WO1998026811A2

WO1998026811A2 - Releasable adhesive closure

Info

Publication number: WO1998026811A2
Application number: PCT/US1997/023587
Authority: WO
Inventors: Theodore L. Parker; Thomas C. Wehman
Original assignee: Vidacare International, Inc.
Priority date: 1996-12-18
Filing date: 1997-12-18
Publication date: 1998-06-25
Also published as: AU5803498A; WO1998026811A3

Abstract

A wound closure patch includes an adhesive and a detackifying agent. The detackifying agent is activated by heat, cold, intense light, or a chemical reagent and can be in a surrounding relationship to a non-adhesive area. The non-adhesive area permits the wound to breathe. The wound closure patch may include a gas permeable cover.

Description

RELEASABLE ADHESIVE CLOSURE

CROSS-REFERENCE TO RELATED APPLICATION This application claims priority to the U.S. provisional application entitled RELEASABLE ADHESIVE CLOSURE, Serial No. 60/033,185, filed December 18, 1996, and invented by Theodore L. Parker and Thomas C. Wehman.

BACKGROUND OF THE INVENTION

Field of the Invention

This invention relates generally to a wound closure patch, and more particularly to a wound closure patch that includes an adhesive with a detackifying agent that is activated by heat, cold, intense light, or a chemical reagent.

Description of Related Art

Often it is necessary to very quickly stop bleeding from an artery during surgery as well as other times when the artery has been nicked. One method of stopping blood flow from the artery is to apply pressure directly to the artery with the use of one's finger.

Mechanical devices for effecting non-invasive compression of arteries include the use of pressure cuffs. Typically, the cuff includes a strip of non- elastic material to be wrapped around a limb. An elastic inflatable bladder is superimposed on the non-elastic material. When the bladder is inflated, pressure exerted by all parts of the enwrapment on the limb is increased. U.S. Patent No. 3,171,410 discloses a pneumatic dressing which exemplifies traditional pressure cuff devices. Other mechanical devices have been used for decades to achieve hemostasis. Many of these have been based on a C- or U-shaped clamp that use a ratcheting effect to allow the operator to apply or release pressure to the puncture site. These clamps have proven to be efficient alternatives to manual compression for control of bleeding after the removal of transfemoral sheaths.

One C-clamp device features a rigid footplate, as disclosed in U.S. Patent No. 3,799,249 (hereafter the '249 patent). The apparatus of the '249 patent is used to exert non-calibrated and unevenly distributed pressure to the body surface overlying an artery. The use of C-clamps can also cause hematomas and they can only be used for a limited time.

U.S. Patent No. 3,625,219 discloses a transparent rubber membrane clamped to a transparent plastic plate to form an expandable pressure chamber. Clamping screws are used to maintain various members of the chamber support structure in place, and must be loosened to adjust the position of the chamber relative the area to which pressure is to applied.

Further, another type of mechanical device is disclosed in U.S. Patent Number 4,233,980 (hereafter the '980 patent). In the '980 patent, an inflatable bladder is formed with two sheets of transparent, non-elastic material that provide lateral restraint. The bladder is inflated by the introduction of a fluid. Vertical expansion is accomplished by the separation of the two sheets of material due to inflation. The bladder is typically mounted on a pressure plate. The pressure plate is mounted on a positioning arm.

Pressure-sensitive adhesives (hereafter PSAs) are used for a variety of industrial, consumer and medical applications. PSAs are characterized as being normally tacky and exhibit instant tack when applied to a substrate. A variety of polymers have been used to manufacture PSAs, for example acrylic and methacrylic ester homo- or copolymers, butyl rubber-based systems, silicones, urethanes, vinyl esters and amides, olefin copolymer materials, natural or synthetic rubbers, and the like. Flexible polymeric film materials are also known such as described in

European Patent Application Nos. 0107915 and 0147119 and PCT/GB91/00496, all of which are incorporated herein by reference, to disclose materials with particular moisture vapor transmission rates which might be used as backing materials in connection with the certain aspects of the present invention. Film materials which have moisture vapor transmission rates generally compatible with human skin are most preferred.

S.C. Temin, Encyclopedia of Polymer Science and Engineering, Vol. 13, at 345-68 (1988), and Handbook of Pressure-Sensitive Adhesive Technology (Donates Satas ed., 1982) both provide a comprehensive overview of medical and other adhesives, and are incorporated herein by reference. A PCT publication WO91/14462, published October 3, 1991, refers to medical devices comprised of a substrate with a particular moisture vapor transmission rate with an adhesive thereon which is tacky at skin temperature but less tacky or not tacky at room temperature. A similar medical adhesive device is disclosed in WO91/14461. The disclosure of both of these PCT publications is incorporated herein by reference to the extent they disclose such devices including particular backing layers, adhesives, and methods of use and manufacture.

It would be desirable to provide a wound healing patch with an adhesive that loses its tackifying properties upon the application of heat, cold, intense light, or a chemical reagent.

SUMMARY OF THE INVENTION An object of the present invention is to provide a wound closure patch that includes a detackifying agent. Another object of the present invention is to provide a wound closure patch which includes an adhesive and a detackifying agent that is activated by heat, cold, intense light, or a chemical reagent.

It is a further object of this invention to provide a wound closure patch that includes an adhesive and a detackifying agent. The detackifying agent is activated by heat, cold, intense light, or a chemical reagent, and can be in a surrounding relationship to a non-adhesive area. The non-adhesive area permits the wound to breathe. The wound closure patch may include a gas permeable cover.

These and other objects of the invention will become more apparent from the following description and the accompanying drawings.

BRIEF DESCRIPTION OF THE FIGURES FIG. 1 illustrates a perspective view of one embodiment of the wound closure patch formed in accordance with the concepts of the present invention. FIG. 2 illustrates another embodiment of the wound closure patch of the present invention with an adhesive surrounding a non-adhesive area.

FIG. 3 illustrates another aspect of the present invention directed to the removal of an activated wound closure patch.

DETAILED DESCRIPTION

Referring now to FIGURE 1, one embodiment of a wound closure patch 10 of the present invention is shown. Wound closure patch 10 is comprised of a non-adhesive strip 12 with an adhesive strip 14 on either side. Adhesive strip 14 contains a pressure sensitive adhesive which is tenacious in the presence of water or blood. The pressure sensitive adhesive may be a cyanoacrylate adhesive, but may also be any other adhesive suitable for use at a wound site. Adhesive strip 14 also contains a detackifying agent 16 which makes it easy to remove the strip from the wound site when necessary. Detackifying agent 16 is activated by heat, cold, intense light, or a chemical reagent. Non-adhesive strip 12 allows the wound or puncture to breathe.

Referring to FIGURE 2, another embodiment of wound closure patch 10 of the present invention is shown. A square shaped wound closure patch 10 is shown but wound closure patch 10 may of course be formed into many different shapes and sizes, to provide for the best fit over the wound site. For example, wound closure patch 10 may come in circular or butterfly shapes, suitable for use on circular wound sites or on joints. Wound closure patch 10 may also come in several different thicknesses, depending on the application and the amount of blood or other bodily fluids which may need to be absorbed. The wound closure patch 10 shown in FIGURE 2 also includes adhesive area 24 surrounding non- adhesive area 22. Disposed over adhesive area 24 is a transparent adhesive cover 28. Transparent adhesive cover 28 is gas permeable and will offer some protection to the wound by preventing the entry of bacteria. An antiseptic or antibiotic healing enhancer can be impregnated into the adhesive area 24. Adhesive area 24 contains the same type of adhesive as adhesive strip 14, and adheres until commanded to release by way of heat, cold, intense light, or chemical reagent.

Referring to FIGURE 3, adhesive strip 14 may be removed by an intense light source 30, which causes the adhesive in adhesive strip 14 to detackify. Other embodiments, not shown, may use heat, cold, a chemical reagent like EDTA (ethylenediamine tetraacetic acid), or a solution of calciumides or sodiumides to cause the adhesive to detackify and lose its adhesive properties.

Another aspect of the present invention includes a method of applying and removing a releasable adhesive closure. After a wound and adjacent wound site are cleaned and repaired, a wound closure patch 10 of suitable shape and size may be selected to be placed over the wound. Non-adhesive area 22 is placed directly over the wound, to avoid wound closure patch 10 from sticking to the wound. Adhesive area 24 is then placed at a periphery of the wound, to at least partially surround the wound and prevent entry of bacteria and other contaminants. Adhesive area 24 will adhere to the periphery of the wound, because its adhesive is pressure sensitive, or activated by some other method such as heat or light. When wound closure patch 10 needs to be removed as shown in FIGURE 3, detackifying agent 16 contained in wound closure patch 10 is activated. As discussed earlier, this activation may occur by heat, cold, intense light, or chemical reagent. Activation of detackifying agent 16 may include other suitable methods known in the art according to the particular detackifying agent 16 used. In this way, wound closure patch 10 can be easily removed, avoiding discomfort to the patient and additional trauma to the wound site. The foregoing description of a preferred embodiment of the invention has been presented for purposes of illustration and description. It is not intended to be exhaustive or to limit the invention to the precise forms disclosed. Obviously, many modifications and variations will be apparent to practitioners skilled in this art. It is intended that the scope of the invention be defined by the following claims and their equivalents.

What is claimed is:

Claims

1. A wound closure patch for closing a wound at a wound site, comprising: a non-adhesive area configured to be placed over the wound, the non- adhesive area allowing the wound to breathe; and an adhesive area configured to be placed over the wound site, the adhesive area containing a detackifying agent for detackifying the adhesive area for easy release from the wound site.

2. The wound closure patch of claim 1, wherein the adhesive area contains a pressure sensitive adhesive.

3. The wound closure patch of claim 1, wherein the adhesive area is impregnated with an antiseptic.

4. The wound closure patch of claim 1, wherein the adhesive area is impregnated with an antibiotic healing enhancer.

5. The wound closure patch of claim 1, wherein the detackifying agent is activated by heat.

6. The wound closure patch of claim 1, wherein the detackifying agent is activated by cold.

7. The wound closure patch of claim 1, wherein the detackifying agent is activated by intense light.

8. The wound closure patch of claim 1, wherein the detackifying agent is activated by a chemical reagent.

9. The wound closure patch of claim 8, wherein the chemical reagent is EDTA (ethylenediamine tetraacetic acid).

10. The wound closure patch of claim 8, wherein the chemical reagent is a solution of calciumides.

11. The wound closure patch of claim 8, wherein the chemical reagent is a solution of sodiumides.

12. The wound closure patch of claim 1, wherein the adhesive area includes two adhesive strips on either side of the non-adhesive area.

13. The wound closure patch of claim 1, wherein the adhesive area surrounds the non-adhesive area.

14. The wound closure patch of claim 1, further comprising an adhesive cover positioned over the non-adhesive area and the adhesive area.

15. The wound closure patch of claim 14, wherein the adhesive cover is gas permeable.

16. A wound closure patch for closing a wound at a wound site, comprising: a non-adhesive area configured to be placed over the wound, the non- adhesive area allowing the wound to breathe; an adhesive area having adhesive properties and configured to be placed over the wound site, the adhesive area containing a pressure sensitive adhesive; and a detackifying agent micro-encapsulated in the adhesive area, the detackifying agent capable of causing the adhesive area to lose its adhesive properties when the detackifying agent is activated.

17. The wound closure patch of claim 16, wherein the detackifying agent is activated by heat.

18. The wound closure patch of claim 16, wherein the detackifying agent is activated by cold.

19. The wound closure patch of claim 16, wherein the detackifying agent is activated by intense light.

20. The wound closure patch of claim 16, wherein the detackifying agent is activated by a chemical reagent.

21. The wound closure patch of claim 20, wherein the chemical reagent is EDTA (ethylenediamine tetraacetic acid).

22. The wound closure patch of claim 20, wherein the chemical reagent is a solution of calciumides.

23. The wound closure patch of claim 20, wherein the chemical reagent is a solution of sodiumides.

24. The wound closure patch of claim 16, wherein the adhesive area includes two adhesive strips on either side of the non-adhesive area.

25. The wound closure patch of claim 16, wherein the adhesive area surrounds the non-adhesive area.

26. The wound closure patch of claim 16, further comprising an adhesive cover positioned over the non-adhesive area and the adhesive area.

27. The wound closure patch of claim 26, wherein the adhesive cover is gas permeable.

28. A wound closure patch for closing a wound at a wound site, comprising: a non-adhesive area configured to be placed over the wound, the non- adhesive area not sticking to the wound and allowing the wound to breathe; an adhesive area having a pressure sensitive adhesive with adhesive properties, the adhesive area configured to be placed over the wound site; a detackifying agent micro-encapsulated in the adhesive area, the detackifying agent capable of causing the pressure sensitive adhesive to lose its adhesive properties when the detackifying agent is activated; and an adhesive cover positioned over the non-adhesive and adhesive areas, the adhesive cover being gas permeable.

29. The wound closure patch of claim 16, wherein the detackifying agent is activated by heat.

30. The wound closure patch of claim 16, wherein the detackifying agent is activated by cold.

31. The wound closure patch of claim 16, wherein the detackifying agent is activated by intense light.

32. The wound closure patch of claim 16, wherein the detackifying agent is activated by a chemical reagent.

33. The wound closure patch of claim 20, wherein the chemical reagent is EDTA (ethylenediamine tetraacetic acid).

34. The wound closure patch of claim 20, wherein the chemical reagent is a solution of calciumides.

35. The wound closure patch of claim 20, wherein the chemical reagent is a solution of sodiumides.

36. The wound closure patch of claim 16, wherein the adhesive area includes two adhesive strips on either side of the non-adhesive area.

37. The wound closure patch of claim 16, wherein the adhesive area surrounds the non-adhesive area.