WO1999010487A3 - Novel transcriptional regulators and uses therefor - Google Patents

Novel transcriptional regulators and uses therefor Download PDF

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Publication number
WO1999010487A3
WO1999010487A3 PCT/US1998/017691 US9817691W WO9910487A3 WO 1999010487 A3 WO1999010487 A3 WO 1999010487A3 US 9817691 W US9817691 W US 9817691W WO 9910487 A3 WO9910487 A3 WO 9910487A3
Authority
WO
WIPO (PCT)
Prior art keywords
transcriptional regulators
uses therefor
novel transcriptional
promoter
rnas
Prior art date
Application number
PCT/US1998/017691
Other languages
French (fr)
Other versions
WO1999010487A9 (en
WO1999010487A2 (en
Inventor
Kevin A Jarrell
Shamol Saha
Mark Ptashne
Original Assignee
Harvard College
Univ Boston
Kevin A Jarrell
Shamol Saha
Mark Ptashne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Univ Boston, Kevin A Jarrell, Shamol Saha, Mark Ptashne filed Critical Harvard College
Priority to AU91212/98A priority Critical patent/AU9121298A/en
Publication of WO1999010487A2 publication Critical patent/WO1999010487A2/en
Publication of WO1999010487A3 publication Critical patent/WO1999010487A3/en
Publication of WO1999010487A9 publication Critical patent/WO1999010487A9/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1048—SELEX
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention provides RNA molecules that regulate transcription. Specifically, the invention provides RNAs that, when recruited to a site operatively linked to a promoter, increase or decrease the rate or extent of transcription from that promoter. Methods of isolating such RNAs, termed 'riboregulators', and methods of using them, are also provided.
PCT/US1998/017691 1997-08-27 1998-08-26 Novel transcriptional regulators and uses therefor WO1999010487A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU91212/98A AU9121298A (en) 1997-08-27 1998-08-26 Novel transcriptional regulators and uses therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5685797P 1997-08-27 1997-08-27
US60/056,857 1997-08-27

Publications (3)

Publication Number Publication Date
WO1999010487A2 WO1999010487A2 (en) 1999-03-04
WO1999010487A3 true WO1999010487A3 (en) 1999-07-01
WO1999010487A9 WO1999010487A9 (en) 1999-09-10

Family

ID=22006994

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/017691 WO1999010487A2 (en) 1997-08-27 1998-08-26 Novel transcriptional regulators and uses therefor

Country Status (2)

Country Link
AU (1) AU9121298A (en)
WO (1) WO1999010487A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003290937A1 (en) * 2002-11-15 2004-06-15 Trustees Of Boston University Cis/trans riboregulators
US8017755B2 (en) 2003-05-23 2011-09-13 President And Fellows Of Harvard College RNA-based transcriptional regulators

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996029429A1 (en) * 1995-03-23 1996-09-26 Wisconsin Alumni Research Foundation System to detect protein-rna interactions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996029429A1 (en) * 1995-03-23 1996-09-26 Wisconsin Alumni Research Foundation System to detect protein-rna interactions

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
D.J. SENGUPTA ET AL.: "A three-hybrid system to detect RNA-protein interaction in vivo", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA, vol. 93, 1996, pages 8496 - 8501, XP002038710 *
E.R. JUPE ET AL.: "The 3'untranslated region of prohibitin and cellular immortalization", EXPERIMENTAL CELL RESEARCH, vol. 224, 1996, pages 128 - 135, XP000609312 *
F. RATINEJAD ET AL.: "Tumor suppression by RNA from the 3'untranslated region of alfa-tropomyosin", CELL, vol. 75, 1993, pages 1107 - 1117, XP002101802 *
G. GILL AND M. PTASHNE: "Negative effect of the transcriptional activator GAL4", NATURE, vol. 334, no. 6184, 1988, pages 721 - 724, XP000002975 *
M.D. CRESPI ET AL.: "enod40, a gene expressed during nodule organogenensis, codes for a non-translatable RNA involved in plant growth", EMBO JOURNAL, vol. 13, no. 21, 1994, pages 5099 - 5112, XP002101803 *
S.A. RICE ET AL.: "Bacterial reverse transcriptase and msDNA", VIRUS GENES, vol. 11, no. 2/3, 1996, pages 95 - 104, XP002101801 *
U. PUTZ ET AL: "A tri-hybrid system for the analysis and detection of RNA-protein interactions", NUCLEIC ACIDS RESEARCH, vol. 24, no. 23, 1996, pages 4838 - 4840, XP000198724 *

Also Published As

Publication number Publication date
AU9121298A (en) 1999-03-16
WO1999010487A9 (en) 1999-09-10
WO1999010487A2 (en) 1999-03-04

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