WO1999010326A1 - Preparation of pyridine derivatives - Google Patents
Preparation of pyridine derivatives Download PDFInfo
- Publication number
- WO1999010326A1 WO1999010326A1 PCT/GB1998/002465 GB9802465W WO9910326A1 WO 1999010326 A1 WO1999010326 A1 WO 1999010326A1 GB 9802465 W GB9802465 W GB 9802465W WO 9910326 A1 WO9910326 A1 WO 9910326A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- formula
- process according
- carried out
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98940348A EP1005457A1 (en) | 1997-08-23 | 1998-08-24 | Preparation of pyridine derivatives |
AU88690/98A AU8869098A (en) | 1997-08-23 | 1998-08-24 | Preparation of pyridine derivatives |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9717849.5A GB9717849D0 (en) | 1997-08-23 | 1997-08-23 | Preparation of pyridene derivatives |
GB9717849.5 | 1997-08-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999010326A1 true WO1999010326A1 (en) | 1999-03-04 |
Family
ID=10817902
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1998/002465 WO1999010326A1 (en) | 1997-08-23 | 1998-08-24 | Preparation of pyridine derivatives |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1005457A1 (en) |
AU (1) | AU8869098A (en) |
GB (1) | GB9717849D0 (en) |
WO (1) | WO1999010326A1 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6245913B1 (en) * | 1999-06-30 | 2001-06-12 | Wockhardt Europe Limited | Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole |
US7622490B2 (en) | 2001-05-11 | 2009-11-24 | Tibotec Pharmaceuticals, Ltd. | Broadspecturm 2-amino-benzoxazole sulfonamide HIV protease inhibitors |
EP2145888A1 (en) | 2003-09-18 | 2010-01-20 | Conforma Therapeutics Corporation | Deazapurine derivatives as HSP90-Inhibitors |
CN104557693A (en) * | 2015-01-16 | 2015-04-29 | 江苏中邦制药有限公司 | Synthesis method of 3,5-dimethyl-4-nitropyridine-N-oxide |
CN111303018A (en) * | 2020-03-16 | 2020-06-19 | 浙江华洲药业有限公司 | Synthetic method of omeprazole intermediate |
CN114805193A (en) * | 2022-04-19 | 2022-07-29 | 南京红太阳医药研究院有限公司 | Preparation method of omeprazole intermediate |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0103553A1 (en) * | 1982-08-26 | 1984-03-21 | Aktiebolaget Hässle | Intermediates for the preparation of omeprazole |
EP0484265A1 (en) * | 1990-10-31 | 1992-05-06 | Centro Genesis Para La Investigacion, S.L. | A process for the preparation of omeprazol |
JPH0559004A (en) * | 1991-08-28 | 1993-03-09 | Tokyo Tanabe Co Ltd | Production of 2-hydroxymethyl-4-methoxy-3,5-dimethylpyridine by new method for introducing methoxy group |
JPH0570434A (en) * | 1991-09-17 | 1993-03-23 | Tokyo Tanabe Co Ltd | Production of novel 2-hydroxymethyl-4-methoxy-3,5-dimethylpyridine and its intermediate and their production |
JPH0570432A (en) * | 1991-07-17 | 1993-03-23 | Tokyo Tanabe Co Ltd | Novel 4-methoxy-2-(2-tetrahydropyranyloxymethyl) pyridine compound and its intermediate and their production |
JPH05222038A (en) * | 1992-02-12 | 1993-08-31 | Tokyo Tanabe Co Ltd | Production of new 5-methoxy-2-((@(3754/24)4-methoxy-3,5-dimethyl-2-pyridyl)methyl)thio)imidazo(4,5-b)pyridine, intermediate for producing the same and its production |
ES2035767B1 (en) * | 1991-04-05 | 1994-02-01 | Genesis Para La Investigacion | PROCEDURE FOR OBTAINING 2-HYDROXIMETIL-3,5-DIMETILPIRIDINAS 4-SUBSTITUTED. |
ES2097089A1 (en) * | 1995-02-01 | 1997-03-16 | Esteve Quimica Sa | Process for the preparation of 2-hydroxymethyl-3,5- dimethyl-4-methoxypyridine |
-
1997
- 1997-08-23 GB GBGB9717849.5A patent/GB9717849D0/en not_active Ceased
-
1998
- 1998-08-24 EP EP98940348A patent/EP1005457A1/en not_active Withdrawn
- 1998-08-24 AU AU88690/98A patent/AU8869098A/en not_active Abandoned
- 1998-08-24 WO PCT/GB1998/002465 patent/WO1999010326A1/en not_active Application Discontinuation
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0103553A1 (en) * | 1982-08-26 | 1984-03-21 | Aktiebolaget Hässle | Intermediates for the preparation of omeprazole |
EP0484265A1 (en) * | 1990-10-31 | 1992-05-06 | Centro Genesis Para La Investigacion, S.L. | A process for the preparation of omeprazol |
ES2035767B1 (en) * | 1991-04-05 | 1994-02-01 | Genesis Para La Investigacion | PROCEDURE FOR OBTAINING 2-HYDROXIMETIL-3,5-DIMETILPIRIDINAS 4-SUBSTITUTED. |
JPH0570432A (en) * | 1991-07-17 | 1993-03-23 | Tokyo Tanabe Co Ltd | Novel 4-methoxy-2-(2-tetrahydropyranyloxymethyl) pyridine compound and its intermediate and their production |
JPH0559004A (en) * | 1991-08-28 | 1993-03-09 | Tokyo Tanabe Co Ltd | Production of 2-hydroxymethyl-4-methoxy-3,5-dimethylpyridine by new method for introducing methoxy group |
JPH0570434A (en) * | 1991-09-17 | 1993-03-23 | Tokyo Tanabe Co Ltd | Production of novel 2-hydroxymethyl-4-methoxy-3,5-dimethylpyridine and its intermediate and their production |
JPH05222038A (en) * | 1992-02-12 | 1993-08-31 | Tokyo Tanabe Co Ltd | Production of new 5-methoxy-2-((@(3754/24)4-methoxy-3,5-dimethyl-2-pyridyl)methyl)thio)imidazo(4,5-b)pyridine, intermediate for producing the same and its production |
ES2097089A1 (en) * | 1995-02-01 | 1997-03-16 | Esteve Quimica Sa | Process for the preparation of 2-hydroxymethyl-3,5- dimethyl-4-methoxypyridine |
Non-Patent Citations (3)
Title |
---|
PATENT ABSTRACTS OF JAPAN vol. 017, no. 373 (C - 1083) 14 July 1993 (1993-07-14) * |
PATENT ABSTRACTS OF JAPAN vol. 017, no. 391 (C - 1087) 22 July 1993 (1993-07-22) * |
PATENT ABSTRACTS OF JAPAN vol. 017, no. 674 (C - 1140) 10 December 1993 (1993-12-10) * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6245913B1 (en) * | 1999-06-30 | 2001-06-12 | Wockhardt Europe Limited | Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole |
US7622490B2 (en) | 2001-05-11 | 2009-11-24 | Tibotec Pharmaceuticals, Ltd. | Broadspecturm 2-amino-benzoxazole sulfonamide HIV protease inhibitors |
US7863306B2 (en) | 2001-05-11 | 2011-01-04 | Tibotec Pharmaceuticals Ltd | Broadspectrum 2-amino-benzoxazole sulfonamide HIV protease inhibitors |
EP2145888A1 (en) | 2003-09-18 | 2010-01-20 | Conforma Therapeutics Corporation | Deazapurine derivatives as HSP90-Inhibitors |
CN104557693A (en) * | 2015-01-16 | 2015-04-29 | 江苏中邦制药有限公司 | Synthesis method of 3,5-dimethyl-4-nitropyridine-N-oxide |
CN111303018A (en) * | 2020-03-16 | 2020-06-19 | 浙江华洲药业有限公司 | Synthetic method of omeprazole intermediate |
CN114805193A (en) * | 2022-04-19 | 2022-07-29 | 南京红太阳医药研究院有限公司 | Preparation method of omeprazole intermediate |
Also Published As
Publication number | Publication date |
---|---|
AU8869098A (en) | 1999-03-16 |
GB9717849D0 (en) | 1997-10-29 |
EP1005457A1 (en) | 2000-06-07 |
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