WO1998050067A3 - Use or a secretion vector for fertility control by oral vaccination - Google Patents

Use or a secretion vector for fertility control by oral vaccination Download PDF

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Publication number
WO1998050067A3
WO1998050067A3 PCT/EP1998/002679 EP9802679W WO9850067A3 WO 1998050067 A3 WO1998050067 A3 WO 1998050067A3 EP 9802679 W EP9802679 W EP 9802679W WO 9850067 A3 WO9850067 A3 WO 9850067A3
Authority
WO
WIPO (PCT)
Prior art keywords
oral vaccination
fertility control
secretion vector
vaccination
fertility
Prior art date
Application number
PCT/EP1998/002679
Other languages
German (de)
French (fr)
Other versions
WO1998050067A9 (en
WO1998050067A2 (en
Inventor
Peter Donner
Werner Goebel
Andreas Demuth
Ivaylo Gentschev
Juergen Hess
Stefan Kaufmann
Original Assignee
Schering Ag
Peter Donner
Werner Goebel
Andreas Demuth
Ivaylo Gentschev
Juergen Hess
Stefan Kaufmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EEP199900516A priority Critical patent/EE9900516A/en
Priority to CA002288602A priority patent/CA2288602A1/en
Priority to AU79107/98A priority patent/AU7910798A/en
Priority to SK1517-99A priority patent/SK151799A3/en
Application filed by Schering Ag, Peter Donner, Werner Goebel, Andreas Demuth, Ivaylo Gentschev, Juergen Hess, Stefan Kaufmann filed Critical Schering Ag
Priority to BR9809244-8A priority patent/BR9809244A/en
Priority to EP98929286A priority patent/EP1015023A1/en
Priority to JP54774098A priority patent/JP2002501507A/en
Priority to PL98336786A priority patent/PL336786A1/en
Priority to IL13252198A priority patent/IL132521A0/en
Publication of WO1998050067A2 publication Critical patent/WO1998050067A2/en
Publication of WO1998050067A9 publication Critical patent/WO1998050067A9/en
Priority to IS5199A priority patent/IS5199A/en
Priority to BG103850A priority patent/BG103850A/en
Priority to NO995429A priority patent/NO995429L/en
Publication of WO1998050067A3 publication Critical patent/WO1998050067A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0006—Contraceptive vaccins; Vaccines against sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Farming Of Fish And Shellfish (AREA)

Abstract

The invention relates to a fertility-control method by oral vaccination using attenuated salmonellae or other gram-negative attenuated vaccination strains. Different systems of expression are used which enable a specific MHCII/CD4 or MHCI/CD8 immune response to be generated.
PCT/EP1998/002679 1997-05-07 1998-05-07 Use or a secretion vector for fertility control by oral vaccination WO1998050067A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
EP98929286A EP1015023A1 (en) 1997-05-07 1998-05-07 Use or a secretion vector for fertility control by oral vaccination
AU79107/98A AU7910798A (en) 1997-05-07 1998-05-07 Use or a secretion vector for fertility control by oral vaccination
SK1517-99A SK151799A3 (en) 1997-05-07 1998-05-07 Use or a secretion vector for fertility control by oral vaccination
PL98336786A PL336786A1 (en) 1997-05-07 1998-05-07 Application of a secretion vector in controlling fertility by means of an orally administered vaccine
BR9809244-8A BR9809244A (en) 1997-05-07 1998-05-07 Application of a secretion vector to control fertility through oral vaccination
CA002288602A CA2288602A1 (en) 1997-05-07 1998-05-07 Use of a secretion vector for fertility control by oral vaccination
JP54774098A JP2002501507A (en) 1997-05-07 1998-05-07 Use of secretory vectors in oral vaccination for birth control
EEP199900516A EE9900516A (en) 1997-05-07 1998-05-07 Use of secretion vector for fertility control by oral vaccination
IL13252198A IL132521A0 (en) 1997-05-07 1998-05-07 Use of a secretion vector for birth control by oral vaccination
IS5199A IS5199A (en) 1997-05-07 1999-09-28 Use of a secretory gene for fertility control by oral immunization
BG103850A BG103850A (en) 1997-05-07 1999-11-02 The application of secreting vector for fertility control by peroral vaccination
NO995429A NO995429L (en) 1997-05-07 1999-11-05 Use of a secretion vector for fertility control in oral vaccination

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19720761.8 1997-05-07
DE19720761A DE19720761A1 (en) 1997-05-07 1997-05-07 Process for the synthesis and secretion of proteins or protein fragments suitable for contraception by attenuated Salmonella or another Gram-negative attenuated vaccine strain to produce an oral vaccination

Publications (3)

Publication Number Publication Date
WO1998050067A2 WO1998050067A2 (en) 1998-11-12
WO1998050067A9 WO1998050067A9 (en) 1999-03-25
WO1998050067A3 true WO1998050067A3 (en) 2000-06-29

Family

ID=7829783

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/002679 WO1998050067A2 (en) 1997-05-07 1998-05-07 Use or a secretion vector for fertility control by oral vaccination

Country Status (18)

Country Link
EP (1) EP1015023A1 (en)
JP (1) JP2002501507A (en)
KR (1) KR20010012257A (en)
CN (1) CN1255067A (en)
AU (1) AU7910798A (en)
BG (1) BG103850A (en)
BR (1) BR9809244A (en)
CA (1) CA2288602A1 (en)
DE (1) DE19720761A1 (en)
EE (1) EE9900516A (en)
HU (1) HUP0002752A2 (en)
IL (1) IL132521A0 (en)
IS (1) IS5199A (en)
NO (1) NO995429L (en)
PL (1) PL336786A1 (en)
SK (1) SK151799A3 (en)
TR (1) TR199902671T2 (en)
WO (1) WO1998050067A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10206325A1 (en) * 2002-02-14 2003-09-04 Medinnova Ges Med Innovationen Coated microorganism
US6989160B2 (en) * 2002-03-19 2006-01-24 Council Of Scientific And Industrial Research Therapeutic/edible compositions comprising herbal ingredients and methods for treating hyperglycemia
RU2435863C2 (en) * 2005-05-12 2011-12-10 Адзиномото Ко., Инк. Method for producing protein

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992009684A1 (en) * 1990-11-21 1992-06-11 Washington University Recombinant avirulent salmonella antifertility vaccines
WO1995015764A1 (en) * 1993-12-10 1995-06-15 The University Of North Carolina At Chapel Hill Sperm antigen corresponding to a sperm zona binding protein autoantigenic epitope

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992009684A1 (en) * 1990-11-21 1992-06-11 Washington University Recombinant avirulent salmonella antifertility vaccines
WO1995015764A1 (en) * 1993-12-10 1995-06-15 The University Of North Carolina At Chapel Hill Sperm antigen corresponding to a sperm zona binding protein autoantigenic epitope

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE MEDLINE US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; O'GAORA P ET AL: "Yersinia enterocolitica aroA mutants as carriers of the B subunit of the Escherichia coli heat-labile enterotoxin to the murine immune system.", XP002078678 *
GENTSCHEV I ET AL: "Development of antigen-delivery systems, based on the Escherichia coli hemolysin secretion pathway.", GENE, (1996 NOV 7) 179 (1) 133-40. JOURNAL CODE: FOP. ISSN: 0378-1119., Netherlands, XP002078662 *
GENTSCHEV I ET AL: "The Escherichia coli hemolysin secretion apparatus--a versatile antigen delivery system in attenuated Salmonella.", BEHRING INSTITUTE MITTEILUNGEN, (1997 FEB) (98) 103-13. JOURNAL CODE: 9KI. ISSN: 0301-0457., GERMANY: Germany, Federal Republic of, XP002078677 *
HESS J ET AL: "Protection against murine listeriosis by an attenuated recombinant Salmonella typhimurium vaccine strain that secretes the naturally somatic antigen superoxide dismutase.", INFECTION AND IMMUNITY, (1997 APR) 65 (4) 1286-92. JOURNAL CODE: GO7. ISSN: 0019-9567., United States, XP002078663 *
MICROBIAL PATHOGENESIS, (1990 AUG) 9 (2) 105-16. JOURNAL CODE: MIC. ISSN: 0882-4010., ENGLAND: United Kingdom *

Also Published As

Publication number Publication date
JP2002501507A (en) 2002-01-15
KR20010012257A (en) 2001-02-15
HUP0002752A2 (en) 2000-12-28
WO1998050067A9 (en) 1999-03-25
EP1015023A1 (en) 2000-07-05
NO995429D0 (en) 1999-11-05
BR9809244A (en) 2000-06-27
SK151799A3 (en) 2000-06-12
IL132521A0 (en) 2001-03-19
EE9900516A (en) 2000-06-15
CA2288602A1 (en) 1998-11-12
PL336786A1 (en) 2000-07-17
DE19720761A1 (en) 1998-11-12
NO995429L (en) 2000-01-07
TR199902671T2 (en) 2000-09-21
IS5199A (en) 1999-09-28
BG103850A (en) 2000-05-31
WO1998050067A2 (en) 1998-11-12
CN1255067A (en) 2000-05-31
AU7910798A (en) 1998-11-27

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