WO1998051359A1 - Inhalateur de poudre equipe d'un dispositif de dosage - Google Patents

Inhalateur de poudre equipe d'un dispositif de dosage Download PDF

Info

Publication number
WO1998051359A1
WO1998051359A1 PCT/NL1998/000271 NL9800271W WO9851359A1 WO 1998051359 A1 WO1998051359 A1 WO 1998051359A1 NL 9800271 W NL9800271 W NL 9800271W WO 9851359 A1 WO9851359 A1 WO 9851359A1
Authority
WO
WIPO (PCT)
Prior art keywords
dosing
operating
operating means
dosing device
dispensing opening
Prior art date
Application number
PCT/NL1998/000271
Other languages
English (en)
Inventor
Erwin Petrus Boes
Johannes Hubertus Jozef Maria Kelders
Original Assignee
R + D Injector Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R + D Injector Ag filed Critical R + D Injector Ag
Priority to AU75546/98A priority Critical patent/AU7554698A/en
Publication of WO1998051359A1 publication Critical patent/WO1998051359A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0066—Inhalators with dosage or measuring devices with means for varying the dose size
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Definitions

  • the invention relates to a device for dosed dispensing of a powder-form or granular material, provided with a container for the material having at least one dispensing opening through which a user can suck up the dosed material, operable dosing means arranged in the vicinity of the dispensing opening and operating means co-acting with the dosing means and movable manually by the user, wherein the dosing means are adapted to dispense a single dose of material at an operating movement of the operating means.
  • a dosing device is known from US-A-5 437 270.
  • the known dosing device is intended for dosed dispensing of a powder for inhaling by a user, for instance a prophylactic or a pharmacon.
  • the device is provided with a container in which a powder can be received, with a dispensing opening and a rotatable dosing wheel connecting thereto.
  • the dosing wheel which takes a conical form, has a number of regularly distributed chambers which are recessed into the cone surface.
  • the dosing wheel is operated by a push-button via a ratchet mechanism with resetting spring.
  • the chambers By rotating the dosing wheel the chambers are guided one by one past the dispensing opening of the container and subsequently displaced to an opening in an inhalation mouthpiece.
  • the chambers When placed in register with the dispensing opening the chambers are herein filled in each case with a measured dose of the powder which can be sucked up by the user when the chamber lies in register with the opening in the inhalation mouthpiece.
  • the chambers After passing this opening, the chambers are carried along a brush when the dosing wheel is further rotated, whereby powder which may have been left behind in the chamber is swept into a receiving space in order to prevent powder collecting in the chambers and too high a dose being dispensed.
  • a single pressing of the control button results in the dosing wheel being displaced through one position, whereby only one filled chamber at a time is thus placed into communication with the inhalation mouthpiece and a single dose is thus dispensed.
  • this dosing device Compared with conventional dosing devices, such as are marketed for instance by the company Astra under the name Turbuhaler, this dosing device has the advantage that it is considerably simpler to use.
  • the conventional device which was normally placed on an end surface of the container, first had to be turned over before dispensing so that powder could flow from the container to a dosing disc. In this overturned position the container and the dosing disc herein had to be rotated relative to one another, whereafter the device had to be placed in a horizontal position to enable inhalation of the metered powder.
  • the dosing device according to US-A-5 437 270 can be operated simply with one hand by pressing the control button.
  • the button due to the presence of a resetting spring in the operating mechanism, the button always returns automatically to its starting position at the end of an operating movement.
  • the known dosing device has the drawback however that it is of relatively complicated structure and, in addition, cannot be adapted readily for dosing different quantities, since the dispensed dose is determined by the dimensions of the chambers in the dosing wheel and is therefore fixed at a determined size of these chambers . Because the dimensioning of all openings in the known dosing device is adapted to the dimensions of the chambers, the whole device will therefore have to be adapted in order to change the dose to be dispensed.
  • the present invention has for its object to provide an improved dosing device of the above described type, wherein this drawback does not occur.
  • the dosing means are adapted for continuous transport of material from the container directly to the dispensing opening and are displaceable through a limited stroke by the operating means.
  • the dose for dispensing can in this manner be simply adjusted by adapting the stroke through which the dosing means can be displaced.
  • the movement of the operating means is preferably bounded herein, for instance by placing a stop.
  • the dosing means are preferably rotatable.
  • a relatively compact construction is hereby obtained.
  • Easy operation for instance by performing a squeezing movement, is then obtained when the operating means are movable substantially in a straight line and a transmission is arranged between the operating means and dosing means.
  • This can then be achieved advantageously, at least when the operating means are movable counter to a spring bias, in that the transmission is adapted to connect the operating means and the dosing means during the operating movement and to disconnect them during a return movement under the influence of the spring bias .
  • a structurally simple embodiment of the transmission is obtained when this latter comprises a gear rack connected to the operating means and, co-acting therewith, a toothed wheel connected to the dosing means, and one outer end of the gear rack co-acts with loopshaped guide means. With these loop-shaped guide means the gear rack is placed into engagement with the toothed wheel during the operating movement and is guided at a distance along the toothed wheel during the return movement .
  • the dosing means comprise a screw conveyor arranged in the container and having an end part closing the dispensing opening, and a helical groove of the screw conveyor extends through the end par .
  • the operating means can herein be adapted to cause the screw conveyor to rotate through at least one half rotation, whereby the helical groove leading into the end part is displaced between two rest positions staggered through 180°.
  • the device preferably has means arranged in the vicinity of the dispensing opening for removing the material left behind after dosing.
  • These removing means are advantageously connected in controllable manner to the operating means, wherein the operating means can be adapted to operate the removing means during the return movement under the influence of the spring bias.
  • a structurally simple embodiment is herein obtained when the removing means comprise a scraper member movable along the dispensing opening and the operating means have a carrier for placing into engagement with the scraper member.
  • the scraper member can herein be movable counter to a spring bias so that it always returns to its starting position.
  • the carrier advantageously has at least one control cam co-acting with a guide connected to the container, whereby the carrier-is placed-as-required in or out of engagement with the scraper member.
  • a second container is preferably present which co-acts with the removing means so that this material, which will generally be a medicine, is prevented from being released into the environment in uncontrolled manner .
  • the device preferably has an inhalation mouthpiece connected to the dispensing opening.
  • figure 1 is a schematic, perspective view of a first embodiment of the dosing device according to the invention before use;
  • figure 2 is a longitudinal section through the device of figure 1 along the line II-II, wherein the inhalation mouthpiece has been removed;
  • figure 3 is a schematic bottom view of the transmission between the operating means and the dosing means in figure 2 ;
  • figure 4 is a view corresponding with figure 2 of the dosing device at the end of an operating movement;
  • figure 5 is a view corresponding with figure 3 of the transmission in the situation shown in figure 4;
  • figure 6 is a schematic, perspective view with exploded parts of the top part of the container and removing means co-acting therewith;
  • figure 7 is a cross- sectional view on enlarged scale corresponding with figures 2 and 4 in which the removal of left-over material is shown;
  • figures 8A-E show schematically the operation of the removing means ;
  • figure 9 is a longitudinal section through the
  • a dosing device 1 for a powder- form or granular material comprises a housing 2 (figure 1) , in which is arranged a container 5 for the material 8 (figure 2) as well as operating means 3 which are arranged slidably in housing 2 and which co-act with dosing means 44 arranged in the vicinity of a dispensing opening 6 of container 5.
  • Dosing device 1 further comprises an inhalation mouthpiece 4 connected to dispensing opening 6.
  • Operating means 3 comprise a handgrip 18 which in the shown example, as stated, is arranged slidably, i.e. linearly movable, in housing 2. Side walls 48, 49 and bottom 46, 47 of handgrip 18 and housing 2 herein form sliding surfaces . Further arranged between operating handgrip 18 and housing 2 is a pressure spring 19 which is received on shaft ends 24, 25 of operating handgrip 18 respectively housing 2, and which urges operating handgrip 18 back to its rest position.
  • container 5 is cylindrical and provided on its end remote from dispensing opening 6 with a sealing cap 11.
  • the material 8 in container 5 is urged in the direction of dispensing opening 6 by a piston 9, which is biased by a pressure spring 10 in the direction of dispensing opening 6.
  • Piston 9 is provided in the middle with an opening 51 and is slidable round a shaft part 51 of a screw conveyor 12 which forms part of dosing means 44.
  • Screw conveyor 12 is adapted for continuous transport of material 8 from container 5 to dispensing opening 6 and is provided at the top with a continuous helical groove 13 leading to an end part 14 which sealingly closes dispensing opening 6 of container 5.
  • the end part 15 of helical groove 13 is practically parallel to the shaft 51 of screw 12 and thus forms the actual dosing opening.
  • transmission 45 Arranged between screw conveyor 12 ' and operating handgrip 18 is a transmission 45 whereby the linear movement of operating handgrip 18 is converted into a rotation movement of screw conveyor 12.
  • transmission 45 comprises a toothed wheel 16 connected to the screw conveyor and a gear rack 17 which can be placed into engagement with the wheel and which is connected to operating handgrip 18.
  • the gear rack 17 is in engagement with toothed wheel 16 but, at the end of this movement when handgrip 18 is fully pressed in (figure 4) , is disengaged from toothed wheel 16, so that during the return movement of handgrip 18 the toothed wheel 16, and thereby the screw conveyor 12, are not rotated back again under the influence of the force of spring 19.
  • gear rack 17 is pivotally connected by means of a shaft 20 to handgrip 18, while the other outer end is provided with a pin 21 which co-acts with guide means 22 which are connected fixedly to housing 2 and thus to container 5.
  • guide means 22 comprise a loop-shaped guide track 23 in which pin 21 is received. Owing to the loop shape of guide track 23, the free outer end of gear rack 17 is placed practically transversely of the direction of the operating movement and is thereby disengaged from toothed wheel 16 (figure 5) .
  • the screw conveyor 12 is thus rotated, whereby material 8 is transported upward through helical groove 13 to the opening 15 (figure 4) , whereafter the user can inhale the thus dosed material .
  • the operating handgrip 18 can be released, whereafter it returns to its starting position under the influence of the spring bias without screw conveyor 12 being further rotated herein.
  • means 27 are arranged in the vicinity of dispensing opening 6 for removing left-over material. These removing means 27 are likewise operated by operating means 3, this during the return movement thereof.
  • the removing means 27 comprise a scraper member 28 which is movable along dispensing opening 6 and is provided with an opening 36 which virtually corresponds with dispensing opening 6 and which is divided by means of a bridge piece 37 into two half-openings 38 and 39.
  • Scraper member 28 is provided with protruding cams 40 which can be placed in engagement with carriers 35 connected to operating handgrip 18.
  • Scraper member 28 is further connected to a pressure spring 30 which supports against the inside of operating handgrip 18 and whereby scraper member 28 is biased to its rest position.
  • the carriers are arranged on spring arms 31 which are connected to operating handgrip 18 and are provided with control cams 32 which co-act with guides 33 in the side walls 34 of housing 2.
  • each guide 33 takes the form of a profiled cam track with a widened part 42 and a downward bending part 43.
  • each control cam 32 is situated at the beginning of the cam track 33 (figure 8A) .
  • the control cam 32 is moved to the left in the figure, wherein it follows the track 33 having therein the curved part 43, so that arm 31 will be bent downward and carrier 35 is also moved downward.
  • the control cam 43 arrives at the widened part 42 and finally comes into contact with cam 40 of scraper member 28. Since scraper member 28 rests against the rear wall 49 of housing 2, it will not move, so that carrier 35 is urged downward by cam 40 while arm 31 bends.
  • Cam 32 can follow this movement because -su ficient space is provided in widened part 42 for this purpose.
  • the device is moreover simple to use with one hand, since the operating means are movable linearly and can thus be easily squeezed and return automatically to their starting position under the influence of a spring.
  • the control cam 32 does not co-act with a cam track 33 recessed into side wall 34 but instead with a fixed cam 53 protruding from the side wall.
  • Control cam 32 is herein provided with an inclining bottom surface 54 whereby arm 31 is bent slightly upward when it reaches fixed cam 53.
  • forms of continuously operating dosing means other than the screw conveyor shown here can be considered, for instance slide mechanisms and the like.
  • manner m which the movement of the operating means s bounded could also be embodied otherwise than shown here.
  • a simple stop can for instance be envisaged here.
  • the scraper member could also be embodied for instance pivotally instead of slidably.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Filling Or Emptying Of Bunkers, Hoppers, And Tanks (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

L'invention concerne un appareil servant à distribuer des doses d'une substance en poudre ou en granules placée dans un contenant. L'appareil comprend un orifice de distribution par lequel un utilisateur peut aspirer une dose de ladite substance, un dispositif de dosage fonctionnel placé à proximité de l'orifice de distribution, et un moyen de commande fonctionnant en coopération avec le dispositif de dosage et pouvant être actionné manuellement par l'utilisateur. Le dispositif de dosage est adapté pour délivrer une dose unique de la substance lorsque le moyen de commande est actionné. Le dispositif de dosage, qui est pivotable, est adapté pour permettre un transfert continu de substance du contenant directement à l'orifice de distribution, et se déplace sous l'effet d'une pression limitée du moyen de commande, le mouvement de ce dernier étant en conséquence limité. Le moyen de commande peut être déplacé de manière linéaire grâce à une transmission disposée entre lui et le dispositif de dosage. Cette transmission comprend, par exemple, une crémaillère associée au moyen de commande et fonctionnant en coopération avec une roue dentée associée au dispositif de dosage, si bien qu'une extrémité avant de la crémaillère fonctionne en coopération avec un moyen de guidage en boucle.
PCT/NL1998/000271 1997-05-14 1998-05-14 Inhalateur de poudre equipe d'un dispositif de dosage WO1998051359A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU75546/98A AU7554698A (en) 1997-05-14 1998-05-14 Powder inhaler with metering device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1006058 1997-05-14
NL1006058A NL1006058C2 (nl) 1997-05-14 1997-05-14 Doseerinrichting.

Publications (1)

Publication Number Publication Date
WO1998051359A1 true WO1998051359A1 (fr) 1998-11-19

Family

ID=19764970

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL1998/000271 WO1998051359A1 (fr) 1997-05-14 1998-05-14 Inhalateur de poudre equipe d'un dispositif de dosage

Country Status (3)

Country Link
AU (1) AU7554698A (fr)
NL (1) NL1006058C2 (fr)
WO (1) WO1998051359A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001087390A3 (fr) * 2000-05-12 2002-06-13 Iep Pharmaceutical Devices Inc Valve de dosage de poudre/liquide
US9179691B2 (en) 2007-12-14 2015-11-10 Aerodesigns, Inc. Delivering aerosolizable food products
CN111617374A (zh) * 2020-07-01 2020-09-04 广州金智医疗器械有限公司 一种口腔溃疡用药粉辅助喷涂装置

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4006846A (en) * 1976-01-30 1977-02-08 Eppco Indexing powder dispensing device
US4534345A (en) * 1981-07-08 1985-08-13 Aktiebolaget Draco Dosage inhalator
US5347999A (en) * 1990-08-30 1994-09-20 Boehringer Ingelheim Kg Inhalation device free from propellant gas having brush abrading powder from tablet
EP0640354A2 (fr) * 1990-09-26 1995-03-01 Pharmachemie B.V. Inhalateur pour poudres à tourbillon
US5437270A (en) * 1990-07-13 1995-08-01 Innovata Biomed Limited Powder inhaler having a multi-positioned metering cup
EP0705614A1 (fr) * 1989-04-28 1996-04-10 Riker Laboratories, Inc. Dispositif d'inhalation de poudre sèche

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4006846A (en) * 1976-01-30 1977-02-08 Eppco Indexing powder dispensing device
US4534345A (en) * 1981-07-08 1985-08-13 Aktiebolaget Draco Dosage inhalator
EP0705614A1 (fr) * 1989-04-28 1996-04-10 Riker Laboratories, Inc. Dispositif d'inhalation de poudre sèche
US5437270A (en) * 1990-07-13 1995-08-01 Innovata Biomed Limited Powder inhaler having a multi-positioned metering cup
US5347999A (en) * 1990-08-30 1994-09-20 Boehringer Ingelheim Kg Inhalation device free from propellant gas having brush abrading powder from tablet
EP0640354A2 (fr) * 1990-09-26 1995-03-01 Pharmachemie B.V. Inhalateur pour poudres à tourbillon

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001087390A3 (fr) * 2000-05-12 2002-06-13 Iep Pharmaceutical Devices Inc Valve de dosage de poudre/liquide
US6626171B2 (en) 2000-05-12 2003-09-30 Iep Pharmaceutical Devices Inc. Powder/liquid metering valve
US9179691B2 (en) 2007-12-14 2015-11-10 Aerodesigns, Inc. Delivering aerosolizable food products
CN111617374A (zh) * 2020-07-01 2020-09-04 广州金智医疗器械有限公司 一种口腔溃疡用药粉辅助喷涂装置
CN111617374B (zh) * 2020-07-01 2021-02-26 刘平平 一种口腔溃疡用药粉辅助喷涂装置

Also Published As

Publication number Publication date
AU7554698A (en) 1998-12-08
NL1006058C2 (nl) 1998-11-17

Similar Documents

Publication Publication Date Title
US10765820B2 (en) Dry powder inhalation apparatus
US3456645A (en) Inhalation-actuated aerosol dispensing device
EP0758911B1 (fr) Inhalateur a poudre
US5105981A (en) Selectively shakeable freestanding particulate matter reservoir
US6718972B2 (en) Dose metering system for medicament inhaler
EP0488609A1 (fr) Inhalateur de poudre
AU598250B2 (en) Indicating device
EP1962933B1 (fr) Inhalateur avec compteur de doses actionne par la respiration
EP1267977B1 (fr) Inhalateur de poudre
US3032081A (en) Dispensing apparatus
EP1164363A1 (fr) Cuillère de mesure avec compteur de doses
CA2393428A1 (fr) Inhalateur de poudre multidose
WO1998051359A1 (fr) Inhalateur de poudre equipe d'un dispositif de dosage
WO2000064518A1 (fr) Inhalateur de poudre
HUT64420A (en) Dispenser on a bulk material container
US2653734A (en) Automatic sugar bowl
JPH01502809A (ja) 流動性材料ディスペンサー
NO126256B (fr)
CA2486068A1 (fr) Inhalateur a poudre
NL9002147A (nl) Inrichting voor het gedoseerd afgeven van een produkt uit een samendrukbare verpakking, alsmede verpakking bestemd voor toepassing bij deze inrichting.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: JP

Ref document number: 1998549085

Format of ref document f/p: F

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA