WO1998025596A3 - Use of a 6-aryl pyrimidine compound for treating multiple sclerosis - Google Patents

Use of a 6-aryl pyrimidine compound for treating multiple sclerosis Download PDF

Info

Publication number
WO1998025596A3
WO1998025596A3 PCT/US1997/021402 US9721402W WO9825596A3 WO 1998025596 A3 WO1998025596 A3 WO 1998025596A3 US 9721402 W US9721402 W US 9721402W WO 9825596 A3 WO9825596 A3 WO 9825596A3
Authority
WO
WIPO (PCT)
Prior art keywords
multiple sclerosis
pyrimidine compound
treating multiple
aryl pyrimidine
aryl
Prior art date
Application number
PCT/US1997/021402
Other languages
French (fr)
Other versions
WO1998025596A2 (en
Inventor
Stephen E Buxser
Francis A Fitzpatrick
Original Assignee
Upjohn Co
Stephen E Buxser
Francis A Fitzpatrick
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co, Stephen E Buxser, Francis A Fitzpatrick filed Critical Upjohn Co
Priority to EP97953042A priority Critical patent/EP0948331A2/en
Priority to AU56871/98A priority patent/AU5687198A/en
Priority to CA002269681A priority patent/CA2269681A1/en
Priority to JP52670098A priority patent/JP2001505911A/en
Publication of WO1998025596A2 publication Critical patent/WO1998025596A2/en
Publication of WO1998025596A3 publication Critical patent/WO1998025596A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preliminary Treatment Of Fibers (AREA)
  • Spinning Or Twisting Of Yarns (AREA)
  • Treatment Of Fiber Materials (AREA)

Abstract

A method for treating multiple sclerosis by systemic administration of a 6-aryl pyrimidine compound or a pharmaceutically acceptable salt thereof in association with a pharmaceutical carrier to a human having symptoms of multiple sclerosis.
PCT/US1997/021402 1996-12-12 1997-12-03 Use of a 6-aryl pyrimidine compound for treating multiple sclerosis WO1998025596A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP97953042A EP0948331A2 (en) 1996-12-12 1997-12-03 Method for treating multiple sclerosis
AU56871/98A AU5687198A (en) 1996-12-12 1997-12-03 Method for treating multiple sclerosis
CA002269681A CA2269681A1 (en) 1996-12-12 1997-12-03 Use of a 6-aryl pyrimidine compound for treating multiple sclerosis
JP52670098A JP2001505911A (en) 1996-12-12 1997-12-03 How to treat multiple sclerosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3264896P 1996-12-12 1996-12-12
US60/032,648 1996-12-12

Publications (2)

Publication Number Publication Date
WO1998025596A2 WO1998025596A2 (en) 1998-06-18
WO1998025596A3 true WO1998025596A3 (en) 1998-08-13

Family

ID=21866063

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/021402 WO1998025596A2 (en) 1996-12-12 1997-12-03 Use of a 6-aryl pyrimidine compound for treating multiple sclerosis

Country Status (5)

Country Link
EP (1) EP0948331A2 (en)
JP (1) JP2001505911A (en)
AU (1) AU5687198A (en)
CA (1) CA2269681A1 (en)
WO (1) WO1998025596A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU768201B2 (en) * 1999-01-22 2003-12-04 Amgen, Inc. Kinase inhibitors
US6495558B1 (en) 1999-01-22 2002-12-17 Amgen Inc. Kinase inhibitors
WO2001068613A1 (en) * 2000-03-17 2001-09-20 Nissan Chemical Industries, Ltd. Pyrimidinone derivatives and herbicides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2048250A (en) * 1979-03-19 1980-12-10 Upjohn Co 2-amino-6-aryl-4-pyrimidinols and their pharmaceutical uses
WO1995011235A1 (en) * 1993-10-20 1995-04-27 The Upjohn Company Pyrimidinones as antiarthritic and anti-inflammatories
US5434157A (en) * 1979-03-19 1995-07-18 The Upjohn Company 6-aryl pyrimidine compounds and method for treating viral infections and inducing interferon production

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2048250A (en) * 1979-03-19 1980-12-10 Upjohn Co 2-amino-6-aryl-4-pyrimidinols and their pharmaceutical uses
US5434157A (en) * 1979-03-19 1995-07-18 The Upjohn Company 6-aryl pyrimidine compounds and method for treating viral infections and inducing interferon production
WO1995011235A1 (en) * 1993-10-20 1995-04-27 The Upjohn Company Pyrimidinones as antiarthritic and anti-inflammatories

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
D.A. STRINGFELLOW: "6-ARYL PYRIMIDINOLES: INTERFERON INDUCERS-IMMUNOMODULATORS-ANTIVIRAL AND ANTINEOPLASTIC AGENTS", PROGRESS IN CANCER RESEARCH AND THERAPY, vol. 16, 1981, pages 215 - 228, XP002065068 *
J.E.F. REYNOLDS: "MARTINDALE THE EXTRA PHARMACOPOEIA", 1996, ROYAL PHARMACEUTICAL SOCIETY, LONDON, XP002065070 *
M. YU ET AL.: "INTERFERON-BETA INHIBITS PROGRESSION OF RELAPSING-REMITTING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS", JOURNAL OF NEUROIMMUNOLOGY, vol. 64, 1996, pages 91 - 100, XP002065069 *

Also Published As

Publication number Publication date
EP0948331A2 (en) 1999-10-13
CA2269681A1 (en) 1998-06-18
WO1998025596A2 (en) 1998-06-18
AU5687198A (en) 1998-07-03
JP2001505911A (en) 2001-05-08

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