WO1998026091A3 - Method and kit for HLA class I typing - Google Patents

Method and kit for HLA class I typing Download PDF

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Publication number
WO1998026091A3
WO1998026091A3 PCT/CA1997/000955 CA9700955W WO9826091A3 WO 1998026091 A3 WO1998026091 A3 WO 1998026091A3 CA 9700955 W CA9700955 W CA 9700955W WO 9826091 A3 WO9826091 A3 WO 9826091A3
Authority
WO
WIPO (PCT)
Prior art keywords
hla class
typing
kit
subject
group
Prior art date
Application number
PCT/CA1997/000955
Other languages
French (fr)
Other versions
WO1998026091A2 (en
Inventor
Rainer H Blaszcyk
James Leushner
Original Assignee
Visible Genetics Inc
Rainer H Blaszcyk
James Leushner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Visible Genetics Inc, Rainer H Blaszcyk, James Leushner filed Critical Visible Genetics Inc
Priority to CA002274737A priority Critical patent/CA2274737A1/en
Priority to AU53964/98A priority patent/AU5396498A/en
Publication of WO1998026091A2 publication Critical patent/WO1998026091A2/en
Publication of WO1998026091A3 publication Critical patent/WO1998026091A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to methods and materials for determining the HLA Class I type of a subject, wherein group-specific sequences are used to design primer molecules which may be used in amplification protocols which accurately identify the HLA group(s) and/or allele(s) carried by the subject.
PCT/CA1997/000955 1996-12-12 1997-12-12 Method and kit for hla class i typing WO1998026091A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002274737A CA2274737A1 (en) 1996-12-12 1997-12-12 Method and kit for hla class i typing
AU53964/98A AU5396498A (en) 1996-12-12 1997-12-12 Method and kit for hla class i typing

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76618996A 1996-12-12 1996-12-12
US08/766,189 1996-12-12

Publications (2)

Publication Number Publication Date
WO1998026091A2 WO1998026091A2 (en) 1998-06-18
WO1998026091A3 true WO1998026091A3 (en) 1998-09-17

Family

ID=25075674

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1997/000955 WO1998026091A2 (en) 1996-12-12 1997-12-12 Method and kit for hla class i typing

Country Status (3)

Country Link
AU (1) AU5396498A (en)
CA (1) CA2274737A1 (en)
WO (1) WO1998026091A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19715430A1 (en) * 1997-04-14 1998-11-26 Boehringer Mannheim Gmbh Method for typing alleles
ES2256953T3 (en) * 1997-07-23 2006-07-16 Rijksuniversiteit Leiden TYPE PROCEDURE FOR THE LOWEST HISTOCOMPATIBILITY ANTIGEN HA-1.
US5910413A (en) * 1997-10-10 1999-06-08 Visible Genetics, Inc. Method and kit for amplification, sequencing and typing of classical HLA class I genes
EP0953650A1 (en) 1998-04-20 1999-11-03 Innogenetics N.V. Method for typing of HLA alleles
US6790616B1 (en) 1998-11-26 2004-09-14 Shionogi & Co., Ltd. Method for typing of HLA class I alleles
ATE478961T1 (en) * 1999-04-09 2010-09-15 Innogenetics Nv METHOD FOR AMPLIFICATION OF HLA CLASS I ALLELES
US8236771B2 (en) 2004-05-18 2012-08-07 National Institute Of Transplantation Foundation Vectors and methods for long-term immune evasion to prolong transplant viability
US20160312281A1 (en) * 2013-12-10 2016-10-27 Conexio Genomics Pty Ltd Methods and probes for identifying gene alleles

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0414469A2 (en) * 1989-08-25 1991-02-27 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
WO1992019771A1 (en) * 1991-05-08 1992-11-12 Regents Of The University Of Minnesota Dna sequence-based hla class i typing method
EP0540997A1 (en) * 1991-11-05 1993-05-12 F. Hoffmann-La Roche Ag Methods and reagents for HLA class I DNA typing
DE4411594C1 (en) * 1994-03-30 1995-12-14 Deutsches Rheumaforschungszent Test kit for detecting HLA gene alleles by PCR amplification
WO1995033855A1 (en) * 1994-06-03 1995-12-14 Ludwig Institute For Cancer Research Isolated nucleic acid molecule which codes for a tumor rejection antigen precursor, and uses thereof
WO1997020197A2 (en) * 1995-11-29 1997-06-05 The Anthony Nolan Bone Marrow Trust Method for identifying an unknown allele
WO1997023645A1 (en) * 1996-01-04 1997-07-03 Sloan-Kettering Institute For Cancer Research Methods and reagents for typing hla class i genes
WO1997031126A1 (en) * 1996-02-20 1997-08-28 The Perkin-Elmer Corporation Methods and reagents for typing hla class i genes
WO1997031017A1 (en) * 1996-02-20 1997-08-28 Ludwig Institute For Cancer Research Tumor rejection antigens presented by hla-b44 molecules, and uses thereof
WO1997041259A1 (en) * 1996-05-01 1997-11-06 Visible Genetics Inc. Method for sequencing of nucleic acid polymers

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0414469A2 (en) * 1989-08-25 1991-02-27 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
WO1992019771A1 (en) * 1991-05-08 1992-11-12 Regents Of The University Of Minnesota Dna sequence-based hla class i typing method
US5424184A (en) * 1991-05-08 1995-06-13 Regents Of The University Of Minnesota DNA sequence-based HLA class I typing method
EP0540997A1 (en) * 1991-11-05 1993-05-12 F. Hoffmann-La Roche Ag Methods and reagents for HLA class I DNA typing
US5451512A (en) * 1991-11-05 1995-09-19 Hoffmann-La Roche Inc. Methods and reagents for HLA class I A locus DNA typing
DE4411594C1 (en) * 1994-03-30 1995-12-14 Deutsches Rheumaforschungszent Test kit for detecting HLA gene alleles by PCR amplification
WO1995033855A1 (en) * 1994-06-03 1995-12-14 Ludwig Institute For Cancer Research Isolated nucleic acid molecule which codes for a tumor rejection antigen precursor, and uses thereof
WO1997020197A2 (en) * 1995-11-29 1997-06-05 The Anthony Nolan Bone Marrow Trust Method for identifying an unknown allele
WO1997023645A1 (en) * 1996-01-04 1997-07-03 Sloan-Kettering Institute For Cancer Research Methods and reagents for typing hla class i genes
WO1997031126A1 (en) * 1996-02-20 1997-08-28 The Perkin-Elmer Corporation Methods and reagents for typing hla class i genes
WO1997031017A1 (en) * 1996-02-20 1997-08-28 Ludwig Institute For Cancer Research Tumor rejection antigens presented by hla-b44 molecules, and uses thereof
WO1997041259A1 (en) * 1996-05-01 1997-11-06 Visible Genetics Inc. Method for sequencing of nucleic acid polymers

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BLASCZYK R ET AL: "COMPLETE SUBTYPING OF THE HLA-A LOCUS BY SEQUENCE-SPECIFIC AMPLIFICATION FOLLOWED BY DIRECT SEQUENCING OR SINGLE-STRAND CONFORMATION POLYMORPHISM ANALYSIS", TISSUE ANTIGENS, vol. 46, no. 2, 1 August 1995 (1995-08-01), pages 86 - 95, XP000573581 *
BLASCZYK R ET AL: "SEQUENCE ANALYSIS OF THE 2ND INTRON REVEALED COMMON SEQUENCE MOTIFS PROVIDING THE MEANS FOR A UNIQUE SEQUENCING BASED TYPING PROTOCOL OF THE HLA-A LOCUS", TISSUE ANTIGENS, vol. 47, no. 2, 1 February 1996 (1996-02-01), pages 102 - 110, XP000573588 *
CEREB ET AL.: "DIMORPHIC PRIMERS DERIVED FROM INTRON 1 FOR USE IN THE MOLECULAR TYPING OF HLA-B ALLELES", TISSUE ANTIGENS, vol. 50, 1997, pages 74 - 76, XP002070448 *
CEREB ET AL.: "ERRATUM", TISSUE ANTIGENS, vol. 48, no. 3, September 1996 (1996-09-01), pages 235 - 236 *
CEREB ET AL.: "LOCUS-SPECIFIC CONSERVATION OF THE HLA CLASS I INTRONS BY INTRA-LOCUS HOMOGENIZATION", IMMUNOGENETICS, vol. 47, 1997, pages 30 - 36, XP002070447 *
CEREB ET AL.: "NUCLEOTIDE SEQUENCES OF MHC CLASS I INTRONS 1,2, AND 3 IN HUMANS AND INTRON 2 IN NONHUMAN PRIMATES", TISSUE ANTIGENS, vol. 47, no. 6, June 1996 (1996-06-01), pages 498 - 511, XP002070446 *
CEREB N ET AL: "LOCUS-SPECIFIC AMPLIFICATION OF HLA CLASS I GENES FROM GENOMIC DNA: LOCUS-SPECIFIC SEQUENCES IN THE FIRST AND THIRD INTRONS OF HLA-A, -B, AND -C ALLELES", TISSUE ANTIGENS, vol. 45, 1995, pages 1 - 11, XP000197333 *
KOTSCH ET AL.: "SEQUENCING OF HLA CLASS I GENES BASED ON THE CONSERVED DIVERSITY OF THE NONCODING REGIONS: SEQUENCING-BASED TYPING OF THE HLA-A GENE", TISSUE ANTIGENS, vol. 50, no. 2, August 1997 (1997-08-01), pages 178 - 191, XP002070449 *
KRAUSA P ET AL: "GENETIC POLYMORPHISM WITHIN HLA-A*02: SIGNIFICANT ALLELIC VARIATION REVEALED IN DIFFERENT POPULATIONS", TISSUE ANTIGENS, vol. 45, no. 4, 1 April 1995 (1995-04-01), pages 223 - 231, XP000573595 *

Also Published As

Publication number Publication date
AU5396498A (en) 1998-07-03
CA2274737A1 (en) 1998-06-18
WO1998026091A2 (en) 1998-06-18

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