WO1999014333A3 - Procede de production amelioree de proteines de surface pneumococciques - Google Patents

Procede de production amelioree de proteines de surface pneumococciques Download PDF

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Publication number
WO1999014333A3
WO1999014333A3 PCT/US1998/019740 US9819740W WO9914333A3 WO 1999014333 A3 WO1999014333 A3 WO 1999014333A3 US 9819740 W US9819740 W US 9819740W WO 9914333 A3 WO9914333 A3 WO 9914333A3
Authority
WO
WIPO (PCT)
Prior art keywords
pspa
production
improved method
surface proteins
pneumococcal surface
Prior art date
Application number
PCT/US1998/019740
Other languages
English (en)
Other versions
WO1999014333A2 (fr
Inventor
Robert Becker
Mary-Ann Gray
Derek Pyle
Original Assignee
Pasteur Merieux Connaught
Robert Becker
Gray Mary Ann
Derek Pyle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Merieux Connaught, Robert Becker, Gray Mary Ann, Derek Pyle filed Critical Pasteur Merieux Connaught
Priority to AU95745/98A priority Critical patent/AU9574598A/en
Priority to EP98949414A priority patent/EP1015591A2/fr
Priority to CA002304128A priority patent/CA2304128A1/fr
Publication of WO1999014333A2 publication Critical patent/WO1999014333A2/fr
Publication of WO1999014333A3 publication Critical patent/WO1999014333A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Cette invention concerne des procédés améliorés permettant de préparer des compositions immunologiques ou vaccinales contenant des polypeptides du type PspA. D'une manière plus spécifique cette invention concerne des compositions vaccinales dans lesquelles le polypeptide PspA ou du type PspA provenant de Rx1 ou d'autres représentants du clade 2 ou de la famille 1 ont été produits au moyen de procédés de recombinaison. On décrit des structures de recombinaison qui expriment une forme tronquée, sensiblement homogène de polypeptides du type PspA actifs du point de vue immunologique dans des cellules hôtes transformées avec ces mêmes structures.
PCT/US1998/019740 1997-09-18 1998-09-18 Procede de production amelioree de proteines de surface pneumococciques WO1999014333A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU95745/98A AU9574598A (en) 1997-09-18 1998-09-18 Improved method of production of pneumococcal surface proteins
EP98949414A EP1015591A2 (fr) 1997-09-18 1998-09-18 Procede de production amelioree de proteines de surface pneumococciques
CA002304128A CA2304128A1 (fr) 1997-09-18 1998-09-18 Procede de production amelioree de proteines de surface pneumococciques

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93298297A 1997-09-18 1997-09-18
US08/932,982 1997-09-18

Publications (2)

Publication Number Publication Date
WO1999014333A2 WO1999014333A2 (fr) 1999-03-25
WO1999014333A3 true WO1999014333A3 (fr) 1999-06-03

Family

ID=25463238

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/019740 WO1999014333A2 (fr) 1997-09-18 1998-09-18 Procede de production amelioree de proteines de surface pneumococciques

Country Status (4)

Country Link
EP (1) EP1015591A2 (fr)
AU (1) AU9574598A (fr)
CA (1) CA2304128A1 (fr)
WO (1) WO1999014333A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000076587A1 (fr) * 1999-06-16 2000-12-21 Aventis Pasteur Traitement a base d'anticorps destine a une infection par streptococcus pneumoniae

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014488A1 (fr) * 1991-02-15 1992-09-03 Uab Research Foundation Gene de structure de proteine de pneumocoque
WO1996040290A1 (fr) * 1995-06-07 1996-12-19 Connaught Laboratories, Inc. Compositions renfermant une association immunologique, et procedes correspondants
WO1997009994A1 (fr) * 1995-09-15 1997-03-20 Uab Research Foundation Genes pneumococciques, parties de ces genes, leurs produits d'expression, et utilisations de ces genes, parties et produits

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014488A1 (fr) * 1991-02-15 1992-09-03 Uab Research Foundation Gene de structure de proteine de pneumocoque
WO1996040290A1 (fr) * 1995-06-07 1996-12-19 Connaught Laboratories, Inc. Compositions renfermant une association immunologique, et procedes correspondants
WO1997009994A1 (fr) * 1995-09-15 1997-03-20 Uab Research Foundation Genes pneumococciques, parties de ces genes, leurs produits d'expression, et utilisations de ces genes, parties et produits

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YOTHER J ET AL: "STRUCTURAL PROPERTIES AND EVOLUTIONARY RELATIONSHIPS OF PSPA, A SURFACE PROTEIN OF STREPTOCOCCUS PNEUMONIAE, AS REVEALED BY SEQUENCE ANALYSIS", JOURNAL OF BACTERIOLOGY, vol. 174, no. 2, 1 January 1992 (1992-01-01), pages 601 - 609, XP000600024 *

Also Published As

Publication number Publication date
WO1999014333A2 (fr) 1999-03-25
AU9574598A (en) 1999-04-05
CA2304128A1 (fr) 1999-03-25
EP1015591A2 (fr) 2000-07-05

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