WO1998023274A1 - Androgenic and bisphosphonic agents coadministered to treat diseases - Google Patents
Androgenic and bisphosphonic agents coadministered to treat diseases Download PDFInfo
- Publication number
- WO1998023274A1 WO1998023274A1 PCT/US1997/021306 US9721306W WO9823274A1 WO 1998023274 A1 WO1998023274 A1 WO 1998023274A1 US 9721306 W US9721306 W US 9721306W WO 9823274 A1 WO9823274 A1 WO 9823274A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bisphosphonic acid
- androgen
- disease
- agents
- bisphosphonic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
Definitions
- This invention is concerned with a novel method for the prevention and/or treatment of diseases involving calcium or phosphate metabolism.
- diseases involving bone resorption especially osteoporosis, Paget's disease, malignant hypercalcemia, periodontal disease, joint loosening and metastatic bone disease, by the administration of an androgen and a bisphosphonic acid or a pharmaceutically acceptable salt thereof either combined in a single pharmaceutical formulation or as separate entities administered more or less concurrently.
- This invention is also concerned with a pharmaceutical formulation in which an agent with androgenic activity and bisphosphonic acid or pharmaceutically acceptable salt thereof are combined.
- bisphosphonic acid is meant to refer to the acid or the pharmaceutically acceptable salt thereof.
- the novel method of prevention and or treatment of diseases involving bone resorption of this invention comprises the administration to a patient in need thereof of an effective amount of a bisphosphonic acid and an effective amount of an androgen.
- the disease states involving bone resorption that can be prevented and/or treated by the novel combination of this invention are osteoporosis, Paget's disease, malignant hypercalcemia, periodontal disease, joint loosening and metastatic bone disease, especially osteoporosis.
- Examples of the bisphosphonic acids that may be used as an active ingredient in the novel method and formulation of this invention include:
- the pharmaceutically acceptable salts of bisphosphonic acids may also be employed in the instant invention.
- basic salts of bisphosphonic acids include ammonium salts, alkali metal salts such as potassium and sodium (including mono-, di- and tri-sodium) salts (which are preferred), alkaline earth metal salts such as calcium and magnesium salts, salts with organic bases such as dicyclohexylamine salts, N-methyl-D- glucamine, and salts with amino acids such as arginine, lysine, and so forth.
- the non-toxic, physiologically acceptable salts are preferred.
- the salts may be prepared by methods known in the art, such as in U.S. Patent No. 4.922.077.
- the bisphosphonic acid is 4-amino-l-hydroxybutylidene-l, 1-bisphosphonic acid. It is even more preferred that the bisphosphonic acid is a sodium salt of 4-amino- l-hydroxybutylidene-l,l-bisphosphonic acid, in particular, 4-amino-l-hydroxybutylidene-l,l-bisphosphonic acid monosodium salt trihydrate.
- Examples of the androgens that may be used as an active ingredient in the novel method and formulation of this invention include but not limited to danazol, 5a-dihydrotestosterone, testosterone, nandrolane decanoate, methyltestosterone, methanadrostenolone, stanozolol, fluoxymesterone, oxymetholone, oxandrolone, oxymethol, norethandrolone, ethylestranol, 4- androsten-19-al-3,17-dione, 19-nortestosterone, norethandrone, norethisterone, dehydroepiandrosterone, epiandrosterone sulfate, androstenedione and androstenediol, testosterone propionate, testosterone cytpionate, and testosterone enanthate, preferably testosterone.
- the bisphosphonic acid and the androgenic agent can be administered combined in a single dosage form, which forms another aspect of the present invention, or as separate entities administered more or less concurrently.
- the active ingredients are provided in doses that are the same as would be administered if given as sole medicament.
- oral doses of 2.5 to 100 mg/day are approprate.
- doses of about 2.5 to about 10 mg/day, and especially about 5 mg/day should be employed.
- daily doses of about 5 to 20 mg/day may be used, especially about 10 mg/day.
- a bisphosphonic acid and an androgenic agent may be administered separately or in combination.
- the administration of one element may be prior to, concurrently with, or subsequent to the administration of the other agent.
- the active ingredients of the combination of the present invention may be administered by oral, parenteral (e.g., intramuscular, intraperitoneal, intravenous or subcutaneous injection, or implant), nasal, vaginal, rectal, sublingual, or topical routes of administration and may be formulated, alone or together, in suitable dosage unit formulations containing conventional non-toxic pharmaceutically acceptable carriers, adjuvants and vehicles appropriate for each route of administration.
- parenteral e.g., intramuscular, intraperitoneal, intravenous or subcutaneous injection, or implant
- nasal, vaginal, rectal, sublingual, or topical routes of administration may be formulated, alone or together, in suitable dosage unit formulations containing conventional non-toxic pharmaceutically acceptable carriers, adjuvants and vehicles appropriate for each route of administration.
- compositions for the administration of the compounds of this invention may conveniently be presented in dosage unit form and may be prepared by any of the methods well known in the art of pharmacy. All methods include the step of bringing the active ingredient into association with the carrier which constitutes one or more accessory ingredients.
- the pharmaceutical compositions are prepared by uniformly and intimately bringing the active ingredient into association with a liquid carrier or a finely divided solid carrier or both, and then, if necessary, shaping the product into the desired formulation.
- the active ingredient(s) is included in an amount sufficient to produce the desired effect upon the process or condition of the disease.
- compositions containing the active ingredient(s) suitable for oral administration may be in the form of discrete units such as hard or soft capsules, tablets, troches or lozenges, each containing a predetermined amount of the active ingredient(s); in the form of a dispersible powder or granules; in the form of a solution or a suspension in an aqueous liquid or non- aqueous liquid; in the form of syrups or elixirs; or in the form of an oil-in-water emulsion or a water-in-oil emulsion.
- compositions intended for oral use may be prepared according to any method known to the art for the manufacture of pharmaceutical compositions and such compositions may contain one or more agents selected from the group consisting of sweetening agents, flavoring agents, coloring agents and preserving agents in order to provide pharmaceutically elegant and palatable preparation.
- Solid dosage forms for oral administration include capsules, tablets, pills, powders and granules.
- the active compounds are admixed with at least one inert pharmaceutically acceptable carrier such as sucrose, lactose, or starch.
- Such dosage forms can also comprise, as is normal practice, additional substances other than inert diluents, e.g., lubricating agents such as magnesium stearate.
- the dosage forms may also comprise buffering agents.
- Tablets containing the active ingredient in admixture with non-toxic pharmaceutically acceptable excipients may also be manufactured by known methods.
- the excipients used may be for example, (1) inert diluents such as calcium carbonate, lactose, calcium phosphate or sodium phosphate; (2) granulating and disintegrating agents such as corn starch, or alginic acid; (3) binding agents such as starch, gelatin or acacia; and (4) lubricating agents such as magnesium stearate, stearic acid or talc.
- the tablets may be uncoated or they may be coated by known techniques to delay disintegration and absorption in the gastroinestinal tract and thereby provide a sustained action over a longer period.
- a time delay material such as glyceryl monostearate or glyceryl disearate may be employed. They may also be coated by the techniques described in the U.S. Pat. Nos. 4,256,108; 4,160,452; and 4,265,874 to form osmotic therapeutic tablets for controlled release.
- formulations for oral use may be in the form of hard gelatin capsules wherein the active ingredient is mixed with an inert solid diluent, for example calcium carbonate, calcium phosphate or kaolin. They may also be in the form of soft gelatin capsules wherein the active ingredient is mixed with water or an oil medium, for example peanut oil, liquid paraffin, or olive oil.
- an inert solid diluent for example calcium carbonate, calcium phosphate or kaolin.
- water or an oil medium for example peanut oil, liquid paraffin, or olive oil.
- Liquid dosage forms for oral administration include pharmaceutically acceptable emulsions, solutions, suspensions, syrups, and elixirs containing inert diluents commonly used in the art, such as water. Besides such inert diluents, compositions can also include adjuvants, such as wetting agents, emulsifying and suspending agents, and sweetening, flavoring, and perfuming agents.
- Aqueous suspensions normally contain the active materials in admixture with excipients suitable for the manufacture of aqueous suspensions. Such excipients may be
- suspending agents such as sodium carboxymethyl-cellulose, methylcellulose, hydroxypropylmethyl-cellulose, sodium alginate, polyvinyl-pyrrolidone, gum tragacanth and gum acacia;
- aqueous suspensions may also contain one or more preservatives, for example, ethyl or n-propyl p-hydroxybenzoate; one or more coloring agents; one or more flavoring agents; and one or more sweetening agents such as sucrose or saccharin.
- Oily suspensions may be formulated by suspending the active ingredient in a vegetable oil, for example arachis oil, olive oil, sesame oil or coconut oil, or in a mineral oil such as liquid paraffin.
- the oily suspensions may contain a thickening agent, for example beeswax, hard paraffin or cetyl alcohol. Sweetening agents and flavoring agents may be added to provide a palatable oral preparation. These compositions may be prepared by the addition of an antioxidant such as ascorbic acid.
- Dispersible powders and granules are suitable for the preparation of an aqueous suspension. They provide the active ingredient in admixture with a dispersing or wetting agent, a suspending agent and one or more preservatives. Suitable dispersing or wetting agents and suspending agents are exemplified by those already mentioned above. Additional excipients, for example, those sweetening, flavoring and coloring agents described above may also be present.
- the pharmaceutical compositions of the invention may also be in the form of oil-in-water emulsions.
- the oily phase may be a vegatable oil such as olive oil or arachis oil, or a mineral oil such as liquid paraffin or a mixture thereof.
- Suitable emulsifying agents may be (1) naturally-occuring gums such as gum acacia and gum tragacanth, (2) naturally-occuring phosphatides such as soy bean and lecithin, (3) esters or partial esters derived from fatty acids and hexitol anhydrides, for example, sorbitan monooleate, (4) condensation products of said partial esters with ethylene oxide, for example polyoxyethylene sorbitan monooleate.
- the emulsions may also contain sweetening and flavoring agents.
- Syrups and elixirs may be formulated with sweetening agents, for example, glycerol, propylene glycol, sorbitol or sucrose.
- Such formulations may also contain a demulcent, a preservative and flavoring and coloring agents.
- the pharmaceutical compositions may be in the form of a sterile injectable aqueous or oleagenous suspension or solution.
- the suspension may be formulated according to known methods using those suitable dispersing or wetting agents and suspending agents which have been mentioned above.
- the sterile injectable preparation may also be a sterile injectable solution or suspension in a non-toxic parenterally-acceptable diluent or solvent, for example as a solution in 1,3-butane diol.
- the acceptable vehicles and solvents that may be employed are water, Ringer's solution and isotonic sodium chloride solution.
- sterile, fixed oils are conventionally employed as a solvent or suspending medium.
- any bland fixed oil may be employed including synthetic mono- or diglycerides.
- fatty acids such as oleic acid find use in the preparation of injectables.
- Preparations according to this invention for parenteral administration include sterile aqueous or non-aqueous solutions, suspension, or emulsions.
- non-aqueous solvents or vehicles are propylene glycol, polyethylene glycol, vegetable oils, such as olive oil and corn oil, gelatin, and injectable organic esters such as ethyl oleate.
- Such dosage forms may also contain adjuvants such as preserving, wetting, emulsifying, and dispersing agents.
- compositions may be sterilized by, for example, filtration through a bacteria-retaining filter, by incorporating sterilizing agents into the compositions, by irradiating the compositions, or by heating the compositions. They can also be manufactured in the form of sterile solid compositions which can be dissolved in sterile water, or some other sterile injectable medium immediately before use.
- the active ingredient(s) of this invention may also be administered in the form of suppositories for rectal administration.
- This composition can be prepared by mixing the drug with a suitable non-irritating excipient which is solid at ordinary temperatures but liquid at body temperature and will therefore melt in the rectum to release the drug.
- a suitable non-irritating excipient which is solid at ordinary temperatures but liquid at body temperature and will therefore melt in the rectum to release the drug.
- Such materials are cocoa butter and polyethylene gylcols.
- Compositions for nasal or sublingual administration are also prepared with standard excipients well known in the art.
- the active ingredient(s) of this invention may be formulated in liquid or semi-liquid preparations such as liniments or lotions; oil-in-water or water-in-oil emulsions such as creams, ointments, jellies or pastes, including tooth-pastes; or solutions or suspensions such as drops, and the like.
- the pharmaceutical composition and method of the present invention may further comprise other therapeutically active compounds usually applied in the treatment of the above mentioned pathological conditions, for instance vitamin D2 and D3 and hydroxylated derivatives, e.g. la-hydroxy- vitamin D3, la-hydroxy- vitamin D2, la-25-dihydroxy-vitamin D3, la-25-dihydroxy-vitamin D2, calcitonin (human, porcine or salmon), mitramycin, sodium fluoride, and non- steroid antiinflammatory drugs, such as acetylsali cyclic acid, indomethacin, naprosyn, and timegadine.
- vitamin D2 and D3 and hydroxylated derivatives e.g. la-hydroxy- vitamin D3, la-hydroxy- vitamin D2, la-25-dihydroxy-vitamin D3, la-25-dihydroxy-vitamin D2, calcitonin (human, porcine or salmon), mitramycin, sodium fluoride, and non- steroid antiinflammatory drugs, such as acetylsali cyclic
- the amount of active ingredient(s) in the formulations of this invention may be varied. However, it is convenient for the unit dose, such as a tablet, to contain the amount of active ingredient(s) that would be administered in the prophylaxis or therapy of a particular bone resorption disease. Accordingly, formulations comprising 2.5 mg, 5.0 mg and 10 mg of the bisphosphonic acid and 0.125 - 2.5 mg, 0.25 - 5.0 mg and 0.5 - 10 mg respectively, of the androgen would be appropriate.
- the active ingredients are premixed with 1/3 of the microcrystalline cellulose and 1/2 of the anhydrous lactose in a ribbon blender for 5 minutes at 20 rpm.
- To the premix is added the remaining 2/3 of the microcrystalline cellulose and the remaining 1/2 of the anhydrous lactose and blended for 10 minutes at 20 rpm.
- the croscarmellose sodium is added to the blended powders and mixed for 5 minutes at 20 rpm.
- magnesium stearate is added to the mixture by passing it through a 90 mesh screen and blended for an additional 5 minutes at 20 rpm.
- the lubricated mixture is compressed to provide tablets with the equivalent of 5mg of alendronate anhydrous free acid and 0.25 - 5 mg of androgen.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002271664A CA2271664A1 (en) | 1996-11-25 | 1997-11-21 | Androgenic and bisphosphonic agents coadministered to treat diseases |
JP52475398A JP2001507338A (en) | 1996-11-25 | 1997-11-21 | Androgenic and bisphosphonic acid co-administered to treat disease |
AU74086/98A AU743121B2 (en) | 1996-11-25 | 1997-11-21 | Androgenic and bisphosphonic agents coadministered to treat diseases |
EP97949529A EP0949928A4 (en) | 1996-11-25 | 1997-11-21 | Androgenic and bisphosphonic agents coadministered to treat diseases |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3173496P | 1996-11-25 | 1996-11-25 | |
US60/031,734 | 1996-11-25 | ||
US3234196P | 1996-12-04 | 1996-12-04 | |
US60/032,341 | 1996-12-04 | ||
GBGB9700697.7A GB9700697D0 (en) | 1997-01-15 | 1997-01-15 | Combination of an androgen and a bisphosphonic acid in the prevention and/or treatment of diseases involving calcium or phosphate metabolism |
GB9700697.7 | 1997-01-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998023274A1 true WO1998023274A1 (en) | 1998-06-04 |
Family
ID=27268672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/021306 WO1998023274A1 (en) | 1996-11-25 | 1997-11-21 | Androgenic and bisphosphonic agents coadministered to treat diseases |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0949928A4 (en) |
JP (1) | JP2001507338A (en) |
AU (1) | AU743121B2 (en) |
CA (1) | CA2271664A1 (en) |
WO (1) | WO1998023274A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000025794A1 (en) * | 1998-10-30 | 2000-05-11 | Gador S.A. | Uses of 1-amino-3-(n,n-dimethylamino)-propylidene-1,1-bisphosphonic acid |
WO2000028982A2 (en) * | 1998-11-19 | 2000-05-25 | The Board Of Trustees For The University Of Arkansas | Increasing bone strength with selected bisphosphonates |
WO2001035975A2 (en) * | 1999-11-12 | 2001-05-25 | Genelabs Technologies, Inc. | Treatment of subnormal bone mineral density |
WO2016003284A1 (en) | 2014-07-04 | 2016-01-07 | Osteo-Pharma B.V. | Compositions and products for use in the treatment of bone fractures and defects |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1640010A1 (en) * | 2003-07-01 | 2006-03-29 | Astellas Pharma Inc. | Agent inducing increase in bone mass |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5284841A (en) * | 1993-02-04 | 1994-02-08 | Merck & Co., Inc. | Benzo-fused lactams promote release of growth hormone |
US5547685A (en) * | 1995-05-16 | 1996-08-20 | Eli Lilly And Company | Methods for inhibiting bone loss with vanadyl sulfate |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0573604T3 (en) * | 1991-02-26 | 1995-05-29 | Procter & Gamble Pharma | Method of treating osteoporosis |
JP2746041B2 (en) * | 1992-02-14 | 1998-04-28 | 三菱化学株式会社 | New steroid derivatives |
DE4218292C1 (en) * | 1992-06-03 | 1994-02-03 | Mattern Et Partner Pharmazeuti | Use of a medicinal product containing mestanolone and / or 4-chloro-1-dehydromethyltestosterone |
AU5953894A (en) * | 1992-12-23 | 1994-07-19 | Merck & Co., Inc. | Bisphosphonate/estrogen therapy for treating and preventing bone loss |
-
1997
- 1997-11-21 WO PCT/US1997/021306 patent/WO1998023274A1/en not_active Application Discontinuation
- 1997-11-21 CA CA002271664A patent/CA2271664A1/en not_active Abandoned
- 1997-11-21 EP EP97949529A patent/EP0949928A4/en not_active Withdrawn
- 1997-11-21 AU AU74086/98A patent/AU743121B2/en not_active Ceased
- 1997-11-21 JP JP52475398A patent/JP2001507338A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5284841A (en) * | 1993-02-04 | 1994-02-08 | Merck & Co., Inc. | Benzo-fused lactams promote release of growth hormone |
US5547685A (en) * | 1995-05-16 | 1996-08-20 | Eli Lilly And Company | Methods for inhibiting bone loss with vanadyl sulfate |
Non-Patent Citations (1)
Title |
---|
See also references of EP0949928A4 * |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000025794A1 (en) * | 1998-10-30 | 2000-05-11 | Gador S.A. | Uses of 1-amino-3-(n,n-dimethylamino)-propylidene-1,1-bisphosphonic acid |
WO2000028982A3 (en) * | 1998-11-19 | 2002-07-11 | Univ Arkansas | Increasing bone strength with selected bisphosphonates |
WO2000028982A2 (en) * | 1998-11-19 | 2000-05-25 | The Board Of Trustees For The University Of Arkansas | Increasing bone strength with selected bisphosphonates |
US7612034B2 (en) | 1999-11-12 | 2009-11-03 | Genelabs Technologies, Inc. | Treatment of subnormal bone mineral density |
WO2001035975A3 (en) * | 1999-11-12 | 2001-12-27 | Genelabs Tech Inc | Treatment of subnormal bone mineral density |
US6605591B1 (en) | 1999-11-12 | 2003-08-12 | Genelabs Technologies, Inc. | Treatment of subnormal bone mineral density |
US6854468B2 (en) | 1999-11-12 | 2005-02-15 | Genelabs Technologies, Inc. | Treatment of subnormal bone mineral density |
AU784160B2 (en) * | 1999-11-12 | 2006-02-16 | Genelabs Technologies, Inc. | Treatment of subnormal bone mineral density |
WO2001035975A2 (en) * | 1999-11-12 | 2001-05-25 | Genelabs Technologies, Inc. | Treatment of subnormal bone mineral density |
KR20170045193A (en) * | 2014-07-04 | 2017-04-26 | 오스테오-파르마 비.브이. | Compositions and products for use in the treatment of bone fractures and defects |
WO2016003284A1 (en) | 2014-07-04 | 2016-01-07 | Osteo-Pharma B.V. | Compositions and products for use in the treatment of bone fractures and defects |
CN106659728A (en) * | 2014-07-04 | 2017-05-10 | 奥斯特优制药有限公司 | Compositions and products for use in the treatment of bone fractures and defects |
US20170151267A1 (en) * | 2014-07-04 | 2017-06-01 | Osteo-Pharma B.V. | Compositions and products for use in the treatment of bone fractures and defects |
RU2697873C2 (en) * | 2014-07-04 | 2019-08-21 | Остео-Фарма Б.В. | Compositions and products for use in treating fractures and bone defects |
AU2015284868B2 (en) * | 2014-07-04 | 2020-07-02 | Osteo-Pharma B.V. | Compositions and products for use in the treatment of bone fractures and defects |
US11541063B2 (en) | 2014-07-04 | 2023-01-03 | Osteo-Pharma B.V. | Compositions and products for use in the treatment of bone fractures and defects |
KR102570057B1 (en) * | 2014-07-04 | 2023-08-23 | 오스테오-파르마 비.브이. | Compositions and products for use in the treatment of bone fractures and defects |
Also Published As
Publication number | Publication date |
---|---|
AU7408698A (en) | 1998-06-22 |
AU743121B2 (en) | 2002-01-17 |
EP0949928A1 (en) | 1999-10-20 |
JP2001507338A (en) | 2001-06-05 |
EP0949928A4 (en) | 2000-09-13 |
CA2271664A1 (en) | 1998-06-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU5953894A (en) | Bisphosphonate/estrogen therapy for treating and preventing bone loss | |
US20040097468A1 (en) | Method of treating osteoporosis and other bone disorders with upfront loading of bisphosphonates, and kits for such treatment | |
HU219382B (en) | Parathyroid hormon and raloxifene for increasing bone mass | |
JP2002529490A (en) | Methods for inhibiting tooth-absorbable lesions | |
US6376477B2 (en) | Combination of an agent that binds to the androgen receptor and a bisphosphonic acid in the prevention and/or treatment of diseases involving calcium or phosphate metabolism | |
US4396615A (en) | Method of treating androgen-related disorders | |
HU215124B (en) | Process for producing synergetic pharmaceutical compositions containing estrogen and diphosphonate for treating osteoporosis | |
EP1972341A1 (en) | Pharmaceutical compositions comprising a bisphosphonate and vitamin D | |
AU743121B2 (en) | Androgenic and bisphosphonic agents coadministered to treat diseases | |
EP1231983B1 (en) | Combination of dhea and calcitonin for the treatment of subnormal bone mineral density | |
US6399592B1 (en) | Bishphosphonate/estrogen synergistic therapy for treating and preventing bone loss | |
EP1016412A1 (en) | Dental remedies containing pth | |
CA2469779C (en) | Method for the treatment of bone disorders | |
NZ250293A (en) | Fracture treatment using methanebisphosphonic acid derivatives and pharmaceutical compositions | |
JP2003292453A (en) | Medicinal agent composition for treating bone disease | |
JP2003095974A (en) | Composite medicine for safely stimulating osteoplasty | |
ITMI20120393A1 (en) | AQUEOUS FORMULATIONS OF BISPHOSPHONATES, VITAMIN D AND BENZYL ALCOHOL SUITABLE FOR INTRAMUSCULAR OR SUBCUTANEOUS USE | |
JP2000504718A (en) | Topical bisphosphonates to prevent bone resorption | |
XU et al. | Recent advances in pharmacologic prevention and treatment of osteoporosis | |
SK25299A3 (en) | Transdermal therapeutical approach involving a combination of active substances containing oestriol | |
EA007601B1 (en) | COMPOSITION CONTAINING AN ANDROGENOUS 11β-HALOGEN STEROID AND A PROGESTATIONAL HORMONE AND MALE CONTRACEPTIVE BASED ON SAID COMPOSITION | |
MXPA96004968A (en) | Use of bisphosphonates to inhibit bone rebassion after the implantation of orthopedic protesis | |
ZA200203527B (en) | Treatment of subnormal bone mineral density. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AL AM AU AZ BA BB BG BR BY CA CN CU CZ EE GE HU ID IL IS JP KG KR KZ LC LK LR LT LV MD MG MK MN MX NO NZ PL RO RU SG SI SK SL TJ TM TR TT UA US UZ VN YU AM AZ BY KG KZ MD RU TJ TM |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
ENP | Entry into the national phase |
Ref document number: 2271664 Country of ref document: CA |
|
ENP | Entry into the national phase |
Ref country code: JP Ref document number: 1998 524753 Kind code of ref document: A Format of ref document f/p: F |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1997949529 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 74086/98 Country of ref document: AU |
|
WWP | Wipo information: published in national office |
Ref document number: 1997949529 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 74086/98 Country of ref document: AU |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1997949529 Country of ref document: EP |