WO1999006831A3 - Breast cancer resistance genes, methods for their detection and uses thereof - Google Patents

Breast cancer resistance genes, methods for their detection and uses thereof Download PDF

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Publication number
WO1999006831A3
WO1999006831A3 PCT/EP1998/004754 EP9804754W WO9906831A3 WO 1999006831 A3 WO1999006831 A3 WO 1999006831A3 EP 9804754 W EP9804754 W EP 9804754W WO 9906831 A3 WO9906831 A3 WO 9906831A3
Authority
WO
WIPO (PCT)
Prior art keywords
breast cancer
methods
detection
resistance genes
cancer resistance
Prior art date
Application number
PCT/EP1998/004754
Other languages
French (fr)
Other versions
WO1999006831A9 (en
WO1999006831A2 (en
Inventor
Lambert C J Dorssers
Original Assignee
Lambert C J Dorssers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lambert C J Dorssers filed Critical Lambert C J Dorssers
Priority to AU90710/98A priority Critical patent/AU9071098A/en
Publication of WO1999006831A2 publication Critical patent/WO1999006831A2/en
Publication of WO1999006831A9 publication Critical patent/WO1999006831A9/en
Publication of WO1999006831A3 publication Critical patent/WO1999006831A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to the finding of genes associated with the development of estrogen independent malignant cell growth, particularly of breast cancer cells. The invention provides assay methods for the diagnosis or prognosis of malignant cell growth, which method comprises measuring the expression of one or more of the BCAR1, BCAR2 or BCAR3 genes in a biological sample from a patient. Measurement may be by immunological techniques or by hybridisation with nucleic acids, utilising novel sequences and antibodies of the invention.
PCT/EP1998/004754 1997-07-29 1998-07-29 Breast cancer resistance genes, methods for their detection and uses thereof WO1999006831A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU90710/98A AU9071098A (en) 1997-07-29 1998-07-29 Breast cancer resistance genes, methods for their detection and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5410197P 1997-07-29 1997-07-29
US60/054,101 1997-07-29

Publications (3)

Publication Number Publication Date
WO1999006831A2 WO1999006831A2 (en) 1999-02-11
WO1999006831A9 WO1999006831A9 (en) 1999-07-29
WO1999006831A3 true WO1999006831A3 (en) 1999-09-02

Family

ID=21988820

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/004754 WO1999006831A2 (en) 1997-07-29 1998-07-29 Breast cancer resistance genes, methods for their detection and uses thereof

Country Status (2)

Country Link
AU (1) AU9071098A (en)
WO (1) WO1999006831A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO972006D0 (en) 1997-04-30 1997-04-30 Forskningsparken I Aas As New method for diagnosis of diseases
US6891022B1 (en) 1998-04-23 2005-05-10 Genentech, Inc. NSP molecules
EP1071773A1 (en) * 1998-04-23 2001-01-31 Genentech, Inc. Sh2 domain-containing peptides
GB0412301D0 (en) 2004-06-02 2004-07-07 Diagenic As Product and method
FR2881830B1 (en) * 2005-02-09 2007-05-04 Ct De Rech Pour Les Pathologie PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF PROSTATE CANCER
WO2007073774A1 (en) * 2005-12-23 2007-07-05 Universita' Degli Studi Di Torino Genotoxic testing
WO2010009171A2 (en) * 2008-07-14 2010-01-21 Wyeth Src activation for determining cancer prognosis and as a target for cancer therapy
EP2669682B1 (en) 2012-05-31 2017-04-19 Heinrich-Heine-Universität Düsseldorf Novel prognostic and predictive biomarkers (tumor markers) for human breast cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992003973A1 (en) * 1990-09-05 1992-03-19 Board Of Regents, The University Of Texas System Onset of antiestrogen resistance in breast cancer
US5292638A (en) * 1990-12-07 1994-03-08 The Regents Of The University Of California Method of determining functional estrogen receptors for prognosis of cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992003973A1 (en) * 1990-09-05 1992-03-19 Board Of Regents, The University Of Texas System Onset of antiestrogen resistance in breast cancer
US5292638A (en) * 1990-12-07 1994-03-08 The Regents Of The University Of California Method of determining functional estrogen receptors for prognosis of cancer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DORSSERS, L. C. J. ET AL: "Identification and cloning of a human breast cancer antiestrogen resistance locus (bcar1) by provirus insertion mutagenesis.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, (1993) VOL. 34, NO. 0, PP. 497. MEETING INFO.: 84TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ORLANDO, FLORIDA, USA MAY 19-22, 1993 ISSN: 0197-016X., XP002091638 *
DORSSERS, L.C.J. ET AL.,: "Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: Identification of bcar-1, a common integration site.", MOLECULAR ENDOCRINOLOGY, vol. 7, no. 7, - 1993, pages 870-878, XP002091641 *
VAN AGTHOVEN, T. ET AL.,: "Ectopic expression of epidermal growth factor receptors induces hormone independence in zr-75-1 human breast cancer cells.", CANCER RESEARCH, vol. 52, 1992, pages 5082 - 5088, XP002091640 *
VAN DER FLIER S ET AL: "Identification of the gene within the bcar1 locus causing antiestrogen resistance in human breast cancer cells in vitro (Meeting abstract).", PROC ANNU MEET AM ASSOC CANCER RES, (1996). VOL. 37, PP. A1596., XP002091639 *

Also Published As

Publication number Publication date
AU9071098A (en) 1999-02-22
WO1999006831A9 (en) 1999-07-29
WO1999006831A2 (en) 1999-02-11

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