WO1998025659A1 - Syringe with collapsible plunger tip - Google Patents
Syringe with collapsible plunger tip Download PDFInfo
- Publication number
- WO1998025659A1 WO1998025659A1 PCT/US1997/022247 US9722247W WO9825659A1 WO 1998025659 A1 WO1998025659 A1 WO 1998025659A1 US 9722247 W US9722247 W US 9722247W WO 9825659 A1 WO9825659 A1 WO 9825659A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- syringe
- leading
- plunger
- tip
- plunger tip
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150213—Venting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150236—Pistons, i.e. cylindrical bodies that sit inside the syringe barrel, typically with an air tight seal, and slide in the barrel to create a vacuum or to expel blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150244—Rods for actuating or driving the piston, i.e. the cylindrical body that sits inside the syringe barrel, typically with an air tight seal, and slides in the barrel to create a vacuum or to expel blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150763—Details with identification means
- A61B5/150778—Details with identification means having complementary physical shapes for indexing or registration purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3123—Details having air entrapping or venting means, e.g. purging channels in pistons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31501—Means for blocking or restricting the movement of the rod or piston
- A61M5/31505—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit
- A61M2005/31506—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit formed as a single piece, e.g. moulded
Definitions
- the present invention relates to blood collection syringes and to plunger tips for blood collection syringes. More particularly, the present invention relates to techniques for minimizing contact of blood collected in a blood collection syringe with extraneous gases.
- Another technique used to remove extraneous gases from biood collected in a blood collection syringe is the removal of gases during sample collection through passageways in the plunger tip into an interior chamber of the plunger tip and then out past the plunger rod through the rear port in the syringe barrel.
- a reactive material is placed in the passageways that seals upon contact with blood or other physiological fluid.
- the syringe plunger is set in a retracted position prior to sample collection, and blood and gases fill the syringe under arterial pressure. Gases flow along the passageways and into the interior of the plunger tip until blood contacts the reactive material in the passageway. At that point, a barrier is formed in which neither gases nor blood flows beyond the plunger tip.
- the foregoing technique is limited by the possibility that premature contact of the reactive material with blood may cause the passageways to occlude before all extraneous gases are removed from the barrel of the syringe. This can occur, for example, when the syringe is held in an improper orientation.
- gas exchange may well take place at the beginning of sampling, when both blood and air are passing into the barrel of the syringe.
- some gas exchange may well take place in the passageways, adjacent the reactive material, after blood collection is complete. For these reasons, the technique does not prevent all contact of the blood sample with extraneous gases.
- Another limitation to syringe configurations where initial blood flow is trapped inside a reactive membrane is that anticoagulant present in the syringe reacts with the first blood introduced into the syringe. This same blood then flows into passageways, interior chambers, and/or reactive membranes, where it is effectively separated from the blood subsequently collected in the syringe. The blood which is subsequently collected in the syringe may not come into contact with anticoagulant. The net result is that waste blood initially collected is fully anticoagulated, and blood subsequently collected is insufficiently anticoagulated.
- plunger tip designs are often modified to accommodate specially shaped air permeable membranes, hydrophobic materials and membranes, liquid reactive materials, and the like.
- the plunger tips are not integrally formed, but rather are a combination of two or more pieces. Such designs require additional assembly, which adds to the both the labor and materials costs of blood collection syringes.
- a fluid collection technique of the present invention minimizes contact of the fluid during and after collection with extraneous gases.
- a plunger tip is mounted on a plunger positioned in a syringe barrel.
- the plunger tip includes a hollow sealing member having leading and trailing members with a resilient wall extending therebetween.
- An interior chamber is defined by the wall and the leading and trailing members.
- Circumferential sealing rings extend from the leading and trailing member for sealing engagement with the syringe barrel. At least one slit is formed in and extends through the leading member.
- the plunger is first fully extended to the head of the syringe barrel until the resilient wall of the plunger tip collapses and the leading and trailing members of the plunger tip are adjacent to each other. Upon collapse of the resilient wall of the plunger tip, the volume of the interior chamber becomes minimized.
- FIG. 1 is an isometric view of a fluid collection syringe of the present invention, including a preferred plunger tip, wherein contact of the fluid to be collected with extraneous gases is prevented.
- FIG. 2 is an exploded view of the syringe shown in FIG. 1.
- FIG. 3 is an isometric view of the plunger tip component of the syringe shown in FIG. 1.
- FIG. 4 is a vertical section view of the plunger tip shown in FIGS.
- FIG. 5 is a vertical section view of the syringe shown in FIGS. 1 and 2, showing the plunger tip fully inserted to the leading wall of the syringe barrel, with the walls of the plunger tip compressed, the volume of the interior chamber of the plunger tip minimized, and air previously residing in the interior chamber expelled out the syringe tip.
- FIG. 6 is a vertical section view of the syringe shown in FIG. 5 after the syringe has been connected to a tube containing fluid to be collected in the syringe, the plunger tip has been released and gases in the tip of the syringe and leading fluid in the tube has collected in the interior chamber of the plunger tip.
- FIG. 7 is a vertical section view of the syringe shown in FIG. 6 after the plunger assembly of the syringe has been drawn rearwardly and fluid has been collected in the syringe barrel.
- FIG. 8 is an isometric view of an alternative embodiment of a plunger tip of the present invention.
- FIG. 9 is an isometric view of an alternative embodiment of a syringe of the present invention containing the alternative embodiment of the plunger tip shown in FIG. 8, along with an alternative plunger rod containing a plurality of longitudinal ribs.
- DETAILED DESCRIPTION A presently preferred embodiment of a syringe 20 and a plunger tip 22 of the present invention adapted for collecting blood for subsequent chemical analysis is illustrated in FIGS. 1 -7.
- syringe 20 includes a tubular barrel 24 defining an elongated and generally cylindrical blood collection chamber 26 having a diameter D1. Barrel 24 of syringe 20 tapers at its forward end to form a leading barrel wall 28.
- a hollow syringe tip 30 Extending centrally and outwardly from leading barrel wall 28 is a hollow syringe tip 30 which terminates in a delivery port 32.
- a leading portion 34 of collection chamber 26 is that portion of the collection chamber 26 adjacent leading wall 28.
- a tip portion 35 of collection chamber 26 is that portion of collection chamber 26 circumscribed by hollow syringe tip 30.
- Extending inwardly from barrel 24 into collection chamber 26 are a pair of spaced apart, ridge-like barrel stops 36 spaced apart a distance of arc length A1 .
- Barrel 24 terminates at its back end at a rear port 37 from which outwardly extend transverse and opposing barrel flanges 38.
- Rear port 37 is sized to receive an elongated syringe plunger 40 to which plunger tip 22 is mounted, as is described in further detail below.
- syringe 20 and its components are described herein with reference to leading, rear, forward, backward, and the like, such modifiers are for convenience in describing the orientation of such components relative to each other. In actual use when plunger tip 22 is assembled on plunger 40 and plunger 40 is inserted in syringe 20, syringe 20 can be operated in most any orientation.
- plunger tip 22 essentially comprises a hollow sealing member 42.
- Sealing member 42 includes a leading member 44 having an exterior surface 46, an interior surface 48, and a circumferential outer edge 49.
- An annular leading sealing ring 50 having a diameter D2 is formed in leading member 44, with leading sealing ring 50 preferably coextensive with outer edge 49.
- Sealing member 42 also includes a trailing member 52 having an outer surface 54 and an inner surface 56.
- An annular trailing sealing ring 58 having a diameter D3 is formed in trailing member 52.
- a thin, flexible and resilient plunger tip wall 60 of thickness T1 extends from leading member 44 to trailing member 52, defining therebetween an interior chamber 62 of the sealing member 42.
- Plunger tip 22 is preferably made from a thermoplastic elastomer such as Kraton TM or other resilient material.
- Leading member 44 of plunger tip 22 is preferably conical, conforming generally with leading wall 28 of syringe barrel 24.
- a plurality of slits 66 are also formed in leading member 44, with slits 66 extending from exterior surface 46 to interior surface 48.
- slits 66 each radially extend from adjacent depression 64 towards circumferential outer edge 49 of leading member 44.
- Trailing member 52 of plunger tip 22 is preferably disk-shaped and includes an aperture 70 extending from inner surface 56 to outer surface 54.
- Aperture 70 is defined by a collar 72 and has an aperture diameter D4.
- An inner rim 74 of collar 72 has a thickness T2 and surrounds aperture 70.
- Plunger 40 (FIG. 2) includes an elongated substantially cylindrical plunger rod 76.
- a pair of opposed, spaced apart, ridge-like plunger stops 78, each having an arc length A2 are formed on plunger rod 76.
- a plunger handle 80 having an elongated face 82 extends transversely from a rear portion of plunger rod 76.
- Formed in a forward portion of plunger rod 76 is a forward plunger member 83 which comprises a disk 84 having a forward face 86 from which a plunger neck 88 longitudinally and forwardly extends.
- Plunger neck 88 has a neck diameter D5 and a neck height H 1 .
- Plunger neck 88 terminates in a plunger boss 90.
- plunger boss 90 of forward plunger member 83 is inserted in aperture 70 of plunger tip 22.
- the plunger boss 90 rests in sealing engagement on inner collar rim 74 of trailing member 52, with forward face 86 of plunger 40 in contact with outer surface 54 of trailing member 52.
- a seal is created between the forward portion of plunger 40 because neck height H1 is slightly smaller than thickness T2 of inner rim 74.
- Plunger 40, with plunger tip 22 is then inserted through rear port 37 into blood collection chamber 26 of syringe 20.
- leading sealing ring diameter D2 and trailing sealing ring diameter D3 are equal and slightly larger than diameter D1 of collection chamber 26, so that both leading and trailing sealing rings form an effective seal with the barrel wall 24 of the syringe 20.
- neck diameter D5 of plunger neck 88 be slightly larger than aperture diameter D4 of plunger tip aperture 70 and that neck height H 1 is slightly smaller than thickness T2 of inner rim 74 of collar 72 of trailing member 52, so that an effective seal is formed between the interior chamber 62 of plunger tip 22 and the forward face 86 of plunger 40.
- arc length A1 which is the distance between adjacent barrel stops 36 is slightly larger than arc length A2 which is the arc length of plunger stops 78.
- the smaller width of arc length A2 are sized to pass between the distance A1 between adjacent barrel stops 36 when the plunger 40 is rotated in the collection chamber 26 of syringe 20.
- the volume of interior chamber 62 is equal to or slightly greater than the total volume of the "dead space" at the head of syringe 20.
- This "dead space” is the total of the expected volume of tip portion 35 of collection chamber 26, plus leading portion 34 (if any) of collection chamber 26, plus any other "dead space” in the line to which syringe tip 30 is attached.
- Plunger tip 22' includes a plurality of slits 66' formed in leading member 44'. Each slit 66' is concentric with a portion of circumferential outer edge 49' of leading member 44'. Plunger tip 22' also differs from plunger tip 22 in that it is substantially frustoconical, and includes a depression 100 centrally formed in leading member 44' which receives lyophyilized anticoagulant 101. Despite this variation, the use and benefits of the present invention, described further below, relate to plunger tip 22' as well as other embodiments of the present invention.
- Syringe 20' which includes a plunger tip 22' is shown in FIG. 9.
- Syringe 20' includes plunger 40' having a plurality of longitudinal ribs 92.
- four longitudinal ribs 92 are present, in cross section forming an "X" with adjacent ribs forming a 90 ° angle.
- a pair of opposing, web-like, wedge-shaped plunger stops 94, each having an arc length A2 are formed on ribs 92, with each plunger stop 94 extending between a pair of adjacent ribs 92.
- a plunger handle 80' having a elongated face 82' extends transversely from a rear portion of plunger rod 76'.
- the construction of the disk 84' to which a plunger tip 22' is attached is the same as that of plunger 40, with the use and benefits of the present invention, described further below, relate to plunger 40' as well as other embodiments of the present invention.
- Use of the syringe 20 in performance of the technique of the present invention is now described with reference to a conventional technique for collection of blood with a blood collection syringe from an indwelling arterial catheter. It should be understood, however, that the technique of the present invention, applies also to collection of a single sample with a syringe to which a needle is attached and to other systems in which a syringe is attached to a fluid sampling line.
- a syringe 20 is attached by a luer lock 95 to a third line 96 of a three-way stopcock 97.
- Tubing (not shown) from an arterial line (not shown) feeds into a first line 98 of three-way stopcock 97.
- a second line 99 of the three-way stopcock feeds into a waste collection syringe (not shown) attached by a luer lock (not shown) to second line 99.
- Stopcock 97 provides selective fluid communication from the arterial line into either second line 99 and thence into the waste collection syringe, or into the third line 96 and thence into syringe 20.
- plunger 40 Prior to connection of syringe 20 to third line 96 of three-way stopcock 97, with elongated plunger handles 80 aligned with flanges 38 of syringe 20, plunger 40 is fully depressed into syringe barrel 24, until (a) exterior surface 46 of leading member 44 contacts leading wall 28 of barrel 24, (b) resilient wall 60 of plunger tip 22 collapses, and (c) plunger 40 snaps into a locked position after plunger stops 94 ride over barrel stops 36. At that point, inner surface 56 of trailing member 52 is adjacent, preferably touching interior surface 48 of leading member 44, and the volume of interior chamber 62 of plunger tip 22 is minimized, i.e.
- syringe 20 is attached to third line 96, by engagement of luer lock 95 with third line 96, as is shown in FIG. 5.
- Blood is then allowed to flow from the arterial line through first line 98 of stopcock 97 into the waste collection syringe, thereby forcing air from the first and second lines 98 and 99 into the waste collection syringe. Air remains, however, in third line 96. Stopcock 97 is opened to direct flow of blood from the first line 98 into third line 96.
- plunger 40 is turned a quarter turn (90 ° ) thereby unlocking/disengaging plunger stops 78 from barrel stops 36.
- the resiliency of resilient wall 60 of plunger tip 22 causes plunger 40 to travel backwards along barrel wall 24 until plunger tip 22 is in a fully extended position.
- air and extraneous gases present in third line 96, in tip portion 35 of syringe collection chamber 26, and in the leading portion of the collection chamber 26, if any, is drawn by the air pressure differential into interior chamber 62 through slits 66.
- a small portion of blood may also flow through slits 66 into interior chamber 62, until the differential in pressure from interior chamber 62 to first line 98 is minimal.
- slits 66 close, preventing air and blood in interior chamber 62 from flowing out slits 66 into collection chamber 26.
- the benefits just described are achieved with a syringe and plunger tip construction which is economical to manufacture and assemble.
- the preferred plunger tip is of a unitary construction without need for special membranes, materials or inserts.
- the syringe of the present invention can be operated in most any orientation.
- the syringe tip need not be maintained in an upwardly pointing orientation in order to maintain any extraneous gases at the syringe tip for later manual expulsion.
- the syringe tip need not be maintained in a downwardly or laterally pointing orientation during fluid collection to prevent premature contact of fluids with the plunger tip during fluid collection, thereby prematurely occluding the plunger tip and preventing gases from flowing therethrough.
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU55166/98A AU5516698A (en) | 1996-12-13 | 1997-12-04 | Syringe with collapsible plunger tip |
EP97951552A EP0961623A4 (en) | 1996-12-13 | 1997-12-04 | Syringe with collapsible plunger tip |
JP52682098A JP2001506881A (en) | 1996-12-13 | 1997-12-04 | Syringe with retractable plunger tip |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76635196A | 1996-12-13 | 1996-12-13 | |
US08/766,351 | 1996-12-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998025659A1 true WO1998025659A1 (en) | 1998-06-18 |
Family
ID=25076180
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/022247 WO1998025659A1 (en) | 1996-12-13 | 1997-12-04 | Syringe with collapsible plunger tip |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0961623A4 (en) |
JP (1) | JP2001506881A (en) |
AU (1) | AU5516698A (en) |
WO (1) | WO1998025659A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003057281A1 (en) * | 2001-12-21 | 2003-07-17 | 3M Innovative Properties Company | Self-venting movable seal and plunger |
US7596318B2 (en) | 2003-07-08 | 2009-09-29 | University Of Science And Technology Of China | Addressing method of quanta network and quanta network router |
LU93154B1 (en) * | 2016-07-19 | 2018-01-23 | Abu Al Rubb Khalil Mahmoud | Syringe plunger and syringe |
CN114668931A (en) * | 2017-04-19 | 2022-06-28 | 巴克斯特国际公司 | Non-clogging dispensing device |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5466223A (en) * | 1994-06-20 | 1995-11-14 | Becton, Dickinson And Company | Needle assembly having single-handedly activatable needle barrier |
US5498244A (en) * | 1993-09-22 | 1996-03-12 | American Home Products Corporation | Safety guard for medical instruments |
US5562624A (en) * | 1994-05-06 | 1996-10-08 | Righi; Nardino | Non-reusable safety syringe |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4299238A (en) * | 1980-06-24 | 1981-11-10 | Baidwan Balinderjeet S | Vented piston and push-rod subassembly for use in a syringe barrel |
US4448206A (en) * | 1981-08-17 | 1984-05-15 | Martell Michael D | Vented, aspirating syringe |
US4821738A (en) * | 1987-11-19 | 1989-04-18 | Marquest Medical Products, Inc. | Arterial blood gas syringe |
JP2726112B2 (en) * | 1989-07-17 | 1998-03-11 | 株式会社ニッショー | Blood collection equipment |
-
1997
- 1997-12-04 AU AU55166/98A patent/AU5516698A/en not_active Abandoned
- 1997-12-04 JP JP52682098A patent/JP2001506881A/en active Pending
- 1997-12-04 WO PCT/US1997/022247 patent/WO1998025659A1/en not_active Application Discontinuation
- 1997-12-04 EP EP97951552A patent/EP0961623A4/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5498244A (en) * | 1993-09-22 | 1996-03-12 | American Home Products Corporation | Safety guard for medical instruments |
US5562624A (en) * | 1994-05-06 | 1996-10-08 | Righi; Nardino | Non-reusable safety syringe |
US5466223A (en) * | 1994-06-20 | 1995-11-14 | Becton, Dickinson And Company | Needle assembly having single-handedly activatable needle barrier |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003057281A1 (en) * | 2001-12-21 | 2003-07-17 | 3M Innovative Properties Company | Self-venting movable seal and plunger |
US7596318B2 (en) | 2003-07-08 | 2009-09-29 | University Of Science And Technology Of China | Addressing method of quanta network and quanta network router |
LU93154B1 (en) * | 2016-07-19 | 2018-01-23 | Abu Al Rubb Khalil Mahmoud | Syringe plunger and syringe |
WO2018015438A1 (en) * | 2016-07-19 | 2018-01-25 | Khalil Mahmoud Abu Al-Rubb | Syringe plunger and syringe |
CN114668931A (en) * | 2017-04-19 | 2022-06-28 | 巴克斯特国际公司 | Non-clogging dispensing device |
Also Published As
Publication number | Publication date |
---|---|
JP2001506881A (en) | 2001-05-29 |
AU5516698A (en) | 1998-07-03 |
EP0961623A4 (en) | 2001-09-05 |
EP0961623A1 (en) | 1999-12-08 |
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