WO1998054310A3 - Methods for activating inactive genes and methods for altering the rate of development of cells, tissues and organisms - Google Patents

Methods for activating inactive genes and methods for altering the rate of development of cells, tissues and organisms Download PDF

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Publication number
WO1998054310A3
WO1998054310A3 PCT/US1998/010006 US9810006W WO9854310A3 WO 1998054310 A3 WO1998054310 A3 WO 1998054310A3 US 9810006 W US9810006 W US 9810006W WO 9854310 A3 WO9854310 A3 WO 9854310A3
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WO
WIPO (PCT)
Prior art keywords
methods
cell
organism
rate
tissue
Prior art date
Application number
PCT/US1998/010006
Other languages
French (fr)
Other versions
WO1998054310A2 (en
Inventor
Yuying Tan
Original Assignee
Anticancer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Anticancer Inc filed Critical Anticancer Inc
Priority to EP98923455A priority Critical patent/EP1003848A2/en
Publication of WO1998054310A2 publication Critical patent/WO1998054310A2/en
Publication of WO1998054310A3 publication Critical patent/WO1998054310A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Husbandry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention is based on the unexpected observation that DNA methylation, particularly at cytosine residues, that regulates gene activation states and the rate of development and differentiation of cells and organisms, can be altered by providing methioninase to a cell, tissue or organism. In addition, other methylation reactions within a cell can be altered by providing methioninase to a cell, tissue or organism. Based on these observations, the present invention provides methods of activating inactive genes, methods for decreasing the rate of development of cell, tissues or an organism, methods of treating obesity and methods of treating Parkinson's disease and other neurological disorders, by either providing a methioninase containing composition to a cell, tissue or organism or by introducing a methioninase encoding DNA molecule into the cell, tissue or organism. The present invention further provides organisms and cells that have been altered such that their rate of maturation is decreased and/or the degree of methylation of cellular constituents (DNA, RNA, lipids, proteins small cellular molecules, etc.) is decreased.
PCT/US1998/010006 1997-05-30 1998-05-15 Methods for activating inactive genes and methods for altering the rate of development of cells, tissues and organisms WO1998054310A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP98923455A EP1003848A2 (en) 1997-05-30 1998-05-15 Methods for activating inactive genes and methods for altering the rate of development of cells, tissues and organisms

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4803397P 1997-05-30 1997-05-30
US60/048,033 1997-05-30

Publications (2)

Publication Number Publication Date
WO1998054310A2 WO1998054310A2 (en) 1998-12-03
WO1998054310A3 true WO1998054310A3 (en) 1999-03-04

Family

ID=21952396

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/010006 WO1998054310A2 (en) 1997-05-30 1998-05-15 Methods for activating inactive genes and methods for altering the rate of development of cells, tissues and organisms

Country Status (2)

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EP (1) EP1003848A2 (en)
WO (1) WO1998054310A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138384B1 (en) 1997-08-29 2006-11-21 The Regents Of The University Of California Modulators of DNA cytosine-5 methyltransferase and methods for use thereof
DE10038733A1 (en) * 2000-08-02 2002-02-21 Epigenomics Ag Procedure for determining the age of individuals

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040284A1 (en) * 1995-06-07 1996-12-19 Anticancer, Inc. Use of methioninase in anti-methionine and anti-homocysteine chemotherapy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040284A1 (en) * 1995-06-07 1996-12-19 Anticancer, Inc. Use of methioninase in anti-methionine and anti-homocysteine chemotherapy

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CHIU C.P., BLAU H.M.: "5-azacytidine permits gene activation in a previously noninducible cell type", CELL, vol. 40, no. 2, February 1985 (1985-02-01), US, pages 417 - 424, XP002082384 *
HOFFMAN R.M. AND TAN Y.: "Anti-methionine therapy as a potential universal modulator for anti-tumor and anti-metastatic therapy", CLINICAL AND EXPERIMENTAL METASTASIS, vol. 14,supp.1, September 1996 (1996-09-01), London, GB, pages 85, XP002082383 *
HOFFMAN R.M.: "Methioninase: a therapeutic for diseases related to altered methionine methabolism and transmethylation: cancer, heart disease, obesity aging and Parkinson's disease", HUMAN CELL, vol. 10, no. 1, March 1997 (1997-03-01), JP, pages 69 - 80, XP002082379 *
MAKOS M. ET AL.: "Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 89, March 1992 (1992-03-01), WASHINGTON US, pages 1929 - 1933, XP002082385 *
TAN Y. ET AL.: "Overexpression and large-scale production of recombinant l-methionine-alpha-deamino-gamma-mercaptomethane-lyase for novel anticancer therapy", PROTEIN EXPRESSION AND PURIFICATION, vol. 9, no. 2, March 1997 (1997-03-01), us, pages 233 - 245, XP002082381 *
TAN Y. ET AL.: "Serum Methionine depletion without side effects by methioninase in metastatic breast cancer patients", ANTICANCER RESEARCH, vol. 16, no. 6c, November 1996 (1996-11-01), GR, pages 3937 - 3942, XP002082380 *
TURKER M.S. ET AL.: "The mouse APRT gene as a model for studying epigenetic gene inactivation", ADVANCEDS IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol. 370, 1995, US, pages 647 - 652, XP002082382 *

Also Published As

Publication number Publication date
EP1003848A2 (en) 2000-05-31
WO1998054310A2 (en) 1998-12-03

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