WO1998028419A3 - Methods and compositions for modulation of vesicular release - Google Patents

Methods and compositions for modulation of vesicular release Download PDF

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Publication number
WO1998028419A3
WO1998028419A3 PCT/US1997/023498 US9723498W WO9828419A3 WO 1998028419 A3 WO1998028419 A3 WO 1998028419A3 US 9723498 W US9723498 W US 9723498W WO 9828419 A3 WO9828419 A3 WO 9828419A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
modulation
compositions
release
complex
Prior art date
Application number
PCT/US1997/023498
Other languages
French (fr)
Other versions
WO1998028419A2 (en
Inventor
Richard H Scheller
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Priority to AU59001/98A priority Critical patent/AU5900198A/en
Publication of WO1998028419A2 publication Critical patent/WO1998028419A2/en
Publication of WO1998028419A3 publication Critical patent/WO1998028419A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Methods of identifying compounds capable of affecting binding of a secretion associated 17S (SA-17S) complex to a syntaxin-containing (SC) complex are disclosed. Compounds identified by such methods are useful for modulating vesicular release, such as release at neural synapses. The invention also includes selected proteins which make up the SA-17S complex.
PCT/US1997/023498 1996-12-20 1997-12-19 Methods and compositions for modulation of vesicular release WO1998028419A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU59001/98A AU5900198A (en) 1996-12-20 1997-12-19 Methods and compositions for modulation of vesicular release

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3390596P 1996-12-20 1996-12-20
US60/033,905 1996-12-20

Publications (2)

Publication Number Publication Date
WO1998028419A2 WO1998028419A2 (en) 1998-07-02
WO1998028419A3 true WO1998028419A3 (en) 1998-08-27

Family

ID=21873133

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/023498 WO1998028419A2 (en) 1996-12-20 1997-12-19 Methods and compositions for modulation of vesicular release

Country Status (2)

Country Link
AU (1) AU5900198A (en)
WO (1) WO1998028419A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU779787B2 (en) * 1999-05-14 2005-02-10 Curagen Corporation Secreted polypeptides and corresponding polynucleotides
EP1198475B1 (en) * 1999-07-23 2005-03-02 Arkion Life Sciences Highly purified cytokine activating factor and methods of use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996015149A2 (en) * 1994-11-10 1996-05-23 University Of Washington Methods and compositions for screening for presynaptic calcium channel blockers

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996015149A2 (en) * 1994-11-10 1996-05-23 University Of Washington Methods and compositions for screening for presynaptic calcium channel blockers

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
HAZUKA C. ET AL.: "Characterization of a cDNA encoding a subunit of the rat brain rsec6/8 complex", GENE, vol. 187, no. 1, March 1997 (1997-03-01), pages 67 - 73, XP002064785 *
HSU S. ET AL.: "The mammalian brain rsec6/8 complex", NEURON, vol. 17, no. 6, December 1996 (1996-12-01), pages 1209 - 1219, XP002064780 *
KEE Y. ET AL.: "Subunit structure of the mammalian exocyst complex", PNAS,U.S.A., vol. 94, no. 26, 23 December 1997 (1997-12-23), pages 14438 - 14443, XP002064786 *
PEVSNER J. ET AL.: "Specificity and regulation of a synaptic vesicle docking complex", NEURON, vol. 13, no. 2, August 1994 (1994-08-01), pages 353 - 361, XP002064782 *
SCHELLER R.: "Membrane trafficking in the presynaptic nerve terminal", NEURON, vol. 14, no. 5, May 1995 (1995-05-01), pages 893 - 897, XP002064783 *
TERBUSH D. ET AL.: "The exocyst is a multiprotein complex required for exocytosis in saccharomyces cerevisiae", THE EMBO JOURNAL, vol. 15, no. 23, 1996, pages 6483 - 6494, XP002064784 *
TING A. ET AL.: "rSec6 and rSec8, mammalian homologs of yeast proteins essential for secretion", PNAS,U.S.A., vol. 92, no. 21, 10 October 1995 (1995-10-10), pages 9613 - 9617, XP002064781 *

Also Published As

Publication number Publication date
AU5900198A (en) 1998-07-17
WO1998028419A2 (en) 1998-07-02

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