WO1998047481A1 - Use of 5ht3 antagonists for promoting intestinal lavage - Google Patents
Use of 5ht3 antagonists for promoting intestinal lavage Download PDFInfo
- Publication number
- WO1998047481A1 WO1998047481A1 PCT/EP1998/002356 EP9802356W WO9847481A1 WO 1998047481 A1 WO1998047481 A1 WO 1998047481A1 EP 9802356 W EP9802356 W EP 9802356W WO 9847481 A1 WO9847481 A1 WO 9847481A1
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- WIPO (PCT)
- Prior art keywords
- antagonist
- laxative
- combination
- administration
- antagonists
- Prior art date
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- 0 O=C([C@@](C1)*1(CC1)Cc2c1nc[n]2)C1=C*(C=I)c2c1cccc2 Chemical compound O=C([C@@](C1)*1(CC1)Cc2c1nc[n]2)C1=C*(C=I)c2c1cccc2 0.000 description 4
- RRJGZTSNHOTHBH-UHFFFAOYSA-N CC(C)N(c(cccc1)c1N1C(N)=O)C1=O Chemical compound CC(C)N(c(cccc1)c1N1C(N)=O)C1=O RRJGZTSNHOTHBH-UHFFFAOYSA-N 0.000 description 1
- MRKWJINONYUYNR-UHFFFAOYSA-N CNc1ccccc1C(C(N)=O)=N Chemical compound CNc1ccccc1C(C(N)=O)=N MRKWJINONYUYNR-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- the present invention is concerned with the use of 5HT 3 antagonists for accelerating intestinal lavage in combination with a laxative, in particular an osmotic agent.
- the present invention is also concerned with the use of said 5HT3 antagonists in combination with a laxative for the treatment of constipation.
- These agents may also be used to help eliminate parasites following appropriate therapy, for instance these can be used after or in combination with anthelmintics. These osmotic agents may also be used to help eliminate toxic material in some cases of poisoning.
- 5HT3 receptors appear to mediate the excitatory actions of 5-HT (serotonin) in the peripheral nervous system.
- the peripheral 5HT3 receptor plays a pivotal role in the process of emesis induced by cytotoxic chemotherapy and radiotherapy.
- Peripheral 5HT3 antagonists are also being studied for the treatment of irritable bowel syndrome and visceral pain.
- Evidence has accumulated showing the presence of 5HT3 receptors in the central nervous system.
- Central 5HT3 receptors have been implicated in cognition and memory disorders, anxiety and dopamine modulation of the mesolimbic structures. Antagonists of the 5HT3 receptor have been proposed for treating these disorders.
- 5HT3 receptor antagonists In animal models of anxiety, 5HT3 receptor antagonists have been shown to exert anxiolytic properties similar to those of benzodiazepines but without sedative, anticonvulsant and muscle relaxant actions.
- Ondansetron hydrochloride launched in 1990 as an antiemetic, is being studied in clinical trials for the treatment of age-related cognition disorders and generalized anxiety. Recent studies have suggested an interrelation between the serotonergic and dopaminergic systems, especially through the 5HT3 receptor. 5HT3 antagonists may thus have potential as therapeutic agents for the treatment of hyperdopaminergic disease states such as schizophrenia, without presenting the side effects liability generally associated with classic neuroleptics. (Joseph R. Prous, "The Year's Drug News, Therapeutic Targets, 1994 Edition)
- 5-HT3-receptor antagonists can be identified by the fact that they are active, for example, in antagonising the Von Bezold-Jarisch chemoreflex evoked by serotonin in rats (Pharmacology and Toxicology, 70, Supp II, 17-22 (1992)).
- 5HT 3 receptor antagonists slow colonic transit and may even cause mild constipation.
- 5HT 3 antagonists have a synergistic effect with osmotic agents to obtain intestinal lavage, i.e. an induced form of diarrhea which is quite the opposite of constipation.
- 5HT3 antagonists are Azasetron HC1, Granisetron HC1, Ondansetron HC1, Tropisetron, DAT-582, Dolasetron mesylate, Itasetron, N-3389, Pancopride,
- 5HT 3 antagonist is (-)-cis-4-amino-5-chloro-2,3-dihydro-N-[l- [3-[(3,4-dihydro-4-oxo-2-pyrimidinyl)amino]propyl]-3-methoxy-4-piperidinyl]-2,2-di- methyl-7-benzofurancarboxamide, which will be referred to hereinafter as "COMPOUND A”, which is described as compound number 1 of WO 94/12494, published 9 June 1994.
- the pharmaceutically acceptable acid or base addition salt of the 5HT 3 antagonists are also intended to be included in the present invention.
- the pharmaceutically acceptable acid addition salts as mentioned hereinabove are meant to comprise the therapeutically active non-toxic acid addition salt forms which the 5HT 3 antagonists are able to form. The latter can conveniently be obtained by treating the base form with such appropriate acid.
- Appropriate acids comprise, for example, inorganic acids such as hydrohalic acids, e.g. hydrochloric or hydrobromic acid, sulfuric, nitric, phosphoric and the like acids; or organic acids such as, for example, acetic, propanoic, hydroxyacetic, lactic, pyruvic, oxalic (i.e.
- ethanedioic malonic
- succinic i.e. butanedioic acid
- maleic fumaric, malic, tartaric, citric, methanesulfonic, ethanesulfonic, benzenesulfonic, p-toluenesulfonic, cyclamic, salicylic, p-aminosalicylic, pamoic and the like acids.
- the 5HT3 antagonists containing an acidic proton may also be converted into their non- toxic metal or amine addition salt forms by treatment with appropriate organic and inorganic bases.
- Appropriate base salt forms comprise, for example, the ammonium salts, the alkali and earth alkaline metal salts, e.g. the lithium, sodium, potassium, magnesium, calcium salts and the like, salts with organic bases, e.g. the benzathine, N-methyl-D-glucamine, hydrabamine salts, and salts with amino acids such as, for example, arginine, lysine and the like.
- addition salt as used hereinabove also comprises the solvates which the compounds of formula (I) as well as the salts thereof, are able to form.
- solvates are for example hydrates, alcoholates and the like.
- Laxatives are drugs that promote defecation. Precise mechanisms of action of many laxatives remain uncertain because of the complex factors that affect colonic function, prominent variations of water and electrolyte transport among experimental species and preparations, and a certain costiveness of research in this area. Three general mechanisms of laxative action can be described. (1) By their hydrophilic or osmotic properties, laxatives may cause retention of fluid in colonic contents, thereby increasing bulk and softness and facilitating transit. (2) Laxatives may act, both directly and indirectly, on the colonic mucosa to decrease net absorption of water and ⁇ aCl. (3) Laxatives may increase intestinal motility, causing decreased absorption of salt and water secondary to decreased transit time.
- laxatives i.e. 1) dietary fiber and bulk-forming laxatives, 2) saline and osmotic laxatives and 3) stimulant laxatives, (see Goodman and Gilman, seventh edition, pp 994 to 1003).
- the bulk-forming laxatives include a wide range of natural and semisynthetic polysaccharides and cellular derivatives that are only partially digested.
- the undigested portions are hydrophilic and swell in the presence of water to form a viscous solution or gel.
- the increased intraluminal pressure reflexively stimulates peristalsis, diminishes colonic transit time and produces a soft gelatinous stool (" Remington's Pharmaceutical Sciences", page 783 - 786, 1990, Mack Publishing Company, Easton, Pennsylvania, 18th edition).
- the stimulant laxatives act on the intestinal tract to increase its motor activity.
- the more commonly employed agents are the anthraquinone laxatives, such as, e.g. cascara sagrada and senna; the diphenylmethane derivatives, such as, e.g. phenolphtalein and bisacodyl; and castor oil ("Remington's Pharmaceutical Sciences", page 783 - 786, 1990, Mack Publishing Company, Easton, Pennsylvania, 18th edition).
- Saline and osmotic laxatives are the primary class of laxatives envisaged in this invention.
- Saline and osmotic laxatives include various magnesium salts; the sulfate, phosphate, and tartrate salts of sodium and potassium; the dissacharide lactulose; glycerin; and sorbitol. They are poorly and slowly absorbed and act by their osmotic properties in the luminal fluid.
- KleanPrep ® and GoLytely ® Two examples of these osmotic agents which are commercially available for intestinal cleansing are KleanPrep ® and GoLytely ® .
- the present invention is concerned with the use of a 5HT 3 antagonist for the manufacture of a medicament that will improve, accelerate or promote the intestinal cleansing by laxatives, in particular osmotic agents.
- a method of treatment whereby an effective amount of a 5HT 3 antagonist is administered to a warm- blooded animal, in particular a mammal, in combination with a laxative, in particular an osmotic agent.
- the patients envisaged in this treatment are people whose bowel needs to be cleaned prior to diagnostic or surgical procedures.
- Another group of patients are those patients who are to be prevented from straining at the stool, these patients include people suffering from hernia or cardiovascular disease.
- the combination of the present invention can be indicated, both before and after surgery, to maintain soft feces in patients with hemorrhoids and other anorectal disorders.
- Osmotic agents at cathartic doses are frequently employed prior to radiological examination of the gastrointestinal tract, kidneys, or other abdominal or retroperitoneal structures and prior to elective bowel surgery. Hence, also for these applications the presently described combination may be useful.
- combination of the present invention can also be used in the treatment of drug overdosage and poisoning, by removing agents from the intestine.
- the combination of the present invention may also be employed in further combination with with certain anthelmintics.
- the present invention provides a method to accelerate and/or enforce the action of laxatives, especially osmotic agents.
- the laxatives can be administered or co-administered orally or rectally.
- co-administration means that the laxative and the 5HT3 ⁇ antagonist are present in the gastro-intestinal tract during at least partially overlapping times. Additionally, “co-administration” comprehends administering more than one dose of said laxative within 1 hour after a dose of the 5HT3-antagonist, in other words, the 5HT 3 -antagonist need not be administered again before or with every administration of said laxative, but may be administered intermittently during the course of treatment.
- the present invention is also concerned with the use of said 5HT 3 antagonists in combination with a laxative for the treatment of constipation, such as acute constipation, chronic constipation or refractory constipation. Consequently, a method is provided to treat constipation, such as, e.g. acute constipation, chronic constipation or refractory constipation, in warm-blooded animals, in particular mammals, by administration of a laxative in combination with an effective amount of a 5HT3 antagonist.
- constipation such as, e.g. acute constipation, chronic constipation or refractory constipation
- the 5HT3-antagonists may be formulated into various pharmaceutical forms for administration purposes.
- an effective amount of a particular compound, in base or acid addition salt form, as the active ingredient is intimately mixed with a pharmaceutically acceptable carrier.
- Said carrier may take a wide variety of forms depending on the form of preparation desired for administration.
- These pharmaceutical compositions are desirably in unitary dosage form suitable, preferably, for administration orally, rectally or by parenteral injection.
- any of the usual pharmaceutical media may be employed, such as, for example, water, glycols, oils, alcohols and the like in the case of oral liquid preparations such as suspensions, syrups, elixirs and solutions; or solid carriers such as starches, sugars, kaolin, lubricants, binders, disintegrating agents and the like in the case of powders, pills, capsules and tablets. Because of their ease in administration, tablets and capsules represent the most advantageous oral dosage unit form, in which case solid pharmaceutical carriers are _ obviously employed.
- the carrier will usually comprise sterile water, at least in large part, though other ingredients, for example, to aid solubility, may be included.
- Injectable solutions may be prepared in which the carrier comprises saline solution, glucose solution or a mixture of saline and glucose solution. Injectable suspensions may also be prepared in which case appropriate liquid carriers, suspending agents and the like may be employed.
- the carrier optionally comprises a penetration enhancing agent and/or a suitable wetting agent, optionally combined with suitable additives of any nature in minor proportions, which additives do not cause a significant deleterious effect to the skin. Said additives may facilitate the administration to the skin and/or may be helpful for preparing the desired compositions.
- These compositions may be administered in various ways, e.g., as a transdermal patch, as a spot-on. as an ointment.
- Dosage unit form refers to physically discrete units suitable as unitary dosages, each unit containing a predetermined quantity of active ingredient calculated to produce the desired therapeutic effect in association with the required pharmaceutical carrier.
- dosage unit forms are tablets (including scored or coated tablets), capsules, pills, powder packets, wafers, injectable solutions or suspensions, teaspoonfuls, tablespoonfuls and the like, and segregated multiples thereof.
- the dosages of the drugs used in the present invention must, in the final analysis, be set by the physician in charge of the case, using knowledge of the drugs, the properties of the drugs in combination as determined in clinical trials, and the characteristics of the patient, including diseases other than that for which the physician is treating the patient.
- an effective amount of a 5HT3 antagonist would be from about 0.001 mg kg to about 50 mg/kg body weight, preferably from about 0.02 mg/kg to about 5 mg/kg body weight.
- a method of treatment may also include administering the active ingredient on a regimen of between two or four intakes per day.
- this invention provides a therapeutic package suitable for commercial sale, comprising a container, an dosage form of a 5HT3 antagonist and a laxative, in particular an osmotic agent.
- This laxative or osmotic agent is often in the form of a powder, which is normally to be dissolved or suspended in a certain amount of water. Consequently, the present invention also relates to a product comprising a 5HT 3 antagonist and a laxative, in particular an osmotic agent, for simultaneous, separate or sequential use in the treatment of constipation or for promoting intestinal lavage, provided that said product does not contain an opioid antagonist.
- Such a product may comprise a kit comprising a container containing a pharmaceutical composition of a laxative, and another container comprising a pharmaceutical composition of the 5HT 3 antagonist.
- the product with separate compositions of the laxative and the 5HT 3 antagonist has the advantage that appropriate amounts of each component, and timing and sequence of administration can be selected in function of the patient.
- WO-96/14071 published on 17 May 1996, discloses combinations consisting of laxatives, ⁇ -adrenergic agents, antiemetic agents, gastric protectors, optionally proton pump inhibitors, anxiolytic compounds, an anesthetic sleep-inducing agent, and an opioid antagonist, such as nalaxone or naltrexone; intended to suppress dependence on opioids.
- Labelled membranes were collected and raised by rapid- filtration under suction over Walkman GF B plan fibre filters (presoaked in 0.1 % polyethyleneimine for at least 1 hour) using a 40-well filtration manifold. Test compounds were added at appropriate concentrations (60 minutes incubation time), in such a way that the inhibition curves were defined by at least eight to twelve concentration points, measured in duplicate. All experiments were repeated independently at least two times. Radioactivity on the filters was counted in a Packard Tri-carb 1600CA liquid scintillation analyzer. Counting data were collected directly in a Macintosh SE personal computer and further transferred to a Macintosh II personal computer.
- Counting data from assays in the presence of a compound were automatically expressed as percent of total binding measured in the absence of test compound. Inhibition curves plotting percent of total binding versus the log concentrations of the test compound were automatically generated.
- the sigmoidal inhibition curves were analyzed by computerized curve-fitting, with a programme using non-linear regression analysis for one- or two site curve fitting (modifications of equations described in Oestreicher E.G. and Pinto G.F., Comput. Biol. Med., 17, 53-68 (1987).
- the -log IC 5 o values (PIC50', IC50 defined as the concentration producing 50% inhibition of specific radioligand binding) were derived from individual curves.
- the K j values of the test compounds are presented as logarithmic mean and corresponding 95% confidence limits of the various determinations; and are presented in Table 1 in the column labelled "5HT 3 receptor K; (95% c.l.) nM".
- Beagle dogs (of both sexes and varying in body weight, 16 hours deprived from food) were orally pretreated with the test compound (0.5 ml/kg) and challenged 1 hour later with an oral administration of magnesium sulphate (MgSO 7H 2 ⁇ , 64g/l, 0.26M; 200 ml).
- MgSO 7H 2 ⁇ , 64g/l, 0.26M; 200 ml magnesium sulphate
- the onset of MgSO4-induced intestinal lavage was assessed over a period of 4 hours after challenge. Liquid stools within 4 hours occured almost never in control animals treated with distilled water (3.0% false positives; n>100) and were considered to reflect significant acceleration of the MgSOAnduced intestinal lavage.
- Doses in the active dose range were given to five animals each, tested in separate experimental sessions including solvent-treated control animals.
- test compounds were obtained from the companies of origin : bemesetron, BIMU-8, DAU-6236, granisetron, ondansetron, tropisetron, YM-060, renzapride and zacopride, as well as Compound A.
- test compounds have been listed in Table 1. All compounds showed affinity for the 5HT3 receptor, inhibited 5-hydroxykynuramine (5-OH-K)-induced contractions of the guinea-pig ileum, antagonized the Von Bezold Jarisch reflex and stimulated gastric emptying in rats, and the accelerated appearance of MgSO4-induced loose stools in dogs.
- 5-OH-K 5-hydroxykynuramine
- Table 1 Binding to the serotonin 5HT 3 receptor (Kj, nM); and acceleration of MgSO 4 induced diarrhea in dogs (ED5 0 , ⁇ g/kg, po).
- the dogs were orally pretreated with test compound or distilled water (0.5 ml/kg) and 1 hour later challenged by gavage with KleanPrep ® solution.
- the KleanPrep ® solution was administered more than once at 15 minutes intervals.
- the standard administration volume was 200 ml. The occurrence of liquid stools at 1, 2, 3, 4, 5 and 6 hours after the first administration of KleanPrep ® was noted.
- the KleanPrep ® solution consisted of polyethyleneglycol 3350 (59 g/1), sodium sulfate (5.685 g/1), sodium hydrogencarbonate (1.685 g/1), sodium chloride (1.465 g/1), potassium chloride (0.7425 g/1), aspartate (0.0494 g/1) and vanille (0.3291 g/1).
- Two dogs produced the first liquid stool after the 7th administration of KleanPrep ® (corresponding to a total volume of 1400 ml; the first liquid stool at 95 and 101 min).
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Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/403,248 US6235745B1 (en) | 1997-04-18 | 1998-04-14 | Use of 5HT3, antagonists for promoting intestinal lavage |
EP98922759A EP0975327B1 (en) | 1997-04-18 | 1998-04-14 | Use of 5ht3 antagonists for promoting intestinal lavage |
KR10-1999-7007936A KR100529512B1 (en) | 1997-04-18 | 1998-04-14 | Use of 5HT3 antagonists for promoting intestinal lavage |
JP54502298A JP2001523239A (en) | 1997-04-18 | 1998-04-14 | Use of 5HT (3) antagonists to promote intestinal lavage |
DE69816060T DE69816060T2 (en) | 1997-04-18 | 1998-04-14 | USE OF 5HT3 ANTAGONISTS TO PROMOTE THE COLON |
DK98922759T DK0975327T3 (en) | 1997-04-18 | 1998-04-14 | Use of 5HT3 antagonists to promote intestinal lavage |
AU75282/98A AU745361B2 (en) | 1997-04-18 | 1998-04-14 | Use of 5HT3 antagonists for promoting intestinal lavage |
CA002286076A CA2286076C (en) | 1997-04-18 | 1998-04-14 | Use of 5ht3 antagonists for promoting intestinal lavage |
AT98922759T ATE243993T1 (en) | 1997-04-18 | 1998-04-14 | USE OF 5HT3 ANTAGONISTS TO PROMOTE INTESTINAL FLUSHMENT |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97201149.8 | 1997-04-18 | ||
EP97201149 | 1997-04-18 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/403,248 A-371-Of-International US6235745B1 (en) | 1997-04-18 | 1998-04-14 | Use of 5HT3, antagonists for promoting intestinal lavage |
US09/801,978 Division US6555546B2 (en) | 1997-04-18 | 2001-03-08 | Use of 5HT3 antagonists for promoting intestinal lavage |
Publications (1)
Publication Number | Publication Date |
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WO1998047481A1 true WO1998047481A1 (en) | 1998-10-29 |
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ID=8228223
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/EP1998/002356 WO1998047481A1 (en) | 1997-04-18 | 1998-04-14 | Use of 5ht3 antagonists for promoting intestinal lavage |
Country Status (12)
Country | Link |
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US (2) | US6235745B1 (en) |
EP (1) | EP0975327B1 (en) |
JP (1) | JP2001523239A (en) |
KR (1) | KR100529512B1 (en) |
AT (1) | ATE243993T1 (en) |
AU (1) | AU745361B2 (en) |
CA (1) | CA2286076C (en) |
DE (1) | DE69816060T2 (en) |
DK (1) | DK0975327T3 (en) |
ES (1) | ES2202855T3 (en) |
PT (1) | PT975327E (en) |
WO (1) | WO1998047481A1 (en) |
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WO2002041918A2 (en) * | 2000-11-24 | 2002-05-30 | Janssen Pharmaceutica N.V. | Use of a triple combination comprising a 5ht3 antagonist, a 5ht4 agonist and a laxative for promoting intestinal lavage |
WO2002085901A1 (en) * | 2001-04-19 | 2002-10-31 | Pharmacia & Upjohn Company | Substituted azabicyclic moieties for the treatment of disease (nicotinic acethylcholine receptor agonists) |
WO2007019888A2 (en) * | 2005-08-12 | 2007-02-22 | Ctg Pharma S.R.L. | Therapeutic compositions containing mesalamine and a co-agent for treating colon diseases |
US10342848B2 (en) | 2013-02-25 | 2019-07-09 | Bausch Health Ireland Limited | Agonists of guanylate cyclase and their uses |
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- 1998-04-14 ES ES98922759T patent/ES2202855T3/en not_active Expired - Lifetime
- 1998-04-14 DK DK98922759T patent/DK0975327T3/en active
- 1998-04-14 WO PCT/EP1998/002356 patent/WO1998047481A1/en active IP Right Grant
- 1998-04-14 EP EP98922759A patent/EP0975327B1/en not_active Expired - Lifetime
- 1998-04-14 DE DE69816060T patent/DE69816060T2/en not_active Expired - Lifetime
- 1998-04-14 CA CA002286076A patent/CA2286076C/en not_active Expired - Lifetime
- 1998-04-14 AT AT98922759T patent/ATE243993T1/en not_active IP Right Cessation
- 1998-04-14 US US09/403,248 patent/US6235745B1/en not_active Expired - Lifetime
- 1998-04-14 PT PT98922759T patent/PT975327E/en unknown
- 1998-04-14 KR KR10-1999-7007936A patent/KR100529512B1/en not_active IP Right Cessation
- 1998-04-14 AU AU75282/98A patent/AU745361B2/en not_active Ceased
- 1998-04-14 JP JP54502298A patent/JP2001523239A/en not_active Ceased
-
2001
- 2001-03-08 US US09/801,978 patent/US6555546B2/en not_active Expired - Lifetime
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EP1090638A1 (en) * | 1999-10-08 | 2001-04-11 | Sanofi-Synthelabo | Use of (R)-zacopride or a salt thereof for the manufacture of a medicament for the treatment of sleep apnea |
WO2001026657A1 (en) * | 1999-10-08 | 2001-04-19 | Sanofi-Synthelabo | Use of (r)-zacopride or a salt thereof for the manufacture of a medicament for the treatment of sleep apnea |
WO2002041918A2 (en) * | 2000-11-24 | 2002-05-30 | Janssen Pharmaceutica N.V. | Use of a triple combination comprising a 5ht3 antagonist, a 5ht4 agonist and a laxative for promoting intestinal lavage |
WO2002041918A3 (en) * | 2000-11-24 | 2002-07-11 | Janssen Pharmaceutica Nv | Use of a triple combination comprising a 5ht3 antagonist, a 5ht4 agonist and a laxative for promoting intestinal lavage |
WO2002085901A1 (en) * | 2001-04-19 | 2002-10-31 | Pharmacia & Upjohn Company | Substituted azabicyclic moieties for the treatment of disease (nicotinic acethylcholine receptor agonists) |
US6869946B2 (en) | 2001-04-19 | 2005-03-22 | Pfizer Inc | Substituted azabicyclic moieties for the treatment of disease |
WO2007019888A2 (en) * | 2005-08-12 | 2007-02-22 | Ctg Pharma S.R.L. | Therapeutic compositions containing mesalamine and a co-agent for treating colon diseases |
WO2007019888A3 (en) * | 2005-08-12 | 2007-07-12 | Ctg Pharma S R L | Therapeutic compositions containing mesalamine and a co-agent for treating colon diseases |
US10342848B2 (en) | 2013-02-25 | 2019-07-09 | Bausch Health Ireland Limited | Agonists of guanylate cyclase and their uses |
US10967043B2 (en) | 2013-02-25 | 2021-04-06 | Bausch Health Ireland Limited | Agonists of guanylate cyclase and their uses |
WO2020067456A1 (en) * | 2018-09-28 | 2020-04-02 | 武田薬品工業株式会社 | Heterocyclic compound |
US11970483B2 (en) | 2018-09-28 | 2024-04-30 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
Also Published As
Publication number | Publication date |
---|---|
EP0975327B1 (en) | 2003-07-02 |
KR20000075858A (en) | 2000-12-26 |
DE69816060D1 (en) | 2003-08-07 |
AU745361B2 (en) | 2002-03-21 |
ATE243993T1 (en) | 2003-07-15 |
US20010020025A1 (en) | 2001-09-06 |
JP2001523239A (en) | 2001-11-20 |
ES2202855T3 (en) | 2004-04-01 |
AU7528298A (en) | 1998-11-13 |
CA2286076A1 (en) | 1998-10-29 |
CA2286076C (en) | 2006-12-12 |
US6235745B1 (en) | 2001-05-22 |
KR100529512B1 (en) | 2005-11-22 |
DE69816060T2 (en) | 2004-04-22 |
EP0975327A1 (en) | 2000-02-02 |
PT975327E (en) | 2003-11-28 |
DK0975327T3 (en) | 2003-10-20 |
US6555546B2 (en) | 2003-04-29 |
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