WO1999019366A3 - Chelates of chitosans and alkaline-earth metal insoluble salts and the use thereof as medicaments useful in osteogenesis - Google Patents

Chelates of chitosans and alkaline-earth metal insoluble salts and the use thereof as medicaments useful in osteogenesis Download PDF

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Publication number
WO1999019366A3
WO1999019366A3 PCT/EP1998/006321 EP9806321W WO9919366A3 WO 1999019366 A3 WO1999019366 A3 WO 1999019366A3 EP 9806321 W EP9806321 W EP 9806321W WO 9919366 A3 WO9919366 A3 WO 9919366A3
Authority
WO
WIPO (PCT)
Prior art keywords
chelates
chitosans
alkaline
earth metal
osteogenesis
Prior art date
Application number
PCT/EP1998/006321
Other languages
French (fr)
Other versions
WO1999019366A2 (en
WO1999019366A9 (en
Inventor
Riccardo Muzzarelli
Sergio Rosini
Silvia Trasciatti
Original Assignee
Abiogen Pharma Srl
Riccardo Muzzarelli
Sergio Rosini
Silvia Trasciatti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abiogen Pharma Srl, Riccardo Muzzarelli, Sergio Rosini, Silvia Trasciatti filed Critical Abiogen Pharma Srl
Priority to AU18703/99A priority Critical patent/AU1870399A/en
Priority to EP98963401A priority patent/EP1023329A2/en
Publication of WO1999019366A2 publication Critical patent/WO1999019366A2/en
Publication of WO1999019366A3 publication Critical patent/WO1999019366A3/en
Publication of WO1999019366A9 publication Critical patent/WO1999019366A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides

Abstract

Amorphous or partially crystalline chelates of chitosans, functionalized at the nitrogen with polycarboxylic functions, with alkaline-earth metal insoluble salts. Said chelates are useful for the preparation of medicaments promoting the reparation of bone tissue.
PCT/EP1998/006321 1997-10-10 1998-10-06 Chelates of chitosans and alkaline-earth metal insoluble salts and the use thereof as medicaments useful in osteogenesis WO1999019366A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU18703/99A AU1870399A (en) 1997-10-10 1998-10-06 Chelates of chitosans and alkaline-earth metal insoluble salts and the use thereof as medicaments useful in osteogenesis
EP98963401A EP1023329A2 (en) 1997-10-10 1998-10-06 Chelates of chitosans and alkaline-earth metal insoluble salts and the use thereof as medicaments useful in osteogenesis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI97A002298 1997-10-10
IT002298 IT1295308B1 (en) 1997-10-10 1997-10-10 AMORPHOUS COMPLEXES OF CHITOSANS AND INSOLUBLE SALTS OF EARTH ALKALINE METALS AND THEIR USE AS USEFUL MEDICATIONS IN OSTEOGENESIS

Publications (3)

Publication Number Publication Date
WO1999019366A2 WO1999019366A2 (en) 1999-04-22
WO1999019366A3 true WO1999019366A3 (en) 1999-06-24
WO1999019366A9 WO1999019366A9 (en) 1999-08-05

Family

ID=11378022

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/006321 WO1999019366A2 (en) 1997-10-10 1998-10-06 Chelates of chitosans and alkaline-earth metal insoluble salts and the use thereof as medicaments useful in osteogenesis

Country Status (4)

Country Link
EP (1) EP1023329A2 (en)
AU (1) AU1870399A (en)
IT (1) IT1295308B1 (en)
WO (1) WO1999019366A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04149203A (en) * 1990-10-15 1992-05-22 Kao Corp Chitosan derivative, its production, and detergent builder and humectant therefrom
EP0555807A1 (en) * 1992-02-10 1993-08-18 Matsumoto Dental College Bone substitute product and method of producing the same
EP0718313A2 (en) * 1994-12-22 1996-06-26 Ciba-Geigy Ag N-cyanomethylated chitosan and hydrolysis products thereof
US5597811A (en) * 1995-04-10 1997-01-28 Amerchol Corporation Oxirane carboxylic acid derivatives of polyglucosamines

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04149203A (en) * 1990-10-15 1992-05-22 Kao Corp Chitosan derivative, its production, and detergent builder and humectant therefrom
EP0555807A1 (en) * 1992-02-10 1993-08-18 Matsumoto Dental College Bone substitute product and method of producing the same
EP0718313A2 (en) * 1994-12-22 1996-06-26 Ciba-Geigy Ag N-cyanomethylated chitosan and hydrolysis products thereof
US5597811A (en) * 1995-04-10 1997-01-28 Amerchol Corporation Oxirane carboxylic acid derivatives of polyglucosamines

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 117, no. 22, 30 November 1992, Columbus, Ohio, US; abstract no. 214891, INA YOSHIMATA ET AL.: "N,N-dicarboxymethylglucosamine-type chitosan derivatives as builders for detergents." *
PATENT ABSTRACTS OF JAPAN vol. 16, no. 431 (C - 983) 9 September 1992 (1992-09-09) *

Also Published As

Publication number Publication date
IT1295308B1 (en) 1999-05-04
WO1999019366A2 (en) 1999-04-22
WO1999019366A9 (en) 1999-08-05
AU1870399A (en) 1999-05-03
ITMI972298A1 (en) 1999-04-10
EP1023329A2 (en) 2000-08-02

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