WO1998057985A3 - Human rip-interacting factor (rif) - Google Patents

Human rip-interacting factor (rif) Download PDF

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Publication number
WO1998057985A3
WO1998057985A3 PCT/US1998/012778 US9812778W WO9857985A3 WO 1998057985 A3 WO1998057985 A3 WO 1998057985A3 US 9812778 W US9812778 W US 9812778W WO 9857985 A3 WO9857985 A3 WO 9857985A3
Authority
WO
WIPO (PCT)
Prior art keywords
rif
rip
human
interacting factor
human rip
Prior art date
Application number
PCT/US1998/012778
Other languages
French (fr)
Other versions
WO1998057985A2 (en
Inventor
Blanche Shamoon
Original Assignee
Chiron Corp
Blanche Shamoon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp, Blanche Shamoon filed Critical Chiron Corp
Priority to AU80745/98A priority Critical patent/AU8074598A/en
Publication of WO1998057985A2 publication Critical patent/WO1998057985A2/en
Publication of WO1998057985A3 publication Critical patent/WO1998057985A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

A novel human protein termed RIP-interacting factor (RIF) is disclosed. RIF physically interacts with RIP and is involved in the human apoptotic pathway. RIF protein and coding sequences can be used to treat diseases characterized by defects in the regulation of cell proliferation and to detect human cell nuclei.
PCT/US1998/012778 1997-06-19 1998-06-19 Human rip-interacting factor (rif) WO1998057985A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU80745/98A AU8074598A (en) 1997-06-19 1998-06-19 Human rip-interacting factor (rif)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5019697P 1997-06-19 1997-06-19
US60/050,196 1997-06-19

Publications (2)

Publication Number Publication Date
WO1998057985A2 WO1998057985A2 (en) 1998-12-23
WO1998057985A3 true WO1998057985A3 (en) 1999-03-11

Family

ID=21963905

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/012778 WO1998057985A2 (en) 1997-06-19 1998-06-19 Human rip-interacting factor (rif)

Country Status (2)

Country Link
AU (1) AU8074598A (en)
WO (1) WO1998057985A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1263982A4 (en) * 2000-03-08 2005-03-09 Nat Jewish Med & Res Center Phosphatidyl serine receptors and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5674734A (en) * 1995-05-18 1997-10-07 President And Fellows Of Harvard College Cell death protein

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5674734A (en) * 1995-05-18 1997-10-07 President And Fellows Of Harvard College Cell death protein

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GRIMM S. ET AL.: "RIP and FADD: two "death domain"-containing proteins can induce apoptosis by convergent, but dissociable, pathways.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 93, no. 20, 1996, WASHINGTON US, pages 10923 - 10927, XP002086330 *
TING A.T. ET AL.: "RIP mediates tumor necrosis factor receptor 1 activation of NF-kappa-B but not Fas/APO-1 initiated apoptosis", EMBO JOURNAL, vol. 15, no. 22, 1996, EYNSHAM, OXFORD GB, pages 6189 - 6196, XP002086329 *

Also Published As

Publication number Publication date
WO1998057985A2 (en) 1998-12-23
AU8074598A (en) 1999-01-04

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