WO1998042833A3 - Kv potassium channel polypeptides and polynucleotides - Google Patents

Kv potassium channel polypeptides and polynucleotides Download PDF

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Publication number
WO1998042833A3
WO1998042833A3 PCT/EP1998/001901 EP9801901W WO9842833A3 WO 1998042833 A3 WO1998042833 A3 WO 1998042833A3 EP 9801901 W EP9801901 W EP 9801901W WO 9842833 A3 WO9842833 A3 WO 9842833A3
Authority
WO
WIPO (PCT)
Prior art keywords
polynucleotides
potassium channel
polypeptides
channel polypeptides
disclosed
Prior art date
Application number
PCT/EP1998/001901
Other languages
French (fr)
Other versions
WO1998042833A2 (en
Inventor
Antoine Michel Alain Bril
Thierry Paul Gerard Calmels
Jean-Francois Simon Pie Faivre
Jean-Luc Javre
Sabine Rouanet
Original Assignee
Smithkline Beecham Lab
Antoine Michel Alain Bril
Thierry Paul Gerard Calmels
Faivre Jean Francois Simon Pie
Javre Jean Luc
Sabine Rouanet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Lab, Antoine Michel Alain Bril, Thierry Paul Gerard Calmels, Faivre Jean Francois Simon Pie, Javre Jean Luc, Sabine Rouanet filed Critical Smithkline Beecham Lab
Priority to EP98929258A priority Critical patent/EP0914433A2/en
Priority to JP10542352A priority patent/JP2000506745A/en
Priority to US09/142,791 priority patent/US6368823B1/en
Publication of WO1998042833A2 publication Critical patent/WO1998042833A2/en
Publication of WO1998042833A3 publication Critical patent/WO1998042833A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

hKv4.3 potassium channel family polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hKv4.3 polypeptides and polynucleotides in the design of protocols for the treatment of cardiac arrhythmias and Alzheimer's disease, among others, and diagnostic assays for such conditions.
PCT/EP1998/001901 1997-03-27 1998-03-23 Kv potassium channel polypeptides and polynucleotides WO1998042833A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP98929258A EP0914433A2 (en) 1997-03-27 1998-03-23 Kv potassium channel polypeptides and polynucleotides
JP10542352A JP2000506745A (en) 1997-03-27 1998-03-23 New compound
US09/142,791 US6368823B1 (en) 1997-03-27 1998-03-23 Kv potassium channel polypeptides and polynucleotides

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9706377.0 1997-03-27
GBGB9706377.0A GB9706377D0 (en) 1997-03-27 1997-03-27 Novel compound
EP97403007.4 1997-12-11
EP97402971.2 1997-12-11

Publications (2)

Publication Number Publication Date
WO1998042833A2 WO1998042833A2 (en) 1998-10-01
WO1998042833A3 true WO1998042833A3 (en) 1999-02-18

Family

ID=10809959

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/001901 WO1998042833A2 (en) 1997-03-27 1998-03-23 Kv potassium channel polypeptides and polynucleotides

Country Status (2)

Country Link
GB (1) GB9706377D0 (en)
WO (1) WO1998042833A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395477B1 (en) * 1998-10-23 2002-05-28 American Home Products Corporation Human potassium channel polynucleotide and polypeptides and uses thereof
GB2388603B (en) * 2002-05-15 2005-11-09 * Devgen Nv Methods for identifying and developing compounds that interact with voltage-ga ted potassium channels of the Kv4 family

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 1 February 1997 (1997-02-01), DIXON J.E. ET AL.: "KV4.3 K+ channel (Rattus norvegicus)" *
DATABASE EMBL 23 January 1996 (1996-01-23), SERODIO P. ET AL.: "Rattus norvegicus Shal-related potassium channel Kv4.3 mRNA, complete cds" *
DATABASE EMBL 4 November 1995 (1995-11-04), TSAUR M.L. ET AL.: "Rattus norvegicus voltage-gated potassium channel Kv4.3 mRNA, complete cds", XP002079152 *
DATABASE EMBL 6 November 1996 (1996-11-06), DIXON J.E. ET AL.: "Rattus norvegicus Kv4.3 potassium channel mRNA, complete cds" *
DIXON J.E. ET AL: "Role of the Kv4.3 K+ channel in ventricular muscle: A molecular correlate for the transient outward current", CIRCULATION RESEARCH, 1996, 79/4 (659-668), USA, XP002079151 *
SERODIO P. ET AL: "Cloning of a novel component of A-type K+ channels operating at subthreshold potentials with unique expression in heart and brain", JOURNAL OF NEUROPHYSIOLOGY, 1996, 75/5 (2174-2179), USA, XP002079150 *

Also Published As

Publication number Publication date
WO1998042833A2 (en) 1998-10-01
GB9706377D0 (en) 1997-05-14

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