WO1998025604A1 - Azacycles a spiro-substitution utilises en tant que modulateurs de l'activite du recepteur de la chimiokine - Google Patents

Azacycles a spiro-substitution utilises en tant que modulateurs de l'activite du recepteur de la chimiokine Download PDF

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Publication number
WO1998025604A1
WO1998025604A1 PCT/US1997/023093 US9723093W WO9825604A1 WO 1998025604 A1 WO1998025604 A1 WO 1998025604A1 US 9723093 W US9723093 W US 9723093W WO 9825604 A1 WO9825604 A1 WO 9825604A1
Authority
WO
WIPO (PCT)
Prior art keywords
spiro
piperidine
dichlorophenyl
butyl
methyl
Prior art date
Application number
PCT/US1997/023093
Other languages
English (en)
Inventor
Sander G. Mills
Martin S. Springer
Malcolm Maccoss
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9704366.5A external-priority patent/GB9704366D0/en
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Priority to AU56049/98A priority Critical patent/AU5604998A/en
Publication of WO1998025604A1 publication Critical patent/WO1998025604A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention porte sur des azacycles à spiro-substitution répondant à la formule (I) (R1, R2, R3, R4, R5, k, l et m étant définis dans le descriptif) et utilisés en tant que modulateurs de l'activité du récepteur de la chimiokine. Ces composés sont notamment efficaces comme modulateurs des récepteurs des chimiokines CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3 et/ou CXCR-4.
PCT/US1997/023093 1996-12-13 1997-12-12 Azacycles a spiro-substitution utilises en tant que modulateurs de l'activite du recepteur de la chimiokine WO1998025604A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU56049/98A AU5604998A (en) 1996-12-13 1997-12-12 Spiro-substituted azacycles as modulators of chemokine receptor activity

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US3289096P 1996-12-13 1996-12-13
US60/032,890 1996-12-13
US3353596P 1996-12-20 1996-12-20
US60/033,535 1996-12-20
GB9704366.5 1997-03-03
GBGB9704366.5A GB9704366D0 (en) 1997-03-03 1997-03-03 Spiro-substituted azacycles as modulators of chemokine receptor activity

Publications (1)

Publication Number Publication Date
WO1998025604A1 true WO1998025604A1 (fr) 1998-06-18

Family

ID=27268757

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/023093 WO1998025604A1 (fr) 1996-12-13 1997-12-12 Azacycles a spiro-substitution utilises en tant que modulateurs de l'activite du recepteur de la chimiokine

Country Status (2)

Country Link
AU (1) AU5604998A (fr)
WO (1) WO1998025604A1 (fr)

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WO2001028987A1 (fr) * 1999-10-15 2001-04-26 Du Pont Pharmaceuticals Company Amines benzyle cycloalkyle comme modulateurs de l'activite du recepteur de la chimiokine
WO2001029000A2 (fr) * 1999-10-15 2001-04-26 Du Pont Pharmaceuticals Company Amines bicyliques et tricycliques en tant que modulateurs de l'activite du recepteur de chemokine
US6288084B1 (en) 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
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US6329385B1 (en) 1998-01-21 2001-12-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
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US6433165B1 (en) 1998-01-21 2002-08-13 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
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US6613905B1 (en) 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
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WO2020106750A1 (fr) 2018-11-19 2020-05-28 Progenity, Inc. Méthodes et dispositifs pour traiter une maladie au moyen d'une biothérapie
WO2021119482A1 (fr) 2019-12-13 2021-06-17 Progenity, Inc. Dispositif ingérable pour administrer un agent thérapeutique dans le tractus gastro-intestinal
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US6509346B2 (en) 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
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US7271176B2 (en) 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US6503926B2 (en) 1998-09-04 2003-01-07 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6288083B1 (en) 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
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US6486180B1 (en) 1998-12-18 2002-11-26 Bristol-Myers Squibb Pharma Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
US6492400B1 (en) 1998-12-18 2002-12-10 Bristol-Myers Squibb Pharma Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
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US6784200B2 (en) 2000-10-13 2004-08-31 Bristol-Myers Squibb Pharma Company Bicyclic and tricyclic amines as modulators of chemokine receptor activity
US7175988B2 (en) 2001-02-09 2007-02-13 Human Genome Sciences, Inc. Human G-protein Chemokine Receptor (CCR5) HDGNR10
WO2002085354A1 (fr) 2001-04-18 2002-10-31 Euro-Celtique S.A. Composes spiro-indene et spiro-indane
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US6992091B2 (en) 2002-09-12 2006-01-31 Bristol-Myers Squibb Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
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