WO1998048000A3 - A cell strain with activated anti-cancer cytotoxic activity - Google Patents

A cell strain with activated anti-cancer cytotoxic activity Download PDF

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Publication number
WO1998048000A3
WO1998048000A3 PCT/US1998/008240 US9808240W WO9848000A3 WO 1998048000 A3 WO1998048000 A3 WO 1998048000A3 US 9808240 W US9808240 W US 9808240W WO 9848000 A3 WO9848000 A3 WO 9848000A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
patient
obtaining
cytotoxic
cancer cells
Prior art date
Application number
PCT/US1998/008240
Other languages
French (fr)
Other versions
WO1998048000A2 (en
Inventor
John C Hiserodt
Original Assignee
Univ California
John C Hiserodt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, John C Hiserodt filed Critical Univ California
Priority to AU71545/98A priority Critical patent/AU7154598A/en
Publication of WO1998048000A2 publication Critical patent/WO1998048000A2/en
Publication of WO1998048000A3 publication Critical patent/WO1998048000A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5152—Tumor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/47—Brain; Nervous system

Abstract

The disclosed invention encompasses methods for obtaining compositions comprising cell populations enriched for cancer-specific, cytotoxic T-lymphocytes. The methods comprise the steps of obtaining cancer cells from a patient, obtaining leukocytes from the patient, and co-culturing the cancer cells with the leukocytes to allow outgrowth of a cancer-specific cytotoxic T-lymphocyte (CSCTL) population. In certain embodiments, the method includes the additional step of inducing an anti-cancer immune response in the patient. Substantially pure populations of CSCTLs are provided that are cytotoxic toward autologous cancer cells, and particularly suitable for treating glioblastomas and other solid tumors. This invention further provides methods for treating cancer in a patient using cellular compositions of the invention, and use of cellular compositions for preparing medicaments for cancer treatment.
PCT/US1998/008240 1997-04-23 1998-04-23 A cell strain with activated anti-cancer cytotoxic activity WO1998048000A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU71545/98A AU7154598A (en) 1997-04-23 1998-04-23 A cell strain with activated anti-cancer cytotoxic activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4460197P 1997-04-23 1997-04-23
US60/044,601 1997-04-23

Publications (2)

Publication Number Publication Date
WO1998048000A2 WO1998048000A2 (en) 1998-10-29
WO1998048000A3 true WO1998048000A3 (en) 1999-01-28

Family

ID=21933268

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/008240 WO1998048000A2 (en) 1997-04-23 1998-04-23 A cell strain with activated anti-cancer cytotoxic activity

Country Status (2)

Country Link
AU (1) AU7154598A (en)
WO (1) WO1998048000A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1231262A4 (en) * 1999-10-21 2004-09-08 Keisuke Teshigawara Method of in vitro culture of lymphocytes and gene therapy compositions

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0690125A2 (en) * 1994-06-28 1996-01-03 The Institute Of Physical & Chemical Research Process for induction culture of cytotoxict lymphocytes having killing activity against tumor cells
US5484596A (en) * 1984-01-31 1996-01-16 Akzo N.V. Active specific immunotherapy
WO1996029394A1 (en) * 1995-03-17 1996-09-26 The Regents Of The University Of California Method for treating tumors
WO1998004282A1 (en) * 1996-07-25 1998-02-05 The Regents Of The University Of California Cancer immunotherapy using autologous tumor cells combined with allogeneic cytokine-secreting cells
WO1998016238A2 (en) * 1996-10-11 1998-04-23 The Regents Of The University Of California Cancer immunotherapy using tumor cells combined with mixed lymphocytes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484596A (en) * 1984-01-31 1996-01-16 Akzo N.V. Active specific immunotherapy
EP0690125A2 (en) * 1994-06-28 1996-01-03 The Institute Of Physical & Chemical Research Process for induction culture of cytotoxict lymphocytes having killing activity against tumor cells
WO1996029394A1 (en) * 1995-03-17 1996-09-26 The Regents Of The University Of California Method for treating tumors
WO1998004282A1 (en) * 1996-07-25 1998-02-05 The Regents Of The University Of California Cancer immunotherapy using autologous tumor cells combined with allogeneic cytokine-secreting cells
WO1998016238A2 (en) * 1996-10-11 1998-04-23 The Regents Of The University Of California Cancer immunotherapy using tumor cells combined with mixed lymphocytes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J.R. SPORN ET AL.,: "Adoptive immunotherapy with peripheral blood lymphocytes cocultured in vitro with autologous tumor cells and interleukine", CANCER IMMUNOLOGY AND IMMUNOTHERAPY, vol. 37, no. 3, 1993, Sttutgart, DE, pages 175 - 180, XP002081415 *
N.J. CROWLEY ET AL.,: "Generation of human autologous melanoma-specific cytotoxic T-cells using HLA-A2-matched allogeneic melanomas", CANCER RESEARCH, vol. 50, no. 1, 1990, pages 492 - 495, XP002066686 *
R. S. YAMAMOTO ET AL.,: "Generation of stimulated, lymphokine activated T killer (T-LAK) cells from peripheral blood of normal donors and adult patients with recurrent glioblastoma", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 137, 1991, pages 225 - 235, XP002081416 *

Also Published As

Publication number Publication date
AU7154598A (en) 1998-11-13
WO1998048000A2 (en) 1998-10-29

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