WO1999003521A1 - Injection member - Google Patents
Injection member Download PDFInfo
- Publication number
- WO1999003521A1 WO1999003521A1 PCT/DK1998/000292 DK9800292W WO9903521A1 WO 1999003521 A1 WO1999003521 A1 WO 1999003521A1 DK 9800292 W DK9800292 W DK 9800292W WO 9903521 A1 WO9903521 A1 WO 9903521A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- injection
- jet
- injection member
- needle
- length
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
Definitions
- the invention relaters to an injection member for a jet spray injection device through which device a dose of medicine is administered for subcutaneous or intramuscular injection.
- a classic injection device comprises a syringe which is provided with a needle which has a length enabling it to penetrate cutis and enter subcutis where a dose of medicine is depos- ited by being pressed from the syringe out through the needle.
- jet injection systems have no needle but a spray nozzle through which the medicine is sprayed to give the medicine a speed enabling it to penetrate the cutis and be dispersed in the subcutis.
- dosing is difficult, in part due to the anatomical condition of the skin (cutis) where the first layer (stratum corneum) consists of dead, keratinised cells.
- the layer is much more resistant to water penetration than to lipid penetration, and it forms a strong mechanical barrier, especially considering the thickness of the layer, which has a mean of 0.1 mm on the most of the body (thin skin).
- the stratum corneum is enlarged in a few specific areas (thick skin): e. g. the hand and the foot sole, areas where injection normally is avoided. Beneath stratum corneum follows the various other layers of epidermis, with living skin cells, blood vessels, sensory nerve endings ect. Epidermis is followed by dermis which is mainly connective tissue. Then follows subcutis (mostly adipose tissue and connective tissue), the size of subcutis is very variable in the in- dividual person and between persons. By the spray injection it is difficult to estimate how much of the medicine glances off from the dead cells at the skin surface and how much actually reaches the subcutis.
- An injection member according to the invention is characterised in that it comprises a jet nozzle designed as a needle having a length in the range from 0,05mm to 6 mm combined with the jet spray nozzle.
- the use of the injection member according to the invention will reduce the risk of damaging the often very large medicine molecules during the passage of the skin. Furthermore, less injection force need to be applied and a more precise definition of the injection depth is pos- sible so that superficial or too profound deposits is avoided.
- the size of the pointer or the needle may be so small that it does not cause pain but is, if at all, felt as a small pressure on the skin. The risk for bleeding due to needle trauma is also reduced to almost zero.
- the needle or pointer may have a length in the range 0.05 mm to 4 mm, preferably between 0.3 mm and 2 mm.
- Such needles will be too short for conventional injection but may be used for jet injection to ensure that the jet has not to penetrate the stratum corneum.
- the nozzle may be designed as a pointer having a length from 0.05 mm to 0.3 mm, more preferred 0.1 mm to 0.2 mm. With this length the pointer is long enough to weaken or penetrate the sta- tum corneum but not long enough to cause significant contact with the layer of living cells beneath stratum corneum and insertion in subcutis is impossible. Neither will the pointer be able to get in contact with the sensory nerve endings located in cutis. Medicine delivered as a jet through the pointer will not partly glance off from the keratine layer, thus the injected dose will be more accurate. Moreover the risk of pain release as seen with conventional subcutaneous needles will be minimised to that of the jet stream.
- the shape of the pointer may be that of a conventional needle , but it may have other forms and the peripheral end may be sharp or blunted.
- the inner diameter of the pointer may be from 0.1 mm to 3 mm.
- the injection member may appropriately be a changeable unit which can be mounted on a jet injection syringe. This will allow the injection member to be changed each time an injection has been made. Also the needle may at each injection be chosen to have a length suited for the user and the intended point of injection.
- the thickness of the cutis and subcutis lies in the intervals described in the following table.
- the mean values may be seen as the values valid for the preferred injection zones.
- the injection member may be provided with an array of short needles. Hereby a better distribution of the injected liquid is ensured .
- Figure 1 schematically shows a sectional view of the skin during the injection of a liquid in a jet from an injection member according to the invention
- Figure 2 shows schematically a sectional view of the skin during injection of a liquid in multiple jets from another embodiment of the injection member according to the invention.
- a keratin layer 1 stratum corneum, overlies the epidermal 2 and dermal layer 3. These three layers forms cutis, the skin, 4. Beneath this is subcutis 5 followed by a muscle 6 in its fascia.
- An injection member 7 is pressed against the upper surface of the skin so that a pointer 8 penetrates the keratin layer 1. From this position a jet 9 is expelled from the pointer 8 at a speed allowing it to penetrate the remaining part of cutis and to intrude the subcutis 5 where it forms a deposit 10 which subsequently is taken up by the blood/lymph system. During its passage into subcutis 5 the jet 9 is decelerated so it will not penetrate the muscle fascia 6.
- the jet need not be expelled with as high an energy content as needs a jet which must pierce the surface of the cutis. If an intramuscular injection is wanted the velocity and the pressure by which the jet is expelled must be correspondingly higher so that the liquid is not decelerated to an extend disabling its penetration ability until it has passed the muscle membrane 3.
- the injection member may be equipped with a number of needles or pointers.
- an injection member with three needles 8 are shown.
- FIG 3 shows an injection member 7 mounted on a cartridge 12 in a housing 13 of an injection device.
- the cartridge 12 is closed by a rubber membrane 14 which is by a metal cap 16 clamped sealingly to a flange 15 forming an integral part of the cartridge 12.
- the injection member is clicked onto the ampoule by circular hook edge 17 gripping behind the flange 15.
- a needle element 18 penetrates the membrane to establish communication between the in- side of the cartridge and a nozzle 19 which is surrounded by a ring shaped or tubular pointer 8.
- the injection member may be released from the ampoule by breaking the hook edge out of engagement with the flange, and the member may be replaced by a new injection member.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000502812A JP2003514587A (en) | 1997-07-14 | 1998-07-01 | Injection parts |
DE69821110T DE69821110T2 (en) | 1997-07-14 | 1998-07-01 | INJECTION PART |
EP98933563A EP0996477B1 (en) | 1997-07-14 | 1998-07-01 | Injection member |
AU83333/98A AU8333398A (en) | 1997-07-14 | 1998-07-01 | Injection member |
AT98933563T ATE257718T1 (en) | 1997-07-14 | 1998-07-01 | INJECTION PART |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK86197 | 1997-07-14 | ||
DK0861/97 | 1997-07-14 | ||
US5349697P | 1997-07-23 | 1997-07-23 | |
US60/053,496 | 1997-07-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999003521A1 true WO1999003521A1 (en) | 1999-01-28 |
Family
ID=26064796
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DK1998/000292 WO1999003521A1 (en) | 1997-07-14 | 1998-07-01 | Injection member |
Country Status (5)
Country | Link |
---|---|
US (1) | US6231540B1 (en) |
EP (1) | EP0996477B1 (en) |
JP (1) | JP2003514587A (en) |
AU (1) | AU8333398A (en) |
WO (1) | WO1999003521A1 (en) |
Cited By (20)
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US6099504A (en) * | 1997-10-22 | 2000-08-08 | Elan Corporation, Plc | Pre-filled injection delivery device |
US6190367B1 (en) | 1999-09-22 | 2001-02-20 | Becton, Dickinson And Company | Medical site prep device |
WO2001032255A1 (en) | 1999-10-25 | 2001-05-10 | Antares Pharma, Inc. | Locking mechanism for a jet injector |
US6428528B2 (en) | 1998-08-11 | 2002-08-06 | Antares Pharma, Inc. | Needle assisted jet injector |
EP1925333A1 (en) | 2000-06-29 | 2008-05-28 | Becton, Dickinson and Company | Intradermal delivery of substances |
US7678078B1 (en) | 2008-10-21 | 2010-03-16 | KMG Pharma LLC | Intravitreal injection device, system and method |
US8915889B2 (en) | 2008-08-05 | 2014-12-23 | Antares Pharma, Inc. | Multiple dosage injector |
US8945063B2 (en) | 2009-03-20 | 2015-02-03 | Antares Pharma, Inc. | Hazardous agent injection system |
US9180259B2 (en) | 2005-01-24 | 2015-11-10 | Antares Pharma, Inc. | Prefilled syringe jet injector |
US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
US9333309B2 (en) | 2002-02-11 | 2016-05-10 | Antares Pharma, Inc. | Intradermal injector |
US9364611B2 (en) | 2012-05-07 | 2016-06-14 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
US9446195B2 (en) | 2011-07-15 | 2016-09-20 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
EP3178465A1 (en) | 2010-12-06 | 2017-06-14 | Follica, Inc. | Methods for treating baldness and promoting hair growth |
US9707354B2 (en) | 2013-03-11 | 2017-07-18 | Antares Pharma, Inc. | Multiple dosage injector with rack and pinion dosage system |
US9744302B2 (en) | 2013-02-11 | 2017-08-29 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
US9808582B2 (en) | 2006-05-03 | 2017-11-07 | Antares Pharma, Inc. | Two-stage reconstituting injector |
US9950125B2 (en) | 2012-04-06 | 2018-04-24 | Antares Pharma, Inc. | Needle assisted jet injection administration of testosterone compositions |
WO2021005009A1 (en) | 2019-07-05 | 2021-01-14 | Iomx Therapeutics Ag | Antibodies binding igc2 of igsf11 (vsig3) and uses thereof |
WO2022008027A1 (en) | 2020-07-06 | 2022-01-13 | Iomx Therapeutics Ag | Antibodies binding igv of igsf11 (vsig3) and uses thereof |
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US6835184B1 (en) * | 1999-09-24 | 2004-12-28 | Becton, Dickinson And Company | Method and device for abrading skin |
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US20030163111A1 (en) * | 2002-02-26 | 2003-08-28 | Daellenbach Keith K. | End effector for needle-free injection system |
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US20050160858A1 (en) * | 2002-07-24 | 2005-07-28 | M 2 Medical A/S | Shape memory alloy actuator |
US6883222B2 (en) * | 2002-10-16 | 2005-04-26 | Bioject Inc. | Drug cartridge assembly and method of manufacture |
JP2006504476A (en) | 2002-11-05 | 2006-02-09 | エム2・メディカル・アクティーゼルスカブ | Disposable, wearable insulin administration device, combination of the device and program control device, and operation control method of the device |
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US9205197B2 (en) | 2003-03-03 | 2015-12-08 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device dose setting mechanism |
GB0304822D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
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US7753879B2 (en) * | 2004-01-29 | 2010-07-13 | M2 Group Holdings, Inc. | Disposable medicine dispensing device |
CA2584760C (en) | 2004-10-21 | 2013-12-24 | Novo Nordisk A/S | Dial-down mechanism for wind-up pen |
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WO2006114396A1 (en) * | 2005-04-24 | 2006-11-02 | Novo Nordisk A/S | Injection device |
US8591457B2 (en) | 2005-08-10 | 2013-11-26 | Alza Corporation | Method for making a needle-free jet injection drug delivery device |
US8409142B2 (en) | 2005-09-26 | 2013-04-02 | Asante Solutions, Inc. | Operating an infusion pump system |
US7534226B2 (en) | 2005-09-26 | 2009-05-19 | M2 Group Holdings, Inc. | Dispensing fluid from an infusion pump system |
US8105279B2 (en) | 2005-09-26 | 2012-01-31 | M2 Group Holdings, Inc. | Dispensing fluid from an infusion pump system |
US8057436B2 (en) | 2005-09-26 | 2011-11-15 | Asante Solutions, Inc. | Dispensing fluid from an infusion pump system |
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US8551046B2 (en) | 2006-09-18 | 2013-10-08 | Asante Solutions, Inc. | Dispensing fluid from an infusion pump system |
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US8585657B2 (en) | 2011-06-21 | 2013-11-19 | Asante Solutions, Inc. | Dispensing fluid from an infusion pump system |
US9533106B2 (en) | 2011-12-29 | 2017-01-03 | Novo Nordisk A/S | Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism |
US8454562B1 (en) | 2012-07-20 | 2013-06-04 | Asante Solutions, Inc. | Infusion pump system and method |
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US9457141B2 (en) | 2013-06-03 | 2016-10-04 | Bigfoot Biomedical, Inc. | Infusion pump system and method |
US9561324B2 (en) | 2013-07-19 | 2017-02-07 | Bigfoot Biomedical, Inc. | Infusion pump system and method |
US10569015B2 (en) | 2013-12-02 | 2020-02-25 | Bigfoot Biomedical, Inc. | Infusion pump system and method |
US10137246B2 (en) | 2014-08-06 | 2018-11-27 | Bigfoot Biomedical, Inc. | Infusion pump assembly and method |
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- 1998-07-01 EP EP98933563A patent/EP0996477B1/en not_active Expired - Lifetime
- 1998-07-01 JP JP2000502812A patent/JP2003514587A/en active Pending
- 1998-07-01 AU AU83333/98A patent/AU8333398A/en not_active Abandoned
- 1998-07-09 US US09/112,494 patent/US6231540B1/en not_active Expired - Fee Related
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Cited By (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6830560B1 (en) | 1997-10-22 | 2004-12-14 | Elan Corporation Plc | Automatic syringe |
US6099504A (en) * | 1997-10-22 | 2000-08-08 | Elan Corporation, Plc | Pre-filled injection delivery device |
USRE44846E1 (en) | 1998-08-11 | 2014-04-15 | Antares Pharma, Inc. | Needle assisted jet injector |
US6428528B2 (en) | 1998-08-11 | 2002-08-06 | Antares Pharma, Inc. | Needle assisted jet injector |
US6565553B2 (en) | 1998-08-11 | 2003-05-20 | Antares Pharma, Inc. | Needle assisted jet injector |
EP1336419A1 (en) | 1998-08-11 | 2003-08-20 | Medi-Ject Corporation | Needle assisted jet injector |
US6746429B2 (en) | 1998-08-11 | 2004-06-08 | Antares Pharma, Inc. | Needle assisted jet injector |
US7776015B2 (en) | 1998-08-11 | 2010-08-17 | Antares Pharma Inc. | Needle assisted jet injector |
US6190367B1 (en) | 1999-09-22 | 2001-02-20 | Becton, Dickinson And Company | Medical site prep device |
WO2001032255A1 (en) | 1999-10-25 | 2001-05-10 | Antares Pharma, Inc. | Locking mechanism for a jet injector |
US6391003B1 (en) | 1999-10-25 | 2002-05-21 | Antares Pharma, Inc. | Locking mechanism for a jet injector |
EP1925333A1 (en) | 2000-06-29 | 2008-05-28 | Becton, Dickinson and Company | Intradermal delivery of substances |
US9737670B2 (en) | 2002-02-11 | 2017-08-22 | Antares Pharma, Inc. | Intradermal injector |
US9333309B2 (en) | 2002-02-11 | 2016-05-10 | Antares Pharma, Inc. | Intradermal injector |
US11446441B2 (en) | 2005-01-24 | 2022-09-20 | Antares Pharma, Inc. | Prefilled syringe injector |
US10478560B2 (en) | 2005-01-24 | 2019-11-19 | Antares Pharma, Inc. | Prefilled syringe injector |
US9180259B2 (en) | 2005-01-24 | 2015-11-10 | Antares Pharma, Inc. | Prefilled syringe jet injector |
US9629959B2 (en) | 2005-01-24 | 2017-04-25 | Antares Pharma, Inc. | Prefilled syringe jet injector |
US11547808B2 (en) | 2006-05-03 | 2023-01-10 | Antares Pharma, Inc. | Two-stage reconstituting injector |
US10688250B2 (en) | 2006-05-03 | 2020-06-23 | Antares Pharma, Inc. | Two-stage reconstituting injector |
US9808582B2 (en) | 2006-05-03 | 2017-11-07 | Antares Pharma, Inc. | Two-stage reconstituting injector |
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Also Published As
Publication number | Publication date |
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US6231540B1 (en) | 2001-05-15 |
JP2003514587A (en) | 2003-04-22 |
AU8333398A (en) | 1999-02-10 |
EP0996477B1 (en) | 2004-01-14 |
EP0996477A1 (en) | 2000-05-03 |
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