WO1999018230A3 - Method to detect mrit and bcl-2 or caspase association alterations - Google Patents

Method to detect mrit and bcl-2 or caspase association alterations Download PDF

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Publication number
WO1999018230A3
WO1999018230A3 PCT/US1998/021132 US9821132W WO9918230A3 WO 1999018230 A3 WO1999018230 A3 WO 1999018230A3 US 9821132 W US9821132 W US 9821132W WO 9918230 A3 WO9918230 A3 WO 9918230A3
Authority
WO
WIPO (PCT)
Prior art keywords
mrit
bcl
polypeptide
association
caspase
Prior art date
Application number
PCT/US1998/021132
Other languages
French (fr)
Other versions
WO1999018230A2 (en
Inventor
Preet M Chaudhary
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Priority to AU97903/98A priority Critical patent/AU9790398A/en
Publication of WO1999018230A2 publication Critical patent/WO1999018230A2/en
Publication of WO1999018230A3 publication Critical patent/WO1999018230A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2510/00—Detection of programmed cell death, i.e. apoptosis

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention provides a method of identifiying an effective agent that alters the association of a Bcl-2 polypeptide with an MACH Related Inducer of Toxicity (MRIT) polypeptide by contacting a Bcl-2 family polypeptide and an MRIT polypeptide with an agent under conditions that allow said Bcl-2 family polypeptide to associate with said MRIT polypeptide; and detecting an altered association of said Bcl-2 family polypeptide and said MRIT polypeptide.
PCT/US1998/021132 1997-10-07 1998-10-07 Method to detect mrit and bcl-2 or caspase association alterations WO1999018230A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU97903/98A AU9790398A (en) 1997-10-07 1998-10-07 Mrit family of cell death proteins, nucleic acids encoding same, and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94622697A 1997-10-07 1997-10-07
US08/946,226 1997-10-07

Publications (2)

Publication Number Publication Date
WO1999018230A2 WO1999018230A2 (en) 1999-04-15
WO1999018230A3 true WO1999018230A3 (en) 1999-06-17

Family

ID=25484154

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/021132 WO1999018230A2 (en) 1997-10-07 1998-10-07 Method to detect mrit and bcl-2 or caspase association alterations

Country Status (2)

Country Link
AU (1) AU9790398A (en)
WO (1) WO1999018230A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1076711A2 (en) * 1998-05-13 2001-02-21 Incyte Pharmaceuticals, Inc. Human apoptosis associated proteins
CA2332346A1 (en) * 1998-07-08 2000-01-20 Merck Frosst Canada & Co. Usurpin, a mammalian ded-caspase homologue that precludes caspase-8 recruitment and activation by the cd-95 (fas, apo-1) receptor complex

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
D.K.M. HAN ET AL.: "MRIT, a novel death-effector domain-containing protein, interacts with caspase and BclXL and initiates cell death", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 94, no. 21, 14 October 1997 (1997-10-14), Washington DC USA, pages 11333 - 11338, XP002071904 *

Also Published As

Publication number Publication date
AU9790398A (en) 1999-04-27
WO1999018230A2 (en) 1999-04-15

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