WO1999013918A3 - Icam-1 selective echogenic microbubbles - Google Patents

Icam-1 selective echogenic microbubbles Download PDF

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Publication number
WO1999013918A3
WO1999013918A3 PCT/US1998/019597 US9819597W WO9913918A3 WO 1999013918 A3 WO1999013918 A3 WO 1999013918A3 US 9819597 W US9819597 W US 9819597W WO 9913918 A3 WO9913918 A3 WO 9913918A3
Authority
WO
WIPO (PCT)
Prior art keywords
icam
selective
gas
filled
binding molecules
Prior art date
Application number
PCT/US1998/019597
Other languages
French (fr)
Other versions
WO1999013918A2 (en
Inventor
Flordeliza S Villanueva
William R Wagner
Original Assignee
Univ Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pittsburgh filed Critical Univ Pittsburgh
Priority to AU94007/98A priority Critical patent/AU9400798A/en
Publication of WO1999013918A2 publication Critical patent/WO1999013918A2/en
Publication of WO1999013918A3 publication Critical patent/WO1999013918A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Methods of preparing gas-filled or gas precursor-filled microbubbles with attached ICAM-binding molecules are described. Gas-filled microbubbles conjugated to anti-ICAM antibodies or other ICAM-binding molecules are useful, for example, in ultrasonic imaging of vascular endothelial cell dysfunction, and in therapeutic drug delivery or gene therapy directed to dysfunctioning endothelial cells.
PCT/US1998/019597 1997-09-18 1998-09-18 Icam-1 selective echogenic microbubbles WO1999013918A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU94007/98A AU9400798A (en) 1997-09-18 1998-09-18 Icam-1 selective echogenic microbubbles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5939997P 1997-09-18 1997-09-18
US60/059,399 1997-09-18

Publications (2)

Publication Number Publication Date
WO1999013918A2 WO1999013918A2 (en) 1999-03-25
WO1999013918A3 true WO1999013918A3 (en) 1999-06-03

Family

ID=22022698

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/019597 WO1999013918A2 (en) 1997-09-18 1998-09-18 Icam-1 selective echogenic microbubbles

Country Status (2)

Country Link
AU (1) AU9400798A (en)
WO (1) WO1999013918A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846076B2 (en) 2006-05-26 2014-09-30 Z-Medica, Llc Hemostatic sponge
US8858969B2 (en) 2010-09-22 2014-10-14 Z-Medica, Llc Hemostatic compositions, devices, and methods
US8938898B2 (en) 2006-04-27 2015-01-27 Z-Medica, Llc Devices for the identification of medical products
US9072806B2 (en) 2012-06-22 2015-07-07 Z-Medica, Llc Hemostatic devices
US9326995B2 (en) 2005-04-04 2016-05-03 The Regents Of The University Of California Oxides for wound healing and body repair

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999055837A2 (en) * 1998-04-28 1999-11-04 Nycomed Imaging As Improvements in or relating to separation processes
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
EP1663090A4 (en) 2003-09-12 2010-07-21 Z Medica Corp Calcium zeolite hemostatic agent
US7025726B2 (en) 2004-01-22 2006-04-11 The Regents Of The University Of Nebraska Detection of endothelial dysfunction by ultrasonic imaging
AU2006214371A1 (en) 2005-02-15 2006-08-24 Virginia Commonwealth University Mineral technologies (MT) for acute hemostasis and for the treatment of acute wounds and chronic ulcers
CA2684752A1 (en) * 2007-04-20 2008-10-30 Oregon Health & Science University Ultrasound imaging with targeted microbubbles
EP2251694A4 (en) * 2008-02-29 2011-03-16 Univ Shinshu Kit for detecting cancer cells metastasizing into sentinel lymph node
US8778307B2 (en) 2009-06-05 2014-07-15 University Of Maryland, College Park Targeted carriers for drug delivery across the gastrointestinal epithelium
US20150219636A1 (en) 2014-01-28 2015-08-06 Targeson, Inc. Isolation of cells and biological substances using buoyant microbubbles
CN111973731B (en) * 2020-08-06 2023-03-24 温州医科大学 Targeted localization and delivery of nitric oxide formulations for coronary heart disease

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0727225A2 (en) * 1995-02-14 1996-08-21 Sonus Pharmaceuticals, Inc. Compositions and methods for directed ultrasound imaging
WO1996025947A2 (en) * 1995-02-21 1996-08-29 Arch Development Corporation Induction of e-selectin for targetting therapeutic agents
WO1996040285A1 (en) * 1995-06-07 1996-12-19 Imarx Pharmaceutical Corp. Novel targeted compositions for diagnostic and therapeutic use
WO1998053857A1 (en) * 1997-05-27 1998-12-03 Mallinckrodt Medical, Inc. Selectively binding ultrasound contrast agents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0727225A2 (en) * 1995-02-14 1996-08-21 Sonus Pharmaceuticals, Inc. Compositions and methods for directed ultrasound imaging
WO1996025947A2 (en) * 1995-02-21 1996-08-29 Arch Development Corporation Induction of e-selectin for targetting therapeutic agents
WO1996040285A1 (en) * 1995-06-07 1996-12-19 Imarx Pharmaceutical Corp. Novel targeted compositions for diagnostic and therapeutic use
WO1998053857A1 (en) * 1997-05-27 1998-12-03 Mallinckrodt Medical, Inc. Selectively binding ultrasound contrast agents

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
P.G.M. BLOEMEN ET AL.: "adhesion molecules: a new target for immunoliposome-mediated drug delivery", FEBS LETTERS., vol. 357, 1995, AMSTERDAM NL, pages 140 - 144, XP002092050 *
UNGER, EVAN C. ET AL: "In vitro studies of a new thrombus -specific ultrasound contrast agent", AM. J. CARDIOL. (1998), 81(12A, SYMPOSIUM: NINTH INTERNATIONAL CONGRESS O ECHOCARDIOGRAPHY: CLINICAL CARDIOLOGY, 1997), 58G-61G CODEN: AJCDAG;ISSN: 0002-9149, 1998, XP002092049 *
VILLANUEVA, FLORDELIZA S. ET AL: "Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells", CIRCULATION (1998), 98(1), 1-5 CODEN: CIRCAZ;ISSN: 0009-7322, 1998, XP002092048 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9326995B2 (en) 2005-04-04 2016-05-03 The Regents Of The University Of California Oxides for wound healing and body repair
US8938898B2 (en) 2006-04-27 2015-01-27 Z-Medica, Llc Devices for the identification of medical products
US8846076B2 (en) 2006-05-26 2014-09-30 Z-Medica, Llc Hemostatic sponge
US9078782B2 (en) 2006-05-26 2015-07-14 Z-Medica, Llc Hemostatic fibers and strands
US9333117B2 (en) 2006-05-26 2016-05-10 Z-Medica, Llc Clay-based hemostatic agents and devices for the delivery thereof
US8858969B2 (en) 2010-09-22 2014-10-14 Z-Medica, Llc Hemostatic compositions, devices, and methods
US9072806B2 (en) 2012-06-22 2015-07-07 Z-Medica, Llc Hemostatic devices
US9352066B2 (en) 2012-06-22 2016-05-31 Z-Medica, Llc Hemostatic devices

Also Published As

Publication number Publication date
WO1999013918A2 (en) 1999-03-25
AU9400798A (en) 1999-04-05

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