wherein the array is used to carry out an immunoassay, a hybridization assay, a ligand-binding assay or receptor-binding assay, or a substrate analog affinity assay. 52
32. A method according to claim 24, wherein binding to the analyte binding reagents is detected using radioactivity, fluorescence, phosphorescence or chemiluminesceπce.
33. A wafer comprising a plurality of array members in an array, wherein at least one array member is homogeneous, forms part of two opposing surfaces of the wafer and extends uniformly between the two surfaces.
34. A wafer comprising a plurality of array members in an array, wherein each array member is homogeneous, forms part of two opposing surfaces of the wafer and extends uniformly between the two surfaces.
35. A wafer comprising a plurality of array members in an array, wherein at least one array member is homogeneous and disposed within a structural member, forms part of two opposing surfaces of the wafer and extends within the structural member uniformly between the two surfaces.
36. A wafer comprising a plurality of array members in an array, wherein each array member is homogeneous and disposed within a structural member, forms part of two opposing surfaces of the wafer and extends within the structural member uniformly between the two surfaces.
37. A wafer comprising a plurality of array members in an array for performing chemical, biochemical or biological assays, wherein at least one array member Is an analyte binding reagent, is homogeneous, forms part of two opposing surfaces of the wafer and extends uniformly between the two surfaces.
38. A wafer comprising a plurality of array members in an array for performing chemical, biochemical or biological assays, wherein each array member is an analyte binding reagent, is homogeneous, forms part of two opposing surfaces of the wafer and extends uniformly between the two surfaces.
39. A wafer according to any of claims 33-38, wherein the array members are spaced about .0 to about 1 ,000 micrometers apart. 53
40. A wafer according to any of claims 33-38. wherein the array members have a cross-sectional area of about 1.0 to about 1 ,000,000 ╬╝ 2.
41. A wafer according to any of claims 33-38, wherein the density of array members in the array is about 250 to about 2,500,000 array members per square centimeter of cross sectional surface area of the array.
42. A wafer according to any of claims 33-38, wherein the density in the array is about 10 to about 100,000 array members per square centimeter of total surface area of the array
43. A wafer according to any of claims 33-38, wherein there are about 100 to about 2,500,000 array members in the array.
44. A wafer according to any of claims 33-38, wherein there are about 100 to 2,500,000 different array members in the array.
45. A wafer according to any of claims 33-38, wherein cross-sectioning produces sections about 2.5 to about 2,500 micrometers thick.
46. A wafer according to any of claims 33-38, wherein the array comprises analyte binding reagents that hybridize to DNA or RNA having specific nucleotide sequences.
47. A wafer according to any of claims 33-38, wherein the array comprises analyte binding reagents that bind specific polypeptides.
PCT/US1998/021860 1997-10-16 1998-10-16 Method for producing arrays and devices relating thereto WO1999019711A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002306970A CA2306970A1 (en) 1997-10-16 1998-10-16 Method for producing arrays and devices relating thereto
AU98062/98A AU9806298A (en) 1997-10-16 1998-10-16 Method for producing arrays and devices relating thereto
CA002347125A CA2347125A1 (en) 1998-10-16 1999-10-15 Methods of making patterned arrays of analyte-binding molecules
PCT/US1999/023860 WO2000023803A1 (en) 1998-10-16 1999-10-15 Methods of making patterned arrays of analyte-binding molecules
AU65158/99A AU6515899A (en) 1998-10-16 1999-10-15 Methods of making patterned arrays of analyte-binding molecules

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6220397P 1997-10-16 1997-10-16
US60/062,203 1997-10-16

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09/529,588 A-371-Of-International US20020155495A1 (en) 1997-10-16 1998-10-16 Method for producing arrays and devices relating thereto
US10/460,417 Division US20040063221A1 (en) 1997-10-16 2003-06-13 Method for producing arrays and devices relating thereto

Publications (2)

Publication Number Publication Date
WO1999019711A1 WO1999019711A1 (en) 1999-04-22
WO1999019711B1 true WO1999019711B1 (en) 1999-05-27

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PCT/US1998/021860 WO1999019711A1 (en) 1997-10-16 1998-10-16 Method for producing arrays and devices relating thereto

Country Status (3)

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AU (1) AU9806298A (en)
CA (1) CA2306970A1 (en)
WO (1) WO1999019711A1 (en)

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Publication number Priority date Publication date Assignee Title
AU744815B2 (en) * 1997-09-11 2002-03-07 Bioventures, Inc. Method of making high density arrays
EP1158047B1 (en) 1999-03-05 2009-05-20 Mitsubishi Rayon Co., Ltd. Microarrays having biological substance
WO2000066259A1 (en) * 1999-05-05 2000-11-09 Ut-Battelle, Llc Method and apparatus for combinatorial chemistry
US6406840B1 (en) * 1999-12-17 2002-06-18 Biomosaic Systems, Inc. Cell arrays and the uses thereof
DE10001136C2 (en) * 2000-01-13 2003-09-04 Michael Mengel Process for the production of blocks of material with multiple test samples
JP3510882B2 (en) 2000-06-20 2004-03-29 三菱レイヨン株式会社 Biologically related substance microarray and manufacturing method thereof
DE10034570A1 (en) * 2000-07-14 2002-01-31 Max Delbrueck Centrum Process for the production of microarray chips with nucleic acids, proteins or other test substances
AU2001286759A1 (en) * 2000-08-25 2002-03-04 Genospectra, Inc. Three-dimensional probe carriers
DE10110511C1 (en) 2001-02-28 2002-10-10 Attomol Gmbh Molekulare Diagno Method for producing an array for the detection of components from a biological sample
US20060084060A1 (en) 2002-04-03 2006-04-20 Chiaki Nagahama Gel having biosubstance fixed thereto and microarray utilizing the gel
CN108623332B (en) * 2018-04-16 2021-08-10 佛山市三水新明珠建陶工业有限公司 Production method of ceramic tile with fluorescent anti-counterfeiting mark

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US4459360A (en) * 1981-10-05 1984-07-10 Mast Medical Industries, Ltd. Multiple-component binding assay system and method of making and using it
US4853020A (en) * 1985-09-30 1989-08-01 Itt Electro Optical Products, A Division Of Itt Corporation Method of making a channel type electron multiplier
US4820504A (en) * 1986-02-12 1989-04-11 City Of Hope Multi-specimen tissue blocks and slides
US4914022A (en) * 1987-10-21 1990-04-03 Amc Cancer Research Center Method for preparing multiple tissue samples for microscopic investigation and testing
US5002377A (en) * 1988-07-07 1991-03-26 City Of Hope Multi-specimen slides for immunohistologic procedures

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CA2306970A1 (en) 1999-04-22
WO1999019711A1 (en) 1999-04-22
AU9806298A (en) 1999-05-03

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