WO1998036732A2 - Combination preparation for orally administered antibiotics - Google Patents
Combination preparation for orally administered antibioticsInfo
- Publication number
- WO1998036732A2 WO1998036732A2 PCT/EP1998/000029 EP9800029W WO9836732A2 WO 1998036732 A2 WO1998036732 A2 WO 1998036732A2 EP 9800029 W EP9800029 W EP 9800029W WO 9836732 A2 WO9836732 A2 WO 9836732A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- combination preparation
- active ingredient
- preparation according
- component
- groups
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Definitions
- the invention relates to a combination preparation in the sense of a "kit-of-parts" for the oral administration of antibiotics as an aqueous suspension containing a coated active ingredient and a syrup base.
- Filming, coating or coating active ingredient particles for example active ingredients which are in the form of crystals, agglomerates, granules, pellets or microtablets, is a common method in pharmaceutical technology to improve the stability of the active ingredient in an aqueous environment.
- the choice of coating agent is adapted to the therapeutic task.
- Coating with a high permeability polymer e.g. B .magensaftlöslichem Dimethylaminoethylmethacry- lat methacrylate copolymer of the type Eudragit ® E (Röhm GmbH Chemical Factory), and a suitable layer thickness, allows drug release in the acidic environment of gastric juice.
- the rapid release of the active substance is important if infectious conditions are to be treated within a short time immediately after their appearance and rapid onset of action with higher doses is desired.
- a coating with a lower permeability for example acrylic ester-methacrylic acid ester copolymer of the EUDRAGIT ® NE type, and possibly a greater layer thickness, the release of active ingredient in the stomach can be delayed with a corresponding prolongation of the duration of action. This effect is desirable with a longer therapy duration.
- Coated active ingredient particles are also only stable for a limited time in aqueous suspension.
- the undesired diffusion of the active ingredient into the suspension liquid takes place immediately after the suspension has been prepared. This results in the hydrolytic decomposition of the active ingredient and the significantly increasing deterioration in taste during the period of use of the suspension.
- the object of the present invention is to produce pharmaceutical suspensions (dry juices) with acceptable taste properties and sufficient stability for orally administrable antibiotics.
- the invention relates to a combination preparation for the oral administration of antibiotics as an aqueous suspension containing
- active ingredient component a) consists of coated active ingredient particles which are combined with component b), the suspending agent, before use.
- the two components are contained in two separate containers, which are packaged in a common package in the sense of a "kit of parts".
- the contents of the two containers are combined in a suitable container immediately before use.
- the two separate containers can be designed so that a single dose can be found in each case.
- the contents of the two containers can be combined in a storage vessel from which the measured amount of liquid can be removed until the end of the therapy.
- the storage container can be one of the two containers.
- the suspension produced in this way is characterized by favorable taste and stability properties. After the suspension has been prepared, the pleasant taste of the liquid and the effectiveness of the active ingredient are retained until the end of therapy.
- An oral antibiotic is administered as a single active ingredient or as a combination of active ingredients.
- Suitable active substances are selected from the group of penicillins, cephalosporins, quinolones, aminoglycosides and macrolides and can be combined with another active substance from the substance groups mentioned.
- the penicillins or cephalosporins can be combined with a ⁇ -lactamase inhibitor, for example clavulanic acid or sulbactam or tazobactam.
- a ⁇ -lactamase inhibitor for example clavulanic acid or sulbactam or tazobactam.
- the active ingredient component can be made of amoxicillin and clavulanic acid (Augmentan ® ) or. Ampicillin and Sulbactam (Unacid ® ) or Piperacillin and Tazobactam (Tazobac ® ) exist.
- penicillins such as amoxicillin, ampicillin, bacampicillin, nacillin-Na, propicillin-K, phenoxymethylpenicillin-K, flucloxacillin, dicloxacillin, oxacillin, or pivampicil-lin.
- cephalosporins such as cefaclor, cefadroxil, cefalexin, cefamandole, cefatrizine, cefazolin, cefepim, cefetamet, cefradrin, cefazedone, cef- tazidime, cefbuperazone, cefuroxim, cefiximefefone, cefiximefone , Cefotaxim, Cefotetan, Cefotiam, Cefoxitin, Cefmetazol, Cefperazon, Cefpimizol, Cefpiramide, Cefadroxil, Cefpo- doxim, Cefpodoxim-Proxetil, Cefuroxim-Axitil, Cefpodoxim-Proxitil, Cefterefoxitil, Cefterefoxitil, Cefterefoxamit , Cefuroxim, Cefuroxim-Axe
- the active ingredient component can also be selected from the group of aminoglycosides. Examples of these are neomycin sulfate or paromomycin.
- Macrolides such as azithromycin, clarithromycin, roxithromycin, josamycin or spiramycin I / II / III can also be used as active ingredient.
- rifampicin such as quinolones / nalixidic acid derivatives (gyrase inhibitors), such as e.g. Ciprofloxacin, Norfloxacin, Cinoxacin, Lomefloxacin, Moxifloxacin, Ofloxacin, Fleroxacin, Enoxacin, Perfloxacin, Trovafloxacin, Geprafloxacin, Sparfloxacin, Tusofloxacin, Enrofloxacin or Pipemidklare.
- quinolones / nalixidic acid derivatives such as e.g. Ciprofloxacin, Norfloxacin, Cinoxacin, Lomefloxacin, Moxifloxacin, Ofloxacin, Fleroxacin, Enoxacin, Perfloxacin, Trovafloxacin, Geprafloxacin, Sparfloxacin, Tusofloxacin, Enrofloxacin or Pipemidklare.
- clindamycin or lincomycin can also be used as an active ingredient in the combination preparation according to the invention.
- the active substances mentioned which have a salt-forming group, can, if not already stated, be present as pharmaceutically acceptable salts, for example alkali metal salts (sodium or potassium salts), alkaline earth metal salts (calcium or gastric salts), plasticites, starates, propionates, Choline salts, citrates, embonates, mesila te, sulfates or hydrochloride.
- the active ingredients can additionally contain half to ten moles of water of crystallization.
- the active substances mentioned, or their combinations are present in the dosages prescribed for oral administration.
- a suitable permeable, gastric juice-soluble coating agent consists of a film-like material which is permeable to acidic, aqueous systems, such as the contents of the stomach, and is swellable and / or soluble in these liquids.
- Suitable are e.g. hydrophilic polyacrylates with an average molecular weight of approx. 1.0 x 10 to 1.0 x 10, consisting of acrylic acid polymers or acrylic acid-methacrylic acid copolymers.
- the acid groups of the acrylic acid and / or methacrylic acid monomers are partially or completely esterified by C ⁇ -C4-alkyl groups, especially by methyl and / or ethyl groups, whereby these ester groups can be replaced by hydrophilic groups, especially trimethylammoniumethyl or dimethylaminoethyl.
- EUDRAGIT ® Preferred polyacrylates are available under the registered trademark EUDRAGIT ® from Röhm Chemische Fabrik GmbH.
- EUDRAGIT ® commercial forms are particularly preferred for rapidly disintegrating film coatings, for example swellable, permeable types based on acrylic acid ester / methacrylic acid ester copolymer, in particular ethyl acrylate / methyl methacrylate ester copolymer, for example gastric juice-soluble types such as EUDRAGIT ® E.
- ethyl cellulose methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, polyvinyl acetate, polyvinyl alcohol, copolymers of methacrylic acid and methacrylic acid esters (Eudragit ® S / L) aminomethacrylate copolymers (Eudragit ® RS / RL), and acrylic acid polymers of the Carbopol type (eg Carbopol ® 934).
- polymers such as ethyl cellulose, methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, polyvinyl acetate, polyvinyl alcohol, copolymers of methacrylic acid and methacrylic acid esters (Eudragit ® S / L) aminomethacrylate copolymers (Eudragit ® RS / RL), and acrylic acid polymers of the Carbopol type (eg Carbopol ® 934).
- the permeability of the polymeric coatings can be changed by adding plasticizers.
- plasticizers e.g. Triethyl citrate, acetyl triethyl citrate, tributyl citrate, acetyl tributyl citrate, triacetin, diethyl phthalate, dibutyl phthalate, glyceryl monocaprylate, monoglycerides and acetylated monoglycerides can be used.
- the coating of the drug particles takes place in a conventional manner using conventional coating methods (Rowe, RC, Int. J. Pharm. Tech. & Prod. Mfr., 3. (1) 27-32 (1982)) by dispersing or dissolving the coating agent in the desired ratio in a solvent or mixture, for example in methanol, ethyl acetate, ethanol, isopropanol, tert. Butanol, acetone, methylene chloride, chloroform, water, or mixtures thereof. If necessary, auxiliaries such as Mg stearate, stearic acid, talc or can be added to improve the technical implementation of the coating process
- Silicon dioxide (Syloid® 244 FP, / Cab-o-sil ® , / Aerosil ® 200).
- the solution or dispersion is applied to the active ingredient in powder form using known methods, such as spray coating in the fluidized bed. sprayed.
- the processes and devices are known under the names Aeromatic, Freund, Glatt, Wurster or Weg-Coater), 'and in the boiler under the names Accela Cota process or dip pipe process (Kala, H., et al, Pharmazie, 3_4 ( 11) 755-765 (1979)).
- the coated product is then dried or the solvents are removed.
- process conditions must be selected which allow the process temperatures to be reduced and / or the process times to be shortened. This can e.g. by working at reduced atmospheric pressure (Luy, B., et al, Pharm. Ind., 51, 89-94 (1989)) and / or by using conditioned air.
- the usual grinding processes are used, e.g. Grinding in ball mills, pin mills, mortar mills or air jet mills.
- the preparation of the suspending agent b) is carried out in manner known per se, which is described, for example for the production of conventional syrup bases (Temperli, M., et al, Pharm. Act. Helv., 3. 9, 741 ff (1964)).
- the syrup base is adjusted to a pH between 5 and 10 with a suitable acid or base or a buffer system.
- acids, bases or salts or their combinations can be used for this, such as amino acids, benzoic acid, citric acid, tartaric acid, succinic acid, malic acid, acetic acid, carbonic acid, hydrochloric acid, phosphoric acid or Ren Na + , K + , or Ca ++ salts, sodium hydroxide solution, glycylglycine, glycine, diisopropanolamine, tris (hydroxymethyl) amino methane (HCl), ethylenediamine, and triethanolamine (HCl).
- the syrup can contain viscosity-influencing substances (for example macrogols), wetting agents, preservatives, antioxidants, colorants, taste correctives (flavors), sugar and / or sweeteners.
- sugar or sugar substitutes which can serve as a syrup base are, for example, glucose, hydrogenated glucose (Lycasin ®), sucrose, xylitol, D-xylose, maltose, D-glucose, sorbitol, glycerol, mannitol, dulcitol, maltitol, lactitol, fructose, Dextrose, lactulose or lactose or their combinations.
- Sweeteners which may be included to further round off the taste, are saccharin-Na, dulcin, glycyrrhizin, ammonium glycyrrhizinate, neosperperidine dihydrochalcone, neohesperidin-HCl, glycine, stevioside, L-asparagyl-L-phenylalanamethyl ester (aspartyl ® ), sodium cyclamate or their combinations.
- the combination preparation according to the invention has valuable pharmacological properties and can be used for the therapy of infections of various origins for which the active substance or combination of active substances used is suitable.
- the granules are leveled through a 0.8 mm sieve and the residual solvents are removed in a vacuum drying cabinet.
- the dried granules are mixed with 5 5 kg Syloid 244 FP ®. Finally, the mixture is portioned into sachets of 11.065 g each.
- the dried granulate is passed through a sieve with a mesh size of 1 mm and mixed with 1.1 kg of Aerosil ® .
- the finished mixture can be filled in portions in sachets or in brown glass bottles.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98905269A EP0971691A2 (en) | 1997-02-21 | 1998-01-05 | Combination preparation for orally administered antibiotics |
AU60926/98A AU6092698A (en) | 1997-02-21 | 1998-01-05 | Combination preparation for orally administered antibiotics |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19706978.9 | 1997-02-21 | ||
DE1997106978 DE19706978A1 (en) | 1997-02-21 | 1997-02-21 | Combination preparation for oral antibiotics |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998036732A2 true WO1998036732A2 (en) | 1998-08-27 |
WO1998036732A3 WO1998036732A3 (en) | 1998-10-22 |
Family
ID=7821094
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1998/000029 WO1998036732A2 (en) | 1997-02-21 | 1998-01-05 | Combination preparation for orally administered antibiotics |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0971691A2 (en) |
AU (1) | AU6092698A (en) |
DE (1) | DE19706978A1 (en) |
WO (1) | WO1998036732A2 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000003695A1 (en) * | 1998-07-17 | 2000-01-27 | Lek Pharmaceutical & Chemical Co. Dd | Pharmaceutical suspension formulation comprising amoxycillin, clavulanic acid and cellulose |
WO2001047499A1 (en) * | 1999-12-23 | 2001-07-05 | Smithkline Beecham P.L.C. | Pharmaceutical formulations comprising sodium amoxycillin and potassium clavulanate |
US6872407B2 (en) | 1997-04-11 | 2005-03-29 | Abbott Laboratories | Extended release formulations of erythromycin derivatives |
WO2014122248A1 (en) | 2013-02-11 | 2014-08-14 | Boehringer Ingelheim Vetmedica Gmbh | Kit-of-parts |
US9289390B2 (en) | 2011-08-12 | 2016-03-22 | Boehringer Ingelheim Vetmedica Gmbh | Taste masked pharmaceutical composition |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL161259A0 (en) * | 2001-12-21 | 2004-09-27 | Pfizer Prod Inc | Methods for wet granulating azithromycin |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2122490A (en) * | 1982-06-24 | 1984-01-18 | Astra Laekemedel Ab | Controlled release formulation |
EP0069097B1 (en) * | 1981-06-18 | 1986-09-10 | Astra Läkemedel Aktiebolag | Pharmaceutical mixture |
WO1993000898A1 (en) * | 1991-07-11 | 1993-01-21 | Smithkline Beecham Plc | Pharmaceutical formulation of a beta-lactam antibiotic and clavulanic acid or a water-soluble salt thereof |
EP0551820A1 (en) * | 1992-01-15 | 1993-07-21 | Bayer Ag | Taste-masked pharmaceutical compositions |
WO1993017667A1 (en) * | 1992-03-12 | 1993-09-16 | Taisho Pharmaceutical Co., Ltd. | Composition for oral preparations |
WO1996001628A1 (en) * | 1994-07-07 | 1996-01-25 | Recordati Industria Chimica E Farmaceutica S.P.A. | Pharmaceutical composition for the controlled release of moguisteine in a liquid suspension |
-
1997
- 1997-02-21 DE DE1997106978 patent/DE19706978A1/en not_active Withdrawn
-
1998
- 1998-01-05 AU AU60926/98A patent/AU6092698A/en not_active Abandoned
- 1998-01-05 EP EP98905269A patent/EP0971691A2/en not_active Withdrawn
- 1998-01-05 WO PCT/EP1998/000029 patent/WO1998036732A2/en not_active Application Discontinuation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0069097B1 (en) * | 1981-06-18 | 1986-09-10 | Astra Läkemedel Aktiebolag | Pharmaceutical mixture |
GB2122490A (en) * | 1982-06-24 | 1984-01-18 | Astra Laekemedel Ab | Controlled release formulation |
WO1993000898A1 (en) * | 1991-07-11 | 1993-01-21 | Smithkline Beecham Plc | Pharmaceutical formulation of a beta-lactam antibiotic and clavulanic acid or a water-soluble salt thereof |
EP0551820A1 (en) * | 1992-01-15 | 1993-07-21 | Bayer Ag | Taste-masked pharmaceutical compositions |
WO1993017667A1 (en) * | 1992-03-12 | 1993-09-16 | Taisho Pharmaceutical Co., Ltd. | Composition for oral preparations |
WO1996001628A1 (en) * | 1994-07-07 | 1996-01-25 | Recordati Industria Chimica E Farmaceutica S.P.A. | Pharmaceutical composition for the controlled release of moguisteine in a liquid suspension |
Non-Patent Citations (1)
Title |
---|
See also references of EP0971691A2 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6872407B2 (en) | 1997-04-11 | 2005-03-29 | Abbott Laboratories | Extended release formulations of erythromycin derivatives |
WO2000003695A1 (en) * | 1998-07-17 | 2000-01-27 | Lek Pharmaceutical & Chemical Co. Dd | Pharmaceutical suspension formulation comprising amoxycillin, clavulanic acid and cellulose |
US6511972B1 (en) | 1998-07-17 | 2003-01-28 | Lek Pharmaceutical & Chemical Company D.D. | Pharmaceutical suspension formulation comprising amoxycillin clavulanic acid and cellulose |
WO2001047499A1 (en) * | 1999-12-23 | 2001-07-05 | Smithkline Beecham P.L.C. | Pharmaceutical formulations comprising sodium amoxycillin and potassium clavulanate |
US9289390B2 (en) | 2011-08-12 | 2016-03-22 | Boehringer Ingelheim Vetmedica Gmbh | Taste masked pharmaceutical composition |
WO2014122248A1 (en) | 2013-02-11 | 2014-08-14 | Boehringer Ingelheim Vetmedica Gmbh | Kit-of-parts |
Also Published As
Publication number | Publication date |
---|---|
WO1998036732A3 (en) | 1998-10-22 |
EP0971691A2 (en) | 2000-01-19 |
AU6092698A (en) | 1998-09-09 |
DE19706978A1 (en) | 1998-08-27 |
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