WO1999016908A3 - Technique d'affichage pour identifier les polymorphismes dans le site d'insertion line-1 - Google Patents

Technique d'affichage pour identifier les polymorphismes dans le site d'insertion line-1 Download PDF

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Publication number
WO1999016908A3
WO1999016908A3 PCT/US1998/020620 US9820620W WO9916908A3 WO 1999016908 A3 WO1999016908 A3 WO 1999016908A3 US 9820620 W US9820620 W US 9820620W WO 9916908 A3 WO9916908 A3 WO 9916908A3
Authority
WO
WIPO (PCT)
Prior art keywords
insertion site
polymorphisms
display technique
differences
display
Prior art date
Application number
PCT/US1998/020620
Other languages
English (en)
Other versions
WO1999016908A2 (fr
Inventor
Gary D Swergold
Fang-Miin Sheen
Original Assignee
Us Health
Gary D Swergold
Sheen Fang Miin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health, Gary D Swergold, Sheen Fang Miin filed Critical Us Health
Priority to AU95960/98A priority Critical patent/AU9596098A/en
Publication of WO1999016908A2 publication Critical patent/WO1999016908A2/fr
Publication of WO1999016908A3 publication Critical patent/WO1999016908A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention a trait à une nouvelle technique d'affichage appelée LINE-1 Display, élaborée pour détecter facilement les différences dans les sites d'insertions L1H entre différents individus. La technique LINE-1 Display est capable de détecter deux types de polymorphismes: les différences dans les lieux des sites d'insertion, et les différences dans les longueurs des queues polyA L1H. Les polymorphismes des sites d'insertion sont particulièrement utiles pour l'anthropologie moléculaire humaine, alors que les polymorphismes des longueurs sont particulièrement utiles dans l'étude des cartographies génétiques.
PCT/US1998/020620 1997-09-29 1998-09-29 Technique d'affichage pour identifier les polymorphismes dans le site d'insertion line-1 WO1999016908A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU95960/98A AU9596098A (en) 1997-09-29 1998-09-29 Display technique for identifying line-1 insertion site polymorphisms

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6035397P 1997-09-29 1997-09-29
US60/060,353 1997-09-29

Publications (2)

Publication Number Publication Date
WO1999016908A2 WO1999016908A2 (fr) 1999-04-08
WO1999016908A3 true WO1999016908A3 (fr) 1999-06-24

Family

ID=22028961

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/020620 WO1999016908A2 (fr) 1997-09-29 1998-09-29 Technique d'affichage pour identifier les polymorphismes dans le site d'insertion line-1

Country Status (2)

Country Link
AU (1) AU9596098A (fr)
WO (1) WO1999016908A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3102722T3 (pl) 2014-02-04 2021-03-08 Jumpcode Genomics, Inc. Frakcjonowanie genomu
AU2015222802B2 (en) * 2014-02-27 2021-07-01 Jumpcode Genomics, Inc. Methods for analysis of somatic mobile elements, and uses thereof
WO2016138292A1 (fr) 2015-02-25 2016-09-01 Igenomx International Genomics Corporation Procédés et compositions pour un séquençage à lecture de fragments longs in silico
US11339427B2 (en) 2016-02-12 2022-05-24 Jumpcode Genomics, Inc. Method for target specific RNA transcription of DNA sequences

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HOLMES S.E. ET AL.,: "A new retrotransposable human L1 elemet from the LRE2 locus on chromosome 1q produces a chimaeric insertion", NATURE GENETICS, vol. 7, - 1994, pages 143 - 148, XP002097819 *
LAURENT A.M. ET AL.,: "A rapid and simple method to isolate and characterize highly polymorphic markers from centromeric regions of the human chromosomes", NUCLEIC ACIDS RESEARCH, vol. 22, no. 2, - 1994, pages 194 - 199, XP002097820 *
SASSAMAN D. ET AL.,: "Many human L1 elemets are capable of retrotransposition", NATURE GENETICS, vol. 16, - 1997, pages 37 - 43, XP002097821 *
SWERGOLD G.D. ET AL.,: "LINE-1 display (LID) mapping, a novel method for identifying insertion sites, reveals frequent insertion site polymorphisms in the human population", AM .J. HUMAN GENETICS, vol. 61, no. 4, - 1997, pages sup.1230, XP002097818 *

Also Published As

Publication number Publication date
AU9596098A (en) 1999-04-23
WO1999016908A2 (fr) 1999-04-08

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