WO1999016429A3 - Budesonide alone or in combination with ursodeoxycholic acid in the therapy of cholestatic liver diseases - Google Patents

Budesonide alone or in combination with ursodeoxycholic acid in the therapy of cholestatic liver diseases Download PDF

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Publication number
WO1999016429A3
WO1999016429A3 PCT/EP1998/005567 EP9805567W WO9916429A3 WO 1999016429 A3 WO1999016429 A3 WO 1999016429A3 EP 9805567 W EP9805567 W EP 9805567W WO 9916429 A3 WO9916429 A3 WO 9916429A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapy
liver diseases
combination
ursodeoxycholic acid
cholestatic liver
Prior art date
Application number
PCT/EP1998/005567
Other languages
French (fr)
Other versions
WO1999016429A2 (en
Inventor
Maria Leuschner
Original Assignee
Falk Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19742612A external-priority patent/DE19742612A1/en
Priority claimed from DE29717252U external-priority patent/DE29717252U1/en
Application filed by Falk Pharma Gmbh filed Critical Falk Pharma Gmbh
Priority to BR9806250-6A priority Critical patent/BR9806250A/en
Publication of WO1999016429A2 publication Critical patent/WO1999016429A2/en
Publication of WO1999016429A3 publication Critical patent/WO1999016429A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

According to the invention it was unexpectedly found that budesonide can be used for the treatment of cholestatic liver diseases such as PBC, PSC and AC. In particular budesonide is highly effective when administered together with ursodeoxycholic acid.
PCT/EP1998/005567 1997-09-26 1998-09-02 Budesonide alone or in combination with ursodeoxycholic acid in the therapy of cholestatic liver diseases WO1999016429A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR9806250-6A BR9806250A (en) 1997-09-26 1998-09-02 Busesonde isolated or in combination with ursodeoxycholic acid in the therapy of cholestatic liver diseases.

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DE19742612.3 1997-09-26
DE29717252.2 1997-09-26
DE19742612A DE19742612A1 (en) 1997-09-26 1997-09-26 Budesonide for the treatment of cholestatic liver diseases
DE29717252U DE29717252U1 (en) 1997-09-26 1997-09-26 Drug kit consisting of a budesonide-containing and an ursodeoxycholic acid-containing drug for the treatment of cholestatic liver diseases
US08/940,211 US5858998A (en) 1997-09-26 1997-09-30 Budesonide alone or in combination with ursodeoxycholic acid in the therapy of cholestatic liver diseases
CA002216887A CA2216887C (en) 1997-09-26 1997-09-30 Budesonide alone or in combination with ursodeoxycholic acid in the therapy of cholestatic liver diseases
US08/940,211 1997-09-30

Publications (2)

Publication Number Publication Date
WO1999016429A2 WO1999016429A2 (en) 1999-04-08
WO1999016429A3 true WO1999016429A3 (en) 2001-12-20

Family

ID=27427393

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/005567 WO1999016429A2 (en) 1997-09-26 1998-09-02 Budesonide alone or in combination with ursodeoxycholic acid in the therapy of cholestatic liver diseases

Country Status (2)

Country Link
BR (1) BR9806250A (en)
WO (1) WO1999016429A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3760203A1 (en) 2019-07-03 2021-01-06 Medizinische Universität Graz Medicament for prevention or treatment of a metabolic disorder

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
A. DANIELSSON ET AL.: "Oral budesonide for treatment of autoimmune chronic active hepatitis", ALIMENT PHARMACOL THER, vol. 8, no. 6, December 1994 (1994-12-01), pages 585 - 590, XP002093560 *
A.J.CZAJA: "DIAGNOSIS AND THERAPY OF AUTOIMMUNE LIVER DISEASE", THE MEDICAL CLINICS OF NORTH AMERICA, vol. 80, no. 5, September 1996 (1996-09-01), pages 973 - 994, XP002093561 *
A.SCHÜLER ET AL.: "TREATMENT OF AUTOIMMUNE HEPATITIS WITH BUDESONIDE", HEPATOLOGY, vol. 22, no. 4 Part 2, October 1995 (1995-10-01), pages 488A, XP002093558 *
C.VETTER: "Wichtige Neuerungen bei Hepatitiden und cholestatischen Lebererkrankungen", AKTUELLE WISSENSCHAFT FÜR KLINIK UND PRAXIS, SATELLITENSYMPOSIUM, "AKTUELLE HEPATOLOGIE - DIAGNOSTISCHE UND THERAPEUTISCHE FORTSCHRITTE 1997", 5 April 1997 (1997-04-05), Wiesbaden, pages 2 - 3, XP002093555 *
E.G.TAMBUSCH ET AL.: "Immunsuppressive Therapie der autoimmunen Lebererkrankungen", INTERNIST, vol. 38, no. 6, June 1997 (1997-06-01), pages 574 - 581, XP002093556 *
F.P.VLEGGAAR ET AL.: "TREATMENT WITH BUDESONIDE OR PREDNISONE IN COMBINATION WITH URSODEOXYCHOLIC ACID (UDCA) IN PRIMARY SCLEROSING CHOLANGITIS (PSC): A RANDOMIZED CONTROLLED PILOT STUDY", HEPATOLOGY, vol. 28, no. 4 Part 2, October 1998 (1998-10-01), pages 647A, XP002093559 *
N.LARUSSO: "Search for medical treatment for primary biliary cirrhosis", LANCET, vol. 350, no. 9084, 11 October 1997 (1997-10-11), pages 1046, XP002093557 *
U.LEUSCHNER ET AL.: ""Ursodeoxycholic acid in combination with prednisolone or budenoside in the therapy of primary biliary cirrhosis" in: BILE ACIDS IN HEPATOBILIARY DISEASES: BASIC RESEARCH AND CLINICAL APPLICATIONS (Proceedings of the Falk Symposium No. 93 (XIV International Bile Acid Meeting), Freiburg, 22-24/10/96", 1997, KLUWER ACADEMIC PUBLISHERS, DORDRECHT, XP002093595 *

Also Published As

Publication number Publication date
BR9806250A (en) 2000-01-25
WO1999016429A2 (en) 1999-04-08

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