WO1999002695A3 - Epitopes and active sites of paramyxoviridae proteins and uses thereof - Google Patents

Epitopes and active sites of paramyxoviridae proteins and uses thereof Download PDF

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Publication number
WO1999002695A3
WO1999002695A3 PCT/NL1998/000390 NL9800390W WO9902695A3 WO 1999002695 A3 WO1999002695 A3 WO 1999002695A3 NL 9800390 W NL9800390 W NL 9800390W WO 9902695 A3 WO9902695 A3 WO 9902695A3
Authority
WO
WIPO (PCT)
Prior art keywords
paramyxoviridae
viruses
relates
protein
epitopes
Prior art date
Application number
PCT/NL1998/000390
Other languages
French (fr)
Other versions
WO1999002695A2 (en
Inventor
Johannes Petrus Mari Langedijk
Oirschot Johannes Theodoru Van
Original Assignee
Stichting Inst Dierhouderij
Johannes Petrus Mari Langedijk
Oirschot Johannes Theodorus Va
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Inst Dierhouderij, Johannes Petrus Mari Langedijk, Oirschot Johannes Theodorus Va filed Critical Stichting Inst Dierhouderij
Priority to AU82462/98A priority Critical patent/AU8246298A/en
Publication of WO1999002695A2 publication Critical patent/WO1999002695A2/en
Publication of WO1999002695A3 publication Critical patent/WO1999002695A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
    • C12N2760/18622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to the field of paramyxoviridae, vaccines against infections by such viruses, diagnostics for detecting such viruses and targets for therapeutics against such viruses. In particular, the invention relates to 3-D models identifying a proteinaceous substance comprising at least one virus epitope derived from the attachment protein of a virus from the family of paramyxoviridae, said epitope corresponding to an antigenic site present on the HN protein of paramyxovirus, which site is identified as one of loop β1L01, β1L23, β2L01, β2L23, β3L01, β3L23, β4L01, β4L23, β5L01, β5L23, β6L01 and β6L23, or a functional equivalent thereof. Also, the invention relates to a substance blocking the enzymatic activity of the morbillivirus H protein.
PCT/NL1998/000390 1997-07-08 1998-07-08 Epitopes and active sites of paramyxoviridae proteins and uses thereof WO1999002695A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU82462/98A AU8246298A (en) 1997-07-08 1998-07-08 Epitopes and active sites of paramyxoviridae proteins and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97202100.0 1997-07-08
EP97202100 1997-07-08

Publications (2)

Publication Number Publication Date
WO1999002695A2 WO1999002695A2 (en) 1999-01-21
WO1999002695A3 true WO1999002695A3 (en) 1999-04-08

Family

ID=8228525

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL1998/000390 WO1999002695A2 (en) 1997-07-08 1998-07-08 Epitopes and active sites of paramyxoviridae proteins and uses thereof

Country Status (2)

Country Link
AU (1) AU8246298A (en)
WO (1) WO1999002695A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200502402A (en) * 2002-12-06 2005-01-16 Wyeth Corp Escape mutants of newcastle disease virus as marker vaccines
EP2519636B8 (en) 2009-12-28 2017-08-09 DSM IP Assets B.V. Production of hemagglutinin-neuraminidase protein in microalgae

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001040A1 (en) * 1987-07-27 1989-02-09 Syntro Corporation Attenuated herpes viruses, herpes viruses which include foreign dna encoding an amino acid sequence and vaccines containing same
WO1995021261A1 (en) * 1994-02-04 1995-08-10 Syntro Corporation Recombinant infectious bovine rhinotracheitis virus s-ibr-052 and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001040A1 (en) * 1987-07-27 1989-02-09 Syntro Corporation Attenuated herpes viruses, herpes viruses which include foreign dna encoding an amino acid sequence and vaccines containing same
WO1995021261A1 (en) * 1994-02-04 1995-08-10 Syntro Corporation Recombinant infectious bovine rhinotracheitis virus s-ibr-052 and uses thereof

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BATY, D.U. & RANDALL, R.E.: "Multiple amino-acid substitutions in the HN protein of the paramyxovirus, SV5 are selected for in monoclonal antibody resistant mutants", ARCHIVES OF VIROLOGY, vol. 131, no. 1-2, 1993, pages 217 - 224, XP002053822 *
COELINGH, K. L. ET AL.: "Conserved epitopes on the hemagglutinin -neuraminidase proteins of human and bovine Parainfluenza type 3 viruses: nucleotide sequence analysis of variants selected with monoclonal antibodies", JOURNAL OF VIROLOGY., vol. 60, no. 1, October 1986 (1986-10-01), ICAN SOCIETY FOR MICROBIOLOGY US, pages 90 - 96, XP002053821 *
COLMAN, P.M. ET AL.: "Sequence and structure alignment of Paramyxovirus Hemagglutinin-Neuraminadase with Influenza virus neuraminidase", JOURNAL OF VIROLOGY., vol. 67, no. 6, June 1993 (1993-06-01), ICAN SOCIETY FOR MICROBIOLOGY US, pages 2972 - 2980, XP002053818 *
GOSWAMI, K.K.A. ET AL.: "A neutralising monoclonal antibody against a paramyxovirus reacts with a brain antigen", JOURNAL OF NEUROIMMUNOLOGY, vol. 9, no. 1/2, July 1985 (1985-07-01), pages 99 - 108, XP002053823 *
IORIO, R.M. ET AL.: "Neutralization map of the Hemagglutinin-Neuraminidase glycoprotein of Newcastle Disease Virus : domains recognized by monoclonal antibodies that prevent receptor recognition", JOURNAL OF VIROLOGY., vol. 65, no. 9, September 1991 (1991-09-01), ICAN SOCIETY FOR MICROBIOLOGY US, pages 4999 - 5006, XP002053819 *
KOMADA, H. ET AL.: "Isolation and characterization of monoclonal antibodies to human Parainfluenza Virus type 4 and teir use in revealing antigenic relation between subtypes 4A and 4B", VIROLOGY, vol. 171, no. 1, July 1989 (1989-07-01), ORLANDO US, pages 28 - 37, XP002053825 *
LANGEDIJK, J.P. ET AL.: "Sequence and structure alignment of Paramyxoviridae attachment proteins and discovery of enzymatic activity for a morbillivirus hemagglutinin", JOURNAL OF VIROLOGY., vol. 71, no. 8, August 1997 (1997-08-01), ICAN SOCIETY FOR MICROBIOLOGY US, pages 6155 - 6167, XP002053824 *
PARKS, G.D. ET AL.: "Transposition of domains between the M2 and HN viral membrane proteins results in polypeptides which can adopt more than one membrane orientation", JOURNAL OF CELL BIOLOGY, vol. 109, no. 5, November 1989 (1989-11-01), pages 2023 - 2032, XP002053820 *
SUZU S ET AL: "NUCLEOTIDE SEQUENCE OF THE BOVINE PARAINFLUENZA 3 VIRUS GENOME: THE GENES OF THE F AND HN GLYCOPROTEINS", NUCLEIC ACIDS RESEARCH, vol. 15, no. 7, 10 April 1987 (1987-04-10), pages 2945 - 2958, XP000647319 *

Also Published As

Publication number Publication date
AU8246298A (en) 1999-02-08
WO1999002695A2 (en) 1999-01-21

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