WO1998033896A3 - Microorganisms with increased production of clavulanic acid - Google Patents

Microorganisms with increased production of clavulanic acid Download PDF

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Publication number
WO1998033896A3
WO1998033896A3 PCT/EP1998/000644 EP9800644W WO9833896A3 WO 1998033896 A3 WO1998033896 A3 WO 1998033896A3 EP 9800644 W EP9800644 W EP 9800644W WO 9833896 A3 WO9833896 A3 WO 9833896A3
Authority
WO
WIPO (PCT)
Prior art keywords
microorganisms
clavulanic acid
increased production
clavulanic
acid
Prior art date
Application number
PCT/EP1998/000644
Other languages
French (fr)
Other versions
WO1998033896A2 (en
Inventor
Barry Barton
John Patrick Griffin
Roy Henry Mosher
Ashish Sudhakar Paradkar
Susan Jensen
Cecilia Anders
Original Assignee
Smithkline Beecham Plc
Univ Alberta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU62953/98A priority Critical patent/AU735782B2/en
Priority to SK1054-99A priority patent/SK105499A3/en
Priority to NZ336894A priority patent/NZ336894A/en
Priority to EA199900718A priority patent/EA003773B1/en
Priority to EP98906924A priority patent/EP0970198B1/en
Priority to KR10-1999-7006973A priority patent/KR100514964B1/en
Priority to DE69832783T priority patent/DE69832783T2/en
Application filed by Smithkline Beecham Plc, Univ Alberta filed Critical Smithkline Beecham Plc
Priority to AT98906924T priority patent/ATE312926T1/en
Priority to BR9807144-0A priority patent/BR9807144A/en
Priority to APAP/P/1999/001614A priority patent/AP1320A/en
Priority to CA002279207A priority patent/CA2279207A1/en
Priority to PL98334961A priority patent/PL334961A1/en
Priority to IL13104398A priority patent/IL131043A0/en
Priority to JP53256398A priority patent/JP4227199B2/en
Publication of WO1998033896A2 publication Critical patent/WO1998033896A2/en
Publication of WO1998033896A3 publication Critical patent/WO1998033896A3/en
Priority to NO993758A priority patent/NO993758D0/en
Priority to BG103704A priority patent/BG103704A/en
Priority to US10/214,519 priority patent/US20030166175A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novel bacterial genes, microorganisms and processes for improving the manufacture of 5R clavams, e.g. clavulanic acid.
PCT/EP1998/000644 1997-02-04 1998-02-02 Microorganisms with increased production of clavulanic acid WO1998033896A2 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
IL13104398A IL131043A0 (en) 1997-02-04 1998-02-02 Microorganisms with increased production of clavulanic acid
NZ336894A NZ336894A (en) 1997-02-04 1998-02-02 Bacterial genes specific for biosynthesis of 5S clavams, and manipulation of these genes to produce raised levels of clavulanic acid
EA199900718A EA003773B1 (en) 1997-02-04 1998-02-02 Dna sequences for 5s clavam biosynthesis in streptomyces clavuligerus microorganisms, streptomyces clavuligerus microorganism strains, containing said dna sequences and a process for improving 5r clavam production, in particular, clavulanic acid in streptomyces clavuligerus microorganisms
EP98906924A EP0970198B1 (en) 1997-02-04 1998-02-02 Micro-organisms with increased production of clavulanic acid
KR10-1999-7006973A KR100514964B1 (en) 1997-02-04 1998-02-02 Microorganisms with Increased Production of Clavulanic Acid
DE69832783T DE69832783T2 (en) 1997-02-04 1998-02-02 MICROORGANISMS WITH INCREASED PREPARATION OF CLAVLANIC ACID
APAP/P/1999/001614A AP1320A (en) 1997-02-04 1998-02-02 Microorganisms with increased production of clavulanic acid.
AT98906924T ATE312926T1 (en) 1997-02-04 1998-02-02 MICROORGANISMS WITH INCREASED PRODUCTION OF CLAVULANIC ACID
BR9807144-0A BR9807144A (en) 1997-02-04 1998-02-02 Microorganisms with increased production of clavulanic acid
AU62953/98A AU735782B2 (en) 1997-02-04 1998-02-02 Novel compounds
CA002279207A CA2279207A1 (en) 1997-02-04 1998-02-02 Novel compounds
PL98334961A PL334961A1 (en) 1997-02-04 1998-02-02 Micro-organisms of increased clavulanic acid production
SK1054-99A SK105499A3 (en) 1997-02-04 1998-02-02 Dna comprising one or more genes specific for biosythesis of 5s clavam in s. clavuligerus, a vector containing dna, a host containing such vectors, process for improving the manufacture of 5r clavam and method for identification of microorganisms
JP53256398A JP4227199B2 (en) 1997-02-04 1998-02-02 Microorganisms that produce large amounts of clavulanic acid
NO993758A NO993758D0 (en) 1997-02-04 1999-08-03 New compounds and microorganisms with increased production of clavulanic acid
BG103704A BG103704A (en) 1997-02-04 1999-09-01 New compounds
US10/214,519 US20030166175A1 (en) 1997-02-04 2002-11-07 Process for clavulanic acid production

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9702218.0A GB9702218D0 (en) 1997-02-04 1997-02-04 Novel product
GB9702218.0 1997-02-04

Publications (2)

Publication Number Publication Date
WO1998033896A2 WO1998033896A2 (en) 1998-08-06
WO1998033896A3 true WO1998033896A3 (en) 1998-11-19

Family

ID=10807030

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/000644 WO1998033896A2 (en) 1997-02-04 1998-02-02 Microorganisms with increased production of clavulanic acid

Country Status (32)

Country Link
US (5) US6936458B1 (en)
EP (2) EP1405913A3 (en)
JP (2) JP4227199B2 (en)
KR (2) KR20050053794A (en)
CN (2) CN1192107C (en)
AP (1) AP1320A (en)
AR (2) AR011100A1 (en)
AT (1) ATE312926T1 (en)
AU (1) AU735782B2 (en)
BG (1) BG103704A (en)
BR (1) BR9807144A (en)
CA (1) CA2279207A1 (en)
DE (1) DE69832783T2 (en)
DZ (1) DZ2413A1 (en)
EA (1) EA003773B1 (en)
ES (1) ES2255149T3 (en)
GB (1) GB9702218D0 (en)
HU (1) HUP0001048A3 (en)
ID (1) ID22144A (en)
IL (1) IL131043A0 (en)
MA (1) MA24464A1 (en)
MY (1) MY140928A (en)
NO (1) NO993758D0 (en)
NZ (1) NZ336894A (en)
OA (1) OA11082A (en)
PL (1) PL334961A1 (en)
SK (1) SK105499A3 (en)
TR (1) TR199901862T2 (en)
TW (2) TW589377B (en)
UY (2) UY24874A1 (en)
WO (1) WO1998033896A2 (en)
ZA (1) ZA98868B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1218486A4 (en) * 1999-09-16 2002-11-04 Univ Johns Hopkins Improvement of clavulanic acid production
EP1228218A2 (en) * 1999-10-22 2002-08-07 Smithkline Beecham Plc 5r clavam producing microorganisms with deleted lat and cvm genes
GB0308696D0 (en) 2003-04-15 2003-05-21 Glaxo Group Ltd New process
EP2589663A1 (en) 2011-11-04 2013-05-08 LEK Pharmaceuticals d.d. Process for production of clavulanic acid
CN107964522B (en) * 2018-01-04 2020-12-08 上海交通大学 Streptomyces marinus DUT11 and application thereof in anti-complement activity
MX2022000250A (en) 2019-07-05 2022-02-03 Glaxosmithkline Ip No 2 Ltd Streptomyces clavuligerus.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2108113A1 (en) * 1993-10-08 1995-04-09 Susan E. Jensen Dna sequence encoding enzymes of clavulanic acid biosynthesis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110165A (en) * 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
IE43790B1 (en) * 1975-02-07 1981-06-03 Glaxo Lab Ltd -lactam antibiotic in purified form
GB1585661A (en) 1976-06-08 1981-03-11 Glaxo Lab Ltd Clavam derivatives
JPS589679B2 (en) 1977-02-24 1983-02-22 武田薬品工業株式会社 Antibiotic manufacturing method
US4202819A (en) 1979-05-04 1980-05-13 Hoffman-La Roche Inc. 2-(3-Alanyl)clavam antibiotic
GB8521516D0 (en) * 1985-08-29 1985-10-02 Beecham Group Plc Compounds
GB9020683D0 (en) 1990-09-22 1990-11-07 Univ Strathclyde Isolation of dna

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2108113A1 (en) * 1993-10-08 1995-04-09 Susan E. Jensen Dna sequence encoding enzymes of clavulanic acid biosynthesis

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
A.S. PARADKAR AND S.E. JENSEN: "Functional analysis of the gene encoding the clavaminate synthase 2 isoenzyme involved in clavulanic acid biosynthesis in Streptomyces clavuligerus", JOURNAL OF BACTERIOLOGY, vol. 177, no. 5, 1995, WASHINGTON, DC, US, pages 1307 - 1314, XP002072687 *
E.N. MARSCH ET AL.,: "Two isozymes of clavaminate synthase central to clavulanic acid formation: cloning and sequencing of both genes from Streptomyces clavuligerus", BIOCHEMISTRY, vol. 31, 1992, WASHINGTON, DC, US, pages 12648 - 12657, XP002072686 *
J.E. HODGSON ET AL.,: "Clavulanic acid biosynthesis in Streptomyces clavuligerus: gene cloning and characterization", GENE, vol. 166, 1995, AMSTERDAM, NL, pages 49 - 55, XP002072689 *
J.M. WARD AND J.E. HODGSON: "The biosynthetic genes for clavulanic acid and cephamycin production occur as a 'super-cluster' in three Streptomyces", FEMS MICROBIOLOGICAL LETTERS, vol. 110, 1993, AMSTERDAM, NL, pages 239 - 242, XP000601357 *
K.A. AIDOO ET AL.,: "Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis", GENE, vol. 147, 1994, AMSTERDAM, NL, pages 41 - 46, XP002072688 *

Also Published As

Publication number Publication date
MA24464A1 (en) 1998-10-01
EA003773B1 (en) 2003-08-28
EA199900718A1 (en) 2000-02-28
KR20050053794A (en) 2005-06-08
EP0970198B1 (en) 2005-12-14
AR011100A1 (en) 2000-08-02
TW589377B (en) 2004-06-01
AP1320A (en) 2004-10-29
BR9807144A (en) 2000-01-25
KR100514964B1 (en) 2005-09-15
CN1696301A (en) 2005-11-16
US6936458B1 (en) 2005-08-30
MY140928A (en) 2010-02-12
ES2255149T3 (en) 2006-06-16
GB9702218D0 (en) 1997-03-26
US20030166175A1 (en) 2003-09-04
UY25197A1 (en) 1998-11-27
NO993758L (en) 1999-08-03
JP4227199B2 (en) 2009-02-18
AP9901614A0 (en) 1999-09-30
IL131043A0 (en) 2001-01-28
EP1405913A2 (en) 2004-04-07
DZ2413A1 (en) 2003-01-04
US20030124690A1 (en) 2003-07-03
HUP0001048A2 (en) 2000-08-28
ZA98868B (en) 1999-08-03
CN1251612A (en) 2000-04-26
CN1192107C (en) 2005-03-09
EP1405913A3 (en) 2004-08-04
TW200307041A (en) 2003-12-01
HUP0001048A3 (en) 2001-09-28
TR199901862T2 (en) 2000-12-21
NO993758D0 (en) 1999-08-03
OA11082A (en) 2003-03-13
AR018304A2 (en) 2001-11-14
US20070298470A1 (en) 2007-12-27
ATE312926T1 (en) 2005-12-15
US20030022321A1 (en) 2003-01-30
JP2001511001A (en) 2001-08-07
BG103704A (en) 2000-05-31
DE69832783D1 (en) 2006-01-19
NZ336894A (en) 2001-08-31
JP5042186B2 (en) 2012-10-03
DE69832783T2 (en) 2006-07-20
ID22144A (en) 1999-09-09
CA2279207A1 (en) 1998-08-06
EP0970198A2 (en) 2000-01-12
JP2009022298A (en) 2009-02-05
PL334961A1 (en) 2000-03-27
US7344869B2 (en) 2008-03-18
UY24874A1 (en) 2001-07-31
WO1998033896A2 (en) 1998-08-06
AU735782B2 (en) 2001-07-12
AU6295398A (en) 1998-08-25
KR20000070723A (en) 2000-11-25
SK105499A3 (en) 2000-05-16

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