WO1998054333A3 - Mammalian caax processing enzymes - Google Patents
Mammalian caax processing enzymes Download PDFInfo
- Publication number
- WO1998054333A3 WO1998054333A3 PCT/US1998/011415 US9811415W WO9854333A3 WO 1998054333 A3 WO1998054333 A3 WO 1998054333A3 US 9811415 W US9811415 W US 9811415W WO 9854333 A3 WO9854333 A3 WO 9854333A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mammalian
- caax
- sequences
- protein
- dna
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU77216/98A AU7721698A (en) | 1997-06-02 | 1998-06-02 | Mammalian caax processing enzymes |
US09/454,889 US6518035B1 (en) | 1998-06-02 | 1999-12-03 | Targeted methods of drug screening using co-culture methods |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4736997P | 1997-06-02 | 1997-06-02 | |
US60/047,369 | 1997-06-02 | ||
US5238997P | 1997-07-14 | 1997-07-14 | |
US60/052,389 | 1997-07-14 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US21312098A Continuation | 1998-06-02 | 1998-12-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998054333A2 WO1998054333A2 (en) | 1998-12-03 |
WO1998054333A3 true WO1998054333A3 (en) | 1999-04-08 |
Family
ID=26724942
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/011415 WO1998054333A2 (en) | 1997-06-02 | 1998-06-02 | Mammalian caax processing enzymes |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO1998054333A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6060277A (en) * | 1997-06-24 | 2000-05-09 | Smithkline Beecham Corporation | Human AFC1 |
CA2234418A1 (en) * | 1997-06-24 | 1998-12-24 | Smithkline Beecham Corporation | Human afc1 |
ES2149672B1 (en) * | 1998-01-08 | 2001-05-16 | Univ Oviedo | HUMAN GENE SEQUENCE APPROVES THE AFC1 GENE OF LEAVES INVOLVED IN THE PROTEOLITIC PROCESSING OF PRENILED PROTEINS. |
US6417332B1 (en) * | 1998-02-12 | 2002-07-09 | Smithkline Beecham Corporation | Human RCE1 |
EP1078076A2 (en) * | 1998-05-22 | 2001-02-28 | Onyx Pharmaceuticals, Inc. | Novel nucleic acids and polypeptides related to a farnesyl-directed endopeptidase |
US6518035B1 (en) | 1998-06-02 | 2003-02-11 | Rosetta Inpharmatics, Inc. | Targeted methods of drug screening using co-culture methods |
US6261793B1 (en) * | 1999-03-04 | 2001-07-17 | Schering Corporation | RAS converting endoprotease (RCE) and methods |
US6730786B2 (en) * | 2000-06-22 | 2004-05-04 | Pfizer Inc | Process for the preparation of pyrazolopyrimidinones |
US6667398B2 (en) | 2000-06-22 | 2003-12-23 | Pfizer Inc | Process for the preparation of pyrazolopyrimidinones |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0679716A1 (en) * | 1993-11-12 | 1995-11-02 | Kenichi Matsubara | Gene signature |
WO1998005786A2 (en) * | 1996-08-07 | 1998-02-12 | The Regents Of The University Of California | Afc1 and rce1:isoprenylated caax processing enzymes |
EP0887416A2 (en) * | 1997-06-24 | 1998-12-30 | Smithkline Beecham Corporation | Human AFC1 |
EP0887415A2 (en) * | 1997-06-24 | 1998-12-30 | Smithkline Beecham Corporation | Human RCE1 |
-
1998
- 1998-06-02 WO PCT/US1998/011415 patent/WO1998054333A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0679716A1 (en) * | 1993-11-12 | 1995-11-02 | Kenichi Matsubara | Gene signature |
WO1998005786A2 (en) * | 1996-08-07 | 1998-02-12 | The Regents Of The University Of California | Afc1 and rce1:isoprenylated caax processing enzymes |
EP0887416A2 (en) * | 1997-06-24 | 1998-12-30 | Smithkline Beecham Corporation | Human AFC1 |
EP0887415A2 (en) * | 1997-06-24 | 1998-12-30 | Smithkline Beecham Corporation | Human RCE1 |
Non-Patent Citations (12)
Title |
---|
AKOPYAN T.N. ET AL.: "Proteolytic processing of farnesylated peptides: assay and partial purification from pig brain membranes of an endopeptidase which has the characteristics of E.C. 3.4.24.15", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 198, no. 2, 28 January 1994 (1994-01-28), pages 787 - 794, XP002049582 * |
BOYARTCHUK V.L. ET AL.: "Modulation of Ras and a-factor function by carboxyl-terminal proteolysis", SCIENCE, vol. 275, 21 March 1997 (1997-03-21), pages 1796 - 1800, XP002049583 * |
CHEN Y. ET AL.: "Solubilization, partial purification, and affinity labeling of the membrane-bound isoprenylated protein endoprotease", BIOCHEMISTRY, vol. 35, 12 March 1996 (1996-03-12), pages 3227 - 3237, XP000199958 * |
Database EMBL Emest12, Entry HSAA19855 Accession number AA210930 2 February 1997 96% identity with Seq.ID:37 nt.216-590 * |
Database EMBL Emest13, Entry HSW4115 Accession number W96411 18 July 1996 98% identity with Seq.ID:1 nt.488-841 88% identity with Seq.ID:3 nt.481-830 reverse orientation * |
Database EMBL Emest15, Entry MM3448 Accession number W14344 30 April 1996 87% identity with Seq.ID:1 nt.617-990 100% identity with Seq.ID:3 nt.610-983 * |
Database EMBL Emest16, Entry MMAA21859 Accession number AA021859 29 November 1996 89% identity with Seq.ID:1 nt.7-664 98% identity with Seq.ID:3 nt.3-672 * |
Database EMBL Emest16, Entry MMAA68614 Accession number AA168614 22 December 1996 90% identity with Seq.ID:1 nt.390-839 100% identity with Seq.ID:3 nt.383-832 * |
Database EMBL Emest18, Entry HSZZ64182 Accession number AA359058 18 April 1997 100% identity with Seq.ID:37 nt.1-306 * |
Database EMBL Emest8, Entry HS1228356 Accession number AA428315 25 May 1997 100% identity with Seq.ID:1 nt.130-529 90% identity with Seq.ID:3 nt.123-522 * |
Database EMBL Emest8, Entry HS181310 Accession number N76181 5 April 1996 100% identity with Seq.ID:37 nt.430-721 * |
NISHII W. ET AL.: "Partial purification and characterization of a CAAX-motif-specific protease from bovine brain using a novel fluorometric assay", JOURNAL OF BIOCHEMISTRY, vol. 122, 1997, pages 402 - 408, XP000199959 * |
Also Published As
Publication number | Publication date |
---|---|
WO1998054333A2 (en) | 1998-12-03 |
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