WO1998028419A3 - Methods and compositions for modulation of vesicular release - Google Patents
Methods and compositions for modulation of vesicular release Download PDFInfo
- Publication number
- WO1998028419A3 WO1998028419A3 PCT/US1997/023498 US9723498W WO9828419A3 WO 1998028419 A3 WO1998028419 A3 WO 1998028419A3 US 9723498 W US9723498 W US 9723498W WO 9828419 A3 WO9828419 A3 WO 9828419A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- modulation
- compositions
- release
- complex
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Methods of identifying compounds capable of affecting binding of a secretion associated 17S (SA-17S) complex to a syntaxin-containing (SC) complex are disclosed. Compounds identified by such methods are useful for modulating vesicular release, such as release at neural synapses. The invention also includes selected proteins which make up the SA-17S complex.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU59001/98A AU5900198A (en) | 1996-12-20 | 1997-12-19 | Methods and compositions for modulation of vesicular release |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3390596P | 1996-12-20 | 1996-12-20 | |
US60/033,905 | 1996-12-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998028419A2 WO1998028419A2 (en) | 1998-07-02 |
WO1998028419A3 true WO1998028419A3 (en) | 1998-08-27 |
Family
ID=21873133
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/023498 WO1998028419A2 (en) | 1996-12-20 | 1997-12-19 | Methods and compositions for modulation of vesicular release |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU5900198A (en) |
WO (1) | WO1998028419A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU779787B2 (en) * | 1999-05-14 | 2005-02-10 | Curagen Corporation | Secreted polypeptides and corresponding polynucleotides |
EP1198475B1 (en) * | 1999-07-23 | 2005-03-02 | Arkion Life Sciences | Highly purified cytokine activating factor and methods of use |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996015149A2 (en) * | 1994-11-10 | 1996-05-23 | University Of Washington | Methods and compositions for screening for presynaptic calcium channel blockers |
-
1997
- 1997-12-19 WO PCT/US1997/023498 patent/WO1998028419A2/en active Application Filing
- 1997-12-19 AU AU59001/98A patent/AU5900198A/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996015149A2 (en) * | 1994-11-10 | 1996-05-23 | University Of Washington | Methods and compositions for screening for presynaptic calcium channel blockers |
Non-Patent Citations (7)
Title |
---|
HAZUKA C. ET AL.: "Characterization of a cDNA encoding a subunit of the rat brain rsec6/8 complex", GENE, vol. 187, no. 1, March 1997 (1997-03-01), pages 67 - 73, XP002064785 * |
HSU S. ET AL.: "The mammalian brain rsec6/8 complex", NEURON, vol. 17, no. 6, December 1996 (1996-12-01), pages 1209 - 1219, XP002064780 * |
KEE Y. ET AL.: "Subunit structure of the mammalian exocyst complex", PNAS,U.S.A., vol. 94, no. 26, 23 December 1997 (1997-12-23), pages 14438 - 14443, XP002064786 * |
PEVSNER J. ET AL.: "Specificity and regulation of a synaptic vesicle docking complex", NEURON, vol. 13, no. 2, August 1994 (1994-08-01), pages 353 - 361, XP002064782 * |
SCHELLER R.: "Membrane trafficking in the presynaptic nerve terminal", NEURON, vol. 14, no. 5, May 1995 (1995-05-01), pages 893 - 897, XP002064783 * |
TERBUSH D. ET AL.: "The exocyst is a multiprotein complex required for exocytosis in saccharomyces cerevisiae", THE EMBO JOURNAL, vol. 15, no. 23, 1996, pages 6483 - 6494, XP002064784 * |
TING A. ET AL.: "rSec6 and rSec8, mammalian homologs of yeast proteins essential for secretion", PNAS,U.S.A., vol. 92, no. 21, 10 October 1995 (1995-10-10), pages 9613 - 9617, XP002064781 * |
Also Published As
Publication number | Publication date |
---|---|
AU5900198A (en) | 1998-07-17 |
WO1998028419A2 (en) | 1998-07-02 |
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