WO1998031354A3 - Use of 5-HT2b agonists or potentiators in CNS disorders - Google Patents
Use of 5-HT2b agonists or potentiators in CNS disorders Download PDFInfo
- Publication number
- WO1998031354A3 WO1998031354A3 PCT/EP1998/000380 EP9800380W WO9831354A3 WO 1998031354 A3 WO1998031354 A3 WO 1998031354A3 EP 9800380 W EP9800380 W EP 9800380W WO 9831354 A3 WO9831354 A3 WO 9831354A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- potentiators
- cns disorders
- ht2b
- agonists
- ht2b agonists
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
Abstract
The present invention discloses the use of 5-HT2B agonists or positive allosteric modulators (enhancers) such as paroxetine or BW-723C86 in the treatment of various CNS, affective, behavioral, migraine or feeding disorders, and in particular in depression.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9700899.9 | 1997-01-17 | ||
GBGB9700899.9A GB9700899D0 (en) | 1997-01-17 | 1997-01-17 | Novel treatment |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998031354A2 WO1998031354A2 (en) | 1998-07-23 |
WO1998031354A3 true WO1998031354A3 (en) | 1998-09-17 |
Family
ID=10806125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1998/000380 WO1998031354A2 (en) | 1997-01-17 | 1998-01-13 | Use of 5-ht2b agonists or potentiators in cns disorders |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB9700899D0 (en) |
WO (1) | WO1998031354A2 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000016761A2 (en) | 1998-09-18 | 2000-03-30 | Alcon Laboratories, Inc. | Serotonergic 5ht2 agonists for treating glaucoma |
US6956036B1 (en) | 2000-03-17 | 2005-10-18 | Alcon, Inc. | 6-hydroxy-indazole derivatives for treating glaucoma |
AU2001216035A1 (en) * | 2000-03-17 | 2001-10-03 | Alcon Universal Ltd. | 5-hydroxy indole derivatives for treating glaucoma |
US6806285B1 (en) | 2000-03-17 | 2004-10-19 | Alcon, Inc. | 5-Hydroxyl indole derivatives for treating glaucoma |
AU2001219185A1 (en) | 2000-03-17 | 2001-10-03 | Alcon, Inc. | 2-acylaminobenzimidazole derivatives for treating glaucoma |
US7005443B1 (en) | 2000-03-17 | 2006-02-28 | Alcon, Inc. | 5-Hydroxy indazole derivatives for treating glaucoma |
US7012090B1 (en) | 2000-03-17 | 2006-03-14 | Alcon, Inc. | Pyranoindoles for treating glaucoma |
EP1392658A4 (en) | 2001-06-01 | 2004-10-13 | Alcon Inc | Novel fused indazoles and indoles and their use for the treatment of glaucoma |
EP1392292B1 (en) | 2001-06-01 | 2006-03-01 | Alcon, Inc. | Pyranoindazoles and their use for the treatment of glaucoma |
WO2002098400A1 (en) | 2001-06-01 | 2002-12-12 | Alcon, Inc. | Novel arylaminopropane analogues and their use for the treatment of glaucoma |
TW593302B (en) | 2001-12-20 | 2004-06-21 | Alcon Inc | Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma |
WO2004054572A2 (en) | 2002-12-13 | 2004-07-01 | Alcon, Inc. | Novel benzopyran analogs and their use for the treatment of glaucoma |
AU2004283196B2 (en) | 2003-09-17 | 2011-08-25 | Janssen Pharmaceutica, N.V. | Fused heterocyclic compounds |
WO2005053688A1 (en) | 2003-11-26 | 2005-06-16 | Alcon, Inc. | Substituted furo[2,3-g] indazoles for the treatment of glaucoma |
US7338972B1 (en) | 2003-12-15 | 2008-03-04 | Alcon, Inc. | Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma |
US7129257B1 (en) | 2003-12-15 | 2006-10-31 | Alcon, Inc. | Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma |
TW200520760A (en) | 2003-12-15 | 2005-07-01 | Alcon Inc | Substituted [1,4] oxazino [2,3-g] indazoles for the treatment of glaucoma |
US7425572B2 (en) | 2004-12-08 | 2008-09-16 | Alcon, Inc. | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma |
US7598255B2 (en) | 2005-08-04 | 2009-10-06 | Janssen Pharmaceutica Nv | Pyrimidine compounds as serotonin receptor modulators |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994025012A2 (en) * | 1993-04-28 | 1994-11-10 | Smithkline Beecham Plc | Medicaments for treatment of migraine, epilepsy and feeding disorders |
WO1996029074A1 (en) * | 1995-03-22 | 1996-09-26 | Eli Lilly And Company | Methods of treating or preventing pain or nociception |
-
1997
- 1997-01-17 GB GBGB9700899.9A patent/GB9700899D0/en active Pending
-
1998
- 1998-01-13 WO PCT/EP1998/000380 patent/WO1998031354A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994025012A2 (en) * | 1993-04-28 | 1994-11-10 | Smithkline Beecham Plc | Medicaments for treatment of migraine, epilepsy and feeding disorders |
WO1996029074A1 (en) * | 1995-03-22 | 1996-09-26 | Eli Lilly And Company | Methods of treating or preventing pain or nociception |
Non-Patent Citations (5)
Title |
---|
AINSWORTH K ET AL: "Is #BW# #723C86#-induced hyperphagia an in vivo model of rat central 5-HT-2B receptor function?", BRITISH JOURNAL OF PHARMACOLOGY, 117 (PROC. SUPPL.). 1996. 178P., XP002069367 * |
DUXON ET AL.: "Activation of 5HT-2B receptors in the medial amygdala causes anxiolysis in the social interaction test in the rat", NEUROPHARMACOLOGY, vol. 36, no. 4-5, April 1997 (1997-04-01) - May 1997 (1997-05-01), pages 601 - 608, XP002069368 * |
KENNETT ET AL: "Effects o the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety", BR. J. PHARMACOL., vol. 117, no. 7, April 1996 (1996-04-01), pages 1443 - 1448, XP002069364 * |
KENNETT G A ET AL: "Does chronic administration of paroxetine or the 5-HT-2B receptor agonist, #BW# #723C86#, affect rat 5-HT-2B receptor function?", SOCIETY FOR NEUROSCIENCE ABSTRACTS, 22 (1-3). 1996. 1778., XP002069366 * |
KENNETT GA ET AL: "Effect of chronic administration of selective 5-hydroxytryptamine and noradrenaline uptake inhibitors on a putative index of 5-HT2C/#2B# #receptor# function.", NEUROPHARMACOLOGY, DEC 1994, 33 (12) P1581-8, ENGLAND, XP002069365 * |
Also Published As
Publication number | Publication date |
---|---|
WO1998031354A2 (en) | 1998-07-23 |
GB9700899D0 (en) | 1997-03-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1998031354A3 (en) | Use of 5-HT2b agonists or potentiators in CNS disorders | |
IL158867A0 (en) | Ostepontin and agonists thereof in treatment and/or prevention of neurological diseases | |
EP1040827A3 (en) | Use of 2-alkylpyrrolidines for the treatment of diabetes | |
WO2001079460A3 (en) | Polypeptides having haloperoxidase activity | |
AU2002343557A1 (en) | Substituted aryl 1,4-pyrazine derivatives | |
WO2004047838A3 (en) | Pharmaceutical composition comprising beta-3-adrenoceptor agonists and antimuscarinic agents | |
AU2002339691A1 (en) | Agonists and antagonists of prolixin for the treatment of metabolic disorders | |
ZA989667B (en) | The use of MMP-13 selective inhibitors for the treatment of osteoarthritis and other MMP-mediated disorders. | |
CA2257010A1 (en) | Methods and compositions for the treatment and prevention of tumors, tumor-related disorders and cachexia | |
ZA979961B (en) | 5-HT1F agonists | |
AU1753699A (en) | Application of vasopressin antagonists for treating disturbances or illnesses ofthe inner ear | |
YU13301A (en) | Muscarinic agonists and antagonists | |
EP1724283A3 (en) | Corticotropin releasing factor receptor 2 agonists | |
WO2002039997A3 (en) | Ace-2 modulating compounds and use thereof | |
WO2001015677A3 (en) | Use of 5-ht1b/1d agonists to treat otic pain | |
WO2000040232A3 (en) | Bretylium compositions and kits, and their use in preventing and treating cardiovascular conditions | |
AU2003215190A8 (en) | Methods and compositions for treating aids and hiv-related disorders using 1414, 1481, 1553, 34021, 1720, 1683, 1552, 1682, 1675, 12825, 9952, 5816, 10002, 1611, 1371, 14324, 126, 270, 312, 167, 326, 18926, 6747, 1793, 1784, or 2045 molecules. | |
AU3630297A (en) | Galanin | |
WO2004037168A3 (en) | Treatment of pancreatitis with amylin | |
WO2002003684A3 (en) | Combination for treating psychoses, comprising an antipsychotic and a muscarinic agonist | |
WO2000042201A3 (en) | Human peptidases | |
PL340459A1 (en) | Agonists of 5ht1f | |
AU3896899A (en) | Compositions for the treatment of tumors, and uses thereof | |
WO2004112729A8 (en) | Dual function compounds and uses thereof | |
WO2003059332A3 (en) | Use of an anti-microtubule agent for the treatment of uveitis |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): CA JP US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
NENP | Non-entry into the national phase |
Ref country code: JP Ref document number: 1998533697 Format of ref document f/p: F |
|
122 | Ep: pct application non-entry in european phase |