WO1998059069A3 - Method for identifying cancerigenic agents using a mammal with inhibition of the poly(adp-ribose)-polymerase - Google Patents

Method for identifying cancerigenic agents using a mammal with inhibition of the poly(adp-ribose)-polymerase Download PDF

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Publication number
WO1998059069A3
WO1998059069A3 PCT/DE1998/001797 DE9801797W WO9859069A3 WO 1998059069 A3 WO1998059069 A3 WO 1998059069A3 DE 9801797 W DE9801797 W DE 9801797W WO 9859069 A3 WO9859069 A3 WO 9859069A3
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WO
WIPO (PCT)
Prior art keywords
agents
cancerigenic
adp
ribose
polymerase
Prior art date
Application number
PCT/DE1998/001797
Other languages
German (de)
French (fr)
Other versions
WO1998059069A2 (en
Inventor
Jan-Heiner Kuepper
Alexander Buerkle
Gool Leon Van
Hausen Harald Zur
Original Assignee
Deutsches Krebsforsch
Kuepper Jan Heiner
Alexander Buerkle
Gool Leon Van
Hausen Harald Zur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforsch, Kuepper Jan Heiner, Alexander Buerkle, Gool Leon Van, Hausen Harald Zur filed Critical Deutsches Krebsforsch
Priority to JP50359699A priority Critical patent/JP2002507885A/en
Priority to EP98941257A priority patent/EP1015573A2/en
Publication of WO1998059069A2 publication Critical patent/WO1998059069A2/en
Publication of WO1998059069A3 publication Critical patent/WO1998059069A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

In a process for identifying cancerogenic agents, the potentially cancerigenic agents are administered to a mammal with a DNA repair disturbance caused by inhibiting the poly(ADP-ribose)-polymerase.
PCT/DE1998/001797 1997-06-24 1998-06-24 Method for identifying cancerigenic agents using a mammal with inhibition of the poly(adp-ribose)-polymerase WO1998059069A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP50359699A JP2002507885A (en) 1997-06-24 1998-06-24 Methods for identifying carcinogenic factors using mammals in inhibiting poly (ADP-ribose) polymerase
EP98941257A EP1015573A2 (en) 1997-06-24 1998-06-24 Process for identifying cancerigenic agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1997126824 DE19726824C1 (en) 1997-06-24 1997-06-24 Method of identifying carcinogenic agents
DE19726824.2 1997-06-24

Publications (2)

Publication Number Publication Date
WO1998059069A2 WO1998059069A2 (en) 1998-12-30
WO1998059069A3 true WO1998059069A3 (en) 1999-04-29

Family

ID=7833520

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1998/001797 WO1998059069A2 (en) 1997-06-24 1998-06-24 Method for identifying cancerigenic agents using a mammal with inhibition of the poly(adp-ribose)-polymerase

Country Status (4)

Country Link
EP (1) EP1015573A2 (en)
JP (1) JP2002507885A (en)
DE (1) DE19726824C1 (en)
WO (1) WO1998059069A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995024379A1 (en) * 1994-03-09 1995-09-14 Newcastle University Ventures Limited Benzamide analogs, useful as parp (adp-ribosyltransferase, adprt) dna repair enzyme inhibitors
DE4433130A1 (en) * 1994-09-16 1996-03-21 Deutsches Krebsforsch Identification of DNA-damaging substances by cell lines overexpressing poly (ADP-ribose) polymerase
WO1996018737A2 (en) * 1994-12-16 1996-06-20 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Vectors and viruses for use in gene therapy
EP0757102A1 (en) * 1995-08-04 1997-02-05 Plant Genetic Systems N.V. Genetic transformation using a PARP inhibitor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995024379A1 (en) * 1994-03-09 1995-09-14 Newcastle University Ventures Limited Benzamide analogs, useful as parp (adp-ribosyltransferase, adprt) dna repair enzyme inhibitors
DE4433130A1 (en) * 1994-09-16 1996-03-21 Deutsches Krebsforsch Identification of DNA-damaging substances by cell lines overexpressing poly (ADP-ribose) polymerase
WO1996018737A2 (en) * 1994-12-16 1996-06-20 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Vectors and viruses for use in gene therapy
EP0757102A1 (en) * 1995-08-04 1997-02-05 Plant Genetic Systems N.V. Genetic transformation using a PARP inhibitor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KÜPPER, J.H. ET AL.: "Trans-dominant inhibition of poly(ADP-ribosyl)ation potentiates carcinogen-induced gene amplification in SV40-transformed Chinese Hamter cells", CANCER RESEARCH, vol. 56, no. 12, 15 June 1996 (1996-06-15), MD US, pages 2715 - 2717, XP002090238 *
KÜPPER, J.H. ET AL.: "Trans-dominant inhibition of poly(ADP-Ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N'-Nitro-N-nitroguanidine but does not limit DNA replication of a polyomavirus replicon", MOLECULAR AND CELLULAR BIOLOGY, vol. 15, no. 6, WASHINGTON US, pages 3154 - 3163, XP002090237 *
MOLINETE, M. ET AL.: "Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells", EMBO JOURNAL, vol. 12, no. 5, 1993, EYNSHAM, OXFORD GB, pages 2109 - 2117, XP002090239 *

Also Published As

Publication number Publication date
DE19726824C1 (en) 1999-03-04
JP2002507885A (en) 2002-03-12
WO1998059069A2 (en) 1998-12-30
EP1015573A2 (en) 2000-07-05

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