WO1999006388A8 - Pharmaceutical compounds isolated from aristolochia taliscana - Google Patents

Pharmaceutical compounds isolated from aristolochia taliscana

Info

Publication number
WO1999006388A8
WO1999006388A8 PCT/GB1998/002317 GB9802317W WO9906388A8 WO 1999006388 A8 WO1999006388 A8 WO 1999006388A8 GB 9802317 W GB9802317 W GB 9802317W WO 9906388 A8 WO9906388 A8 WO 9906388A8
Authority
WO
WIPO (PCT)
Prior art keywords
extracts
pharmaceutical compounds
compounds isolated
compounds
aristolochia taliscana
Prior art date
Application number
PCT/GB1998/002317
Other languages
French (fr)
Other versions
WO1999006388A3 (en
WO1999006388A2 (en
Inventor
Hans Achenbach
Original Assignee
Proteome Sciences Plc
Hans Achenbach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proteome Sciences Plc, Hans Achenbach filed Critical Proteome Sciences Plc
Priority to CA002298677A priority Critical patent/CA2298677A1/en
Priority to AU86367/98A priority patent/AU8636798A/en
Priority to EP98937641A priority patent/EP1027344A2/en
Priority to PCT/US1999/002194 priority patent/WO2000006182A1/en
Priority to EP99905622A priority patent/EP1117415A1/en
Priority to AU25746/99A priority patent/AU2574699A/en
Publication of WO1999006388A2 publication Critical patent/WO1999006388A2/en
Publication of WO1999006388A3 publication Critical patent/WO1999006388A3/en
Publication of WO1999006388A8 publication Critical patent/WO1999006388A8/en
Priority to US09/774,769 priority patent/US20020099086A1/en
Priority to US10/322,305 priority patent/US20030147973A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to extracts from Aristolochia taliscana and their uses in medicine, and also to compounds, known and novel isolated from the extracts, and compositions containing the extracts and compounds. The extracts and compounds are useful inter alia as anti-mutagens, antifungal agents and cytotoxic agents. The extracts and compositions of the invention can comprise at least 10 %, preferably at least 20 %, and more preferably at least 25 % by weight of a phenylbenzfuran.
PCT/GB1998/002317 1997-07-31 1998-07-31 Pharmaceutical compounds isolated from aristolochia taliscana WO1999006388A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA002298677A CA2298677A1 (en) 1997-07-31 1998-07-31 Pharmaceutical compounds isolated from aristolochia taliscana
AU86367/98A AU8636798A (en) 1997-07-31 1998-07-31 Pharmaceutical compounds isolated from aristolochia taliscana
EP98937641A EP1027344A2 (en) 1997-07-31 1998-07-31 Pharmaceutical compounds isolated from aristolochia taliscana
PCT/US1999/002194 WO2000006182A1 (en) 1998-07-31 1999-02-02 Use of extracts from aristolochia in the treatment of aids
EP99905622A EP1117415A1 (en) 1998-07-31 1999-02-02 Use of extracts from aristolochia in the treatment of aids
AU25746/99A AU2574699A (en) 1998-07-31 1999-02-02 Use of extracts from aristolochia in the treatment of aids
US09/774,769 US20020099086A1 (en) 1998-07-31 2001-01-31 Use of extracts from aristolochia in the treatment of AIDS
US10/322,305 US20030147973A1 (en) 1998-07-31 2002-12-18 Use of extracts from aristolochia in the treatment of aids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9716244.0A GB9716244D0 (en) 1997-07-31 1997-07-31 Pharmaceutical compounds
GB9716244.0 1997-07-31

Publications (3)

Publication Number Publication Date
WO1999006388A2 WO1999006388A2 (en) 1999-02-11
WO1999006388A3 WO1999006388A3 (en) 1999-04-22
WO1999006388A8 true WO1999006388A8 (en) 2000-06-15

Family

ID=10816797

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/002317 WO1999006388A2 (en) 1997-07-31 1998-07-31 Pharmaceutical compounds isolated from aristolochia taliscana

Country Status (5)

Country Link
EP (1) EP1027344A2 (en)
AU (1) AU8636798A (en)
CA (1) CA2298677A1 (en)
GB (1) GB9716244D0 (en)
WO (1) WO1999006388A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000006182A1 (en) * 1998-07-31 2000-02-10 Proteome Sciences, Inc. Use of extracts from aristolochia in the treatment of aids
US8246969B2 (en) 2001-11-16 2012-08-21 Skinmedica, Inc. Compositions containing aromatic aldehydes and their use in treatments
US7638515B2 (en) 2003-10-08 2009-12-29 Bayer Schering Pharma Aktiengesellschaft Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
PT1670458E (en) 2003-10-08 2007-03-30 Schering Ag 1-amino-2-oxy-substituted tetrahydronaphtalene derivatives, methods for the production thereof, and their use as antiphlogistics
US7662821B2 (en) 2003-10-08 2010-02-16 Bayer Schering Pharma Ag Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US20080153859A1 (en) 2004-04-05 2008-06-26 Hartmut Rehwinkel Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
JP4568527B2 (en) * 2004-04-22 2010-10-27 ポーラ化成工業株式会社 Benzofuran derivative and external preparation for skin containing the same
DE102005017316A1 (en) * 2005-04-14 2006-10-19 Schering Ag Tetrahydronaphthalene derivatives, process for their preparation and their use as anti-inflammatory agents
EP1834948A1 (en) 2006-03-15 2007-09-19 Bayer Schering Pharma Aktiengesellschaft Tetrahydronaphtalene derivatives, methods for the production thereof, and their use as antiinflammatory drugs
KR101778654B1 (en) 2010-04-08 2017-09-14 시므라이즈 아게 Use of Dihydrodehydrodiisoeugenol and preparations comprising Dihydrodehydrodiisoeugenol
EP2655362A1 (en) 2010-12-22 2013-10-30 Abbvie Inc. Hepatitis c inhibitors and uses thereof
MY175521A (en) 2011-01-07 2020-07-01 Allergan Inc Melanin modification compositions and methods of use
US11066378B2 (en) * 2015-06-04 2021-07-20 Taipei Medical University Caffeic acid derivatives for anti-angiogenesis
CN109721580B (en) * 2017-10-27 2022-11-04 中国医学科学院药物研究所 3-phenyl-7, 8-dehydrograpevine derivatives, preparation method, pharmaceutical composition and use thereof
CN109721579B (en) * 2017-10-27 2022-11-04 中国医学科学院药物研究所 7, 8-dehydrograpevine derivatives, preparation method, pharmaceutical composition and use thereof
CN117402196A (en) * 2022-09-13 2024-01-16 中国科学院脑科学与智能技术卓越创新中心 Antitumor active compound and preparation method and application thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3481944A (en) * 1968-11-01 1969-12-02 Sterling Drug Inc Certain aryl and hetero aryl oximes and 4-benzoyloxycyclohexanone oxime
US3745218A (en) * 1971-03-26 1973-07-10 Us Agriculture Preservation process using 2-(4-hydroxyphenyl)-benzofuran
US3917654A (en) * 1973-06-08 1975-11-04 Riku Lab Inc Anti-inflammatory substituted benzofuran
JPS62126128A (en) * 1985-11-27 1987-06-08 Sato Seiyaku Kk External preparation composition
US4714711A (en) * 1986-11-05 1987-12-22 Merck & Co., Inc. 6-hydroxy-2(2-hydroxy-4-methoxyphenyl)benzofuran derivatives to inhibit leukotriene biosynthesis
JPS63167791A (en) * 1986-12-27 1988-07-11 Kanebo Ltd Mutation inhibitor
EP0295851A1 (en) * 1987-06-18 1988-12-21 Merck Frosst Canada Inc. 4,7-diacyloxybenzofuran derivatives
US4782077A (en) * 1987-08-20 1988-11-01 Monoclonetics International, Inc. Taliscanin and other aristolactams for treating neurological disorders, Parkinson's disease, Alzheimer disease and impotence
JP2660969B2 (en) * 1988-06-06 1997-10-08 鐘紡株式会社 Benzofuranyl propenoic acid derivative
JP2746453B2 (en) * 1990-03-13 1998-05-06 鐘紡株式会社 Active oxygen scavenger
DE69019517T2 (en) * 1990-07-05 1995-12-14 Indena Spa Neolignan derivative complexes with phospholipids, their use and pharmaceutical and cosmetic compositions containing them.
DE4117512A1 (en) * 1991-05-25 1992-11-26 Schering Ag 2-PHENYLBENZO (B) FURANES AND THIOPHENES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
JPH09124632A (en) * 1995-10-31 1997-05-13 Sankyo Co Ltd Benzo-heterocyclic derivative
JPH09176074A (en) * 1995-12-28 1997-07-08 Kibun Foods Inc Antimicrobial, antifungal and anti-inflammatory active substance and production thereof

Also Published As

Publication number Publication date
CA2298677A1 (en) 1999-02-11
AU8636798A (en) 1999-02-22
EP1027344A2 (en) 2000-08-16
WO1999006388A3 (en) 1999-04-22
GB9716244D0 (en) 1997-10-08
WO1999006388A2 (en) 1999-02-11

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