WO1998024806A3 - Substituted oxadiazole, thiadiazole and triazole serine protease inhibitors - Google Patents
Substituted oxadiazole, thiadiazole and triazole serine protease inhibitors Download PDFInfo
- Publication number
- WO1998024806A3 WO1998024806A3 PCT/US1997/021636 US9721636W WO9824806A3 WO 1998024806 A3 WO1998024806 A3 WO 1998024806A3 US 9721636 W US9721636 W US 9721636W WO 9824806 A3 WO9824806 A3 WO 9824806A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- thiadiazole
- triazole
- protease inhibitors
- serine protease
- substituted oxadiazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ336046A NZ336046A (en) | 1996-12-06 | 1997-12-05 | Serine protease inhibitors containing substituted oxadiazole, thiadiazole and triazole peptide derivatives |
BR9713684-0A BR9713684A (en) | 1996-12-06 | 1997-12-05 | Serine protease inhibitors |
JP52565698A JP3220169B2 (en) | 1996-12-06 | 1997-12-05 | Serine protease inhibitor |
AU55894/98A AU734615B2 (en) | 1996-12-06 | 1997-12-05 | Serine protease inhibitors |
CA002272548A CA2272548A1 (en) | 1996-12-06 | 1997-12-05 | Serine protease inhibitors |
HU0100669A HUP0100669A3 (en) | 1996-12-06 | 1997-12-05 | Peptide derivatives as serine protease inhibitors, their use and pharmaceutical compositions comprising thereof |
EP97952232A EP0954526A2 (en) | 1996-12-06 | 1997-12-05 | Serine protease inhibitors |
NO992734A NO992734L (en) | 1996-12-06 | 1999-06-04 | Serine protease inhibitors |
Applications Claiming Priority (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/760,916 | 1996-12-06 | ||
US08/771,317 US5801148A (en) | 1994-11-21 | 1996-12-06 | Serine protease inhibitors-proline analogs |
US08/761,313 | 1996-12-06 | ||
US08/760,916 US5861380A (en) | 1994-11-21 | 1996-12-06 | Serine protease inhibitors-keto and di-keto containing ring systems |
US08/762,381 | 1996-12-06 | ||
US08/761,190 | 1996-12-06 | ||
US08/761,190 US5807829A (en) | 1994-11-21 | 1996-12-06 | Serine protease inhibitor--tripeptoid analogs |
US08/761,313 US5869455A (en) | 1994-11-21 | 1996-12-06 | Serine protease inhibitors-N-substituted derivatives |
US08/762,381 US5891852A (en) | 1994-11-21 | 1996-12-06 | Serine protease inhibitors-cycloheptane derivatives |
US08/771,317 | 1996-12-06 | ||
US98529897A | 1997-12-04 | 1997-12-04 | |
US08/984,881 | 1997-12-04 | ||
US08/985,298 | 1997-12-04 | ||
US08/984,884 | 1997-12-04 | ||
US08/985,056 | 1997-12-04 | ||
US08/985,056 US5998379A (en) | 1994-11-21 | 1997-12-04 | Serine protease inhibitors-proline analogs |
US08/985,201 | 1997-12-04 | ||
US08/984,881 US6015791A (en) | 1994-11-21 | 1997-12-04 | Serine protease inhibitors-cycloheptane derivatives |
US08/984,884 US6001811A (en) | 1994-11-21 | 1997-12-04 | Serine protease inhibitors--N-substituted derivatives |
US08/985,201 US6150334A (en) | 1994-11-21 | 1997-12-04 | Serine protease inhibitors-tripeptoid analogs |
Publications (3)
Publication Number | Publication Date |
---|---|
WO1998024806A2 WO1998024806A2 (en) | 1998-06-11 |
WO1998024806A3 true WO1998024806A3 (en) | 1998-10-15 |
WO1998024806B1 WO1998024806B1 (en) | 1999-05-20 |
Family
ID=27581319
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/021636 WO1998024806A2 (en) | 1996-12-06 | 1997-12-05 | Substituted oxadiazole, thiadiazole and triazole serine protease inhibitors |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0954526A2 (en) |
JP (1) | JP3220169B2 (en) |
CN (1) | CN1247542A (en) |
AU (1) | AU734615B2 (en) |
CA (1) | CA2272548A1 (en) |
HU (1) | HUP0100669A3 (en) |
NO (1) | NO992734L (en) |
NZ (1) | NZ336046A (en) |
RU (1) | RU2217436C2 (en) |
TR (2) | TR199901681T2 (en) |
WO (1) | WO1998024806A2 (en) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6004933A (en) * | 1997-04-25 | 1999-12-21 | Cortech Inc. | Cysteine protease inhibitors |
US6656910B2 (en) * | 1997-12-04 | 2003-12-02 | Cortech, Inc. | Serine protease inhibitors |
JP2003535022A (en) * | 1998-06-03 | 2003-11-25 | コーテック インコーポレーテッド | Peptoids and non-peptoids containing alpha-ketooxadiazole as serine protease inhibitors |
WO2000009542A1 (en) * | 1998-08-17 | 2000-02-24 | Cortech, Inc. | SERINE PROTEASE INHIBITORS COMPRISING α-KETO HETEROCYCLES |
FR2782997A1 (en) * | 1998-09-08 | 2000-03-10 | Hoechst Marion Roussel Inc | NOVEL BENZODIAZEPINONE DERIVATIVES, PREPARATION METHOD AND INTERMEDIATES THEREOF, MEDICAMENT APPLICATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME |
WO2000051625A1 (en) * | 1999-03-05 | 2000-09-08 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses |
AU3731400A (en) * | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Methods and compositions useful in inhibiting apoptosis |
AU3511500A (en) * | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions |
AU3719100A (en) * | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Inhibitors of serine protease activity, methods and compositions for treatment of viral infections |
WO2000055145A1 (en) * | 1999-03-12 | 2000-09-21 | Ono Pharmaceutical Co., Ltd. | 1,3,4-oxadiazole derivatives and process for producing the same |
CA2375229A1 (en) | 1999-06-17 | 2000-12-28 | Source Precision Medicine, Inc. | Method and compounds for inhibiting activity of serine elastases |
WO2001007407A1 (en) * | 1999-07-26 | 2001-02-01 | Bristol-Myers Squibb Pharma Company | Lactam inhibitors of hepatitis c virus ns3 protease |
US7122627B2 (en) | 1999-07-26 | 2006-10-17 | Bristol-Myers Squibb Company | Lactam inhibitors of Hepatitis C virus NS3 protease |
WO2001023361A1 (en) * | 1999-09-27 | 2001-04-05 | Ono Pharmaceutical Co., Ltd. | Pyrimidine derivatives, process for preparing the derivatives and drugs containing the same as the active ingredient |
EP1234834A4 (en) * | 1999-12-03 | 2003-01-29 | Ono Pharmaceutical Co | 1,3,4-oxadiazolin-2-one derivatives and drugs containing these derivatives as the active ingredient |
US6797720B2 (en) | 1999-12-03 | 2004-09-28 | Ono Pharmaceutical Co., Ltd. | 1,3,4-oxadiazoline derivative and an agent comprising its derivative as active ingredient |
EP1253143A4 (en) * | 2000-02-03 | 2003-03-26 | Ono Pharmaceutical Co | 1,3,4-oxadiazole derivatives and process for producing the same |
US20030130326A1 (en) * | 2000-02-03 | 2003-07-10 | Tohru Miyazaki | 1,3,4-oxadiazole derivatives and process for producing the same |
WO2002014310A1 (en) * | 2000-08-10 | 2002-02-21 | Ono Pharmaceutical Co., Ltd. | 2-[5-AMINO-6-OXO-2-PHENYL-1,6-DIHYDRO-1-PYRIMIDYL]-N-[1-(2-[5-t-BUTYL-1,3,4-OXADIAZOLYL]CARBONYL)-2-(R,S)-METHYLPROPYL]ACETAMIDE HYDROCHLORIDE |
CA2421499A1 (en) * | 2000-09-08 | 2003-03-06 | Ono Pharmaceutical Co., Ltd. | Novel crystals of 1,3,4-oxadiazole derivative, process for producing the same and pharmaceutical agent containing the same as active ingredient |
CA2423945A1 (en) * | 2000-09-29 | 2003-03-27 | Atsushi Nagai | Restrainers of airway mucus secretion |
WO2003006014A1 (en) * | 2001-07-10 | 2003-01-23 | Ono Pharmaceutical Co., Ltd. | Medicine comprising combination of five-membered heterocyclic compound and drug compensating for or enhancing its activity |
EP1404704B9 (en) * | 2001-07-11 | 2008-02-20 | Vertex Pharmaceuticals Incorporated | Bridged bicyclic serine protease inhibitors |
IL148924A (en) * | 2002-03-26 | 2015-06-30 | Mor Research Applic Ltd | Use of agents that inhibit the activity of intracellular elastase in the preparation of a medicament for treating and/or preventing necrosis of cells and diseases associated therewith |
ES2622522T3 (en) | 2003-08-26 | 2017-07-06 | The Regents Of The University Of Colorado, A Body Corporate | Inhibitors of serine protease activity and its use in methods and compositions for the treatment of bacterial infections |
EP1533306A1 (en) | 2003-11-04 | 2005-05-25 | Ajinomoto Co., Inc. | Azlactone compound and method for preparation thereof |
US7951823B2 (en) | 2006-05-23 | 2011-05-31 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
TWI389899B (en) * | 2006-08-08 | 2013-03-21 | Msd Oss Bv | An orally active thrombin inhibitor |
EA016327B1 (en) | 2007-02-09 | 2012-04-30 | Айрм Ллк | Compounds and compositions as channel activating protease inhibitors |
ATE518840T1 (en) | 2007-05-22 | 2011-08-15 | Boehringer Ingelheim Int | BENZIMIDAZOLONE CHYMASE INHIBITORS |
US9938353B2 (en) | 2011-06-24 | 2018-04-10 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
AU2013202648B2 (en) | 2012-01-10 | 2016-05-19 | Konkuk University | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
RU2670982C2 (en) * | 2013-05-08 | 2018-10-29 | Киссеи Фармасьютикал Ко., Лтд. | DERIVATIVES OF α-SUBSTITUTED GLYCINEAMIDE |
EP3177593A1 (en) * | 2014-08-06 | 2017-06-14 | Novartis AG | Quinolone derivatives as antibacterials |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0528633A1 (en) * | 1991-08-15 | 1993-02-24 | Zeneca Limited | Pyrimidinyl acetamides as elastase inhibitors |
WO1993021212A1 (en) * | 1992-04-16 | 1993-10-28 | Zeneca Limited | Lactam dipeptides having hle inhibiting activity |
FR2694295A1 (en) * | 1992-07-28 | 1994-02-04 | Adir | Novel peptides derived from trifluoromethylketones, process for their preparation and pharmaceutical compositions containing them |
WO1995033762A1 (en) * | 1994-06-02 | 1995-12-14 | Merrell Pharmaceuticals Inc. | Perfluoroalkyl ketone inhibitors of elastase and processes for making the same |
WO1996016080A1 (en) * | 1994-11-21 | 1996-05-30 | Cortech, Inc. | Human neutrophil elastase inhibitors |
-
1997
- 1997-12-05 CA CA002272548A patent/CA2272548A1/en not_active Abandoned
- 1997-12-05 HU HU0100669A patent/HUP0100669A3/en unknown
- 1997-12-05 RU RU99114606/04A patent/RU2217436C2/en not_active IP Right Cessation
- 1997-12-05 TR TR1999/01681T patent/TR199901681T2/en unknown
- 1997-12-05 CN CN97180392A patent/CN1247542A/en active Pending
- 1997-12-05 WO PCT/US1997/021636 patent/WO1998024806A2/en not_active Application Discontinuation
- 1997-12-05 TR TR2001/03270T patent/TR200103270T2/en unknown
- 1997-12-05 NZ NZ336046A patent/NZ336046A/en unknown
- 1997-12-05 JP JP52565698A patent/JP3220169B2/en not_active Expired - Fee Related
- 1997-12-05 AU AU55894/98A patent/AU734615B2/en not_active Ceased
- 1997-12-05 EP EP97952232A patent/EP0954526A2/en not_active Withdrawn
-
1999
- 1999-06-04 NO NO992734A patent/NO992734L/en not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0528633A1 (en) * | 1991-08-15 | 1993-02-24 | Zeneca Limited | Pyrimidinyl acetamides as elastase inhibitors |
WO1993021212A1 (en) * | 1992-04-16 | 1993-10-28 | Zeneca Limited | Lactam dipeptides having hle inhibiting activity |
FR2694295A1 (en) * | 1992-07-28 | 1994-02-04 | Adir | Novel peptides derived from trifluoromethylketones, process for their preparation and pharmaceutical compositions containing them |
WO1995033762A1 (en) * | 1994-06-02 | 1995-12-14 | Merrell Pharmaceuticals Inc. | Perfluoroalkyl ketone inhibitors of elastase and processes for making the same |
WO1996016080A1 (en) * | 1994-11-21 | 1996-05-30 | Cortech, Inc. | Human neutrophil elastase inhibitors |
Non-Patent Citations (2)
Title |
---|
BROWN E.A.: "Design of orally active, non-peptidic inhibitors of HLE", JOURNAL OF MEDICINAL CHEMISTRY, vol. 37, no. 9, 1994, WASHINGTON US, pages 1259 - 1261, XP002069592 * |
SKILES J W ET AL: "ELASTASE INHIBITORS CONTAINING CONFORMATIONALLY RESTRICTED LACTAMS AS P3-P2 DIPEPTIDE REPLACEMENTS", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 3, no. 4, 1993, pages 773 - 778, XP000673137 * |
Also Published As
Publication number | Publication date |
---|---|
AU5589498A (en) | 1998-06-29 |
HUP0100669A2 (en) | 2001-08-28 |
HUP0100669A3 (en) | 2001-12-28 |
NO992734D0 (en) | 1999-06-04 |
CN1247542A (en) | 2000-03-15 |
JP2001507679A (en) | 2001-06-12 |
AU734615B2 (en) | 2001-06-21 |
WO1998024806B1 (en) | 1999-05-20 |
TR200103270T2 (en) | 2003-03-21 |
EP0954526A2 (en) | 1999-11-10 |
RU2217436C2 (en) | 2003-11-27 |
CA2272548A1 (en) | 1998-06-11 |
NO992734L (en) | 1999-08-02 |
TR199901681T2 (en) | 2000-03-21 |
JP3220169B2 (en) | 2001-10-22 |
NZ336046A (en) | 2000-10-27 |
WO1998024806A2 (en) | 1998-06-11 |
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