WO1999007720A3 - Process for the purification of acarbose, pharmaceutical composition containing same and its use for the treatment of diabetes - Google Patents

Process for the purification of acarbose, pharmaceutical composition containing same and its use for the treatment of diabetes Download PDF

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Publication number
WO1999007720A3
WO1999007720A3 PCT/IB1998/001188 IB9801188W WO9907720A3 WO 1999007720 A3 WO1999007720 A3 WO 1999007720A3 IB 9801188 W IB9801188 W IB 9801188W WO 9907720 A3 WO9907720 A3 WO 9907720A3
Authority
WO
WIPO (PCT)
Prior art keywords
acarbose
purification
diabetes
treatment
pharmaceutical composition
Prior art date
Application number
PCT/IB1998/001188
Other languages
French (fr)
Other versions
WO1999007720A2 (en
Inventor
Carl William Lawton
Randall Wolfe Swartz
Original Assignee
Univ Massachusetts Lowell
Carl William Lawton
Randall Wolfe Swartz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Massachusetts Lowell, Carl William Lawton, Randall Wolfe Swartz filed Critical Univ Massachusetts Lowell
Priority to EP98933857A priority Critical patent/EP1003761A2/en
Priority to AU83542/98A priority patent/AU8354298A/en
Priority to JP2000506222A priority patent/JP2001512738A/en
Publication of WO1999007720A2 publication Critical patent/WO1999007720A2/en
Publication of WO1999007720A3 publication Critical patent/WO1999007720A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

The present invention discloses a process for the purification of acarbose comprising loading a prepurified acarbose solution on a chromatography column packed with a non-aromatic strong acid cation exchanger which is hydrophilic and has high mass transfer and subsequent elution.
PCT/IB1998/001188 1997-08-05 1998-08-03 Process for the purification of acarbose, pharmaceutical composition containing same and its use for the treatment of diabetes WO1999007720A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP98933857A EP1003761A2 (en) 1997-08-05 1998-08-03 A process for the purification of acarbose
AU83542/98A AU8354298A (en) 1997-08-05 1998-08-03 A process for the purification of acarbose
JP2000506222A JP2001512738A (en) 1997-08-05 1998-08-03 Purification method of acabose, pharmaceutical composition containing the same, and use thereof for diabetes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI97A001880 1997-08-05
IT97MI001880A IT1293819B1 (en) 1997-08-05 1997-08-05 PROCEDURE FOR THE PREPARATION OF ACARBOSE

Publications (2)

Publication Number Publication Date
WO1999007720A2 WO1999007720A2 (en) 1999-02-18
WO1999007720A3 true WO1999007720A3 (en) 1999-04-15

Family

ID=11377722

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1998/001188 WO1999007720A2 (en) 1997-08-05 1998-08-03 Process for the purification of acarbose, pharmaceutical composition containing same and its use for the treatment of diabetes

Country Status (5)

Country Link
EP (1) EP1003761A2 (en)
JP (1) JP2001512738A (en)
AU (1) AU8354298A (en)
IT (1) IT1293819B1 (en)
WO (1) WO1999007720A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3992497B2 (en) * 1999-10-28 2007-10-17 チョン・クン・ダン・ファーマシューティカル・コーポレーション High purity acarbose manufacturing method
US20020111320A1 (en) * 2000-08-07 2002-08-15 Vilmos Keri Method for purification of acarbose
HRP20010792A2 (en) * 2001-10-26 2003-04-30 Pliva D D Acarbose purification process
TWI280281B (en) * 2003-12-02 2007-05-01 Cpc Corp Taiwan A novel process to recover and purify acarbose from fermentation broth
CN102030786A (en) * 2010-11-12 2011-04-27 丽珠集团新北江制药股份有限公司 Preparation method of acarbose
CN102603822B (en) * 2012-02-21 2013-07-03 河北华荣制药有限公司 Method for improving purity of acarbose

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2347782A1 (en) * 1973-09-22 1975-04-10 Bayer Ag AMINO SUGAR DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT
DE2719912A1 (en) * 1977-05-04 1978-11-16 Bayer Ag METHOD OF INSULATION FROM 0 CURVED CLAMP ON -4,6-DIDEOXY-4 ANGULAR CLAMP ON ANGULAR CLAMP ON 1 S- (1,4,6 / 5) -4,5,6-TRIHYDROXY-3-HYDROXYMETHYL-2-CYCLOHEXEN -1-YL SQUARE CLIP CLOSE -AMINO SQUARE CLIP CLOSE -ALPHA-D-GLUCOPYRANOSYL CURVED CLIP CLOSE - (1- RIGHT ARROW 4) -0- ALPHA-D-GLUCOPYRANOSYL- (1- RIGHT ARROW 4) -D- GLUCOPYRANOSE FROM BRUSH
EP0226121A2 (en) * 1985-12-13 1987-06-24 Bayer Ag Composition containing very pure acarbose
US4767850A (en) * 1984-10-25 1988-08-30 Bayer Aktiengesellschaft Process for the purification of acarbose with polymers

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2347782A1 (en) * 1973-09-22 1975-04-10 Bayer Ag AMINO SUGAR DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT
DE2719912A1 (en) * 1977-05-04 1978-11-16 Bayer Ag METHOD OF INSULATION FROM 0 CURVED CLAMP ON -4,6-DIDEOXY-4 ANGULAR CLAMP ON ANGULAR CLAMP ON 1 S- (1,4,6 / 5) -4,5,6-TRIHYDROXY-3-HYDROXYMETHYL-2-CYCLOHEXEN -1-YL SQUARE CLIP CLOSE -AMINO SQUARE CLIP CLOSE -ALPHA-D-GLUCOPYRANOSYL CURVED CLIP CLOSE - (1- RIGHT ARROW 4) -0- ALPHA-D-GLUCOPYRANOSYL- (1- RIGHT ARROW 4) -D- GLUCOPYRANOSE FROM BRUSH
US4767850A (en) * 1984-10-25 1988-08-30 Bayer Aktiengesellschaft Process for the purification of acarbose with polymers
EP0226121A2 (en) * 1985-12-13 1987-06-24 Bayer Ag Composition containing very pure acarbose

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHIBATA, YASUSHI ET AL: "Synthesis of pseudo-oligosaccharide glycosidase inhibitors. Part VII. Total synthesis of acarbose and adiposin-2", CARBOHYDR. RES. (1989), 189, 309-22, XP002091224 *

Also Published As

Publication number Publication date
WO1999007720A2 (en) 1999-02-18
JP2001512738A (en) 2001-08-28
AU8354298A (en) 1999-03-01
EP1003761A2 (en) 2000-05-31
ITMI971880A1 (en) 1999-02-05
IT1293819B1 (en) 1999-03-10

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