WO1998041648A3 - Target genes for allele-specific drugs - Google Patents

Target genes for allele-specific drugs Download PDF

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Publication number
WO1998041648A3
WO1998041648A3 PCT/US1998/005419 US9805419W WO9841648A3 WO 1998041648 A3 WO1998041648 A3 WO 1998041648A3 US 9805419 W US9805419 W US 9805419W WO 9841648 A3 WO9841648 A3 WO 9841648A3
Authority
WO
WIPO (PCT)
Prior art keywords
allele
target genes
genes
loh
loss
Prior art date
Application number
PCT/US1998/005419
Other languages
French (fr)
Other versions
WO1998041648A9 (en
WO1998041648A2 (en
Inventor
David Housman
Fred D Ledley
Vincent P Stanton Jr
Original Assignee
Variagenics Inc
David Housman
Fred D Ledley
Vincent P Stanton Jr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Variagenics Inc, David Housman, Fred D Ledley, Vincent P Stanton Jr filed Critical Variagenics Inc
Priority to EP98912974A priority Critical patent/EP0973935A2/en
Priority to AU67643/98A priority patent/AU6764398A/en
Priority to CA002283636A priority patent/CA2283636A1/en
Publication of WO1998041648A2 publication Critical patent/WO1998041648A2/en
Publication of WO1998041648A9 publication Critical patent/WO1998041648A9/en
Publication of WO1998041648A3 publication Critical patent/WO1998041648A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer

Abstract

This disclosure concerns genetic targets which have been found to be useful for allele specific anti-tumor therapy. The strategy for such therapy involves the steps of: (1) identification of alternative alleles of genes coding for proteins essential for cell viability or cell growth and the loss of one of these alleles in cancer cells due to loss of heterozygosity (LOH) and (2) the development of inhibitors with high specificity for the single remaining alternative allele of the essential gene retained by the tumor cell after LOH. Particular categories of appropriate target genes are described, along with specific exemplary genes within those categories and methods of using such target genes.
PCT/US1998/005419 1997-03-20 1998-03-19 Target genes for allele-specific drugs WO1998041648A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP98912974A EP0973935A2 (en) 1997-03-20 1998-03-19 Target genes for allele-specific drugs
AU67643/98A AU6764398A (en) 1997-03-20 1998-03-19 Target genes for allele-specific drugs
CA002283636A CA2283636A1 (en) 1997-03-20 1998-03-19 Target genes for allele-specific drugs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4105797P 1997-03-20 1997-03-20
US60/041,057 1997-03-20

Publications (3)

Publication Number Publication Date
WO1998041648A2 WO1998041648A2 (en) 1998-09-24
WO1998041648A9 WO1998041648A9 (en) 1999-01-07
WO1998041648A3 true WO1998041648A3 (en) 1999-04-29

Family

ID=21914484

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/005419 WO1998041648A2 (en) 1997-03-20 1998-03-19 Target genes for allele-specific drugs

Country Status (4)

Country Link
EP (1) EP0973935A2 (en)
AU (1) AU6764398A (en)
CA (1) CA2283636A1 (en)
WO (1) WO1998041648A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9308204B2 (en) 2009-11-02 2016-04-12 Pfizer Inc. Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives

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US7074902B1 (en) 1998-04-27 2006-07-11 Warf Wisconsin Alumni Research Foundation Antibody specific for a DNA repair protein
US7122343B1 (en) * 1998-04-27 2006-10-17 Wisconsin Alumni Research Foundation Methods to alter levels of a DNA repair protein
GB9828840D0 (en) * 1998-12-30 1999-02-17 Univ Nottingham Trent Prostate cancer associated genes and their products
AU7701100A (en) * 1999-09-03 2001-04-10 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of ovarian cancer
US6309882B1 (en) 1999-09-10 2001-10-30 Isis Pharmaceuticals, Inc. Antisense inhibition of replication protein a p70 subunit
DE60039895D1 (en) * 1999-09-14 2008-09-25 Scripps Research Inst NE FOR WHICH YOU CODE
CA2390051A1 (en) * 1999-11-15 2001-05-25 University Of Southern California Thymidylate synthase polymorphism for predicting chemotherapeutic response
AU1939601A (en) * 1999-12-01 2001-06-12 Ludwig Institute For Cancer Research Cancer associated antigens and uses therefor
US20030092601A1 (en) * 1999-12-07 2003-05-15 Hanan Polansky Microcompetition and human disease
GB0000995D0 (en) * 2000-01-18 2000-03-08 Zeneca Ltd Methods
WO2002021134A2 (en) * 2000-09-08 2002-03-14 Eos Biotechnology, Inc. Methods of diagnosing breast cancer and screening for modulators
US6602670B2 (en) 2000-12-01 2003-08-05 Response Genetics, Inc. Method of determining a chemotherapeutic regimen based on ERCC1 expression
US7049059B2 (en) 2000-12-01 2006-05-23 Response Genetics, Inc. Method of determining a chemotherapeutic regimen based on ERCC1 and TS expression
US20020142328A1 (en) 2000-12-01 2002-10-03 Danenberg Kathleen D. Method of determining a chemotherapeutic regimen by assaying gene expression in primary tumors
US7005278B2 (en) 2001-03-02 2006-02-28 Danenberg Kathleen D Method of determining dihydropyrimidine dehydrogenase gene expression
US6956111B2 (en) 2001-03-02 2005-10-18 Response Genetics, Inc. Method of determining dihydropyrimidine dehydrogenase gene expression
US6686155B2 (en) 2001-06-14 2004-02-03 Response Genetics, Inc. Method of determining a chemotherapeutic regimen based on glutathione-S-transferase pi expression
GB0305681D0 (en) 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
NZ544588A (en) 2003-06-20 2010-06-25 Nereus Pharmaceuticals Inc Use of salinosporamide A and analogs thereof for the treatment of cancer, inflammation and infectious diseases
ES2384940T3 (en) 2004-01-16 2012-07-16 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Immunokinase
EP1800695A1 (en) * 2005-12-21 2007-06-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Immuno-RNA-constructs
ES2340206T3 (en) 2005-12-30 2010-05-31 Ventana Medical Systems, Inc. EXPRESSION OF NA + K + -ATPASA IN DISPLASTIA AND CANCER CERVICALES.
US7704967B2 (en) 2006-03-14 2010-04-27 University Of Maryland, Baltimore TFIIS and GDOWN1 as targets for cancer therapy
US8445200B2 (en) 2009-04-15 2013-05-21 The Regents Of The University Of California Genotoxicity as a biomarker for inflammation
HUE045359T2 (en) * 2011-12-14 2019-12-30 Univ Texas Collateral gene inactivation biomarkers and targets for cancer therapy
WO2013174859A1 (en) * 2012-05-22 2013-11-28 Centre Leon Berard Screening methods for identifying compounds which interfere with coup-tfii (nr2f2) or coup-tfi (nr2f1)
US9828641B2 (en) 2013-08-01 2017-11-28 The Regents Of The University Of California Systemic genotoxicity as blood marker for allergic inflammation
WO2015109258A1 (en) * 2014-01-16 2015-07-23 Rowan University Modulation of cellular localization of cyclin c
GB2566516A (en) 2017-09-15 2019-03-20 Univ Oxford Innovation Ltd Electrochemical recognition and quantification of cytochrome c oxidase expression in bacteria
US20210047696A1 (en) * 2018-03-28 2021-02-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treating cancer

Citations (5)

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WO1994011494A1 (en) * 1992-11-09 1994-05-26 Thomas Jefferson University Antisense oligonucleotides to inhibit expression of mutated and wild type genes for collagen
WO1995003335A1 (en) * 1993-07-26 1995-02-02 K.O. Technology, Inc. Inhibitors of alternative alleles of genes as a basis for cancer therapeutic agents
US5491064A (en) * 1992-07-17 1996-02-13 The United States Of America As Represented By The Department Of Health And Human Services HTS-1 gene, a human tumor suppressor gene
WO1997004087A1 (en) * 1995-07-18 1997-02-06 Guido Krupp Ribozymes for the selective inhibition of expression by mhc allele genes, and drugs containing such ribozymes
WO1997032024A1 (en) * 1996-03-01 1997-09-04 Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Allele suppression

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5491064A (en) * 1992-07-17 1996-02-13 The United States Of America As Represented By The Department Of Health And Human Services HTS-1 gene, a human tumor suppressor gene
WO1994011494A1 (en) * 1992-11-09 1994-05-26 Thomas Jefferson University Antisense oligonucleotides to inhibit expression of mutated and wild type genes for collagen
WO1995003335A1 (en) * 1993-07-26 1995-02-02 K.O. Technology, Inc. Inhibitors of alternative alleles of genes as a basis for cancer therapeutic agents
WO1997004087A1 (en) * 1995-07-18 1997-02-06 Guido Krupp Ribozymes for the selective inhibition of expression by mhc allele genes, and drugs containing such ribozymes
WO1997032024A1 (en) * 1996-03-01 1997-09-04 Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Allele suppression

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9308204B2 (en) 2009-11-02 2016-04-12 Pfizer Inc. Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives
US9439902B2 (en) 2009-11-02 2016-09-13 Pfizer Inc. Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives
US9439901B2 (en) 2009-11-02 2016-09-13 Pfizer Inc. Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives

Also Published As

Publication number Publication date
WO1998041648A2 (en) 1998-09-24
CA2283636A1 (en) 1998-09-24
AU6764398A (en) 1998-10-12
EP0973935A2 (en) 2000-01-26

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