WO1999019476A3 - NON-MAMMALIAN MESODERM INDUCTION EARLY RESPONSE (nm-MIER) GENE FAMILY - Google Patents

NON-MAMMALIAN MESODERM INDUCTION EARLY RESPONSE (nm-MIER) GENE FAMILY Download PDF

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Publication number
WO1999019476A3
WO1999019476A3 PCT/CA1998/000958 CA9800958W WO9919476A3 WO 1999019476 A3 WO1999019476 A3 WO 1999019476A3 CA 9800958 W CA9800958 W CA 9800958W WO 9919476 A3 WO9919476 A3 WO 9919476A3
Authority
WO
WIPO (PCT)
Prior art keywords
mier
polypeptides
family
fgf
genes
Prior art date
Application number
PCT/CA1998/000958
Other languages
French (fr)
Other versions
WO1999019476A2 (en
Inventor
Laura Lee Gillespie
Gary David Paterno
Original Assignee
Laura Lee Gillespie
Gary David Paterno
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002212991A external-priority patent/CA2212991A1/en
Application filed by Laura Lee Gillespie, Gary David Paterno filed Critical Laura Lee Gillespie
Priority to AU94264/98A priority Critical patent/AU9426498A/en
Publication of WO1999019476A2 publication Critical patent/WO1999019476A2/en
Publication of WO1999019476A3 publication Critical patent/WO1999019476A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to a family of non-mammalian genes that are transcribed in the immediate early phase following exposure to Fibroblast Growth Factors (FGF) during mesoderm induction, termed Mesoderm Induction Immediate Early Response (MIER) genes. Defining features of the members of this family include that these genes are: a) transcribed in response to fibroblast growth factors (FGF); b) expressed within 40 minutes of FGF treatment; and c) do not require protein synthesis for transcription. There are at least eleven members within this family; as a description, the cloning and characterization of a cDNA representing a member of the nm-MIER family, er1 is presented. The invention relates generally to compositions of and diagnostic methods relating to the nm-MIER gene family, cDNA, nucleotide fragments, polypeptides coded thereby, recombinant host cells and vectors containing nm-MIER encoding polynucleotide sequences, recombinant nm-MIER polypeptides, and antibodies. By way of example, the invention discloses the cloning and functional expression of different Nm-MIER polypeptides. The invention also includes methods for using the isolated, recombinant polynucleotides, polypeptides, and antibodies directed thereto in assays designed to select substances which interact with Nm-MIER polypeptides for use in diagnostic and therapeutic applications in addition to drug design and DNA vaccination methodologies.
PCT/CA1998/000958 1997-10-10 1998-10-13 NON-MAMMALIAN MESODERM INDUCTION EARLY RESPONSE (nm-MIER) GENE FAMILY WO1999019476A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU94264/98A AU9426498A (en) 1997-10-10 1998-10-13 Non-mammalian mesoderm induction early response (nm-mier) gene family

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CA002212991A CA2212991A1 (en) 1997-10-10 1997-10-10 Invertebrate mesoderm induction early response (mier) gene family
CA2,212,991 1997-10-10
CA2,225,180 1998-03-06
CA002225180A CA2225180A1 (en) 1997-10-10 1998-03-06 Non-mammalian mesoderm induction early response (mier) gene family

Publications (2)

Publication Number Publication Date
WO1999019476A2 WO1999019476A2 (en) 1999-04-22
WO1999019476A3 true WO1999019476A3 (en) 1999-07-29

Family

ID=25679545

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1998/000958 WO1999019476A2 (en) 1997-10-10 1998-10-13 NON-MAMMALIAN MESODERM INDUCTION EARLY RESPONSE (nm-MIER) GENE FAMILY

Country Status (3)

Country Link
AU (1) AU9426498A (en)
CA (1) CA2225180A1 (en)
WO (1) WO1999019476A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999019475A2 (en) * 1997-10-10 1999-04-22 Laura Lee Gillespie Mammalian mesoderm induction early response (m-mier) gene family

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999019475A2 (en) * 1997-10-10 1999-04-22 Laura Lee Gillespie Mammalian mesoderm induction early response (m-mier) gene family

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
AMAYA E ET AL: "Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos", CELL, vol. 66, no. 66, 26 July 1991 (1991-07-26), pages 257 - 270 270, XP002099315 *
DATABASE GENEBANK 22 August 1997 (1997-08-22), G.D. PATERNO ET AL.: "X. laevis ER1 gene. cDNA cloning of a novel, developmentally-regulated immediate early gene activated by fibroblast growth factor and encoding a nuclear protein.", XP002099316 *
FRIESEL R E & MACIAG T: "Molecular mechanisms of angiogensis: fibroblast growth factor signal transduction", FASEB JOURNAL, vol. 9, no. 9, July 1995 (1995-07-01), pages 919 - 925 925, XP002099313 *
M. ASASHIMA ET AL.: "Mesoderm induction during early amphibian development", DEVELOPMENT, GROWTH & DIFFERENTIATION, vol. 36, no. 4, 1994, pages 343 - 355, XP002104450 *
N. UENO ET AL.: "Mesoderm induction in early amphibian embryos by activin A and its related gene products in Xenopus laevis.", FRONTIERS IN MUSCLE RESEARCH; MYOGENESIS, MUSCLE CONTRACTION AND MUSCLE DYSTROPHY. PROCEEDINGS OF THE UEHARA MEMORIAL FOUNDATION SYMPOSIUM ON FRONTIERS IN MUSCLE RESEARCH, 15 July 1990 (1990-07-15) - 19 July 1990 (1990-07-19), Tokyo, pages 17 - 28, XP002104449 *
PATERNO G D ET AL: "cDNA cloning of a novel developmentally regulated immediate early gene activated by ibroblast growth factor and encoding a nuclear protein", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 41, 10 October 1997 (1997-10-10), pages 25591 - 25595 25595, XP002099338 *
PATERNO G D ET AL: "Molecular cloning of human er1 cDNA and its differential expression in breats tumours and tumour-derived cell lines", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES, vol. 222, 1998, pages 77 - 82, XP002099314 *

Also Published As

Publication number Publication date
AU9426498A (en) 1999-05-03
WO1999019476A2 (en) 1999-04-22
CA2225180A1 (en) 1999-04-10

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