WO1998033470A3 - Substituted perylenequinones for use in photodynamic therapy - Google Patents

Substituted perylenequinones for use in photodynamic therapy Download PDF

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Publication number
WO1998033470A3
WO1998033470A3 PCT/US1998/000235 US9800235W WO9833470A3 WO 1998033470 A3 WO1998033470 A3 WO 1998033470A3 US 9800235 W US9800235 W US 9800235W WO 9833470 A3 WO9833470 A3 WO 9833470A3
Authority
WO
WIPO (PCT)
Prior art keywords
photodynamic therapy
perylenequinones
substituted
compositions
perylenequinone
Prior art date
Application number
PCT/US1998/000235
Other languages
French (fr)
Other versions
WO1998033470A2 (en
Inventor
Ragupathy Madiyalakan
J William Lown
Gerald G Miller
Ronald B Moore
Zhenjun Diwu
Original Assignee
Altarex Inc
Ragupathy Madiyalakan
J William Lown
Gerald G Miller
Ronald B Moore
Zhenjun Diwu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altarex Inc, Ragupathy Madiyalakan, J William Lown, Gerald G Miller, Ronald B Moore, Zhenjun Diwu filed Critical Altarex Inc
Priority to EP98903386A priority Critical patent/EP1015033A4/en
Priority to JP53289398A priority patent/JP2001508071A/en
Priority to AU60171/98A priority patent/AU6017198A/en
Priority to CA002277362A priority patent/CA2277362A1/en
Publication of WO1998033470A2 publication Critical patent/WO1998033470A2/en
Publication of WO1998033470A3 publication Critical patent/WO1998033470A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention involves a method and compositions for use in photodynamic therapy. Novel perylenequinone derivatives, conjugates comprising perylenequinone derivatives and a binding agent, and methods of treatment using these compositions are disclosed.
PCT/US1998/000235 1997-01-10 1998-01-09 Substituted perylenequinones for use in photodynamic therapy WO1998033470A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP98903386A EP1015033A4 (en) 1997-01-10 1998-01-09 Substituted perylenequinones for use in photodynamic therapy
JP53289398A JP2001508071A (en) 1997-01-10 1998-01-09 Substituted perylenequinones for use in photodynamic therapy
AU60171/98A AU6017198A (en) 1997-01-10 1998-01-09 Substituted perylenequinones for use in photodynamic therapy
CA002277362A CA2277362A1 (en) 1997-01-10 1998-01-09 Substituted perylenequinones for use in photodynamic therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78204897A 1997-01-10 1997-01-10
US08/782,048 1997-01-10

Publications (2)

Publication Number Publication Date
WO1998033470A2 WO1998033470A2 (en) 1998-08-06
WO1998033470A3 true WO1998033470A3 (en) 1998-10-29

Family

ID=25124794

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/000235 WO1998033470A2 (en) 1997-01-10 1998-01-09 Substituted perylenequinones for use in photodynamic therapy

Country Status (5)

Country Link
EP (1) EP1015033A4 (en)
JP (1) JP2001508071A (en)
AU (1) AU6017198A (en)
CA (1) CA2277362A1 (en)
WO (1) WO1998033470A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1204423B1 (en) * 1999-08-18 2005-03-16 AltaRex Medical Corp. Therapeutic antibody against muc-1 antigen and methods for their use
US7147850B2 (en) * 1999-08-18 2006-12-12 Altarex Medical Corp. Therapeutic binding agents against MUC-1 antigen and methods for their use
US6627664B2 (en) * 2001-01-30 2003-09-30 Altachem Pharma Ltd. Perylenequinones for use as sonosensitizers
DE60220642T2 (en) * 2001-01-30 2008-02-21 Altachem Pharma Ltd. PERYLENE QUINONE FOR IMMUNOTHERAPEUTIC USE
US7682603B2 (en) * 2003-07-25 2010-03-23 The Trustees Of The University Of Pennsylvania Polymersomes incorporating highly emissive probes
JP5205264B2 (en) 2005-08-10 2013-06-05 クウェスト・ファーマテック・インコーポレイテッド Perylenequinone derivatives and uses thereof
US8454991B2 (en) 2006-07-24 2013-06-04 Quest Pharmatech Inc. Method and device for photodynamic therapy
US7816563B1 (en) * 2009-12-08 2010-10-19 Alberta Innovates-Technology Futures Method for preparing hypocrellin
CN103665050B (en) * 2013-08-29 2016-04-27 西北工业大学 A kind of Phenyl imidazole phenanthroline hypocrellin platinum complex and preparation method thereof
CN110025785A (en) * 2019-05-31 2019-07-19 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 Hypocrellin A is preparing the application in optical dynamic therapy skin candida albicans infection disease medicament

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN88100621A (en) * 1988-02-12 1988-09-07 董国臣 Internal light-activated compounded medicine for cancerociding-immunization

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494793A (en) * 1986-12-15 1996-02-27 British Technology Group Usa Inc. Monomeric phthalocyanine reagents
WO1994016729A1 (en) * 1993-01-28 1994-08-04 Neorx Corporation Targeted nitric oxide pathway or nitric oxide synthase modulation
WO1997024459A1 (en) * 1995-12-29 1997-07-10 Phanos Technologoes, Inc. Method for reducing unwanted cellular adhesions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN88100621A (en) * 1988-02-12 1988-09-07 董国臣 Internal light-activated compounded medicine for cancerociding-immunization

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
SCHINAZI R.F., ET AL.: "ANTHRAQUINONES AS A NEW CLASS OF ANTIVIRAL AGENTS AGAINST HUMAN IMMUNODEFICIENCY VIRUS.", ANTIVIRAL RESEARCH, ELSEVIER BV, NL, vol. 13., 1 January 1990 (1990-01-01), NL, pages 265 - 272., XP002914629, ISSN: 0166-3542, DOI: 10.1016/0166-3542(90)90071-E *
See also references of EP1015033A4 *
ZHENJUN D., LOWN J.W.: "HYPOCRELLINS AND THEIR USE IN PHOTOSENSITIZATION.", PHOTOCHEMISTRY AND PHOTOBIOLOGY, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 52., no. 03., 1 January 1990 (1990-01-01), US, pages 609 - 616., XP002914630, ISSN: 0031-8655, DOI: 10.1111/j.1751-1097.1990.tb01807.x *
ZHENJUN DIWU, CAILAN ZHANG, LOWN J W: "PHOTOSENSITIZATION WITH ANTICANCER AGENTS 18. PERYLENEQUINONOID DERIVATIVES PIGMENTS AS POTENTIAL PHOTODYNAMIC THERAPEUTIC AGENTS: PREPARATION AND PHOTODYNAMIC PROPERTIES OF AMINO-SUBSTITUTED HYPOCRELLIN", ANTI-CANCER DRUG DESIGN, OXFORD UNIVERSITY PRESS, BASINGSTOKE, vol. 08, 1 January 1993 (1993-01-01), BASINGSTOKE, pages 129 - 143, XP002914628, ISSN: 0266-9536 *

Also Published As

Publication number Publication date
AU6017198A (en) 1998-08-25
EP1015033A2 (en) 2000-07-05
WO1998033470A2 (en) 1998-08-06
EP1015033A4 (en) 2000-07-05
CA2277362A1 (en) 1998-08-06
JP2001508071A (en) 2001-06-19

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