WO1998055506A3 - Thrombin hemmende peptide - Google Patents

Thrombin hemmende peptide Download PDF

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Publication number
WO1998055506A3
WO1998055506A3 PCT/EP1998/003356 EP9803356W WO9855506A3 WO 1998055506 A3 WO1998055506 A3 WO 1998055506A3 EP 9803356 W EP9803356 W EP 9803356W WO 9855506 A3 WO9855506 A3 WO 9855506A3
Authority
WO
WIPO (PCT)
Prior art keywords
thrombin
inhibiting peptide
peptides
relates
peptide
Prior art date
Application number
PCT/EP1998/003356
Other languages
English (en)
French (fr)
Other versions
WO1998055506A2 (de
Inventor
Christiane Noeske-Jungblut
Ursula Egner
Peter Donner
Wolf-Dieter Schleuning
Wolfram Bode
Pablo Fuentes Prior
Original Assignee
Schering Ag
Noeske Jungblut Christiane
Ursula Egner
Peter Donner
Schleuning Wolf Dieter
Wolfram Bode
Pablo Fuentes Prior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag, Noeske Jungblut Christiane, Ursula Egner, Peter Donner, Schleuning Wolf Dieter, Wolfram Bode, Pablo Fuentes Prior filed Critical Schering Ag
Priority to JP50152699A priority Critical patent/JP2002506432A/ja
Priority to EP98932121A priority patent/EP0983301A2/de
Publication of WO1998055506A2 publication Critical patent/WO1998055506A2/de
Publication of WO1998055506A3 publication Critical patent/WO1998055506A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Es werden Peptide der allgemeinen Formel (I), in der Y?1, Y2 und X1-14¿ die in der Beschreibung genannten Bedeutungen haben, und deren Verwendung zur Herstellung von Arzneimitteln beschrieben.
PCT/EP1998/003356 1997-06-06 1998-06-05 Thrombin hemmende peptide WO1998055506A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP50152699A JP2002506432A (ja) 1997-06-06 1998-06-05 トロンビンを阻害するペプチド
EP98932121A EP0983301A2 (de) 1997-06-06 1998-06-05 Thrombin hemmende peptide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19724791.1 1997-06-06
DE19724791A DE19724791B4 (de) 1997-06-06 1997-06-06 Thrombin hemmende Peptide, deren Verwendung und diese enthaltende pharmazeutische Zusammensetzungen

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09445214 A-371-Of-International 2000-05-03
US10/694,847 Division US20040147442A1 (en) 1997-06-06 2003-10-29 Thrombin-inhibiting peptides

Publications (2)

Publication Number Publication Date
WO1998055506A2 WO1998055506A2 (de) 1998-12-10
WO1998055506A3 true WO1998055506A3 (de) 1999-03-04

Family

ID=7832244

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/003356 WO1998055506A2 (de) 1997-06-06 1998-06-05 Thrombin hemmende peptide

Country Status (4)

Country Link
EP (1) EP0983301A2 (de)
JP (1) JP2002506432A (de)
DE (1) DE19724791B4 (de)
WO (1) WO1998055506A2 (de)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994013807A1 (de) * 1992-12-04 1994-06-23 Schering Aktiengesellschaft Thrombininhibitor aus speichel von protostomiern

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994013807A1 (de) * 1992-12-04 1994-06-23 Schering Aktiengesellschaft Thrombininhibitor aus speichel von protostomiern

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NOESKE-JUNGBLUTT E.A.: "Triabin, a highly potent exosite inhibitor of thrombin", J.BIOL.CHEM., vol. 270, no. 48, 1 December 1995 (1995-12-01), pages 28629 - 28634, XP002085300 *

Also Published As

Publication number Publication date
WO1998055506A2 (de) 1998-12-10
DE19724791B4 (de) 2006-09-28
DE19724791A1 (de) 1998-12-10
EP0983301A2 (de) 2000-03-08
JP2002506432A (ja) 2002-02-26

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