WO1999009931A1 - Dual vial connecting system for lyophilized products - Google Patents

Dual vial connecting system for lyophilized products Download PDF

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Publication number
WO1999009931A1
WO1999009931A1 PCT/EP1997/004660 EP9704660W WO9909931A1 WO 1999009931 A1 WO1999009931 A1 WO 1999009931A1 EP 9704660 W EP9704660 W EP 9704660W WO 9909931 A1 WO9909931 A1 WO 9909931A1
Authority
WO
WIPO (PCT)
Prior art keywords
plastic
closing
glass
vial
plastic sleeve
Prior art date
Application number
PCT/EP1997/004660
Other languages
French (fr)
Inventor
Franck Moisio
Franz A. Klug
Original Assignee
Pentapharm Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP97944798A priority Critical patent/EP1009356B1/en
Priority to AT97944798T priority patent/ATE211901T1/en
Application filed by Pentapharm Ag filed Critical Pentapharm Ag
Priority to PCT/EP1997/004660 priority patent/WO1999009931A1/en
Priority to IL13435697A priority patent/IL134356A0/en
Priority to CA 2295827 priority patent/CA2295827C/en
Priority to KR10-2000-7001935A priority patent/KR100484285B1/en
Priority to HU0004820A priority patent/HU223484B1/en
Priority to PL97338582A priority patent/PL338582A1/en
Priority to CZ2000648A priority patent/CZ291703B6/en
Priority to US09/486,566 priority patent/US6237649B1/en
Priority to AU46187/97A priority patent/AU4618797A/en
Priority to DE69709692T priority patent/DE69709692T2/en
Priority to ES97944798T priority patent/ES2172007T3/en
Priority to JP2000507324A priority patent/JP4095770B2/en
Publication of WO1999009931A1 publication Critical patent/WO1999009931A1/en
Priority to IL134356A priority patent/IL134356A/en

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089Containers or vials which are to be joined to each other in order to mix their contents
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3205Separate rigid or semi-rigid containers joined to each other at their external surfaces
    • B65D81/3211Separate rigid or semi-rigid containers joined to each other at their external surfaces coaxially and provided with means facilitating admixture
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/1406Septums, pierceable membranes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/201Piercing means having one piercing end

Definitions

  • the present invention concerns in a dual vial connecting system for temporary connection of two containers, usually a glass or plastic vial and a plastic solvent bottle, the purpose being to reconstitute a dry product, such as a lyophilisate, powder etc., contained in a glass or plastic vial with a corresponding solvent product contained in a plastic solvent bottle, the connecting system having a cylindrical closing and connecting plastic sleeve with a lower portion having inwardly directed securing means for secure connection with the neck of the glass or plastic vial, an upper portion having an internal thread for screwing connection with the plastic solvent bottle and an integrated plastic membrane being perforated by the orifice reducer of the plastic solvent bottle when screwed into the upper inner threaded portion of the closing and connecting plastic sleeve.
  • the two products are kept and stored in separate containers prior to their immediate use.
  • the two containers are hermetically closed.
  • the aim of the present invention is a dual connecting container system which does not require a rubber stopper but ensures a tight closure of the glass or plastic vial containing the lyophilisate etc., as well as a tight connection between the glass or plastic vial and the solvent bottle during the reconstitution phase.
  • this is achieved by the closing and connecting plastic sleeve having a perforable membrane separating the upper inner threaded portion from the lower portion of the closing and connecting plastic sleeve, an inner cylindrical skirt located in the inner lower portion of the closing and connecting plastic sleeve and extending downwardly from the lower surface of the perforable membrane said skirt having an outer diameter coming in contact with the wall of the im er neck of the glass or plastic vial, an elastomer sealing ring fixed at the uppermost position around the outer surface of the said skirt, an elastomer sealing plug with a pre-cut section and a cavity in its centre, the said sealing plug being placed around a cylindrical collar located in the inner upper portion of the closing and connecting plastic sleeve and extending upwardly from the upper surface of the perforable membrane, whereby the perforable membrane, the cylindrical skirt and the collar are integrally moulded parts of the said closing and connecting plastic sleeve.
  • the securing means comprises a threaded imier wall of the inner lower portion for engaging a corresponding thread on the outer surface of the glass or plastic vial neck.
  • the imier wall is provided with cogs engaging corresponding cogs on the outer surface of the glass or plastic vial neck.
  • the thread is interrupted by vertical grooves for keeping an open connection from the glass or plastic vial interior to the outside when the closing and connecting plastic sleeve is only partially screwed onto the said vial.
  • the lower portion of the closing and connecting plastic sleeve has inwardly directed projections for snapping connection with an amiular bulge around the outer surface of the neck of the glass or plastic vial.
  • the elastomer sealing plug has a cavity in its center leaving a thinned area which functions as an elastomer membrane which is pre-cut in its center.
  • the plastic solvent bottle is then squeezed in order to transfer the solvent product into the glass or plastic vial containing the lyophilisate, powder etc., .
  • the assembly is then inverted, having now the glass or plastic vial on top, the recalling of the reconstituted final product into the plastic solvent bottle can be achieved by squeezing and releasing the plastic solvent bottle again several times.
  • the inner wall of the upper tlireaded portion of the closing and comiecting plastic sleeve has an annular rib that operates as a snap and allowing to hold the sealing elastomer plug in place.
  • the elastomer sealing ring assures a tightness when the closing and connecting plastic sleeve is completely screwed onto the tlireaded neck of the glass or plastic vial and comes in contact with the top surface of the neck of the said glass or plastic vial.
  • Fig. 1 shows a schematic representation of the dual vial connecting system according to the invention.
  • Fig. 2 shows the closing and connecting plastic sleeve.
  • Fig. 3 shows an elastomer sealing plug with a pre-cut area.
  • Fig. 4 shows the perforable plastic membrane with notches and weakness zones.
  • FIG. shows an alternative embodiment of a dual vial connecting system according to the invention.
  • Fig 6. shows the closing and connecting plastic sleeve of the alternative embodiment.
  • Fig 7. shows the dual vial connecting system during lyophilisation process.
  • Fig 8. shows the alternative embodiment during lyophilisation process.
  • Fig 9. shows the security blocking system.
  • a glass or plastic vial 1 contains a solid product 2 such as a lyophilisate, powder, etc.,. In order to obtain a ready to use solution, the lyophilisate product 2 has to be mixed or redissolved with a solvent 23 stored separately in a plastic solvent bottle 3 made of a flexible material.
  • the two containers 1 and 3 have to be connected in such a way that the solvent 23 may be transferred into the glass or plastic vial 1 containing the lyophilisate 2 and where the mixing and reconstitution takes place.
  • the assembly is inverted, having now the glass or plastic vial 1 on top so that the solution may be retransferred into the plastic solvent bottle 3 by squeezing and releasing the said plastic solvent bottle 3 several times. During this entire process, no liquid must be lost and no leakage must occur.
  • a closing and connecting plastic sleeve 4 has a cylindrical shape and consists of a lower inner threaded portion 5 and an upper inner tlireaded portion 6 separated from each other by a perforable plastic membrane 7 which is an integral part of the closing and comiecting plastic sleeve 4.
  • the plastic perforable membrane 7 is perforated by the orifice reducer 22 of the plastic solvent bottle 3 during connection of the two containers 1 and 3.
  • the plastic perforable membrane 7 (Fig 4), has in its center notches 8 forming characteristic weakness zones 32 that will break more easily under the pressure of the orifice reducer 22 of the plastic solvent bottle 3 when screwed in the upper imier threaded portion 6 of the closing and connecting plastic sleeve 4.
  • the lower portion 5 of the closing and connecting plastic sleeve 4 has on its inner wall a tliread 24 that fits with the counter-tliread 25 of the neck of the glass or plastic vial 1.
  • a security blocking system 30 is build in the inner wall periphery characterised by cogs 9 having a slight inclination in order to facilitate the screwing of the closing and comiecting plastic sleeve 4 when in contact with the neck of the glass or plastic vial 1 also characterised by cogs 11 having a slight inclination.
  • Tightness between the closing and connecting plastic sleeve 4 and the top surface neck of the glass or plastic vial 1 is ensured by two co-operating features : An inner cylindrical plastic skirt 12 that extends downwardly from the plastic perforable membrane surface 7 and having an outer diameter fitting in the inner portion neck 10 of the glass or plastic vial 1.
  • the imier cylindrical plastic skirt 12 is an integral part of the closing and connecting plastic sleeve 4.
  • the second feature for effective tightness is an elastomer sealing ring 13 placed at the uppe ⁇ nost position around the outer surface of the imier extending downwardly extending cylindrical plastic skirt 12 inside the lower portion 5 of the closing and comiecting plastic sleeve 4.
  • the upper portion 6 of the closing and connecting plastic sleeve 4 has an inner diameter adapted to receive the plastic solvent bottle 3.
  • the imier wall of the upper portion 6 of the closing and comiecting plastic sleeve 4 is provided with a tliread 15 which fits with the counter-tliread 14 of the plastic solvent bottle 3.
  • annular rib 16 is located below the inner tliread 15 in the upper portion 6 of the closing and connecting plastic sleeve 4 , operating as a snap and holding the sealing elastomer plug 18 in place.
  • the elastomer sealing plug 18 is snapped in between the annular rib 16 and the imier upwardly extending plastic collar 17, both located in the upper inner portion 6 of the closing and comiecting plastic sleeve 4 for safe and exact positioning reasons.
  • the elastomer sealing plug 18 prevents gaz exchanges that may occur via the plastic perforable membrane 7 and of having direct contact with the plastic perforable membrane 7 with any kind of pollution or particles.
  • the solution can be retransferred into the plastic solvent bottle 3 by inverting the assembly, the glass or plastic vial 1 being on top, by squeezing and releasing the plastic solvent bottle 3 again several times.
  • the whole procedure can be accomplished without any spilling or leakage.
  • Another advantage of the present invention is its special suitability for lyophilisation process.
  • the glass or plastic vial 1 Prior to lyophilisation , the glass or plastic vial 1 is filled with a liquid active 31 (Fig. 7).
  • the closing and connecting plastic sleeve 4 is slightly screwed onto the tliread 25 of the neck of the glass or plastic vial 1.
  • the cylindrical imier plastic skirt 12 located in the inner lower portion 5 of the closing and comiecting plastic sleeve 4 is in this case not yet in contact with the wall 10 of the inner neck of the glass or plastic vial 1.
  • the glass or plastic vial 1 with its liquid active 31 and its closing and comiecting plastic sleeve 4 which remains not completely screwed, is placed into the freeze-dryer for lyophilisation.
  • the inner tliread 24 located in the lower inner portion 5 of the closing and connecting plastic sleeve 4 is interrupted by vertical grooves 28 winch have the function of escape or evacuation channels needed during the lyophilisation process to insure the removal of the moisture or liquid in gaz form.
  • the closing and connecting plastic sleeve 4 is completely screwed onto the glass or plastic vial 1.
  • the cogs 11 located below the tliread 25 on the neck of the glass or plastic vial 1 in combination with the cogs 9 of the closing and connecting plastic sleeve 4, constitute the security blocking system 30 (Fig 10) which has the advantage of preventing the removal of the closing and connecting plastic sleeve 4 by manual means one completely screwed onto the glass or plastic vial 1.
  • Figs. 5,6 and 8 show an alternative embodiment of the invention.
  • the same elements are designated with the same reference numerals.
  • the lower portion 5 of the closing and connecting plastic sleeve 4 has on its inner wall a number of annularly arranged projections 26 defining an inner diameter fitting in between the two annular bulges 27 on the outside of the neck of the glass or plastic vial 1.
  • This configuration constitutes a snap-in attachment of the closing and connecting plastic sleeve 4 on the said vial 1.
  • the wall of the lower portion 5 of the closing and connecting plastic sleeve 4 is extended below the projections 26 to form a kind of skirt 29 which is adapted to hold the closing and comiecting plastic sleeve 4 in the position shown in (Fig. 8) which is described hereinafter.
  • the upper portion 6 of the closing and connecting plastic sleeve 4 shown in (Figs. 5,6 and 8) is identical to that of the other embodiment (Figs. 1,2, and 7).
  • This alternative embodiment is also characterised by its special suitability for fully automatically lyophilisation process.
  • the glass or plastic vial 1 Prior to lyophilisation, the glass or plastic vial 1 is filled with a liquid active 31.
  • the closing and connecting plastic sleeve 4 is placed on top of the first bulge 27 of the glass or plastic vial 1. It remains positioned on the neck of the glass or plastic vial 1 due to the extended skirt 29 and projections 26 which allow to maintain the closing and connecting plastic sleeve 4 unsnapped during the lyophilisation cycle.
  • the glass or plastic vial 1 with its closing and connecting sleeve 4, which is not snapped is placed in the freeze-dryer for lyophilisation.
  • the lateral spaces between the aimularly arranged projection 26 located in the imier lower portion 5 of the closing and connecting plastic sleeve 4 provide open contact between the interior of the glass or plastic vial 1 and its surrounding and thus guarantee evaporation of the moisture or liquid during lyophilisation cycle.
  • the specifically shaped dual bulges 27 on the glass or plastic vial neck in combination with the annularly arranged projections 26 of the closing and comiecting plastic sleeve 4 have the added advantage of preventing also the removal of the said closing and connecting plastic sleeve 4 by manual means.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Closures For Containers (AREA)
  • Coupling Device And Connection With Printed Circuit (AREA)
  • Drying Of Solid Materials (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • External Artificial Organs (AREA)
  • Stackable Containers (AREA)

Abstract

For temporary connection of two containers (1, 3) such as vials, bottles, etc..., with guaranteed tightness thanks to a cylindrical screwing closing and connection plastic sleeve (4) having a plastic perforable membrane (7) located between its upper portion (6) and lower portion (5) including an elastomer sealing ring (13) fixed around a cylindrical plastic skirt (12) located in the inner lower portion (5), and an elastomer sealing plug (18) fixed by the collar (17) and the annular rib (16) in the inner upper portion (6), a cylindrical plastic skirt (12) coming in contact with the inner neck (10) of the glass or plastic vial (1), the whole assuring complete tightness of the system when stored and when used for the reconstitution of the product (2) contained in a glass or plastic vial (1) with a corresponding solvent (23) contained in a plastic solvent bottle (3).

Description

DUAL VIAL CONNECTING SYSTEM FOR LYOPHILIZED PRODUCTS
The present invention concerns in a dual vial connecting system for temporary connection of two containers, usually a glass or plastic vial and a plastic solvent bottle, the purpose being to reconstitute a dry product, such as a lyophilisate, powder etc., contained in a glass or plastic vial with a corresponding solvent product contained in a plastic solvent bottle, the connecting system having a cylindrical closing and connecting plastic sleeve with a lower portion having inwardly directed securing means for secure connection with the neck of the glass or plastic vial, an upper portion having an internal thread for screwing connection with the plastic solvent bottle and an integrated plastic membrane being perforated by the orifice reducer of the plastic solvent bottle when screwed into the upper inner threaded portion of the closing and connecting plastic sleeve.
For reasons of stability, freshness, marketing aspects, etc., the two products are kept and stored in separate containers prior to their immediate use. During storage, the two containers are hermetically closed.
The aim of the present invention is a dual connecting container system which does not require a rubber stopper but ensures a tight closure of the glass or plastic vial containing the lyophilisate etc., as well as a tight connection between the glass or plastic vial and the solvent bottle during the reconstitution phase. According to the invention, this is achieved by the closing and connecting plastic sleeve having a perforable membrane separating the upper inner threaded portion from the lower portion of the closing and connecting plastic sleeve, an inner cylindrical skirt located in the inner lower portion of the closing and connecting plastic sleeve and extending downwardly from the lower surface of the perforable membrane said skirt having an outer diameter coming in contact with the wall of the im er neck of the glass or plastic vial, an elastomer sealing ring fixed at the uppermost position around the outer surface of the said skirt, an elastomer sealing plug with a pre-cut section and a cavity in its centre, the said sealing plug being placed around a cylindrical collar located in the inner upper portion of the closing and connecting plastic sleeve and extending upwardly from the upper surface of the perforable membrane, whereby the perforable membrane, the cylindrical skirt and the collar are integrally moulded parts of the said closing and connecting plastic sleeve.
According to a preferred embodiment of the invention the securing means comprises a threaded imier wall of the inner lower portion for engaging a corresponding thread on the outer surface of the glass or plastic vial neck. As a safeguard against removal of the closing and connecting plastic sleeve from the glass or plastic vial, the imier wall is provided with cogs engaging corresponding cogs on the outer surface of the glass or plastic vial neck. Moreover, the thread is interrupted by vertical grooves for keeping an open connection from the glass or plastic vial interior to the outside when the closing and connecting plastic sleeve is only partially screwed onto the said vial. According to an alternative embodiment of the invention, the lower portion of the closing and connecting plastic sleeve has inwardly directed projections for snapping connection with an amiular bulge around the outer surface of the neck of the glass or plastic vial.
According to another preferred embodiment, the elastomer sealing plug has a cavity in its center leaving a thinned area which functions as an elastomer membrane which is pre-cut in its center. When screwing the plastic solvent bottle into the upper imier threaded portion of the closing and connecting plastic sleeve, the orifice reducer of the said plastic solvent bottle first penetrates through the pre-cut area of the said sealing plug and then perforates the plastic membrane of the closing and connecting plastic sleeve.
Once the solvent bottle is completely screwed into the closing and connecting plastic sleeve, the wall of the orifice reducer come in contact with the wall of the cavity of the said sealing plug which assures a complete tightness between the two containers, the plastic solvent bottle is then squeezed in order to transfer the solvent product into the glass or plastic vial containing the lyophilisate, powder etc., . When the reconstitution of the lyophilized product, fonning the final product, is completed by shaking the assembly, the assembly is then inverted, having now the glass or plastic vial on top, the recalling of the reconstituted final product into the plastic solvent bottle can be achieved by squeezing and releasing the plastic solvent bottle again several times. According to another embodiment of the present invention, the inner wall of the upper tlireaded portion of the closing and comiecting plastic sleeve has an annular rib that operates as a snap and allowing to hold the sealing elastomer plug in place.
The elastomer sealing ring assures a tightness when the closing and connecting plastic sleeve is completely screwed onto the tlireaded neck of the glass or plastic vial and comes in contact with the top surface of the neck of the said glass or plastic vial.
In the following preferred embodiments of the invention are described with regard to the accompanying drawings, wherein :
Fig. 1 shows a schematic representation of the dual vial connecting system according to the invention. Fig. 2 shows the closing and connecting plastic sleeve. Fig. 3 shows an elastomer sealing plug with a pre-cut area. Fig. 4 shows the perforable plastic membrane with notches and weakness zones.
Fig 5.shows an alternative embodiment of a dual vial connecting system according to the invention. Fig 6. shows the closing and connecting plastic sleeve of the alternative embodiment. Fig 7. shows the dual vial connecting system during lyophilisation process. Fig 8. shows the alternative embodiment during lyophilisation process. Fig 9. shows the security blocking system. A glass or plastic vial 1 contains a solid product 2 such as a lyophilisate, powder, etc.,. In order to obtain a ready to use solution, the lyophilisate product 2 has to be mixed or redissolved with a solvent 23 stored separately in a plastic solvent bottle 3 made of a flexible material. For the mixing and reconstitution process, the two containers 1 and 3 have to be connected in such a way that the solvent 23 may be transferred into the glass or plastic vial 1 containing the lyophilisate 2 and where the mixing and reconstitution takes place. After shaking the solution contained in the glass or plastic vial 1 , the assembly is inverted, having now the glass or plastic vial 1 on top so that the solution may be retransferred into the plastic solvent bottle 3 by squeezing and releasing the said plastic solvent bottle 3 several times. During this entire process, no liquid must be lost and no leakage must occur.
A closing and connecting plastic sleeve 4 has a cylindrical shape and consists of a lower inner threaded portion 5 and an upper inner tlireaded portion 6 separated from each other by a perforable plastic membrane 7 which is an integral part of the closing and comiecting plastic sleeve 4. As it will be explained, the plastic perforable membrane 7 is perforated by the orifice reducer 22 of the plastic solvent bottle 3 during connection of the two containers 1 and 3. In order to facilitate the perforation by the orifice reducer 22 of the plastic bottle 3, the plastic perforable membrane 7 (Fig 4), has in its center notches 8 forming characteristic weakness zones 32 that will break more easily under the pressure of the orifice reducer 22 of the plastic solvent bottle 3 when screwed in the upper imier threaded portion 6 of the closing and connecting plastic sleeve 4. The lower portion 5 of the closing and connecting plastic sleeve 4 has on its inner wall a tliread 24 that fits with the counter-tliread 25 of the neck of the glass or plastic vial 1. Below the inner thread 24 in the lower portion 5 of the closing and connecting plastic sleeve 4, a security blocking system 30 is build in the inner wall periphery characterised by cogs 9 having a slight inclination in order to facilitate the screwing of the closing and comiecting plastic sleeve 4 when in contact with the neck of the glass or plastic vial 1 also characterised by cogs 11 having a slight inclination. When screwing the closing and connecting plastic sleeve 4 onto the glass or plastic vial 1 is completed, it becomes then impossible to unscrew the closing and connecting plastic sleeve 4 off the glass or plastic vial 1 thanks to the shaped cogs 9 and 11 fitting into each other.
Tightness between the closing and connecting plastic sleeve 4 and the top surface neck of the glass or plastic vial 1 is ensured by two co-operating features : An inner cylindrical plastic skirt 12 that extends downwardly from the plastic perforable membrane surface 7 and having an outer diameter fitting in the inner portion neck 10 of the glass or plastic vial 1. The imier cylindrical plastic skirt 12 is an integral part of the closing and connecting plastic sleeve 4. The second feature for effective tightness is an elastomer sealing ring 13 placed at the uppeπnost position around the outer surface of the imier extending downwardly extending cylindrical plastic skirt 12 inside the lower portion 5 of the closing and comiecting plastic sleeve 4. The upper portion 6 of the closing and connecting plastic sleeve 4 has an inner diameter adapted to receive the plastic solvent bottle 3. For the purpose of perfect connection, the imier wall of the upper portion 6 of the closing and comiecting plastic sleeve 4 is provided with a tliread 15 which fits with the counter-tliread 14 of the plastic solvent bottle 3.
Below the inner tliread 15 in the upper portion 6 of the closing and connecting plastic sleeve 4 an annular rib 16 is located, operating as a snap and holding the sealing elastomer plug 18 in place.
On the upper periphery surface of the plastic perforable membrane 7, separating the upper portion 6 from the lower portion 5 of the closing and connecting plastic sleeve 4 an inner cylindrical integral plastic collar 17 extending upwardly and fitting in the cavity 19 of the elastomer sealing plug 18 is holding in place the said sealing plug 18. This elastomer sealing plug 18 with a cavity 19 below its center which therefore functions as a thin elastomer membrane 20 has pre-cut cross lines 21 in its center (Fig. 3).
The elastomer sealing plug 18 is snapped in between the annular rib 16 and the imier upwardly extending plastic collar 17, both located in the upper inner portion 6 of the closing and comiecting plastic sleeve 4 for safe and exact positioning reasons. The elastomer sealing plug 18 prevents gaz exchanges that may occur via the plastic perforable membrane 7 and of having direct contact with the plastic perforable membrane 7 with any kind of pollution or particles. When the plastic solvent bottle 3 is screwed into the upper inner tlireaded portion 6 of the closing and comiecting plastic sleeve 4, its orifice reducer 22 first penetrates tlirough the pre-cut area 21 of the elastomer sealing plug 18, then perforates the perforable plastic membrane 7 and assures complete tightness by being in contact with the wall of the centered cavity 19 of the elastomer sealing plug 18. The two containers 1 and 3 are now connected and the transfer of the solvent product 23 contained in the plastic solvent bottle 3 into the glass or plastic vial 1 containing the lyophilisate 2 can be achieved by squeezing and releasing the plastic solvent bottle 3 several times. After reconstitution, the solution can be retransferred into the plastic solvent bottle 3 by inverting the assembly, the glass or plastic vial 1 being on top, by squeezing and releasing the plastic solvent bottle 3 again several times. The whole procedure can be accomplished without any spilling or leakage.
Another advantage of the present invention is its special suitability for lyophilisation process. Prior to lyophilisation ,the glass or plastic vial 1 is filled with a liquid active 31 (Fig. 7). The closing and connecting plastic sleeve 4 is slightly screwed onto the tliread 25 of the neck of the glass or plastic vial 1. The cylindrical imier plastic skirt 12 located in the inner lower portion 5 of the closing and comiecting plastic sleeve 4 is in this case not yet in contact with the wall 10 of the inner neck of the glass or plastic vial 1. Then the glass or plastic vial 1 with its liquid active 31 and its closing and comiecting plastic sleeve 4, which remains not completely screwed, is placed into the freeze-dryer for lyophilisation. As can be seen in (Fig.2) the inner tliread 24 located in the lower inner portion 5 of the closing and connecting plastic sleeve 4 is interrupted by vertical grooves 28 winch have the function of escape or evacuation channels needed during the lyophilisation process to insure the removal of the moisture or liquid in gaz form. Once the lyophilisation cycle is completed, the closing and connecting plastic sleeve 4 is completely screwed onto the glass or plastic vial 1. These production steps may be performed fully automatically.
The cogs 11 located below the tliread 25 on the neck of the glass or plastic vial 1 in combination with the cogs 9 of the closing and connecting plastic sleeve 4, constitute the security blocking system 30 (Fig 10) which has the advantage of preventing the removal of the closing and connecting plastic sleeve 4 by manual means one completely screwed onto the glass or plastic vial 1.
Figs. 5,6 and 8 show an alternative embodiment of the invention. In the description of these figures the same elements are designated with the same reference numerals. In this alternative embodiment the lower portion 5 of the closing and connecting plastic sleeve 4 has on its inner wall a number of annularly arranged projections 26 defining an inner diameter fitting in between the two annular bulges 27 on the outside of the neck of the glass or plastic vial 1. This configuration constitutes a snap-in attachment of the closing and connecting plastic sleeve 4 on the said vial 1. The wall of the lower portion 5 of the closing and connecting plastic sleeve 4 is extended below the projections 26 to form a kind of skirt 29 which is adapted to hold the closing and comiecting plastic sleeve 4 in the position shown in (Fig. 8) which is described hereinafter.
As in the already described embodiment, tightness between the closing and comiecting plastic sleeve 4 and the neck of the glass or plastic vial 1 is ensured by two co-operating features, i.e. the inner skirt 12 and the elastomer sealing ring 13.
The upper portion 6 of the closing and connecting plastic sleeve 4 shown in (Figs. 5,6 and 8) is identical to that of the other embodiment (Figs. 1,2, and 7).
This alternative embodiment is also characterised by its special suitability for fully automatically lyophilisation process. Prior to lyophilisation, the glass or plastic vial 1 is filled with a liquid active 31. The closing and connecting plastic sleeve 4 is placed on top of the first bulge 27 of the glass or plastic vial 1. It remains positioned on the neck of the glass or plastic vial 1 due to the extended skirt 29 and projections 26 which allow to maintain the closing and connecting plastic sleeve 4 unsnapped during the lyophilisation cycle. Then the glass or plastic vial 1 with its closing and connecting sleeve 4, which is not snapped, is placed in the freeze-dryer for lyophilisation. The lateral spaces between the aimularly arranged projection 26 located in the imier lower portion 5 of the closing and connecting plastic sleeve 4 provide open contact between the interior of the glass or plastic vial 1 and its surrounding and thus guarantee evaporation of the moisture or liquid during lyophilisation cycle.
When the lyophilisation cycle is completed, the closing and comiecting plastic sleeve 4 is snapped onto the glass or plastic vial 1 inside the freeze-dryer. These production steps may be performed fully automatically.
The specifically shaped dual bulges 27 on the glass or plastic vial neck in combination with the annularly arranged projections 26 of the closing and comiecting plastic sleeve 4 have the added advantage of preventing also the removal of the said closing and connecting plastic sleeve 4 by manual means.

Claims

1. A dual vial comiecting system for temporary connection of two containers, usually a glass or plastic vial and a plastic solvent bottle, the purpose being to reconstitute a dry product, such as a lyophilisate, powder, etc., contained in a glass or plastic vial with a corresponding solvent product contained in a plastic solvent bottle, the connecting system having a cylindrical closing and connecting plastic sleeve with a lower portion having inwardly directed securing means for secure connection with the neck of the glass or plastic vial, an upper portion having an internal tliread for screwing connection with the plastic solvent bottle and an integrated plastic membrane being perforated by the orifice reducer of the plastic solvent bottle when screwed into the upper inner threaded portion of the closing and connecting plastic sleeve, characterised by the closing and comiecting plastic sleeve (4) having a perforable membrane (7) separating the upper inner tlireaded portion (6) from the lower portion (5) of the closing and connecting plastic sleeve (4), an inner cylindrical plastic skirt (12) located in the imier lower portion (5) of the closing and connecting plastic sleeve (4) and extending downwardly from the lower surface of the perforable membrane (7), said skirt having an outer diameter coming in contact with the wall (10) of the imier neck of the glass or plastic vial (1), an elastomer sealing ring (13) fixed at the uppeπnost position around the outer surface of the said skirt (12), an elastomer sealing plug (18) with a pre-cut section (21) and a cavity (19) in its center, the said sealing plug being placed around a cylindrical collar (17) located in the upper inner portion (6) of the closing and connecting plastic sleeve (4) and extending upwardly from the upper surface of the perforable membrane (7) and held in place by an annular rib (16), whereby the perforable membrane (7), the cylindrical skirt (12) , the collar (17) and the annular rib (16) are integrally moulded parts of the said closing and connecting plastic sleeve (4).
2. A connecting system according to claim 1 , characterised by a thread (24) in the lower inner portion (5) for engaging a corresponding thread (25) on the outer surface neck of the glass or plastic vial (1).
3. A connecting system according to claim 2, characterised by a security blocking system (30), constituted of cogs (9) with a slight inclination and are build in the lower inner wall periphery portion (5) of the closing and connecting plastic sleeve (4), and cogs (11) with a slight inclination located below the thread (25) of the glass or plastic vial (1).
4. A comiecting system according to claim 2, characterised by the tliread (24) being interrupted by vertical grooves (28) for keeping an open space from the vial interior to the outside when the closing and connecting plastic sleeve (4) is only partially screwed onto the glass or plastic vial (1) assuring the evaporation of moisture in gaz foπn during lyophilisation cycle.
5. A comiecting system according to claim 1 , characterised by the lower portion of the closing and comiecting plastic sleeve (4) having inwardly directed projections (26) for snapping connection with the annular bulges (27) around the outer surface of the neck of the glass or plastic vial (1). The said annularly arranged projections (26) have lateral spaces in between and provide open contact between the interior of the glass or plastic vial (1) and its surrounding and thus guarantee evaporation of the moisture in gaz foπn during lyophilisation cycle.
6. A comiecting system according to claim 5, characterised by a skirt-like extension (29) of the wall of the lower portion (5) of the closing and connecting plastic sleeve (4). The said extension (29) and projections (26) are designed to hold the closing and comiecting plastic sleeve (4) in position on the glass or plastic vial (1) unsnapped during lyophilisation process.
PCT/EP1997/004660 1997-08-27 1997-08-27 Dual vial connecting system for lyophilized products WO1999009931A1 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
CZ2000648A CZ291703B6 (en) 1997-08-27 1997-08-27 Dual vial connecting system for lyophilized products
PL97338582A PL338582A1 (en) 1997-08-27 1997-08-27 Two-vial system for combining two lyophilised products
PCT/EP1997/004660 WO1999009931A1 (en) 1997-08-27 1997-08-27 Dual vial connecting system for lyophilized products
AT97944798T ATE211901T1 (en) 1997-08-27 1997-08-27 CONNECTION SYSTEM FOR TWO VIALS FOR FREEZE-DRIED PRODUCTS
CA 2295827 CA2295827C (en) 1997-08-27 1997-08-27 Dual vial connecting system for lyophilized products
KR10-2000-7001935A KR100484285B1 (en) 1997-08-27 1997-08-27 Dual vial connecting system for lyophilized products
US09/486,566 US6237649B1 (en) 1997-08-27 1997-08-27 Dual vial connecting system for lyophilized products
EP97944798A EP1009356B1 (en) 1997-08-27 1997-08-27 Dual vial connecting system for lyophilized products
IL13435697A IL134356A0 (en) 1997-08-27 1997-08-27 Dual vial connecting system for lyophilized products
HU0004820A HU223484B1 (en) 1997-08-27 1997-08-27 Dual vial connecting system for lyophilized products
AU46187/97A AU4618797A (en) 1997-08-27 1997-08-27 Dual vial connecting system for lyophilized products
DE69709692T DE69709692T2 (en) 1997-08-27 1997-08-27 CONNECTION SYSTEM FOR TWO VIALS FOR FREEZER DRIED PRODUCTS
ES97944798T ES2172007T3 (en) 1997-08-27 1997-08-27 DOUBLE ROAD CONNECTION SYSTEM FOR LIOFILIZED PRODUCTS.
JP2000507324A JP4095770B2 (en) 1997-08-27 1997-08-27 Two vial coupling device for lyophilized products
IL134356A IL134356A (en) 1997-08-27 2000-02-03 Dual vial connecting system for lyophilized products

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP1997/004660 WO1999009931A1 (en) 1997-08-27 1997-08-27 Dual vial connecting system for lyophilized products

Publications (1)

Publication Number Publication Date
WO1999009931A1 true WO1999009931A1 (en) 1999-03-04

Family

ID=8166725

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/004660 WO1999009931A1 (en) 1997-08-27 1997-08-27 Dual vial connecting system for lyophilized products

Country Status (13)

Country Link
US (1) US6237649B1 (en)
EP (1) EP1009356B1 (en)
JP (1) JP4095770B2 (en)
KR (1) KR100484285B1 (en)
AT (1) ATE211901T1 (en)
AU (1) AU4618797A (en)
CA (1) CA2295827C (en)
CZ (1) CZ291703B6 (en)
DE (1) DE69709692T2 (en)
ES (1) ES2172007T3 (en)
HU (1) HU223484B1 (en)
IL (2) IL134356A0 (en)
WO (1) WO1999009931A1 (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002076373A1 (en) * 2001-03-27 2002-10-03 Allen Beaumont Hall Twin chamber dispenser with twist valve
WO2003013730A1 (en) * 2001-08-10 2003-02-20 Gen-Probe Incorporated Connector for use in combining the contents of a pair of containers
FR2935690A1 (en) * 2008-09-11 2010-03-12 Coradin Sas Container assembly for mixing solute and solvent, has container with base comprising lower wall that is displaced for modifying pressure inside container to transfer product from container to another container, when containers are assembled
FR2943993A1 (en) * 2009-03-27 2010-10-08 Oreal Neck for cosmetic product container that is used for preparation of cosmetic composition i.e. oxidation tint, for hair, has coupling skirt including inner thread that is in helical shape before screwing one container on another container
JP2011212442A (en) * 2010-04-01 2011-10-27 Siemens Healthcare Diagnostics Products Gmbh Solvent storage and injection device
CN103776860A (en) * 2012-10-25 2014-05-07 中国科学院生态环境研究中心 Device for concentrating extracting solution during organic phosphorus analysis in deposit sediments
BE1023806B1 (en) * 2016-06-28 2017-07-27 R&O Lab Sprl MIXING CONTAINER ADAPTABLE TO ANY RECEPTOR CONTAINER
US20200369454A1 (en) * 2017-12-08 2020-11-26 Unipharma, Llc Container and method for reconstitution of substances
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Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002219667A1 (en) * 2001-12-29 2003-07-15 Kyung-Han Bae Beverage dispenser having pressurized undiluted solution container
JP2005530656A (en) * 2002-06-25 2005-10-13 アメリカ合衆国 Mixing vial
US6779566B2 (en) 2003-01-14 2004-08-24 Access Business Group International Llc Connector device for sealing and dispensing freeze-dried preparations
US7534062B2 (en) * 2004-01-20 2009-05-19 L'oreal Kit comprising two receptacles and an applicator
FR2867761A1 (en) * 2004-03-19 2005-09-23 Mt Packaging RECHARCHE FOR COSMETIC PRODUCT DISTRIBUTOR
US8251110B2 (en) * 2004-08-17 2012-08-28 Mbhd, Llc Filling adapter
DE202004015492U1 (en) * 2004-10-06 2005-01-05 Azani, Adam Device for mixed drinks
CA2585149A1 (en) * 2004-10-27 2006-05-04 Glaxosmithkline Biologicals S.A. Process for preparing a lyophilised material
CA2652206C (en) 2006-05-25 2014-02-11 Bayer Healthcare Llc Reconstitution device
US20080125333A1 (en) * 2006-05-31 2008-05-29 Antara Biosciences Inc. Devices and kits for detecting one or more target agents
JP2007322379A (en) * 2006-06-05 2007-12-13 Olympus Corp Microreaction vessel
US7607460B2 (en) * 2006-06-12 2009-10-27 Jpro Dairy International, Inc. Coupling assembly
US20080308183A1 (en) * 2007-06-18 2008-12-18 Law Brian R Satellite dosing system
KR100806567B1 (en) * 2007-07-18 2008-02-28 이지성 Devices for gauging dosage
ES2389040T3 (en) * 2008-02-05 2012-10-22 L'oréal Tube head and procedure
JP5685522B2 (en) * 2008-04-01 2015-03-18 ユーコン・メディカル,リミテッド・ライアビリティ・カンパニー Duplex container fluid transfer device
KR101625239B1 (en) * 2008-04-24 2016-05-27 도판 인사츠 가부시키가이샤 Packaging container and package using the same
JP5685579B2 (en) 2009-04-14 2015-03-18 ユーコン・メディカル,リミテッド・ライアビリティ・カンパニー Fluid transfer device
JP2010275019A (en) * 2009-04-30 2010-12-09 Sanyo Chem Ind Ltd Joint
US8684208B2 (en) * 2009-05-14 2014-04-01 Chris Hotell Reusable containers for storing foodstuffs or liquids
US8226126B2 (en) * 2009-08-24 2012-07-24 Jpro Dairy International, Inc. Bottle mixing assembly
USD655017S1 (en) 2010-06-17 2012-02-28 Yukon Medical, Llc Shroud
US20120037252A1 (en) * 2010-08-16 2012-02-16 Stephan Scott A Material Transfer System
USD681230S1 (en) 2011-09-08 2013-04-30 Yukon Medical, Llc Shroud
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USD769444S1 (en) 2012-06-28 2016-10-18 Yukon Medical, Llc Adapter device
FR2995290B1 (en) * 2012-09-13 2014-09-26 Rexam Dispensing Sys FILLABLE VIAL FOR DISPENSING A FLUID PRODUCT
FR2996828B1 (en) * 2012-10-15 2014-10-24 Rexam Dispensing Sys FILLABLE VIAL FOR DISPENSING A FLUID PRODUCT
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FR3087336B1 (en) 2018-10-19 2024-03-22 Coradin Sas DEVICE FOR TEMPORARY CONNECTION OF TWO CONTAINERS
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US10661968B1 (en) * 2019-06-20 2020-05-26 Elc Management Llc Container system for mixing and dispensing
US12042469B2 (en) * 2019-08-23 2024-07-23 Mannkind Corporation Adapter for a fluid transfer device
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US20230061566A1 (en) * 2021-08-25 2023-03-02 Scatter, LLC Systems, kits, and methods for contactless application of mixed concentrates and diluents
KR102677057B1 (en) * 2022-04-22 2024-06-21 임성준 An ampoule container with a freeze-dried filling of the mixture
USD1041621S1 (en) 2022-08-22 2024-09-10 Scatter, LLC Connector for transfer of fluid

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2188565A5 (en) * 1972-06-13 1974-01-18 Semco Emballage Conditio
FR2427960A1 (en) * 1978-06-06 1980-01-04 Dehais Claude Polypropylene adaptor for linking two bottles - with an integral diaphragm for sterile protection
EP0283629A1 (en) * 1987-03-24 1988-09-28 Semco Packaging for extemporaneous preparations
FR2682088A1 (en) * 1991-10-04 1993-04-09 Emballages Conditionnement Package for the extemporaneous preparation of medicinal products

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2552404B1 (en) * 1983-09-26 1987-12-24 Merck Sharp & Dohme ASSEMBLY FOR PREPARING AND DELIVERING A SOLUTION, SHUTTERING PLUG FOR SUCH ASSEMBLY AND METHOD FOR MANUFACTURING THE SAME
US4986322A (en) * 1987-03-24 1991-01-22 Societe Semco System of packaging for ready to use preparations
US4768568A (en) * 1987-07-07 1988-09-06 Survival Technology, Inc. Hazardous material vial apparatus providing expansible sealed and filter vented chambers
JPH05103819A (en) * 1991-08-08 1993-04-27 Nissho Corp Medicine receiving container
US5247972A (en) * 1991-12-17 1993-09-28 Whittier Medical, Inc. Alignment guide for hypodermic syringe
US5531254A (en) * 1994-02-22 1996-07-02 Rosenbach; Arnie Portable hand activated carbonator
US5595314A (en) * 1994-06-02 1997-01-21 Automatic Liquid Packaging, Inc. Torque-resistant closure for a hermetically sealed container
US5526853A (en) * 1994-08-17 1996-06-18 Mcgaw, Inc. Pressure-activated medication transfer system
US5566729A (en) * 1995-04-06 1996-10-22 Abbott Laboratories Drug reconstitution and administration system
DE19513666C1 (en) * 1995-04-11 1996-11-28 Behringwerke Ag Device for bringing together a first liquid and a second solid or liquid component by means of negative pressure under sterile conditions
US5702019A (en) * 1995-09-27 1997-12-30 Becton Dickinson France S.A. Vial having resealable membrane assembly activated by a medical delivery device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2188565A5 (en) * 1972-06-13 1974-01-18 Semco Emballage Conditio
FR2427960A1 (en) * 1978-06-06 1980-01-04 Dehais Claude Polypropylene adaptor for linking two bottles - with an integral diaphragm for sterile protection
EP0283629A1 (en) * 1987-03-24 1988-09-28 Semco Packaging for extemporaneous preparations
FR2682088A1 (en) * 1991-10-04 1993-04-09 Emballages Conditionnement Package for the extemporaneous preparation of medicinal products

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002076373A1 (en) * 2001-03-27 2002-10-03 Allen Beaumont Hall Twin chamber dispenser with twist valve
WO2003013730A1 (en) * 2001-08-10 2003-02-20 Gen-Probe Incorporated Connector for use in combining the contents of a pair of containers
US6910720B2 (en) 2001-08-10 2005-06-28 Gen-Probe Incorporated Connector for use in combining the contents of a pair of containers
FR2935690A1 (en) * 2008-09-11 2010-03-12 Coradin Sas Container assembly for mixing solute and solvent, has container with base comprising lower wall that is displaced for modifying pressure inside container to transfer product from container to another container, when containers are assembled
FR2943993A1 (en) * 2009-03-27 2010-10-08 Oreal Neck for cosmetic product container that is used for preparation of cosmetic composition i.e. oxidation tint, for hair, has coupling skirt including inner thread that is in helical shape before screwing one container on another container
JP2011212442A (en) * 2010-04-01 2011-10-27 Siemens Healthcare Diagnostics Products Gmbh Solvent storage and injection device
CN103776860A (en) * 2012-10-25 2014-05-07 中国科学院生态环境研究中心 Device for concentrating extracting solution during organic phosphorus analysis in deposit sediments
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CN109562882A (en) * 2016-06-28 2019-04-02 R&O实验室有限公司 Suitable for any mixing vessel for receiving container
RU2731936C2 (en) * 2016-06-28 2020-09-09 РэндО ЛАБ СПРЛ Mixing vessel adapted to any receiving vessel
US11247834B2 (en) 2016-06-28 2022-02-15 R&O Lab Sprl Mixing vessel adaptable to any receiving vessel
US20200369454A1 (en) * 2017-12-08 2020-11-26 Unipharma, Llc Container and method for reconstitution of substances

Also Published As

Publication number Publication date
HUP0004820A3 (en) 2001-05-28
IL134356A0 (en) 2001-04-30
EP1009356A1 (en) 2000-06-21
US6237649B1 (en) 2001-05-29
ES2172007T3 (en) 2002-09-16
EP1009356B1 (en) 2002-01-16
ATE211901T1 (en) 2002-02-15
HUP0004820A2 (en) 2001-04-28
CA2295827C (en) 2006-02-14
JP2001513400A (en) 2001-09-04
CZ2000648A3 (en) 2000-08-16
IL134356A (en) 2008-04-13
CZ291703B6 (en) 2003-05-14
JP4095770B2 (en) 2008-06-04
DE69709692T2 (en) 2002-09-12
DE69709692D1 (en) 2002-02-21
KR20010023301A (en) 2001-03-26
AU4618797A (en) 1999-03-16
HU223484B1 (en) 2004-07-28
KR100484285B1 (en) 2005-04-20
CA2295827A1 (en) 1999-03-04

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